A short review of malabsorption and anemia

World Journal of Gastroenterology

Volumn 15, Issue 37, 2009, Pages 4644-4652

  Fernández Bañares, Fernando ^a   Monzón, Helena ^a   Forné, Montserrat ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Anemia; Celiac disease; Cobalamin deficiency; Gastrectomy; Helicobacter pylori

Indexed keywords

ANTIINFECTIVE AGENT; COBALAMIN; CYANOCOBALAMIN; FERROPORTIN; IRON;

ANEMIA; ANEMIA OF CHRONIC DISEASE; CELIAC DISEASE; CLINICAL TRIAL; CYANOCOBALAMIN DEFICIENCY; DRUG ABSORPTION; DRUG DOSE REDUCTION; ERADICATION THERAPY; FOLIC ACID DEFICIENCY; GASTROINTESTINAL SYMPTOM; GENE MUTATION; GERIATRIC PATIENT; GLUTEN FREE DIET; HELICOBACTER INFECTION; HUMAN; IRON ABSORPTION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; MAINTENANCE THERAPY; MALABSORPTION; PATHOGENESIS; PATIENT COMPLIANCE; PERNICIOUS ANEMIA; PREVALENCE; REVIEW; STOMACH SURGERY; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION; GASTRECTOMY; METABOLISM; PARENTERAL NUTRITION;

ANEMIA; ANEMIA, IRON-DEFICIENCY; CELIAC DISEASE; GASTRECTOMY; HELICOBACTER INFECTIONS; HUMANS; IRON; MALABSORPTION SYNDROMES; PARENTERAL NUTRITION; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 70349787009     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.4644     Document Type: Review

References (84)

