Glomerular basement membrane alterations induced by gentamicin administration in rats

Experimental and Toxicologic Pathology

Volumn 60, Issue 1, 2008, Pages 69-75

  Stojiljkovic, Nenad ^a   Mihailovic, Dragan ^a   Veljkovic, Slavimir ^a   Stoiljkovic, Milan ^a   Jovanovic, Ivan ^a  

^a UNIVERSITY OF NI   (Serbia)

Author keywords

Gentamicin; Glomerular basement membrane; Morphometry; Nephrotoxicity; Rats

Indexed keywords

CREATININASE; EOSIN; GENTAMICIN; HEMATOXYLIN; METHENAMINE; POTASSIUM; SODIUM; SODIUM CHLORIDE; UREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; GLOMERULUS BASEMENT MEMBRANE; HISTOLOGY; KIDNEY PROXIMAL TUBULE; MALE; MEMBRANE STRUCTURE; NEPHROTOXICITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OPTICAL DENSITY; PERIODIC ACID SCHIFF STAIN; POTASSIUM BLOOD LEVEL; RAT; SODIUM BLOOD LEVEL; UREA BLOOD LEVEL;

ANIMALS; ANTI-BACTERIAL AGENTS; CREATININE; GENTAMICINS; GLOMERULAR BASEMENT MEMBRANE; INJECTIONS, INTRAPERITONEAL; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES, PROXIMAL; MALE; PERIODIC ACID-SCHIFF REACTION; POTASSIUM; RATS; RATS, WISTAR; SILVER STAINING; SODIUM; UREA;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 44149088045     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2008.02.007     Document Type: Article

References (31)

