Dysregulation of myeloid-specific transcription factors in congenital neutropenia: Rescue by namptnad+sirt1

Annals of the New York Academy of Sciences

Volumn 1176, Issue , 2009, Pages 94-100

  Skokowa, Julia ^a   Welte, Karl ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CEBP ; Nicotinamide phosphoribosyltransferase (NAMPT); PU.1; Severe congenital neutropenia

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; GRANULOCYTE COLONY STIMULATING FACTOR; LYMPHOID ENHANCER FACTOR 1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;

CELL MATURATION; CONFERENCE PAPER; GRANULOPOIESIS; HUMAN; MYELOPOIESIS; NEUTROPENIA; PATHOPHYSIOLOGY; SEVERE CONGENITAL NEUTROPENIA; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 70349833643     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.04963.x     Document Type: Conference Paper

References (23)

1. Skokowa, J., M. Germeshausen, C. Zeidler, et al. 2007. Severe congenital neutropenia: inheritance and pathophysiology. Curr. Opin. Hematol. 14: 22-28.
2. Zeidler, C., M. Germeshausen, C. Klein & K. Welte. 2009. Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia. Br. J. Haematol. 144: 459-467.
3. Horwitz, MS., Z. Duan, B. Korkmaz, et al. 2007. Neutrophil elastase in cyclic and severe congenital neutropenia. Blood 109: 1817-1824.
4. Skokowa, J., G. Cario, M. Uenalan, et al. 2006. LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutrope-nia. Nat. Med. 12: 1191-1197.
5. Welte, K., E. Platzer, L. Lu, et al. 1985. Purifi-cation and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc. Natl. Acad. Sci. USA 82: 1526-1530. (Pubitemid 15120576)
6. Bonilla, M.A., A.P. Gillio, M. Ruggeiro, et al. 1989. Effects of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with congenital agranulocytosis. N. Engl. J. Med. 320: 1574-1580.
7. Welte, K. & D. Dale. 1996. Pathophysiology and treatment of severe chronic neutropenia. Ann. Hema-tol. 72: 158-165. Review.
8. Skokowa, J., D. Lan, B.K. Thakur, et al. 2009. NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat. Med. 15: 151-158.
9. Rongvaux, A., R.J. Shea, M.H. Mulks, et al. 2002. Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur. J. Im-munol. 32: 3225-3234.
10. Belenky, P., K.L. Bogan & C. Brenner. 2007. NAD+ metabolism in health and disease. Trends Biochem. Sci. 32: 12-19.
11. Revollo, JR., A.A. Grimm & S. Imai. 2004. The NAD biosynthesis pathway mediated by nicoti-namide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279: 50754-50763.
12. Bitterman, KJ., R.M. Anderson, H.Y. Cohen, et al. 2002. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 277: 45099-45107.
13. Cohen, HY., C. Miller, K.J. Bitterman, et al. 2004. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390-392.
14. Hirai, H., P. Zhang, T. Dayaram, et al. 2006. C/EBPbeta is required for 'emergency' granu-lopoiesis. Nat. Immunol. 7: 732-739. Epub 2006 Jun 4.
15. Rosenbauer, F. & D.G. Tenen. 2007. Transcription factors in myeloid development: balancing differentiation with transformation. Nat. Rev. Immunol. 7: 105-117. Review.
16. Friedman, A.D. 2007. Transcriptional control of granulocyte and monocyte development. Oncogene 26: 6816-6828. Review.
17. Dahl, R., J.C. Walsh, D. Lancki, et al. 2003. Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat. Immunol. 4: 1029-1036.
18. Rosenbauer, F., B.M. Owens, L. Yu, et al. 2006. Lym-phoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nat. Genet. 38: 27-37.
19. Cochrane, S.W., Y. Zhao, R.S. Welner, et al. 2009. Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions. Blood 113: 1016-1026.
20. Cammenga, J., J.C. Mulloy, F.J. Berguido, et al. 2003. Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells. Blood 101: 2206-2214.
21. Buitenhuis, M., H.W. van Deutekom, L.P. Verha-gen, et al. 2005. Differential regulation of granu-lopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. Blood 105: 4272-4281.
22. Wagner, K., P. Zhang, F. Rosenbauer, et al. 2006. Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy. Proc. Natl. Acad. Sci. USA 103: 6338-6343.
23. Laslo, P., C.J. Spooner, A. Warmflash, et al. 2006. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 126: 755-766.