A controlled, household-randomized, open-label trial of the effect that treatment of Helicobacter pylori infection has on iron deficiency in children in rural Alaska

Journal of Infectious Diseases

Volumn 193, Issue 4, 2006, Pages 537-546

  Gessner, Bradford D ^a   Baggett, Henry C ^a,e   Muth, Pam T ^a   Dunaway, Eitel ^b   Gold, Benjamin D ^c   Feng, Ziding ^d   Parkinson, Alan J ^b  

^a Alaska Section Epidemiology   (United States)

^b NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; BISMUTH SALICYLATE; CARBON 13; CLARITHROMYCIN; FERRITIN; FERROUS SULFATE; HEMOGLOBIN; IRON; LANSOPRAZOLE; UREA;

ABDOMINAL PAIN; ANEMIA; ARTICLE; CHILD; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; FERRITIN BLOOD LEVEL; FOLLOW UP; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HOUSEHOLD; HUMAN; IRON DEFICIENCY; IRON THERAPY; MAJOR CLINICAL STUDY; PREVALENCE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; RASH; UNITED STATES; UREA BREATH TEST; VOMITING;

ALASKA; ANEMIA, IRON-DEFICIENCY; ANTI-BACTERIAL AGENTS; CHILD; DRUG THERAPY, COMBINATION; FAMILY CHARACTERISTICS; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IRON; IRON METABOLISM DISORDERS; MALE; RURAL POPULATION; TREATMENT OUTCOME;

EID: 32044445537     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/499604     Document Type: Article

References (50)

