DNA binding by estrogen receptor-α is essential for the transcriptional response to estrogen in the liver and the uterus

Molecular Endocrinology

Volumn 23, Issue 10, 2009, Pages 1544-1555

  Ahlbory Dieker, Dörthe L ^a   Stride, Brenda D ^c,e   Leder, Gabriele ^b   Schkoldow, Jenny ^a   Trölenberg, Susanne ^a   Seidel, Henrik ^b   Otto, Christiane ^a   Sommer, Anette ^b   Parker, Malcolm G ^d   Schütz, Günther ^c   Wintermantel, Tim M ^a,c  

^a Therapeutic Research Group Women's Healthcare   (Germany)

^b BAYER PHARMA AG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e PHENEX PHARMACEUTICALS AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DNA; ESTROGEN; ESTROGEN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; FEMALE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION PROFILING; GENE LOCUS; GENE REPRESSION; GENETIC MODEL; GENOME; IN VIVO CULTURE; KNOCKOUT MOUSE; LIVER; LOSS OF FUNCTION MUTATION; MAMMARY GLAND; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OVARY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARGET ORGAN; TRANSCRIPTION REGULATION; UTERUS;

AMINO ACID SEQUENCE; ANIMALS; DNA; ESTROGEN RECEPTOR ALPHA; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; INFERTILITY, FEMALE; INTERLEUKIN-1BETA; LIVER; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; REPRESSOR PROTEINS; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC; UTERUS;

MUS;

EID: 70349777489     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0045     Document Type: Article

References (32)

