In-vivo imaging with small animal FDG-PET: A tool to unlock the secrets of epileptogenesis?

Experimental Neurology

Volumn 220, Issue 1, 2009, Pages 1-4

  O'Brien, Terence J ^a   Jupp, Bianca ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ARTICLE; BRAIN ATROPHY; EPILEPSY; EPILEPTIC STATE; EPILEPTOGENESIS; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; HUMAN; IMAGE PROCESSING; IMAGE QUALITY; MEDICAL RESEARCH; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TEMPORAL LOBE EPILEPSY; THREE DIMENSIONAL IMAGING;

EID: 70349798697     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.07.020     Document Type: Note

References (42)

1. Andre V., Dube C., Francois J., Leroy C., Rigoulot M.A., Roch C., Namer I.J., and Nehlig A. Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model. Epilepsia 48 Suppl. 5 (2007) 41-47
2. Bouilleret V., Valenti M.P., Hirsch E., Semah F., and Namer I.J. Correlation between PET and SISCOM in temporal lobe epilepsy. J. Nucl. Med. 43 (2002) 991-998
3. Carne R., O'Brien T.J., Kilpatrick C., MacGregor L., Hicks R., Murphy M., Kaye A., and Cook M.J. MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain 127 (2004) 2276-2285
4. Cavalheiro E.A., Naffah-Mazzacoratti M.G., Mello L.E., and Leite J.P. The pilocarpine model of seizures. In: Pitkänen A., Schwartzkroin P.A., and Moshé S.L. (Eds). Models of Seizures and Epilepsy (2006), Elsevier Academic Press, Burlington 433-448
5. Dedeurwaerdere S., Jupp B., and O'Brien T.J. Positron emission tomography in basic epilepsy research: a view of the epileptic brain. Epilepsia 48 (2007) 56-64
6. Dick A.P., Harik S.I., Klip A., and Walker D.M. Identification and characterization of the glucose transporter of the blood-brain barrier by cytochalasin B binding and immunological reactivity. Proc. Natl. Acad. Sci. U. S. A. 81 (1984) 7233-7237
7. Dube C., Boyet S., Marescaux C., and Nehlig A. Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat. Exp. Neurol. 167 (2001) 227-241
8. Franck G., Sadzot B., Salmon E., Maquet P., Peter J.M., Quaglia L., Delfiore G., and Lamotte D. Study of cerebral metabolism and blood flow in partial complex epilepsy and status epilepticus in man using positron emission tomography. Rev. Electroencephalogr. Neurophysiol. Clin. 16 (1986) 199-216
9. Gaillard W.D., Kopylev L., Weinstein S., Conry J., Pearl P.L., Spanaki M.V., Fazilat S., Fazilat S., Venzina L.G., Dubovsky E., and Theodore W.H. Low incidence of abnormal (18)FDG-PET in children with new-onset partial epilepsy: a prospective study. Neurology 58 (2002) 717-722
10. Goffin K., Van Paesschen W., Dupont P., and Van Laere K. Longitudinal microPET imaging of brain glucose metabolism in rat 2 lithium-pilocarpine model of epilepsy. Exp. Neurol. 217 (2009) 205-209
11. Gröhn O., and Pitkänen A. Magnetic resonance imaging in animal models of epilepsy-noninvasive detection of structural alterations. Epilepsia 48 Suppl 4 (2007) 3-10
12. Guo Y., Gao F., Wang S., Ding Y., Zhang H., Wang J., and Ding M.P. In vivo mapping of temporospatial changes in glucose utilization in rat brain during epileptogenesis: An (18)F-fluorodeoxyglucose-small animal positron emission tomography study. Neuroscience 162 (2009) 972-979
13. Henry T.R., Babb T.L., Engel Jr. J., Mazziotta J.C., Phelps M.E., and Crandall P.H. Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy. Ann. Neurol. 36 (1994) 925-927
14. Hume S.P., and Jones T. Positron emission tomography (PET) methodology for small animals and its application in radiopharmaceutical preclinical investigation. Nucl. Med. Biol. 25 (1998) 729-732
15. Jokeit H., Ebner A., Arnold S., Schuller M., Antke C., Huang Y., Steinmetz H., Seitz R.J., and Witte O.W. Bilateral reductions of hippocampal volume, glucose metabolism, and Wada hemispheric memory performance are related to the duration of mesial temporal lobe epilepsy. J. Neurol. 246 (1999) 926-933
16. Jupp B., and O'Brien T.J. Application of co-registration for imaging of animal models of epilepsy. Epilepsia 48 Suppl. 4 (2007) 82-89
17. Jupp B., Williams J., Binns D., Hicks R., and O'Brien T. Imaging small animal models of epileptogenesis. Neurology Asia 12 Suppl. 1 (2007) 51-54
18. Kawai N., Miyake K., Kuroda Y., Yamashita S., Nishiyama Y., Monden T., Sasakawa Y., and Nagao S. Magnetic resonance imaging and positron emission tomography findings in status epilepticus following severe hypoglycemia. Ann. Nucl. Med. 20 (2006) 371-376
