Screening of antimutagenicity via antioxidant activity in different extracts from the flowers of Phlomis crinita Cav. ssp mauritanica munby from the center of Tunisia

Drug and Chemical Toxicology

Volumn 32, Issue 3, 2009, Pages 283-292

  Dellai, Afef ^a   Mansour, Hedi Ben ^a   Limem, Ilef ^a   Bouhlel, Ines ^a   Sghaier, Mohamed Ben ^a   Boubaker, Jihed ^a   Ghedira, Kamel ^a   Chekir Ghedira, Leila ^a,b  

^a UNIVERSITY OF MONASTIR   (Tunisia)

^b Laboratoire de Biologie Cellulaire et Moléculaire   (Tunisia)

Author keywords

Ames test; Antimutagenic effect; Antioxidant activity; Free radical scavenging activity; Phlomis crinita

Indexed keywords

2 AMINOANTHRACENE; ACETIC ACID ETHYL ESTER; ALKALOID DERIVATIVE; ANTHRAQUINONE DERIVATIVE; CARDIAC GLYCOSIDE; CHLOROFORM; COUMARIN DERIVATIVE; FLAVONOID; IRIDOID; MESYLIC ACID METHYL ESTER; METHANOL; PHLOMIS CRINITA EXTRACT; PLANT EXTRACT; SAPONIN DERIVATIVE; STEROL DERIVATIVE; TANNIN DERIVATIVE; UNCLASSIFIED DRUG; XANTHINE; XANTHINE OXIDASE; 2-ANTHRAMINE; ANTHRACENE DERIVATIVE; ANTIMUTAGENIC AGENT; MUTAGENIC AGENT; RIBOSOMAL PROTEIN S9; RIBOSOME PROTEIN; SCAVENGER; SOLVENT; SUPEROXIDE;

AMES TEST; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG ISOLATION; FLOWER; MUTAGENICITY; NONHUMAN; PHLOMIS; PHLOMIS CRINITA; SALMONELLA TYPHIMURIUM; TUNISIA; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; RAT;

PHLOMIS; PHLOMIS CRINITA; SALMONELLA TYPHIMURIUM;

ANIMALS; ANTHRACENES; ANTIMUTAGENIC AGENTS; FLOWERS; FREE RADICAL SCAVENGERS; METHYL METHANESULFONATE; MUTAGENS; PHLOMIS; PLANT EXTRACTS; RATS; RIBOSOMAL PROTEINS; SALMONELLA TYPHIMURIUM; SOLVENTS; SUPEROXIDES; TUNISIA; XANTHINE OXIDASE;

EID: 70349895471     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540902882200     Document Type: Article

References (55)