1. United Nations Administrative Committee on Coordination, Subcommittee on Nutrition (ACC/SCN). Fourth report on the world nutrition situation. Geneva: ACC/SCN in Collaboration with International Food Policy Research Institute, 2000. Available at: http://www.unsystem.org/ scn/Publications/4RWNS/4rwns.pdf. Accessed 14 December 2004.
2. Konno M, Muraoka S, Takahashi M, Imai T. Iron-deficiency anemia associated with Helicobacter pylori gastritis. J Pediatr Gastroenterol Nutr 2000; 31:52-6.
3. Barabino A, Dufour C, Marino CE, Claudiani F, De Alessandri A. Unexplained refractory iron-deficiency anemia associated with Helicobacter pylori gastric infection in children: further clinical evidence. J Pediatr Gastroenterol Nutr 1999; 28:116-9.
4. Baysoy G, Ertem D, Ademoglu E, Kotiloglu E, Keskin S, Pehlivanoglu E. Gastric histopathology, iron status and iron deficiency anemia in children with Helicobacter pylori infection. J Pediatr Gastroenterol Nutr 2004; 38:146-51.
5. Nahon S, Lahmek P, Massard J, Lesgourgues B, Mariaud de Serre N, Traissac L, et al. Helicobacter pylori-associated chronic gastritis and unexplained iron deficiency anemia: a reliable association? Helicobacter 2003; 8:573-7.
6. Choe YH, Kim SK, Hong YC, The relationship between Helicobacter pylori infection and iron deficiency: seroprevalence study in 937 pubescent children. Arch Dis Child 2003; 88:178.
7. Annibale B, Marignani M, Monarca B, et al. Reversal of iron deficiency anemia after Helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med 1999; 131:668-72.
8. Choe YH, Kim SK, Son BK, Lee DH, Hong YC, Pai SH. Randomized placebo-controlled trial of Helicobacter pylori eradication for iron-deficiency anemia in preadolescent children and adolescents. Helicobacter 1999; 4:135-9.
9. Marignani M, Angeletti S, Bordi C, et al. Reversal of long-standing iron deficiency anemia after eradication of Helicobacter pylori infection. Scand J Gastroenterol 1997; 32:617-22.
10. Ashorn M, Ruuska T, Makipernaa A. Helicobacter pylori and iron deficiency anaemia in children. Scand J Gastroenterol 2001; 36:701-5.
11. Barabino A, Dufour C, Marino CE, Claudiani F, De Alessandri A. Unexplained refractory iron-deficiency anemia associated with Helicobacter pylori gastric infection in children: further clinical evidence, J Pediatr Gastroenterol Nutr 1999; 28:116-9.
12. Kostaki M, Fessatou S, Karpathios T. Refractory iron-deficiency anaemia due to silent Helicobacter pylori gastritis in children. Eur J Pediatr 2003; 162:177-9.
13. Choe YH, Kwon YS, Jung MK, Kang SK, Hwang TS, Hong YC. Helicobacter pylori-associated iron-deficiency anemia in adolescent female athletes. J Pediatr 2001; 139:100-4.
14. Russo-Mancuso G, Branciforte F, Licciardello M, La Spina M. Iron deficiency anemia as the only sign of infection with Helicobacter pylori: a report of 9 pediatric cases. Int J Hematol 2003; 78:429-31.
15. Castro L de P, Coelho LG. Helicobacter pylori in South America. Can J Gastroenterol 1998; 12:509-12.
16. Sarker SA, Mahalanabis D, Hildebrand P, et al. Helicobacter pylori: prevalence, transmission, and serum pepsinogen II concentrations in children of a poor periurban community in Bangladesh. Clin Infect Dis 1997; 25:990-5.
17. Nabwera HM, Nguyen-Van-Tam JS, Logan RF, Logan RP. Prevalence of Helicobacter pylori infection in Kenyan schoolchildren aged 3-15 years and risk factors for infection. Eur J Gastroenterol Hepatol 2000; 12:483-7.
18. Yip R, Limburg PJ, Ahlquist DA, et al. Pervasive occult gastrointestinal bleeding in an Alaska Native population with prevalent iron deficiency: role of Helicobacter pylori gastritis. JAMA 1997; 277:1135-9.
19. Parkinson AJ, Gold BD, Bulkow L, et al. High prevalence of Helicobacter pylori in the Alaska Native population and association with low serum ferritin levels in young adults. Clin Diagn Lab Immunol 2000; 7:885-8.
20. Windsor HM, Abioye-Kuteyi EA, Leber JM, Morrow SD, Bulsara MK, Marshall BJ. Prevalence of Helicobacter pylori in indigenous western Australians: comparison between urban and remote rural populations. Med J Aust 2005; 182:210-3.
21. Centers for Disease Control and Prevention. Iron deficiency anemia in Alaskan Native children-Hooper Bay, Alaska 1999. MMWR Morb Mortal Wkly Rep 1999; 48:714-6.
22. Petersen KM, Parkinson AJ, Nobmann ED, Bulkow L, Yip R, Mokdad A. Iron deficiency anemia among Alaska Natives may be due to fecal loss rather than inadequate intake. J Nutr 1996; 126:2774-83.