1. Catassi C, Fasano A. Celiac disease. Curr Opin Gastroenterol 2008; 24: 687-691
2. Bottaro G, Cataldo F, Rotolo N, Spina M, Corazza GR. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol 1999; 94: 691-696 (Pubitemid 29124868)
3. Hoffbrand AV. Anaemia in adult coeliac disease. Clin Gastroenterol 1974; 3: 71-89
4. Jones S, D'Souza C, Haboubi NY. Patterns of clinical presentation of adult coeliac disease in a rural setting. Nutr J 2006; 5: 24 (Pubitemid 44440837)
5. Cannings-John R, Butler CC, Prout H, Owen D, Williams D, Hood K, Crimmins R, Swift G. A case-control study of presentations in general practice before diagnosis of coeliac disease. Br J Gen Pract 2007; 57: 636-642 (Pubitemid 47232632)
6. Hin H, Bird G, Fisher P, Mahy N, Jewell D. Coeliac disease in primary care: case finding study. BMJ 1999; 318: 164-167 (Pubitemid 29192607)
7. Halfdanarson TR, Litzow MR, Murray JA. Hematologic manifestations of celiac disease. Blood 2007; 109: 412-421
8. Hershko C, Patz J. Ironing out the mechanism of anemia in celiac disease. Haematologica 2008; 93: 1761-1765
9. Fine KD. The prevalence of occult gastrointestinal bleeding in celiac sprue. N Engl J Med 1996; 334: 1163-1167 (Pubitemid 26137975)
10. Logan RF, Howarth GF, West J, Shepherd K, Robinson MH, Hardcastle JD. How often is a positive faecal occult blood test the result of coeliac disease? Eur J Gastroenterol Hepatol 2003; 15: 1097-1100 (Pubitemid 37267225)
11. Mant MJ, Bain VG, Maguire CG, Murland K, Yacyshyn BR. Prevalence of occult gastrointestinal bleeding in celiac disease. Clin Gastroenterol Hepatol 2006; 4: 451-454
12. Harper JW, Holleran SF, Ramakrishnan R, Bhagat G, Green PH. Anemia in celiac disease is multifactorial in etiology. Am J Hematol 2007; 82: 996-1000 (Pubitemid 350004391)
13. Bergamaschi G, Markopoulos K, Albertini R, Di Sabatino A, Biagi F, Ciccocioppo R, Arbustini E, Corazza GR. Anemia of chronic disease and defective erythropoietin production in patients with celiac disease. Haematologica 2008; 93: 1785-1791
14. Garrote JA, Gómez-González E, Bernardo D, Arranz E, Chirdo F. Celiac disease pathogenesis: the proinflammatory cytokine network. J Pediatr Gastroenterol Nutr 2008; 47 Suppl 1: S27-S32
15. Weiss G. Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta 2009; 1790: 682-693
16. Corazza GR, Valentini RA, Andreani ML, D'Anchino M, Leva MT, Ginaldi L, De Feudis L, Quaglino D, Gasbarrini G. Subclinical coeliac disease is a frequent cause of iron-deficiency anaemia. Scand J Gastroenterol 1995; 30: 153-156
17. Car roc c io A, Ianni t to E, Cavataio F, Montal to G, Tumminello M, Campagna P, Lipari MG, Notarbartolo A, Iacono G. Sideropenic anemia and celiac disease: one study, two points of view. Dig Dis Sci 1998; 43: 673-678
18. Unsworth DJ, Lock RJ, Harvey RF. Improving the diagnosis of coeliac disease in anaemic women. Br J Haematol 2000; 111: 898-901 (Pubitemid 32098929)
19. Haslam N, Lock RJ, Unsworth DJ. Coeliac disease, anaemia and pregnancy. Clin Lab 2001; 47: 467-469
20. Annibale B, Severi C, Chistolini A, Antonelli G, Lahner E, Marcheggiano A, Iannoni C, Monarca B, Delle Fave G. Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients. Am J Gastroenterol 2001; 96: 132-137 (Pubitemid 32104820)
21. Howard MR, Turnbull AJ, Morley P, Hollier P, Webb R, Clarke A. A prospective study of the prevalence of undiagnosed coeliac disease in laboratory defined iron and folate deficiency. J Clin Pathol 2002; 55: 754-757 (Pubitemid 35231906)
22. Ransford RA, Hayes M, Palmer M, Hall MJ. A controlled, prospective screening study of celiac disease presenting as iron deficiency anemia. J Clin Gastroenterol 2002; 35: 228-233 (Pubitemid 34913089)
23. Grisolano SW, Oxentenko AS, Murray JA, Burgart LJ, Dierkhising RA, Alexander JA. The usefulness of routine small bowel biopsies in evaluation of iron deficiency anemia. J Clin Gastroenterol 2004; 38: 756-760
24. Mandal AK, Mehdi I, Munshi SK, Lo TC. Value of routine duodenal biopsy in diagnosing coeliac disease in patients with iron deficiency anaemia. Postgrad Med J 2004; 80: 475-477 (Pubitemid 39108041)
