Crystal structure of aclacinomycin methylesterase with bound product analogues. Implications for anthracycline recognition and mechanism

Journal of Biological Chemistry

Volumn 278, Issue 40, 2003, Pages 39006-39013

  Jansson, Anna ^a   Niemi, Jarmo ^b   Mäntsälä, Pekka ^b   Schneider, Gunter ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYST ACTIVITY; CRYSTAL STRUCTURE; ENZYMES; HYDROGEN BONDS;

BINDING POCKET;

BIOCHEMISTRY;

10 DECARBOXYMETHYLACLACINOMYCIN A; 10 DECARBOXYMETHYLACLACINOMYCIN T; ACLACINOMYCIN METHYLESTERASE; AMIDE; AMINO ACID; ANION; ANTHRACYCLINE ANTIBIOTIC AGENT; ASPARTIC ACID; ESTERASE; GLYCINE; HISTIDINE; METHIONINE; OXYGEN; SERINE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SEQUENCE ANALYSIS; STREPTOMYCES; STREPTOMYCES PURPURASCENS; STRUCTURE ANALYSIS;

ACLARUBICIN; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTHRACYCLINES; BINDING SITES; CARBOXYLIC ESTER HYDROLASES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ELECTRONS; GLYCINE; HYDROGEN BONDING; METHIONINE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES PURPURASCENS;

EID: 0141643147     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304008200     Document Type: Article

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