23. Nobmann ED, Byers T, Lanier AP, Hankin JH, Jackson MY. The diet of Alaska Native adults: 1987-88. Am J Clin Nutr 1992;55:1024-32.
24. Centers for Disease Control and Prevention. High prevalence of iron deficiency anemia among Alaskan Native children. MMWR Morb Mortal Wkly Rep 1988; 37:200-2.
25. Alaska Department of Labor and Workforce Development. Alaska population overview: 2001-2002 estimates and census 2000. Anchorage: State of Alaska, 2004.
26. Sherman P, Hassall E, Hunt RH, Fallone CA, Veldhuyzen Van Zanten S, Thomson AB. Canadian Helicobacter Study Group Consensus Conference on the approach to Helicobacter pylori infection in children and adolescents. Can J Gastroenterol 1999; 13:553-9.
27. Gold BD, Colletti RB, Abbott M, et al. Helicobacter pylori infection in children: recommendations for diagnosis and treatment. J Pediatr Gas-troenterol Nutr 2000; 31:490-7.
28. Ni YH, Lin JT, Huang SF, Yang JC, Chang MH. Accurate diagnosis of Helicobacter pylori infection by stool antigen test and 6 other currently available tests in children. J Pediatr 2000; 136:823-7.
29. 13C-urea breath test for childhood Helicobacter pylori infection: a multicenter Japanese study. Am J Gastroenterol 2002; 97:1668-73.
30. 2 production rates in children. J Pediatr Gastroenterol Nutr 1999; 29:297-301.
31. Willows ND, Dewailly E, Gray-Donald K. Anemia and iron status in Inuit infants from northern Quebec. Can J Public Health 2000; 91: 407-10.
32. Whalen EA, Caulfield LE, Harris SB. Prevalence of anemia in First Nations children of northwestern Ontario. Can Fam Physician 1997; 43:659-64.
33. Sinha SK, Martin B, Gold BD, Song Q, Sargent M, Bernstein CN. The incidence of Helicobacter pylori acquisition in children of a Canadian First Nations community and the potential for parent-to-child transmission. Helicobacter 2004; 9:59-68.
34. Nakata H, Ichinose M. Helicobacter pylori and iron deficiency anemia. Intern Med 2003; 42:922-3.
35. American Academy of Pediatrics. PREP The Curriculum. Elk Grove, IL: American Academy of Pediatrics, 2004.
36. Rowland M, Imrie C, Bourke B, Drumm B. How should Helicobacter pylori infected children be managed? Gut 1999;45(Suppl 1):I36-9.
37. Crone J, Gold BD. Helicobacter pylori infection in pediatrics. Helicobacter 2004;9(Suppl 1):49-56.
38. Barabino A. Helicobacter pyiori-related iron deficiency anemia: a review. Helicobacter 2002; 7:71-5.
39. Annibale B, Capurso G, Lahner E, et al. Concomitant alterations in intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency anaemia. Gut 2003; 52:496-501.
40. Annibale B, Capurso G, Delle Fave G. Consequences of Helicobacter pylori infection on the absorption of micronutrients. Dig Liver Dis 2002;34(Suppl 2):S72-7.
41. Ciacci C, Sabbatini F, Cavallaro R, et al. Helicobacter pylori impairs iron absorption in infected individuals. Dig Liver Dis 2004; 36:455-60.
42. Annibale B, Capurso G, Delle Fave G. The stomach and iron deficiency anaemia: a forgotten link. Dig Liver Dis 2003; 35:288-95.
43. Hojo M, Miwa H, Ohkusa T, Ohkura R, Kurosawa A, Sato N. Alteration of histological gastritis after cure of Helicobacter pylori infection. Aliment Pharmacol Ther 2002; 16:1923-32.
44. Satoh K, Kimura K, Takimoto T, Kihira K. A follow-up study of atrophic gastritis and intestinal metaplasia after eradication of Helicobacter pylori. Helicobacter 1998; 3:236-40.
45. Kokkola A, Sipponen P, Rautelin H, et al. The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia. Aliment Pharmacol Ther 2002; 16:515-20.
46. Ohkusa T, Fujiki K, Takashimizu I, et al. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med 2001; 134:380-6.
47. Annibale B, Di Giulio E, Caruana P, et al. The long-term effects of cure of Helicobacter pylori infection on patients with atrophic body gastritis. Aliment Pharmacol Ther 2002; 16:1723-31.
48. Annibale B, Aprile MR, D'ambra G, Caruana P, Bordi C, Delle Fave G. Cure of Helicobacter pylori infection in atrophie body gastritis patients does not improve mucosal atrophy but reduces hypergastrinemia and its related effects on body ECL-cell hyperplasia. Aliment Pharmacol Ther 2000; 14:625-34.
49. Guarner J, Bartlett J, Whistler T, et al. Can pre-neoplastic lesions be detected in gastric biopsies of children with Helicobacter pylori infection? J Pediatr Gastroenterol Nutr 2004; 38:548.
50. Noseworthy IH, Ebers GC, Vandervoort MK, Farquhar RE, Yetisir E, Roberts R. The impact of blinding on the results of a randomized, placebo-controlled multiple sclerosis clinical trial. Neurology 1994; 44: 16-20.