1. Ali B.H. Gentamicin nephrotoxicity in humans and animals: some recent research. Gen Pharmacol 7 (1995) 1477-1487
2. Ali B.H. Agents ameliorating or augmenting experimental gentamicin nephrotoxicity: some recent research. Food Chem Toxicol 41 (2003) 1447-1452
3. Bennett W.M., Elliot W.C., Houghton D.C., Gilbert D.N., Defehr J., and McCarron D.A. Reduction of experimental gentamicin nephrotoxicity in rats by dietary calcium loading. Antimicrob Agents Chemother 22 (1982) 508-512
4. Bennett W.M. Mechanisms of aminoglycoside nephrotoxicity. Clin Exp Pharmacol Physiol 16 (1989) 1-6
5. Bennett W.M., Burdmann E.A., Andoh T.F., Houghton D.C., Lindsley J., and Elzinga L.W. Nephrotoxicity of immunosuppressive drugs. Nephrol Dial Transplant 9 (1994) 141-145
6. Cojocel C., Docius N., Maita K., Smith J.H., and Hook J.B. Renal ultrastructural and biochemical injuries induced by aminoglycosides. Environ Health Perspect 57 (1984) 293-299
7. Davis B.D., Weisblum B., and Davies J. Antibiotic inhibitors of the bacterial ribosome. Bacteriol Rev 32 (1968) 493-528
8. De Rougemont D., Oeschger A., Konrad L., Thiel G., Torhorst J., Wenk M., et al. Gentamicin-induced acute renal failure in the rat. Effect of dehydration, DOCA-saline and furosemide. Nephron 29 (1981) 176-184
9. Erdem A., Gundogan N.U., Usubutun A., Kilinc K., Erdem S.R., Kara A., et al. The protective effect of taurine against gentamicin-induced acute tubular necrosis in rats. Nephrol Dial Transplant 15 (2000) 1175-1182
10. Fent K., Mayer E., and Zbinden G. Nephrotoxicity screening in rats: a validation study. Arch Toxicol 61 (1988) 349-358
11. Gilbert N. Aminoglycosides. In: Mandell G.L., Bennett J.E., and Dolin R. (Eds). Principles and practice of infectious disease. 5th ed. (2000), Churchill Livingstone, New York 307-336
12. Kopple J.D., Ding H., Letoha A., Ivanyi B., Qing D.P., Dux L., et al. l-carnitine ameliorates gentamicin-induced renal injury in rats. Nephrol Dial Transplant 17 (2002) 2122-2131
13. Laurent G., Carlier M.B., Rollman B., Van Hoof F., and Tulkens P. Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin. Biochem Pharmacol 31 (1982) 3861-3870
14. Laurent G., Maldague P., Carlier M.B., and Tulkens P.M. Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats. Antimicrob Agents Chemother 24 (1983) 586-593
15. Martinez-Salgado C., Eleno N., Morales A.I., Perez-Barriocanal F., Arevalo M., and Lopez-Novoa J. Gentamicin treatment induces simultaneous mesangial proliferation and apoptosis in rats. Kidney Int 65 (2004) 2161-2171
16. Mazzon E., Britti D., De Sarro A., Caputi A.P., and Cuzzocrea S. Effect of N-acetylcysteine on gentamicin-mediated nephropathy in rats. Eur J Pharmacol 424 (2001) 75-83
17. Mene P., Simonson M.J., and Dunn M.S. Physiology of the mesangium. Physiol Rev 64 (1989) 1347-1370
18. Mingeot-Leclercq M.P., and Tulkens P.M. Aminoglycosides: nephrotoxicity. Antimicrob Agents Chemother 43 (1999) 1003-1012
19. Mingeot-Leclercq M.P., Glupczynski Y., and Tulkens P.M. Aminoglycosides: activity and resistance. Antimicrob Agents Chemother 43 (1999) 727-737
20. Moudden M., Laurent G., Leclercq M., and Tulkens P. Gentamicin induced apoptosis in renal cell lines and embryonic rat fibroblasts. Toxicol Sci 56 (2000) 229-239
21. Parker R.A., Gilbert D.N., Houghton D.C., Porter G.A., and Bennett W.M. Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats. Antimicrob Agents Chemother 18 (1980) 346-348
22. Parlakpinar H., Tasdemir S., Polat A., Bay-Karabulut A., Vardi N., Ucar M., et al. Protective effect of chelerythrine on gentamicin-induced nephrotoxicity. Cell Biochem Funct 24 (2006) 41-48
23. Pedraza-Chaverrí J., Gonzalez-Orozcoa A.E., Maldonado P.D., Barrera D., Medina-Campos O.N., and Hernandez-Pando R. Diallyl disulfide ameliorates gentamicin induced oxidative stress and nephropathy in rats. Eur J Pharmacol 473 (2003) 71-78
24. Pedraza-Chaverrí J., Barrera D., Maldonado P.D., Chirino Y.I., Macías-Ruvalcaba N.A., Medina-Campos O.N., et al. S-allylmercaptocysteine scavenges hydroxyl radical and singlet oxygen in vitro and attenuates gentamicin-induced oxidative and nitrosative stress and renal damage in vivo. BMC Clin Pharmacol 4 (2004) 5
25. 7-induced nephrotoxicity. BMC Nephrol 6 (2005) 4
26. Rodriguez-Barbero A., L'Azou B., Cambar J., and Lopez-Novoa J.M. Potential use of isolated glomeruli and cultured mesangial cells as in vitro models to assess nephrotoxicity. Cell Biol Toxicol 16 (2000) 145-153
27. Servais H., Jossin Y., Van Bambeke F., Tulkens V.M., and Mingeot-Leclercq M.-P. Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation. Antimicrob Agents Chemother 50 (2006) 1213-1221
28. Smaoui H., Mallie J.-P., Schaeverbeke M., Robert A., and Schaeverbeke J. Gentamicin administered during gestation alters glomerular basement membrane development. Antimicrob Agents Chemother 37 (1993) 1510-1517
29. Sundin D.P., Sandoval R., and Molitoris B.A. Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. J Am Soc Nephrol 12 (2001) 114-123
30. Susin S.A., Lorenzo H.K., Zamzami N., Marzo I., Brenner C., Larochette N., et al. Mitochondrial release of caspase-2 and -9 during the apoptotic process. J Exp Med 189 (1999) 381-394
31. Tulkens P.M., Mingeot-Leclercq M.P., Laurent G., and Brasseur R. Conformational and biochemical analysis of the interactions between phospholipids and aminoglycoside antibiotics in relation with their toxicity. In: Brasseur R. (Ed). Molecular description of biological membrane components by computer-aided conformational analysis (1990), CRC Press Inc., Boca Raton, FL 63-93