Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory t cells

Cancer Research

Volumn 67, Issue 20, 2007, Pages 10058-10066

  Yoshimura, Kiyoshi ^a   Laird, Lindsay S ^a   Chia, Christina Y ^a   Meckel, Kristen F ^a   Slansky, Jill E ^b   Thompson, John M ^a   Jain, Ajay ^a   Pardoll, Drew M ^a   Schulick, Richard D ^a,c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; LIVE VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; CANCER SURVIVAL; CD8+ T LYMPHOCYTE; CELL ACTIVATION; COLORECTAL CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; LISTERIA MONOCYTOGENES; LIVER METASTASIS; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; REGULATORY T LYMPHOCYTE; TREATMENT RESPONSE;

ANIMALS; CANCER VACCINES; COLORECTAL NEOPLASMS; CYCLOPHOSPHAMIDE; INTERFERON TYPE II; KILLER CELLS, NATURAL; LISTERIA MONOCYTOGENES; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY; VACCINES, ATTENUATED;

EID: 35448971357     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-0573     Document Type: Article

References (33)

1. Kelly RJ, Kemeny NE, Leonard GD. Current strategies using hepatic arterial infusion chemotherapy for the treatment of colorectal cancer. Clin Colorectal Cancer 2005;5:166-74.
2. Ruan DT, Warren RS. Liver-directed therapies in colorectal cancer. Semin Oncol 2005;32:85-94.
3. Clary B. Treatment of isolated neuroendocrine liver metastases. J Gastrointest Surg 2006;10:332-4.
4. Weiss L, Grundmann E, Torhorst J, et al. Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1,541 necropsies. J Pathol 1986;150:195-203.
5. Yoshimura K, Jain A, Allen HE, et al. Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Res 2006;66:1096-104.
6. Pan ZK, Ikonomidis G, Pardoll D, Paterson Y. Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine. Cancer Res 1995;55:4776-9.
7. Singh R, Paterson Y. Listeria monocytogenes as a vector for tumor-associated antigens for cancer immunotherapy. Expert Rev Vaccines 2006;5:541-52.
8. Brockstedt DG, Giedlin MA, Leong ML, et al. Listeria-based cancer vaccines that segregate immunogenicity from toxicity. Proc Natl Acad Sci U S A 2004;101:13832-7.
9. Skoble J, Portnoy DA, Welch MD. Three regions within ActA promote Arp2/3 complex-mediated actin nucleation and Listeria monocytogenes motility. J Cell Biol 2000;150:527-38.
10. Jones S, Portnoy DA. Characterization of Listeria monocytogenes pathogenesis in a strain expressing perfringolysin O in place of listeriolysin O. Infect Immun 1994;62:5608-13.
11. Glomski IJ, Gedde MM, Tsang AW, Swanson JA, Portnoy DA. The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. J Cell Biol 2002;156:1029-38.
12. Lauer P, Chow MY, Loessner MJ, Portnoy DA, Calendar R. Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors. J Bacteriol 2002;184:4177-86.
13. Corbett TH, Griswold DP, Jr., Roberts BJ, Peckham JC, Schabel FM. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res 1975;35:2434-9.
14. Jain A, Slansky JE, Matey LC, Allen HE, Pardoll DM, Schulick RD. Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases. Ann Surg Oncol 2003;10:810-20.
15. Mueller SN, Jones CM, Smith CM, Heath WR, Carbone FR. Rapid cytotoxic T lymphocyte activation occurs in the draining lymph nodes after cutaneous herpes simplex virus infection as a result of early antigen presentation and not the presence of virus. J Exp Med 2002;195:651-6.
16. Lohr J, Knoechel B, Abbas AK. Regulatory T cells in the periphery. Immunol Rev 2006;212:149-62.
17. Terabe M, Khanna C, Bose S, et al. CD1d-restricted natural killer T cells can down-regulate tumor immunosurveillance independent of interleukin-4 receptorsignal transducer and activator of transcription 6 or transforming growth factor-β. Cancer Res 2006;66:3869-75.
18. Brutkiewicz RR, Sriram V. Natural killer T (NKT) cells and their role in antitumor immunity. Crit Rev Oncol Hematol 2002;41:287-98.
19. Huang AY, Gulden PH, Woods AS, et al. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proc Natl Acad Sci U S A 1996;93:9730-5.
20. McMahan RH, McWilliams JA, Jordan KR, Dow SW, Wilson DB, Slansky JE. Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines. J Clin Invest 2006;116:2543-51.
21. Mitchell MS. Combinations of anticancer drugs and immunotherapy. Cancer Immunol Immunother 2003;52:686-92.
22. Portnoy DA, Auerbuch V, Glomski IJ. The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity. J Cell Biol 2002;158:409-14.
23. Alexander HR, Jr. Surgical approaches to liver metastases. Cancer J 2002;8 Suppl 1:S68-81.
24. Takamori H, Hiraoka T, Kanemitsu K, Tsuji T. Pancreatic liver metastases after curative resection combined with intraoperative radiation for pancreatic cancer. Hepatogastroenterology 2004;51:1500-3.
25. Beyer M, Schultze JL. Regulatory T cells in cancer. Blood 2006;108:804-11.
26. Terabe M, Park JM, Berzofsky JA. Role of IL-13 in regulation of anti-tumor immunity and tumor growth. Cancer Immunol Immunother 2004;53:79-85.
27. Pamer EG. Immune responses to Listeria monocytogenes. Nat Rev Immunol 2004;4:812-23.
28. Torres D, Barrier M, Bihl F, et al. Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect Immun 2004;72:2131-9.
29. Ozoren N, Masumoto J, Franchi L, et al. Distinct roles of TLR2 and the adaptor ASC in IL-1β/IL-18 secretion in response to Listeria monocytogenes. J Immunol 2006;176:4337-42.
30. Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001;410:1099-103.
31. Way SS, Thompson LJ, Lopes JE, et al. Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cell Microbiol 2004;3:235-42.
32. Herskovits AA, Auerbuch V, Portnoy DA. Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog 2007;3:e51.
33. Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006;1:93-103.