19. Knowlton R.C., Abou-Khalil B., Sawrie S.M., Martin R.C., Faught R.E., and Kuzniecky R.I. In vivo hippocampal metabolic dysfunction in human temporal lobe epilepsy. Arch. Neurol. 59 (2000) 1882-1886
20. Knowlton R.C., Laxer K.D., Klein G., et al. In vivo hippocampal glucose metabolism in mesial temporal lobe epilepsy. Neurology 57 (2001) 1184-1190
21. Kornblum H.I., Araujo D.M., Annala A.J., Tatsukawa K.J., Phelps M.E., and Cherry S.R. In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat. Biotechnol. 18 (2000) 655-660
22. Kwan P., and Brodie M.J. Early identification of refractory epilepsy. N. Engl. J. Med. 342 (2000) 314-319
23. Lamusuo S., Jutila L., Ylinen A., Kalviainen R., Mervaala E., Haaparanta M., Jaaskelainen S., Partanen K., Vapalahti M., and Rinne J. [18F]FDG-PET reveals temporal hypometabolism in patients with temporal lobe epilepsy even when quantitative MRI and histopathological analysis show only mild hippocampal damage. Arch. Neurol. 58 (2001) 933-939
24. Lee S.K., Lee S.Y., Kim K.K., Hong K.S., Lee D.S., and Chung C.K. Surgical outcome and prognostic factors of cryptogenic neocortical epilepsy. Ann. Neurol. 58 (2005) 525-532
25. Liefaard L.C., Ploeger B.A., Molthoff C.F., de Jong H.W., Dijkstra J., van der Weerd L., Lammertsma A.A., Danhof M., and Voskuyl R.A. Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography. Epilepsia 50 (2009) 88-98
26. Mirrione M.M., Schiffer W.K., Siddiq M., Dewey S.L., and Tsirka S.E. PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy. Synapse 59 (2006) 119-121
27. Nelissen N., Van Paesschen W., Baete K., Van Laere K., Palmini A., Van Billoen H., and Dupont P. Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis. Neuroimage 32 (2006) 684-695
28. O'Brien T.J., Newton M.R., Cook M.J., Berlangieri S.U., Kilpatrick C., Morris K., and Berkovic S.F. Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy. Epilepsia 38 (1997) 74-80
29. O'Brien T.J., Hicks R.J., Ware R., Binns D.S., Murphy M., and Cook M.J. The utility of a 3-D, large-field-of-view, PENN-PET scanner for in the presurgical evaluation of partial epilepsy. J. Nucl. Med. 42 (2001) 1166-1173
30. O'Brien T., Miles K., Ware R., Cook M., Binns D., and Hicks R. The cost-effective use of 18-FDG-PET in the pre-surgical evaluation of medically refractory focal epilepsy. J. Nuc. Med. 49 (2008) 931-937
31. Paxinos G. The Rat Brain, In Stereotaxic Coordinates (1998), Academic Press, inc, San Diego
32. Radtke R.A., Hanson M.W., Hoffman J.M., et al. Temporal lobe hypometabolism on PET: predictor of seizure control after temporal lobectomy. Neurology 43 (1993) 1088-1092
33. Roulet-Perez E., Ballhausen D., Bonafé L., Cronel-Ohayon S., and Maeder-Ingvar M. Glut-1 deficiency syndrome masquerading as idiopathic generalized epilepsy. Epilepsia 49 (2008) 1955-1958
34. Rousset O.G., Ma Y., and Evans A.C. Correction for partial volume effects in PET: principle and validation. J. Nucl. Med. 39 (1998) 904-911
35. Semah F., Baulac M., Hasboun D., et al. Is interictal temporal hypometabolism related to mesial temporal sclerosis? A positron emission tomography/magnetic resonance imaging confrontation. Epilepsia 36 (1995) 447-456
36. Silva Brum L.F., and Elisabetsky E. Antiepileptogenic properties of phenobarbital: behavior and neurochemical analysis. Pharmacol. Biochem. Behav. 67 (2000) 411-416
37. Theodore W.H., DiChiro G., Margolin R., Fishbein D., Porter R.J., and Brooks R.A. Barbiturates reduce human cerebral glucose metabolism. Neurology 36 (1986) 60-64
38. Theodore W.H., Gaillard W.D., De Carli C., Bhatia S., and Hatta J. Hippocampal volume and glucose metabolism in temporal lobe epileptic foci. Epilepsia 42 (2001) 130-132
39. Vielhaber S., Von Oertzen J.H., Kudin A.F., Schoenfeld A., Menzel C., Biersack H.J., Kral T., Elger C.E., and Kunz W.S. Correlation of hippocampal glucose oxidation capacity and interictal FDG-PET in temporal lobe epilepsy. Epilepsia 44 (2003) 193-199
40. Vinton A., Carne R., Hicks R., Desmond P., Kilpatrick C., Kaye A., and O'Brien T. The extent of resection of FDG-PET hypometabolism relates to outcome of temporal lobectomy. Brain 130 (2007) 546-548
41. Wang D., Pascual J.M., Yang H., Engelstad K., Mao X., Cheng J., Yoo J., Noebels J.L., and De Vivo D.C. A mouse model for Glut-1 haploinsufficiency. Hum. Mol. Genet. 15 (2006) 1169-1179
42. Yun C.H., Lee S.K., Lee S.Y., Kim K.K., Jeong S.W., and Chung C.K. Prognostic factors in neocortical epilepsy surgery: multivariate analysis. Epilepsia 47 (2006) 574-579