25. Hershko C, Hoffbrand AV, Keret D, Souroujon M, Maschler I, Monselise Y, Lahad A. Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica 2005; 90: 585-595 (Pubitemid 40780877)
26. Kalayci AG, Kanber Y, Birinci A, Yildiz L, Albayrak D. The prevalence of coeliac disease as detected by screening in children with iron deficiency anaemia. Acta Paediatr 2005; 94: 678-681 (Pubitemid 40839794)
27. Zamani F, Mohamadnejad M, Shakeri R, Amiri A, Najafi S, Alimohamadi SM, Tavangar SM, Ghavamzadeh A, Malekzadeh R. Gluten sensitive enteropathy in patients with iron deficiency anemia of unknown origin. World J Gastroenterol 2008; 14: 7381-7385
28. Carter D, Maor Y, Bar-Meir S, Avidan B. Prevalence and predictive signs for gastrointestinal lesions in premenopausal women with iron deficiency anemia. Dig Dis Sci 2008; 53: 3138-3144
29. Green PH. The many faces of celiac disease: clinical presentation of celiac disease in the adult population. Gastroenterology 2005; 128: S74-S78 (Pubitemid 40460825)
30. Goddard AF, McIntyre AS, Scott BB. Guidelines for the management of iron deficiency anaemia. British Society of Gastroenterology. Gut 2000; 46 Suppl 3-4: IV1-IV5
31. Andrès E, Loukili NH, Noel E, Kaltenbach G, Abdelgheni MB, Perrin AE, Noblet-Dick M, Maloisel F, Schlienger JL, Blicklé JF. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 2004; 171: 251-259 (Pubitemid 39061592)
32. Dali-Youcef N, Andrès E. An update on cobalamin deficiency in adults. QJM 2009; 102: 17-28
33. Andrès E, Vogel T, Federici L, Zimmer J, Kaltenbach G. Update on oral cyanocobalamin (vitamin B12) treatment in elderly patients. Drugs Aging 2008; 25: 927-932
34. Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T. Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study. Clin Ther 2003; 25: 3124-3134 (Pubitemid 38096149)
35. Andrès E, Affenberger S, Vinzio S, Kurtz JE, Noel E, Kaltenbach G, Maloisel F, Schlienger JL, Blicklé JF. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med 2005; 118: 1154-1159 (Pubitemid 41363768)
36. Kaptan K, Beyan C, Ifran A. Helicobacter pylori and vitamin B12 deficiency. Haematologica 2006; 91: ELT10 (Pubitemid 44453688)
37. Toh BH, van Driel IR, Gleeson PA. Pernicious anemia. N Engl J Med 1997; 337: 1441-1448
38. Khan S, Del-Duca C, Fenton E, Holding S, Hirst J, Doré PC, Sewell WA. Limited value of testing for intrinsic factor antibodies with negative gastric parietal cell antibodies in pernicious anaemia. J Clin Pathol 2009; 62: 439-441
39. Andrès E, Vidal-Alaball J, Federici L, Loukili NH, Zimmer J, Kaltenbach G. Clinical aspects of cobalamin deficiency in elderly patients. Epidemiology, causes, clinical manifestations, and treatment with special focus on oral cobalamin therapy. Eur J Intern Med 2007; 18: 456-462 (Pubitemid 47379536)
40. Beyan C, Beyan E, Kaptan K, Ifran A, Uzar AI. Postgastrectomy anemia: evaluation of 72 cases with postgastrectomy anemia. Hematology 2007; 12: 81-84
41. Love AL, Billett HH. Obesity, bariatric surgery, and iron deficiency: true, true, true and related. Am J Hematol 2008; 83: 403-409
42. Folope V, Coëffier M, Déchelotte P. [Nutritional deficiencies associated with bariatric surgery] Gastroenterol Clin Biol 2007; 31: 369-377
43. Simon SR, Zemel R, Betancourt S, Zidar BL. Hematologic complications of gastric bypass for morbid obesity. South Med J 1989; 82: 1108-1110 (Pubitemid 20010546)
44. Alvarez-Cordero R, Aragon-Viruette E. Post-operative Complications in a Series of Gastric Bypass Patients. Obes Surg 1992; 2: 87-89
45. Halverson JD. Micronutrient deficiencies after gastric bypass for morbid obesity. Am Surg 1986; 52: 594-598 (Pubitemid 17181161)
46. Marceau P, Hould FS, Simard S, Lebel S, Bourque RA, Potvin M, Biron S. Biliopancreatic diversion with duodenal switch. World J Surg 1998; 22: 947-954
47. Rabkin RA, Rabkin JM, Metcalf B, Lazo M, Rossi M, Lehman-Becker LB. Nutritional markers following duodenal switch for morbid obesity. Obes Surg 2004; 14: 84-90 (Pubitemid 38130721)