1. Ames, B.N., Kammen, H.O., Yamasaki, E. (1975). Methods for detecting carcinogens and mutagenicity with the Salmonella/mammalian- microsome mutagenicity test. Mutat Res 31:347-364.
2. Ansah, C.H., Khan, A., Gooderham, J.N. (2005). In vitro genotoxicity of the west African antimalarian herbal Crytolepsis sanguinolenta and its major alkaloid crytolepine. Toxicology 208:141-147.
3. Argolo, A.C.C., Sant'Ana, A.E.F., Pleisch, M., Coelho, L.C.B.B. (2004). Antioxidant activity of leaf extracts from Bauhinia monandra. Bio Technol 95:229-233.
4. Baratto, M.C., Tattinin, M., Galardi, C., Pinelli, P., Romani, A., Visioli, F., et al. (2003). Antioxidant activity of galloyl quinic derivatives isolated from Pistacia lentiscus leaves. Free Rad Res 37:405-412.
5. Bucar, F., Ninov, S., Inokova, I., Kartnig, T., Schubert-Zsilavecz, M., Asenove, I. (1998). Flavonoids from Phlomis nissoli. Pytochemistry 3:573-575.
6. Ben Mansour, H., Boubaker, J., Bouhlel, I., Mahmoud, A., Bernillon, S., Ben Chiban, J. (2007). Antigenotoxic activities of crude extracts from Acacia salicina leaves. Environ Mol Mut 48:58-66.
7. Bradford, M.M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Ann Biochem 72:248-254.
8. Calomme, M., Pieters, L., Vlietink, A., Berghe, D.V. (1996). Inhibition of bacterial mutagenesis flavonoids. Planta Med 62:222-226
9. Chiang, H. (1992). Antitumor agent, physalin F, from Physalis angulata L. Anticancer Res 12:837-843.
10. Chibani, J., Ghedira, K., Chekir-Ghedira, L. (2007). Antigenotoxic activities of crude extracts from Acacia salicina leaves. Environ Mol Mutat 48:58-66.
11. Cimanga, K., De Bruyne, T., Hu, J.P., Cos, P., Apers, S., Piters, L., et al. (1999). Constituents from Morinda morindoïdes leaves as inhibitors of xanthine oxidase and scavengers of superoxide anions. Pharm Pharmacol Com 5:419-424.
12. Cos, P., Ying, L., Calomme, M., Hu, J.P., Cimanga, K., Van, Poel B, et al. (1998). Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J Nat Prod 61:71-76.
13. Couladis, M., Tanimanidis, A., Tzakou, O., Chinou, I.B., Harvala, C. (2000). Essential oil of Phlomis lanata growing in Greece: chemical composition and antimicrobial activity. Planta Med 66:670-672.
14. Couladis, M., Tzakou, O., Verkokidou, E., Harvala, C. (2003). Screening of some Greek aromatic plants for antioxidant activity. Phytother Res 17:194-195.
15. De, Flora S. (1998). Mechanisms of inhibitors of mutagenesis and carcinogenesis. Mutat Res 420:151-158.
16. Dohou, N., Yamni, K., Tahrouch, S., Hassani Idrissi, L.M., Badoc, A., Gmira, N. (2003). Phytochemical Screening of an endemic Ibéro-Marocan, Thymelaea lythoroïdes. Bull Soc Pharm 142:61-78.
17. Edenharder, R., Grûnhage, D. (2000). Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. Mutat Res 540:1-18.
18. Elgorashi, E.E., Taylor, J.L.S., Maes, A., Van, S.J., De Kimpe, N., Schaeve, L. (2003). Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Toxicol Lett 143:195-207.
19. Ersoz, T., Alipieva, K.I., Yalcin, F.N., Akbay, P., Handjieva, N., Dönmez, A.A., et al. (2003). Physocalycoside, a new phenylethanoïd glycoside from Phlomis physocalyx Hub.-Mor. Z Nat [c] 58:471-476.
20. Ferguson, R.L., Philpott, M., Karunasinghe, N. (2004). Dietary cancer and prevention using antimutagens. Toxicology 198:147-159.
21. Fernandes, J.B.F., Vargas, V.M.F. (2003). Mutagenic and antimutagenic potential of the medicinal plants M. Laevigata and C. Xanthocarpa. Phyt Res 17:269-273.
22. Finkel, T., Holbrook, N.J. (2000). Oxidative stress and the biology of ageing. Nature 408:239-247.
23. Gonzalez-Avila, M., Arriaga-Alba, M., De la Garza, M., Del Carmen Hermandez-Preteline, M., Dominguez-Ortiz, M.A., Fattel-Fazenda, S., et al. (2003). Antigenotoxic, antimutagenic, and ROS scavenging activities of a Rhoeo discolor ethanolic crude extract. Toxicol In Vitro 17:77-83.
24. Harput, U.S., Calis, I., Sara Coglu, I., Dönmez, A.A., Nagatsu, A. (2006). Secondary metabolites from Phlomis syriaca and their antioxidant activities. Turk J Chem 30:383-390.
25. Hartman, P.E., Ames, B.N., Roth, J.R., Branes, W.N., Levin, D.E. (1986). Target sequences for mutagenesis in Salmonella histidine- requiring mutants. Environ Mutat 8:631-641.
26. Horn, R.C., Ferrao, V.V.M. (2003). Antimutagenic activity of extracts of natural substances in the Salmonella microsome assay. Mutagenesis 18:113-118.
27. Ikuma, N.E.M., Passoni, H.M., Biso, I.F., Longo, C.M., Cardoso, P.R.C., Campaner, S.L., et al. (2006). Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium. Toxicol In Vitro 20:361-366.
28. Koch, W.H., Henrikson, E.N., Cebula, T.A. (1996). Molecular analyses of Salmonella hisG428 ochre revertants for rapid characterization of mutational specificity. Mutagenesis 11:341-348.
29. Kyriacopoulo, I., Magiatis, P., Skaltounis, A., Aligiannis, N., Harvala, C., Samioside, R. (2001). A new phenylethanoid glycoside with free-radical scavenging and antimicrobial activities from Phlomis samia. J Nat Pro 64:1095-1097.
