Mechanism of dominant-negative telomerase function

Cell Cycle

Volumn 8, Issue 19, 2009, Pages 3227-3233

  Nguyen, Binh N ^a   Elmore, Lynne W ^a   Holt, Shawn E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Degradation; Dominant negative; Nuclear export; Telomerase; Telomere; Ubiquitination

Indexed keywords

GREEN FLUORESCENT PROTEIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIMERIZATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TELOMERE; UBIQUITINATION; WILD TYPE;

EID: 70349906783     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.19.9788     Document Type: Article

References (30)

1. Aubert G, Lansdorp PM. Telomeres and aging. Physiol Rev 2008; 88:557-579
2. Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat Genet 1997; 17:498-502. (Pubitemid 27518407)
3. Collins K. Physiological assembly and activity of human telomerase complexes. Mech Ageing Dev 2008; 129:91-98 (Pubitemid 351199863)
4. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, et al. Extension of life-span by introduction of telomerase into normal human cells. Science 1998; 279:349-352 (Pubitemid 28063364)
5. Vaziri H, Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 1998; 8:279-282 (Pubitemid 28111458)
6. Jiang XR, Jimenez G, Chang E, Frolkis M, Kusler B, Sage M, et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat Genet 1999; 21:111-114 (Pubitemid 29036295)
7. Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, et al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat Genet 1999; 21:115-118 (Pubitemid 29036296)
8. Ramirez RD, Herbert BS, Vaughan MB, Zou Y, Gandia K, Morales CP, et al. Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells. Oncogene 2003; 22:433-444
9. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999; 400:464-468
10. Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A, et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 1999; 5:1164-1170 (Pubitemid 29474421)
11. Chan WM, Siu WY, Lau A, Poon RY. How many mutant p53 molecules are needed to inactivate a tetramer? Mol Cell Biol 2004; 24:3536-3551
12. Tesmer VM, Ford LP, Holt SE, Frank BC, Yi X, Aisner DL, et al. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol Cell Biol 1999; 19:6207-6216 (Pubitemid 29399325)
13. Wenz C, Enenkel B, Amacker M, Kelleher C, Damm K, Lingner J. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J 2001; 20:3526-3534 (Pubitemid 32634359)
14. Beattie TL, Zhou W, Robinson MO, Harrington L. Functional multimerization of the human telomerase reverse transcriptase. Mol Cell Biol 2001; 21:6151-6160 (Pubitemid 34263515)
15. Moriarty TJ, Huard S, Dupuis S, Autexier C. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol Cell Biol 2002; 22:1253-1265 (Pubitemid 34094860)
16. Wong JM, Kusdra L, Collins K. Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat Cell Biol 2002; 4:731-736 (Pubitemid 34993712)
17. Bross P, Corydon TJ, Andresen BS, Jørgensen MM, Bolund L, Gregersen N. Protein misfolding and degradation in genetic diseases. Hum Mutat 1999; 14:186-198 (Pubitemid 29407260)
18. Gregersen N, Bross P, Jørgensen MM, Corydon TJ, Andresen BS. Defective folding and rapid degradation of mutant proteins is a common disease mechanism in genetic disorders. J Inherit Metab Dis 2000; 23:441-447 (Pubitemid 30487873)
19. Holt SE, Shay JW. Role of telomerase in cellular proliferation and cancer. J Cell Physiol 1999; 180:10-18
20. Poynter KR, Sachs PC, Breed MS, Bright AT, Nguyen BN, Elmore LW, Holt SE. Genetic inhibition of telomerase: implications for recovery and chemosensitization. Molec Cancer Ther 2009; 8:1319-1327
21. von Mikecz A. The nuclear ubiquitin-proteasome system. J Cell Sci 2006; 119:1977-1984
22. Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, et al. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol 1999; 19:4535-4545 (Pubitemid 29242026)
23. Connell P, Ballinger CA, Jiang J, Wu Y, Thompson LJ, Höhfeld J, et al. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat Cell Biol 2001; 3:93-96 (Pubitemid 32114838)
24. Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, et al. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev 1999; 13:817-826 (Pubitemid 29169841)
25. Kaushik N, Rege N, Yadav PN, Sarafianos SG, Modak MJ, Pandey VN. Biochemical analysis of catalytically crucial aspartate mutants of human immunodeficiency virus type 1 reverse transcriptase. Biochemistry 1996; 35:11536-11546 (Pubitemid 26303670)
26. Delhommeau F, Thierry A, Feneux D, Lauret E, Leclercq E, Courtier MH, et al. Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant. Oncogene 2002; 21:8262-8271 (Pubitemid 35477866)
27. Bae VL, Jackson-Cook CK, Brothman AR, Maygarden SJ, Ware JL. Tumorigenicity of SV40 T antigen immortalized human prostate epithelial cells: association with decreased epidermal growth factor receptor (EGFR) expression. Int J Cancer 1994; 58:721-729
28. Akalin A, Elmore LW, Forsythe HL, Amaker BA, McCollum ED, Nelson PS, et al. A novel mechanism for chaperone-mediated telomerase regulation during prostate cancer progression. Cancer Res 2001; 61:4791-4796 (Pubitemid 32691893)
29. Gan Y, Engelke KJ, Brown CA, Au JL. Telomere amount and length assay. Pharm Res 2001; 18:1655-1659
30. Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE, Liss HS, et al. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem 2000; 275:10072-10076 (Pubitemid 30202057)