Positron emission tomography in basic epilepsy research: A view of the epileptic brain

Epilepsia

Volumn 48, Issue SUPPL. 4, 2007, Pages 56-64

  Dedeurwaerdere, Stefanie ^a   Jupp, Bianca ^a   O'Brien, Terence J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Biological markers; Epilepsy models; Epileptogenesis; Neuroimaging; Small animal PET

Indexed keywords

2' METHOXYPHENYL (N 2' PYRIDINYL) 4 FLUOROBENZAMIDOETHYLPIPERAZINE F 18; ALPHA METHYL LEVO TRYPTOPHAN C 11; ANTICONVULSIVE AGENT; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; CARFENTANIL C 11; FLUMAZENIL; FLUMAZENIL C 11; FLUMAZENIL F 18; FLUORODEOXYGLUCOSE; FLUOROFLUMAZENIL F 18; METHYLNATRINDOL C 11; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

BRAIN FUNCTION; DIFFUSION WEIGHTED IMAGING; DISEASE SEVERITY; DRUG LABELING; EPILEPSY; EPILEPTOGENESIS; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; MEDICAL RESEARCH; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REPORTER GENE; REVIEW; SEIZURE; TEMPORAL LOBE EPILEPSY; VAGUS NERVE STIMULATION;

ANIMALS; BIOLOGICAL MARKERS; BRAIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EPILEPSY; EPILEPSY, TEMPORAL LOBE; FLUORODEOXYGLUCOSE F18; MICE; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RESEARCH DESIGN;

EID: 34548370668     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01242.x     Document Type: Review

References (56)