30. Lee, N.J., Choi, J.H., Koo, B.S., Ryu, S.Y., Han, Y.H., Lee, S.I., et al. (2005). Antimutagenicity and cytotoxicity of the constituents from the aereal parts of Rumex acetosa. Biol Pharm Bull 28:2158-2161.
31. Lee, S.E., Shin, H.T., Hwang, H.J., Kim, J.H. (2003). Antioxidant activity of extracts from Alpinia katsumadai seed. Phytot Res 17:1041-1047.
32. Levin, D.E., Hollstein, M., Christman, M.F., Schwiers, E.A., Ames, B.N. (1982). A new Salmonella tester strain (TA102) with A.T base pairs at the site of mutation detects oxidative mutagens. Proc Natl Acad Sci 79:7445-7449.
33. Marnewick, L.J., Gelderblom, C.A.W., Joubert, E. (2000). An investigation on the antimutagenic properties of South African teas. Mutat Res 471:157-166.
34. Maron, D.M., Ames, B.N. (1983). Revised methods of the Salmonella mutagenicity test. Mutat Res 113:173-215.
35. Marques, R.C.P., DeMedeiros, S.R.B., Da Silva Dias, C., Barbosa-Filho, J.M., Agnez-Lima, L.F. (2003). Evaluation of the mutagenic potential of yangambin and of the hydroalcoholic extract of Ocotea duckei by the Ames test. Mutat Res 536:117-120.
36. Paris, R.R., Moyse, H. (1967). Handbook of Medical material, Volume II. Paris: Masson et Cle.
37. Parisa, S., Mohammad, A., Abbas, S. (2003). Antinociceptive effect of Phlomis olivieri Benth., Phlomis anisodonta Boiss., and Phlomis persica Boiss. total extracts. Pharmacol Res 48:263-266.
38. Pascual, M.E., Carretero, M.E., Slowing, K.U., Villar, A. (2002). Simplified screening by TLC of plant drugs. Pharm Bio 40:139-143.
39. Porter, L.J., Hrstich, L.N., Chan, B.G. (1986). The conversion of procyanidins and prodelphinidins to cyaniding and delphinidin. Phytochemistry 25:223-230.
40. Re, R., Pellegrini, N., Proteggente, A. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Rad Bio Med 26:1231-1237.
41. Reid, K.A., Maes, J., Maes, A., van, Staden J, De Kimpe, N., Mulholland, D.A., et al. (2006). Evaluation of the mutagenic and antimutagenic effects of South African plants. J Ethnopharm 106:44-50.
42. Reyes-López, M., Villa-Treviño, S., Arriaga-Alba, M., Alemán-Lazarini, L., Rodríguez-Mendiola, M., Arias-Castro, C., et al. (2005). The amoebicidal aqueous extract from Castela texana possesses antigenotoxic and antimutagenic properties. Toxicol In Vitro 19:91-97.
43. Sander, C.S., Chang, H., Hamm, F., Elsner, P., Thiele, J.J. (2004). Role of oxidative stress and the antioxidant network in cutaneous carcinogenesis. Int J Dermatol 43:326-335.
44. Saracoglu, I., Kojima, K., Harput, U.S., Ogihara, Y. (1998). A new phenylethanoid glycoside from Phlomis pungens Willd. Var. pungens. Chem Pharm Bull 4:726-727.
45. Saracoglu, I., Inoue, M., Calis, I., Ogihara, Y. (1995). Studies on constituent with cytotoxic and cytostatic and activity of two Turkish medicinal plants, Phlomis armenica and Scutellaria salviflora. Biol Pharm Bull 10:1396-1400.
46. Schuldt, E.Z., Farias, M.R., Ribeiro-do-Valle, R.M., Ckless, K. (2004). Comparative study of radical scavenger activities of crude extract and fractions from Cuphea carthagenensis leaves. Phytomedicine 11:523-529.
47. Skandrani, I., Ben Sghaier, M., Neffati, A., Boubaker, J., Bouhlel, I., Kilani, S., et al. (2007). Antigenotoxic and free radical scavenging activities of extracts from Moricandia arvensis. Drug Chem Toxicol 30:361-382
48. Sokovic, M.D., Marin, P.D., Simic, D., Knezevic-Vukcevic, J., Vajs, V., Petrovic, S. (2002). Antimutagenic activity of essential oil and crude extract of Phlomis Fruticosa. Pharm Bio 40:311-314.
49. Stahl, E., Dumont, E., Jork, H., Kamus, L.J., Rozumek, K.E., Schorn, P.J. (1974). Chromarographic and microscopic analysis of drugs. Practical manual for the European pharmacopoeias. Modern entreprise of edition. Paris: Tec Et Doc.
50. Steele, V.E., Kello, V.G.J. (2005). Development of cancer chemopreventive drugs based on mechanistic approaches. Mutat Res 591:16-23.
51. Wagner, H., Bladt, S. (1996). Plant Drug Analysis, 2nd ed. Heidelberg/New York: Springer-Verlag Berlin.
52. Williamson, G., Faulkner, K., Plumb, G.W. (1998). Glucosinolates and phenolics as antioxidantes from plant foods. E J C P 7:17-21.
53. Yagi, A., Kubash, A., Okamura, N., Hararguchi, H., Moustafa, S.M., Khalifa, T.I. (2002). Antioxidant, free radical scavenging, and anti-inflammatory effects of aloesin derivatives in aloe vera. Planta Med 68:957-960.
54. Zani, F., Cuzzoni, M.T., Daglia, M., Benvenuto, S., Vampa, G., Mazza, P. (1993). Inhibition of mutagenicity in Salmonella typhimurium by Glycyrrhiza glabra extract, glycyrrhizinic acid, 18 alpha-, and 18 beta-glycyrrhetinic acids. Planta Med 59:502-507.
55. Zhang, C., Li, C., Feng, S.I., Shi, J.G. (1991). Iridoid glucosides from Phlomis rotata. Phytochemistry 12:4156-4158.Analyse chromatographique et microscopique des drogues. Manuel pratique pour les pharmacopées Européennes. Entreprise moderne d'edition. Paris: Tec Et Doc