Potential use of isolated glomeruli and cultured mesangial cells as in vitro models to assess nephrotoxicity

Cell Biology and Toxicology

Volumn 16, Issue 3, 2000, Pages 145-153

  Rodriguez Barbero, A ^a   L'azou, B ^b   Cambar, J ^b   Lopez Novoa J M ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Glomeruli; Kidney; Mesangial cells; Nephrotoxicity

Indexed keywords

ALPRAZOLAM; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CADMIUM; CALCIUM CHANNEL BLOCKING AGENT; CISPLATIN; CYCLOSPORIN A; CYCLOSPORIN A DERIVATIVE; CYCLOSPORIN A [8 DEXTRO O (2 HYDROXYETHYL)SERINE]; CYCLOSPORIN G; FELODIPINE; GENTAMICIN; GINKGOLIDE B; IMMUNOSUPPRESSIVE AGENT; NIFEDIPINE; SCAVENGER; TACROLIMUS; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOXANE SYNTHASE INHIBITOR; TOXIN; UNCLASSIFIED DRUG; VASOACTIVE AGENT; VERAPAMIL; XENOBIOTIC AGENT;

ARTICLE; CELL CULTURE; CELL FUNCTION; DRUG SCREENING; GLOMERULUS EPITHELIUM; GLOMERULUS FILTRATION RATE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY BLOOD FLOW; MEDIATOR RELEASE; MESANGIUM CELL; NEPHROTOXICITY; NONHUMAN; PERICYTE; PREDICTION; PRIORITY JOURNAL; TOXICOKINETICS; ULTRAFILTRATION;

EID: 0033803437     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007683320660     Document Type: Article

References (67)

1. + exchange, c-fos expression and mitogenesis in rat mesangial cells
2. Prevention of cyclosporin nephrotoxicity with a platelet-activating factor (PAF) antagonist
3. Oxidant mechanisms in toxic acute renal failure
4. Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor
5. Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity
6. Cadmium nephrotoxicity assessed in isolated rat glomeruli and cultured mesangial cells: Evidence for contraction of glomerular cells
7. Mechanisms of the defect in glomerular ultrafiltration associated with gentamicin administration
8. Renal effects of cyclosporine
9. Nephrotoxicity of immunosuppressive drugs
10. In vitro perfusion of juxtamedullary nephrons in rats
11. Advantages and limitations of the use of isolated kidney tubules in pharmacotoxicology
12. Cisplatin nephrotoxicity
13. Verapamil ameliorates acute cyclosporine A nephrotoxicity and improves immunosuppression after cadaver renal transplantation
14. Renal cytotoxicity of cisplatin in cultured glomerular mesangial and proximal and distal tubular cells
15. Antagonist capacities of nifedipine, captopril, phenoxybenzamine, prostacyclin and indomethacin on cyclosporin A induced impairment of rat renal function
16. Protective effects of O-(beta-hydroxyethyl)-rutoside on cisplatinum-induced renal failure in the rats
17. Effect of valproate on lactate and glutamine metabolism by rat renal cortical tubules
18. Effects of reactive oxygen species on cultured rat mesangial cells and isolated rat glomeruli
19. Segmental effects of norepinephrine and angiotensin II on isolated renal microvessels
20. Cyclosporineinduced acute renal dysfunction in the rat: Evidence for arteriolar vasoconstriction with preservation of tubular function
21. Nephrotoxicity screening in rats: A validation study
22. Verapamil protection against mercuric chloride-induced renal glomerular injury in rats
23. Cyclosporine nephrotoxicity assessed in isolated human glomeruli and cultured mesangial cells
24. FK 506: Effects on glomerular hemodynamics and on mesangial cells in culture
25. Renal circulatory and nephron function in experimental acute renal failure
26. The effect of calcium channel blockers on the cyclosporine dose requirement in renal transplant recipients
27. Glomerular cells in culture
28. Effect of gentamicin on p-aminohippurate metabolism and transport in rat kidney slices
29. Prevention of cyclosporin-induced vasoconstriction effect in rat isolated glomeruli with pharmacological vasoactive agents
30. Use of two in vitro models to study the renal vasoreactivity of cyclosporin
31. Protective effect of verapamil in cyclosporin-incubated human and murine isolated glomeruli
32. In vitro models to study mechanisms involved in cyclosporine A mediated glomerular contraction
33. Renal effects and mesangial cell contraction induced by endothelin are mediated by PAF
34. Potential role of platelet activating factor in acute renal failure
35. Adenosine induces a calcium-dependent glomerular contraction
36. The nephrotoxicity of FK 506 as compared to cyclosporine
37. Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase)
38. Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation
39. Relations between liver cadmium, cumulative exposure and renal function in cadmium alloy workers
40. Physiology of the mesangium
41. Effect of cyclosporine administration on renal hemodynamics in conscious rats
42. Adenosine induces mesangial cell contraction by an A1-type receptor
43. Effects of adenosine and adenosine analogues on cAMP accumulation in cultured rat mesangial cells and isolated glomeruli
44. The effect of calcium blocker with verapamil on experimental cyclosporine nephrotoxicity
45. Cyclosporine A nephrotoxicity: Role of thromboxane and reactive oxygen species
46. Effect of platelet activating factor antagonist on cyclosporin nephrotoxicity: Glomerular hemodynamics evaluation
47. Role of platelet activating factor in gentamicin and cisplatin nephrotoxicity
48. Reactive oxygen species mediate the effects of cyclosporine A on human cultured mesangial cells
49. Cyclosporin A augments vasoconstrictor induced rise in intracellular free calcium in rat mesangial cells
50. Cross talk between transmembrane signalling system: A pre-requisite for a delicate regulation of glomerular haemodynamics by mesangial cells
51. Comparative study of cyclosporin A, cyclosporin G, and the novel cyclosporin derivative IMM 125 in isolated glomeruli and cultured rat mesangial cells: A morphometric analysis
52. Increased glomerular nitric oxide synthesis in gentamicin-induced renal failure
53. Gentamicin treatment increases mesangial cell nitric oxide production
54. Gentamicin activates rat mesangial cells. A role for platelet activating factor
55. Role of PAF in gentamicin-induced renal failure
56. Actions of cyclosporin A on cultured rat mesangial cells
57. Cyclosporine nephrotoxicity
58. Cisplatin nephrotoxicity
59. Pathophysiology of altered glomerular function in amino-glycoside-treated rats
60. Effect of platelet activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release and contraction of cultured rat mesangial cells
61. Modification of cisplatinum toxicity by antioxidants
62. Evidence of renal glomerular receptors for angiotensin II
63. Stimulation of prostaglandin E2 and thromboxane B2 production in cultured rat mesangial cells by platelet-activating factor: Inhibition by a specific receptor antagonist
64. Culture de cellules glomerulaires
65. Endothelin ET(A) and ET(B) receptors mediate vasoconstriction and prostanoid release in isolated kidney of the rat
66. Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat
67. Glomerular hemodynamics in cyclosporine nephrotoxicity following nephrectomy