1. Carne RP, O'Brien TJ, Kilpatrick CJ, MacGregor LR, Hicks RJ, Murphy MA, Bowden SC, Kaye AH, Cook MJ 2004) MRI-negative PET-positive temporal lobe epilepsy: a distinct surgically remediable syndrome. Brain 127 : 2276 2285.
2. Casteels C, Vermaelen P, Nuyts J, Van Der Linden A, Baekelandt V, Mortelmans L, Bormans G, Van Laere K 2006) Construction and evaluation of multitracer small-animal PET probabilistic atlases for voxel-based functional mapping of the rat brain. J Nucl Med 47 : 1858 1866.
3. Catana C, Wu Y, Judenhofer MS, Qi J, Pichler BJ, Cherry SR 2006) Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner. J Nucl Med 47 : 1968 1976.
4. Chatziioannou AF. (2002) Molecular imaging of small animals with dedicated PET tomographs. Eur J Nucl Med Mol Imaging 29 : 98 114.
5. Choi JY, Kim SJ, Hong SB, Seo DW, Hong SC, Kim BT, Kim SE 2003) Extratemporal hypometabolism on FDG PET in temporal lobe epilepsy as a predictor of seizure outcome after temporal lobectomy. Eur J Nucl Med Mol Imaging 30 : 581 587.
6. Collins RC, McLean M, Olney J 1980) Cerebral metabolic response to systemic kainic acid: 14-C-deoxyglucose studies. Life Sci 27 : 855 862.
7. Dedeurwaerdere S, Cornelissen B, Van Laere K, Vonck K, Achten E, Slegers G, Boon P 2005) Small animal positron emission tomography during vagus nerve stimulation in rats: A pilot study. Epilepsy Res 67 : 133 141.
8. Dedeurwaerdere S, Gregoire M, Roselt P, Binns D, Katsifis A, Hicks R, O'Brien T, Meyers D 2006) Evaluation of [18F]fluoroflumazenil for in-vivo PET imaging of GABAA/cBZR density in small animal models of epilepsy. Epilepsia 47 : 301.
9. Dick AP, Harik SI, Klip A, Walker DM 1984) Identification and characterization of the glucose transporter of the blood-brain barrier by cytochalasin B binding and immunological reactivity. Proc Natl Acad Sci USA 81 : 7233 7237.
10. Diehl B, LaPresto E, Najm I, Raja S, Rona S, Babb T, Ying Z, Bingaman W, Luders HO, Ruggieri P 2003) Neocortical temporal FDG-PET hypometabolism correlates with temporal lobe atrophy in hippocampal sclerosis associated with microscopic cortical dysplasia. Epilepsia 44 : 559 564.
11. Duncan JS 2002) Neuroimaging methods to evaluate the etiology and consequences of epilepsy. Epilepsy Res 50 : 131 140.
12. Fong CY, Delgado-Escueta AV 1999) Ictal PET in temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 67 : 409.
13. Gronlund KM, Gerhart DZ, Leino RL, McCall AL, Drewes LR 1996) Chronic seizures increase glucose transporter abundance in rat brain. J Neuropathol Exp Neurol 55 : 832 840.
14. Hauser WA, Kurland LT 1975) The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967. Epilepsia 16 : 1 66.
15. Henry TR, Babb TL, Engel J Jr., Mazziotta JC, Phelps ME, Crandall PH 1994) Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy. Ann Neurol 36 : 925 927.
16. Herschman HR 2003) Micro-PET imaging and small animal models of disease. Curr Opin Immunol 15 : 378 384.
17. Hong SB, Han HJ, Roh SY, Seo DW, Kim SE, Kim MH 2002) Hypometabolism and interictal spikes during positron emission tomography scanning in temporal lobe epilepsy. Eur Neurol 48 : 65 70.
18. Ingvar M, Eriksson L, Rogers GA, Stone-Elander S, Widen L 1991) Rapid feasibility studies of tracers for positron emission tomography: high-resolution PET in small animals with kinetic analysis. J Cereb Blood Flow Metab 11 : 926 931.
19. Jacobs AH, Li H, Winkeler A, Hilker R, Knoess C, Ruger A, Galldiks N, Schaller B, Sobesky J, Kracht L, Monfared P, Klein M, Vollmar S, Bauer B, Wagner R, Graf R, Wienhard K, Herholz K, Heiss WD 2003) PET-based molecular imaging in neuroscience. Eur J Nucl Med Mol Imaging 30 : 1051 1065.
20. Jupp B, Williams J, Binns D, Vosmanski M, Hicks R, O'Brien TJ 2004) MRI and FDG-PET show progressive hippocampal changes during epileptogenesis in the amygdale kindling rat model of TLE. Epilepsia 45 : 19.
21. Jupp B, Binns D, Williams J, Hicks R, O'Brien TJ 2005) Serial FDG-PET during epileptogenesis in the rat kainic acid model of TLE reveals persistent cerebral hypometabolism. Epilepsia 46 : 289.
22. Jupp B, Williams J, Binns D, Hicks R, O'Brien TJ 2007) Imaging small animal models of epileptogenesis. Neurol Asia In press.
23. Knowlton RC, Laxer KD, Klein G, Sawrie S, Ende G, Hawkins RA, Aassar OS, Soohoo K, Wong S, Barbaro N 2001) In vivo hippocampal glucose metabolism in mesial temporal lobe epilepsy. Neurology 57 : 1184 1190.
24. Kobayashi M, Sasabe T, Takeda M, Kondo Y, Yoshikubo S, Imamura K, Onoe H, Sawada T, Watanabe Y 2002) Functional anatomy of chemical senses in the alert monkey revealed by positron emission tomography. Eur J Neurosci 16 : 975 980.
25. Koepp MJ, Hammers A, Labbe C, Woermann FG, Brooks DJ, Duncan JS 2000) 11C-flumazenil PET in patients with refractory temporal lobe epilepsy and normal MRI. Neurology 54 : 332 339.
26. Kornblum HI, Araujo DM, Annala AJ, Tatsukawa KJ, Phelps ME, Cherry SR 2000) In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET). Nat Biotechnol 18 : 655 660.
27. Kuhl DE, Engel J Jr., Phelps ME, Kowell AP 1978) Epileptic patterns of local cerebral metabolism and perfusion in man: investigation by emission computed tomography of 18F-fluorodeoxyglucose and 13N-ammonia. Trans Am Neurol Assoc 103 : 52 53.
28. Kuzniecky RI 2005) Neuroimaging of epilepsy: therapeutic implications. NeuroRx 2 : 384 393.
