Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay

Cancer Letters

Volumn 110, Issue 1-2, 1996, Pages 155-162

  Hagiwara, A ^a   Matsuda, T ^b   Tamano, S ^a   Kitano, M ^b   Imaoka, S ^b   Funae, Y ^b   Takesada, Y ^a,c   Shirai, T ^c   Fukushima, S ^b  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Dose response; F344 rats; GST P positive hepatocytic foci; Hepatic P 450 level; Phenobarbital sodium

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; DIETHYLNITROSAMINE; GLUTATHIONE TRANSFERASE; LIVER ENZYME; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INDUCTION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; TUMOR PROMOTION;

ANIMALS; BIOLOGICAL ASSAY; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE TRANSFERASE; LIVER; MALE; PHENOBARBITAL; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0030596096     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(96)04478-3     Document Type: Article

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