48. Blecker U, Renders F, Lanciers S, Vandenplas Y. Syncopes leading to the diagnosis of a Helicobacter pylori positive chronic active haemorrhagic gastritis. Eur J Pediatr 1991; 150: 560-561
49. Dufour C, Brisigotti M, Fabretti G, Luxardo P, Mori PG, Barabino A. Helicobacter pylori gastric infection and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1993; 17: 225-227 (Pubitemid 23249808)
50. Carnicer J, Badía R, Argemí J. Helicobacter pylori gastritis and sideropenic refractory anemia. J Pediatr Gastroenterol Nutr 1997; 25: 441 (Pubitemid 27419183)
51. Annibale B, Marignani M, Monarca B, Antonelli G, Marcheggiano A, Martino G, Mandelli F, Caprilli R, Delle Fave G. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med 1999; 131: 668-672 (Pubitemid 29517952)
52. Ashorn M, Ruuska T, Mäkipernaa A. Helicobacter pylori and iron deficiency anaemia in children. Scand J Gastroenterol 2001; 36: 701-705 (Pubitemid 32568547)
53. Mahalanabis D, Islam MA, Shaikh S, Chakrabarty M, Kurpad AV, Mukherjee S, Sen B, Khaled MA, Vermund SH. Haematological response to iron supplementation is reduced in children with asymptomatic Helicobacter pylori infection. Br J Nutr 2005; 94: 969-975 (Pubitemid 43092430)
54. Muhsen K, Cohen D. Helicobacter pylori infection and iron stores: a systematic review and meta-analysis. Helicobacter 2008; 13: 323-340
55. Choe YH, Kim SK, Son BK, Lee DH, Hong YC, Pai SH. Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents. Helicobacter 1999; 4: 135-139
56. Choe YH, Lee JE, Kim SK. Effect of helicobacter pylori eradication on sideropenic refractory anaemia in adolescent girls with Helicobacter pylori infection. Acta Paediatr 2000; 89: 154-157
57. Choe YH, Kwon YS, Jung MK, Kang SK, Hwang TS, Hong YC. Helicobacter pylori-associated iron-deficiency anemia in adolescent female athletes. J Pediatr 2001; 139: 100-104
58. Valiyaveettil AN, Hamide A, Bobby Z, Krishnan R. Effect of anti-Helicobacter pylori therapy on outcome of iron-deficiency anemia: a randomized, controlled study. Indian J Gastroenterol 2005; 24: 155-157 (Pubitemid 41391996)
59. Kurekci AE, Atay AA, Sarici SU, Yesilkaya E, Senses Z, Okutan V, Ozcan O. Is there a relationship between childhood Helicobacter pylori infection and iron deficiency anemia? J Trop Pediatr 2005; 51: 166-169 (Pubitemid 41444462)
60. Gessner BD, Baggett HC, Muth PT, Dunaway E, Gold BD, Feng Z, Parkinson AJ. A controlled, household-randomized, open-label trial of the effect that treatment of Helicobacter pylori infection has on iron deficiency in children in rural Alaska. J Infect Dis 2006; 193: 537-546 (Pubitemid 43202745)
61. Sarker SA, Mahmud H, Davidsson L, Alam NH, Ahmed T, Alam N, Salam MA, Beglinger C, Gyr N, Fuchs GJ. Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron supplementation in children. Gastroenterology 2008; 135: 1534-1542
62. Pérez Roldán F, Castellanos Monedero JJ, González Carro P, Villafáñez García MC, Roncero García- Escribano O, Legaz Huidobro ML, Ruiz Carrillo F. [Effect of Helicobacter pylori eradication on iron deficiency anemia of unknown origin] Gastroenterol Hepatol 2008; 31: 213-216
63. Hershko C, Ianculovich M, Souroujon M. A hematologist's view of unexplained iron deficiency anemia in males: impact of Helicobacter pylori eradication. Blood Cells Mol Dis 2007; 38: 45-53 (Pubitemid 44960859)
64. Fagan RP, Dunaway CE, Bruden DL, Parkinson AJ, Gessner BD. Controlled, household-randomized, open-label trial of the effect of treatment of Helicobacter pylori infection on iron deficiency among children in rural Alaska: results at 40 months. J Infect Dis 2009; 199: 652-660
65. Annibale B, Capurso G, Delle Fave G. The stomach and iron deficiency anaemia: a forgotten link. Dig Liver Dis 2003; 35: 288-295 (Pubitemid 41070486)
66. Jamieson JA, Kuhnlein HV. The paradox of anemia with high meat intake: a review of the multifactorial etiology of anemia in the Inuit of North America. Nutr Rev 2008; 66: 256-271
