Constituents from Morinda morindoides leaves as inhibitors of xanthine oxidase and scavengers of superoxide anions

Pharmacy and Pharmacology Communications

Volumn 5, Issue 6, 1999, Pages 419-424

  Cimanga, K ^a   De Bruyne, T ^a   Hu, J P ^a   Cos, P ^a   Apers, S ^a   Pieters, L ^a   Tona, L ^b   Kambu, K ^b   Vanden Berghe, D ^a   Vlietinck, A J ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b UNIVERSITY OF KINSHASA   (Congo)

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; APIGETRIN; CHRYSOERIOL; CHRYSOERIOL 7 NEOHESPERIDOSIDE; FLAVONOID; KAEMPFEROL; KAEMPFEROL 7 RHAMNOSYLSOPHOROSIDE; LUTEOLIN; LUTEOLIN 7 GLUCOSIDE; MORINDA MORINDOIDES EXTRACT; NICOTIFLORIN; PLANT EXTRACT; QUERCETIN; QUERCETIN 7,4' DIMETHYLETHER; QUERCITRIN; SUPEROXIDE; UNCLASSIFIED DRUG; XANTHINE OXIDASE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME INHIBITION; HYDROLYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0032792454     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: 10.1211/146080899128735009     Document Type: Article

References (25)

1. Bindoli, A., Valante, M., Cavallini, L. (1985) Inhibition action of quercetin on xanthine dehydrogenase activity. Pharmacol. Res. Comm. 17: 831-839
2. Bors, W., Saran, M. (1987) Radical scavenging by flavonoid antioxidants. Free Rad. Res. Comm. 2: 289-294
3. Bouquet, A. (1969) Féticheurs et Médecine Traditionnelle du Congo Brazzaville. O.R.S.T.O.M. Paris, p. 211
4. Cimanga, K., De Bruyne, T., Lasure, A., Li, Q., Pieters, L., Claeys, M., Vanden Berghe, D., Kambu, K., Tona, L., Vlietinck, A. J. (1995a) Flavonoid O glycosides from the leaves of Morinda morindoides. Phytochemistry 38: 1301-1303
5. Cimanga, K., De Bruyne, T., Lasure, A., Van Poel, B., Pieters, L., Vanden Berghe, D., Kambu, K., Tona, L., Vlietinck, A. J. (1995b) In vitro anticomplementary activity of constituents from Morinda morindoides. J. Nat. Prod. 58: 372-378
6. Cimanga, K., De Bruyne, T., Van Poel, B., Ma, Y., Claeys, M., Pieters, L., Kambu, K., Tona, L., Bakana, P., Vanden Berghe, D., Vlietinck, A. J. (1997) Complement modulating properties of a kaempferol 7 O rhamnosylsophoroside from the leaves of Morinda morindoides. Planta Med. 63: 220-223
7. Cos, P., Ying, L., Calomme, M., Hu, J. P., Cimanga, K., Van Poel, B., Pieters, L., Vlietinck, A. J., Vanden Berghe, D. (1998) Structure activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers. J. Nat. Prod. 61: 71-76
8. Cotelle, N., Bernier, J. L., Hénichart, J. P., Catteau, J. P., Gaydou, E., Wallet, J. C. (1992) Scavenger and antioxidant properties of ten synthetic flavones. Free Rad. Biol. Med. 13: 211-219
9. Harman, D. (1986) Free radical theory of aging: role of free radicals in the origination and evolution of life, aging, and disease processes. In: Johnson, J. E., Walford, R., Harman, D., Miquel, J. (eds) Free Radicals, Aging, and Degenerative Diseases. Alan R. Liss, Inc., New York, p. 349
10. Hatano, T., Yasuhara, T., Fukuda, T., Noro, T., Okuda, T. (1989) Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarycoumarin and glisoflavone, and inhibitory effect of licorice phenolics on xanthine oxidase. Chem. Pharm. Bull. 37: 3005-3009
11. Hatano, T., Yasuhara, T., Yoshihara, R., Ikegami, Y., Matsuda, M., Yazaki, K., Agata, I., Nishibe, S., Noro, T., Yoshizaki, M., Okuda, T. (1991) Inhibitory effect of galloylated flavonoids on xanthine oxidase. Planta Med. 57: 83-84
12. Hayashi, T., Sava, K., Kawasaki, M., Arisawa, M. (1988) Inhibition of cow's milk xanthine oxidase by flavonoids. J. Nat. Prod. 51: 345-348
13. Hu, J. P., Calomme, M., Lasure, A., De Bruyne, T., Pieters, L., Vlietinck, A., Vanden Berghe, D. A. (1995) Structure activity relationship of flavonoids with superoxide scavenging activity. Biol. Trace Element Res. 47: 327-331
14. Iio, M., Moriyama, A., Matsumoto, Y., Takaki, N., Fukumoto, M. (1985) Inhibition of xanthine oxidase by flavonoids. Agric. Biol. Chem. 49: 2173-2176
15. Kambu, K. (1990) Eléments de Phytothérapie Comparée. Plantes Médicinales Africaines. CRP, Kinshasa, p. 61
16. Liu, J., Xiao, P. G. (1994) Recent advances in the study of antioxidative effects of Chinese medicinal plants. Phytother. Res. 8: 445-451
17. McCord, J. M. (1985) Oxygen derived free radical in postischemic tissue injury. N. Engl. J. Med. 312: 159-163
18. Nakanishi, T., Nishi, M., Inada, A., Obata, H., Tanabe, N., Abe, S., Wakashiro, M. (1990) Two new potent inhibitors of xanthine oxidase from leaves of Perilla frutescens Britton var. Acuta kudo. Chem. Pharm. Bull. 38: 1772-1774
19. Noro, T., Oda, Y., Miyase, T., Ueno, A., Fukushima, S. (1983) Inhibitors of xanthine oxidase from flowers and buds of Daphne genkwa. Chem. Pharm. Bull. 31: 3984-3987
20. Oyangagui, Y. (1984) Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal. Biochem. 142: 290-296
21. Robak, J., Gryglewski, R. J. (1988) Flavonoids are scavengers of superoxide anions. Biochem. Pharmacol. 37: 837-841
22. .-. Free Rad. Biol. Med. 11: 1-8
23. Tate, R. M., Repine, J. E. (1984) Phagocytes, oxygen radicals and lung injury. In: Pryor, W. A. (ed.) Free Radicals in Biology.Vol. 6, Academic Press, New York, pp 199-212
24. Yuting, C., Rongliang, Z., Zhongjian, J., Yong, J. (1990) Flavonoids as superoxide scavengers and antioxidants. Free Rad. Biol. Med. 9: 19-21
25. Zhou, Y. C., Zheng, R. L. (1991) Phenolic compounds and an analog as superoxide anion scavengers and antioxidants. Biochem. Pharmacol. 42: 117-119.