Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells

Cellular Signalling

Volumn 21, Issue 12, 2009, Pages 1775-1783

  Fukumoto, Tetsuya ^a   Kubota, Yoshitsugu ^b   Kitanaka, Akira ^b   Yamaoka, Genji ^c   Ohara Waki, Fusako ^a   Imataki, Osamu ^a   Ohnishi, Hiroaki ^a   Ishida, Toshihiko ^a   Tanaka, Terukazu ^b  

^a Faculty of Medicine   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c KAGAWA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Akt; Erk; Erythropoietin; Gab1; Jak2; PI3K

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ADAPTOR PROTEIN; ERYTHROPOIETIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2 ASSOCIATED BINDER 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; SMALL INTERFERING RNA; SOS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; ERYTHROLEUKEMIA CELL; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMONES; ENZYME INHIBITORS; ERYTHROID CELLS; ERYTHROPOIETIN; GENE KNOCKDOWN TECHNIQUES; GRB2 ADAPTOR PROTEIN; HUMANS; JANUS KINASE 2; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MORPHOLINES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; RECEPTORS, ERYTHROPOIETIN; SOS1 PROTEIN;

EID: 70349770541     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2009.07.013     Document Type: Article

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