67. Yip R, Limburg PJ, Ahlquist DA, Carpenter HA, O'Neill A, Kruse D, Stitham S, Gold BD, Gunter EW, Looker AC, Parkinson AJ, Nobmann ED, Petersen KM, Ellefson M, Schwartz S. Pervasive occult gastrointestinal bleeding in an Alaska native population with prevalent iron deficiency. Role of Helicobacter pylori gastritis. JAMA 1997; 277: 1135-1139 (Pubitemid 27157631)
68. Gisbert JP, Calvet X, Feu F, Bory F, Cosme A, Almela P, Santolaria S, Aznárez R, Castro M, Fernández N, García-Grávalos R, Cañete N, Benages A, Montoro M, Borda F, Pérez-Aisa A, Piqué JM. Eradication of Helicobacter pylori for the prevention of peptic ulcer rebleeding. Helicobacter 2007; 12: 279-286 (Pubitemid 47196329)
69. Zhang ZW, Patchett SE, Perrett D, Katelaris PH, Domizio P, Farthing MJ. The relation between gastric vitamin C concentrations, mucosal histology, and CagA seropositivity in the human stomach. Gut 1998; 43: 322-326 (Pubitemid 28414911)
70. Ruiz B, Rood JC, Fontham ET, Malcom GT, Hunter FM, Sobhan M, Johnson WD, Correa P. Vitamin C concentration in gastric juice before and after anti-Helicobacter pylori treatment. Am J Gastroenterol 1994; 89: 533-539 (Pubitemid 24106219)
71. Sarker SA, Davidsson L, Mahmud H, Walczyk T, Hurrell RF, Gyr N, Fuchs GJ. Helicobacter pylori infection, iron absorption, and gastric acid secretion in Bangladeshi children. Am J Clin Nutr 2004; 80: 149-153 (Pubitemid 41121933)
72. Ciacci C, Sabbatini F, Cavallaro R, Castiglione F, Di Bella S, Iovino P, Palumbo A, Tortora R, Amoruso D, Mazzacca G. Helicobacter pylori impairs iron absorption in infected individuals. Dig Liver Dis 2004; 36: 455-460 (Pubitemid 41115448)
73. Finkelstein RA, Sciortino CV, McIntosh MA. Role of iron in microbe-host interactions. Rev Infect Dis 1983; 5 Suppl 4: S759-S777
74. van Vliet AH, Stoof J, Vlasblom R, Wainwright SA, Hughes NJ, Kelly DJ, Bereswill S, Bijlsma JJ, Hoogenboezem T, Vandenbroucke-Grauls CM, Kist M, Kuipers EJ, Kusters JG. The role of the Ferric Uptake Regulator (Fur) in regulation of Helicobacter pylori iron uptake. Helicobacter 2002; 7: 237-244 (Pubitemid 34894177)
75. Husson MO, Legrand D, Spik G, Leclerc H. Iron acquisition by Helicobacter pylori: importance of human lactoferrin. Infect Immun 1993; 61: 2694-2697 (Pubitemid 23159268)
76. Dhaenens L, Szczebara F, Husson MO. Identification, characterization, and immunogenicity of the lactoferrin-binding protein from Helicobacter pylori. Infect Immun 1997; 65: 514-518 (Pubitemid 27053218)
77. Choe YH, Oh YJ, Lee NG, Imoto I, Adachi Y, Toyoda N, Gabazza EC. Lactoferrin sequestration and its contribution to iron-deficiency anemia in Helicobacter pylori-infected gastric mucosa. J Gastroenterol Hepatol 2003; 18: 980-985 (Pubitemid 37056179)
78. Lee JH, Choe YH, Choi YO. The expression of iron-repressible outer membrane proteins in Helicobacter pylori and its association with iron deficiency anemia. Helicobacter 2009; 14: 36-39
79. Park SA, Lee HW, Hong MH, Choi YW, Choe YH, Ahn BY, Cho YJ, Kim DS, Lee NG. Comparative proteomic analysis of Helicobacter pylori strains associated with iron deficiency anemia. Proteomics 2006; 6: 1319-1328
80. Choe YH, Hwang TS, Kim HJ, Shin SH, Song SU, Choi MS. A possible relation of the Helicobacter pylori pfr gene to iron deficiency anemia? Helicobacter 2001; 6: 55-59 (Pubitemid 32601685)
81. Worst DJ, Otto BR, de Graaff J. Iron-repressible outer membrane proteins of Helicobacter pylori involved in heme uptake. Infect Immun 1995; 63: 4161-4165
82. Jeon BH, Oh YJ, Lee NG, Choe YH. Polymorphism of the Helicobacter pylori feoB gene in Korea: a possible relation with iron-deficiency anemia? Helicobacter 2004; 9: 330-334
83. Berg G, Bode G, Blettner M, Boeing H, Brenner H. Helicobacter pylori infection and serum ferritin: A population-based study among 1806 adults in Germany. Am J Gastroenterol 2001; 96: 1014-1018
84. Baysoy G, Ertem D, Ademoǧlu E, Kotiloǧlu E, Keskin S, Pehlivanoǧlu E. Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 2004; 38: 146-151