1. Hall JM, Couse JF, Korach KS 2001 The multifaceted mechanisms of estradiol and estrogen receptor signaling. J Biol Chem 276:36869-36872 (Pubitemid 37384094)
2. Shang Y, Brown M 2002 Molecular determinants for the tissue specificity of SERMs. Science 295:2465-2468 (Pubitemid 34270263)
3. Castro-Rivera E, Samudio I, Safe S 2001 Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. J Biol Chem 276:30853-30861 (Pubitemid 37384945)
4. O'Brien JE, Peterson TJ, Tong MH, Lee EJ, Pfaff LE, Hewitt SC, Korach KS, Weiss J, Jameson JL 2006 Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor α binding to classical estrogen response elements. J Biol Chem 281:26683-26692 (Pubitemid 44401877)
5. Dubik D, Shiu RP 1992 Mechanism of estrogen activation of c-myc oncogene expression. Oncogene 7:1587-1594
6. Umayahara Y, Kawamori R, Watada H, Imano E, Iwama N, Morishima T, Yamasaki Y, Kajimoto Y, Kamada T 1994 Estrogen regulation of the insulin-like growth factor I gene transcription involves an AP-1 enhancer. J Biol Chem 269:16433-16442 (Pubitemid 24209344)
7. Evans MJ, Eckert A, Lai K, Adelman SJ, Harnish DC 2001 Reciprocal antagonism between estrogen receptor and NF-κB activity in vivo. Circ Res 89:823-830 (Pubitemid 34633854)
8. Boverhof DR, Fertuck KC, Burgoon LD, Eckel JE, Gennings C, Zacharewski TR 2004 Temporal- and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol. Carcinogenesis 25:1277-1291 (Pubitemid 38968056)
9. Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC, Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson SW, O'Dwyer PJ, Fero MJ, Kristensen GB, Borresen-Dale AL, Hastie T, Tibshirani R, van de Rijn M, Teng NN, Longacre TA, Botstein D, Brown PO, Sikic BI 2003 Gene expression patterns in ovarian carcinomas. Mol Biol Cell 14:4376-4386 (Pubitemid 37444641)
10. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS 1997 Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277:1508-1510 (Pubitemid 27449239)
11. Turgeon JL, McDonnell DP, Martin KA, Wise PM 2004 Hormone therapy: physiological complexity belies therapeutic simplicity. Science 304:1269-1273
12. Blum A, Cannon 3rd RO 1998 Effects of oestrogens and selective oestrogen receptor modulators on serum lipoproteins and vascular function. Curr Opin Lipidol 9:575-586
13. Battaglioli T, Martinelli I 2007 Hormone therapy and thromboembolic disease. Curr Opin Hematol 14:488-493
14. Douketis JD, Gordon M, Johnston M, Julian JA, Adachi JR, Ginsberg JS 2000 The effects of hormone replacement therapy on thrombin generation, fibrinolysis inhibition, and resistance to activated protein C: prospective cohort study and review of literature. Thromb Res 99:25-34 (Pubitemid 30440738)
15. García-Pedrero JM, Kiskinis E, Parker MG, Belandia B 2006 The SWI/SNF chromatin remodeling subunit BAF57 is a critical regulator of estrogen receptor function in breast cancer cells. J Biol Chem 281:22656-22664 (Pubitemid 44242294)
16. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O 1993 Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA 90:11162-11166 (Pubitemid 23354389)
17. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M 2000 Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes. Development 127:4277-4291 (Pubitemid 30831336)
18. Jakacka M, Ito M, Martinson F, Ishikawa T, Lee EJ, Jameson JL 2002 An estrogen receptor (ER)α deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo. Mol Endocrinol 16:2188-2201 (Pubitemid 35155533)
19. Hewitt SC, Collins J, Grissom S, Deroo B, Korach KS 2005 Global uterine genomics in vivo: microarray evaluation of the estrogen receptor α-growth factor cross talk mechanism. Mol Endocrinol 19:657-668
20. Hewitt SC, Deroo BJ, Hansen K, Collins J, Grissom S, Afshari CA, Korach KS 2003 Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen. Mol Endocrinol 17:2070-2083 (Pubitemid 37281798)
21. Sinkevicius KW, Burdette JE, Woloszyn K, Hewitt SC, Hamilton K, Sugg SL, Temple KA, Wondisford FE, Korach KS, Woodruff TK, Greene GL 2008 An estrogen receptor-α knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo. Endocrinology 149:2970-2979 (Pubitemid 351724534)
22. Evans MJ, Lai K, Shaw LJ, Harnish DC, Chadwick CC 2002 Estrogen receptor α inhibits IL-1β induction of gene expression in the mouse liver. Endocrinology 143:2559-2570 (Pubitemid 34701319)
23. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schütz G 1998 DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93:531-541 (Pubitemid 28240715)
24. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K 2008 Genome-wide identification of estrogen receptor α-binding sites in mouse liver. Mol Endocrinol 22:10-22
25. Krum SA, Miranda-Carboni GA, Lupien M, Eeckhoute J, Carroll JS, Brown M 2008 Unique ERα cistromes control cell type-specific gene regulation. Mol Endocrinol 22:2393-2406
26. Wintermantel TM, Campbell RE, Porteous R, Bock D, Gröne HJ, Todman MG, Korach KS, Greiner E, Pérez CA, Schütz G, Herbison AE 2006 Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility. Neuron 52:271-280 (Pubitemid 44548337)
27. Vente A, Korn B, Zehetner G, Poustka A, Lehrach H 1999 Distribution and early development of microarray technology in Europe. Nat Genet 22:22 (Pubitemid 29214799)
28. Zhang Y, Buchholz F, Muyrers JP, Stewart AF 1998 A new logic for DNA engineering using recombination in Escherichia coli. Nat Genet 20:123-128
29. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schütz G 1999 Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99-103 (Pubitemid 29418797)
30. Wintermantel TM, Bock D, Fleig V, Greiner EF, Schütz G 2005 The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production. Mol Endocrinol 19:340-349 (Pubitemid 40223459)
31. Valentine JE, Kalkhoven E, White R, Hoare S, Parker MG 2000 Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression. J Biol Chem 275:25322-25329 (Pubitemid 30687029)
32. Wintermantel TM, Elzer J, Herbison AE, Fritzemeier KH, Schutz G 2006 Genetic dissection of estrogen receptor signaling in vivo. Ernst Schering Found Symp Proc:25-44