29. Kwan P, Brodie MJ 2000) Early identification of refractory epilepsy. N Engl J Med 342 : 314 319.
30. Laforest R, Sharp TL, Engelbach JA, Fettig NM, Herrero P, Kim J, Lewis JS, Rowland DJ, Tai YC, Welch MJ 2005) Measurement of input functions in rodents: challenges and solutions. Nucl Med Biol 32 : 679 685.
31. Liefaard L, Ploeger B, Molthoff C, Boellaard R, Lammertsma A, Danhof M, Voskuyl R 2005) Population pharmacokinetic analysis for simultaneous determination of Bmax and KD in vivo by positron emission tomography. Mol Imaging Biol 7 : 411 421.
32. Liefaard L, Ploeger B, Lammerstma A, Danhof M, Voskuyl R 2006) Changes in GABAA-receptor kinetics in amygdala kindled rats studied in vivo with positron emission tomography. Epilepsia 47 : 328.
33. Lucas AJ, Hawkes RC, Ansorge RE, Williams GB, Nutt RE, Clark JC, Fryer TD, Carpenter TA 2006) Development of a combined microPET-MR system. Technol Cancer Res Treat 5 : 337 341.
34. Matsumura A, Mizokawa S, Tanaka M, Wada Y, Nozaki S, Nakamura F, Shiomi S, Ochi H, Watanabe Y 2003) Assessment of microPET performance in analyzing the rat brain under different types of anesthesia: comparison between quantitative data obtained with microPET and ex vivo autoradiography. Neuroimage 20 : 2040 2050.
35. Merlet I, Ostrowsky K, Costes N, Ryvlin P, Isnard J, Faillenot I, Lavenne F, Dufournel D, Le Bars D, Mauguiere F 2004) 5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study. Brain 127 : 900 913.
36. Millan E, Abou-Khalil B, Delbeke D, Konrad P 2001) Frontal localization of absence seizures demonstrated by ictal positron emission tomography. Epilepsy Behav 2 : 54 60.
37. Mirrione MM, Schiffer WK, Siddiq M, Dewey SL, Tsirka SE 2006) PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy. Synapse 59 : 119 121.
38. Myers R, Hume S 2002) Small animal PET. Eur Neuropsychopharmacol 12 : 545 555.
39. O'Brien TJ, Newton MR, Cook MJ, Berlangieri SU, Kilpatrick C, Morris K, Berkovic SF 1997) Hippocampal atrophy is not a major determinant of regional hypometabolism in temporal lobe epilepsy. Epilepsia 38 : 74 80.
40. O'Brien TJ, Hicks RJ, Ware R, Binns DS, Murphy M, Cook MJ 2001) The utility of a 3-dimensional, large-field-of-view, sodium iodide crystal-based PET scanner in the presurgical evaluation of partial epilepsy. J Nucl Med 42 : 1158 1165.
41. Pain F, Laniece P, Mastrippolito R, Gervais P, Hantraye P, Besret L 2004) Arterial input function measurement without blood sampling using a beta-microprobe in rats. J Nucl Med 45 : 1577 1582.
42. Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM 1975) Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med 16 : 210 224.
43. Ploux L, Mastrippolito R 1998) In vivo radiolabel quantification in small-animal models. Nucl Med Biol 25 : 737 742.
44. Raylman RR, Majewski S, Lemieux SK, Velan SS, Kross B, Popov V, Smith MF, Weisenberger AG, Zorn C, Marano GD 2006) Simultaneous MRI and PET imaging of a rat brain. Phys Med Biol 51 : 6371 6379.
45. Schmidt KC, Smith CB 2005) Resolution, sensitivity and precision with autoradiography and small animal positron emission tomography: implications for functional brain imaging in animal research. Nucl Med Biol 32 : 719 725.
46. Scorza FA, Arida RM, Priel MR, Calderazzo L, Cavalheiro EA 2002) Glucose utilisation during status epilepticus in an epilepsy model induced by pilocarpine: a qualitative study. Arq Neuropsiquiatr 60 : 198 203.
47. Semah F, Baulac M, Hasboun D, Frouin V, Mangin JF, Papageorgiou S, Leroy-Willig A, Philippon J, Laplane D, Samson Y 1995) Is interictal temporal hypometabolism related to mesial temporal sclerosis? A positron emission tomography/magnetic resonance imaging confrontation. Epilepsia 36 : 447 456.
48. Sossi V, Ruth TJ 2005) Micropet imaging: in vivo biochemistry in small animals. J Neural Transm 112 : 319 330.
49. Tai Y-C, Laforest R 2005) Instrumentation aspects of animal PET. Ann Rev Biomed Eng 7 : 255 285.
50. Takechi H, Onoe H, Imamura K, Onoe K, Kakiuchi T, Nishiyama S, Yoshikawa E, Mori S, Kosugi T, Okada H, Tsukada H, Watanabe Y 1994) Brain activation study by use of positron emission tomography in unanesthetized monkeys. Neurosci Lett 182 : 279 282.
51. Tatum WOt, Stecker MM 1995) Serial FDG-PET scans in a patient with partial status epilepticus. Epilepsia 36 : 214 215.
52. Theodore WH 2004) Recent advances and trends in epilepsy imaging: pathogenesis and pathophysiology. Rev Neurol Dis 1 : 53 59.
53. Van Bogaert P, De Tiege X, Vanderwinden JM, Damhaut P, Schiffmann SN, Goldman S 2001) Comparative study of hippocampal neuronal loss and in vivo binding of 5-HT1a receptors in the KA model of limbic epilepsy in the rat. Epilepsy Res 47 : 127 139.
54. Wang D, Pascual JM, Yang H, Engelstad K, Mao X, Cheng J, Yoo J, Noebels JL, De Vivo DC 2006) A mouse model for Glut-1 haploinsufficiency. Hum Mol Genet 15 : 1169 1179.
55. Welch MJ, Laforest R, Lewis JS 2007) Production of non-standard PET radionuclides and the application of radiopharmaceuticals labeled with these nuclides. Ernst Schering Research Foundation Workshop, 159 181.
56. Wu HM, Huang SC, Allada V, Wolfenden PJ, Schelbert HR, Phelps ME, Hoh CK 1996) Derivation of input function from FDG-PET studies in small hearts. J Nucl Med 37 : 1717 1722.