Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation

Neuroscience

Volumn 164, Issue 2, 2009, Pages 470-477

  Hall, A A ^a   Leonardo, C C ^a   Collier, L A ^a   Rowe, D D ^a   Willing, A E ^a   Pennypacker, K R ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

human umbilical cord blood cells; inflammation; ischemia; neuroprotection; sigma receptors

Indexed keywords

1,3 DI O TOLYLGUANIDINE; NITRIC OXIDE; OPIATE AGONIST; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL HYPOXIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; EX VIVO STUDY; FEMALE; HYPOGLYCEMIA; MALE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; THERAPY DELAY; TISSUE CULTURE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CELL HYPOXIA; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE MODELS, ANIMAL; FEMALE; GLUCOSE; GUANIDINES; HUMANS; MALE; MICROGLIA; NERVE DEGENERATION; NEURONS; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; STROKE; TIME FACTORS;

EID: 70349745708     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.08.051     Document Type: Article

References (30)

1. Ajmo Jr. C.T., Collier L.A., Leonardo C.C., Hall A.A., Green S.M., Womble T.A., Cuevas J., Willing A.E., and Pennypacker K.R. Blockade of adrenoreceptors inhibits the splenic response to stroke. Exp Neurol 218 (2009) 47-55
2. Ajmo Jr. C.T., Vernon D.O., Collier L., Hall A.A., Garbuzova-Davis S., Willing A., and Pennypacker K.R. The spleen contributes to stroke-induced neurodegeneration. J Neurosci Res 86 (2008) 2227-2234
3. Ajmo Jr. C.T., Vernon D.O., Collier L., Pennypacker K.R., and Cuevas J. Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats. Curr Neurovasc Res 3 (2006) 89-98
4. Albers G.W., Amarenco P., Easton J.D., Sacco R.L., and Teal P. Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (2004) 483S-512S
5. Borlongan C.V., Hadman M., Sanberg C.D., and Sanberg P.R. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 35 (2004) 2385-2389
6. Duckworth E.A., Butler T.L., De Mesquita D., Collier S.N., Collier L., and Pennypacker K.R. Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain Res 1042 (2005) 29-36
7. Elenkov I.J., Wilder R.L., Chrousos G.P., and Vizi E.S. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 52 (2000) 595-638
8. Gee J.M., Kalil A., Shea C., and Becker K.J. Lymphocytes: potential mediators of postischemic injury and neuroprotection. Stroke 38 (2007) 783-788
9. Hall A.A., Herrera Y., Ajmo Jr. C.T., Cuevas J., and Pennypacker K.R. Sigma receptors suppress multiple aspects of microglial activation. Glia 57 (2009) 744-754
10. Jiang L WT Saporta S, Chen N, Sanberg CD, Sanberg PR, Willing AE (in press) Human umbilical cord blood cells decrease microglial survival in vitro. Stem Cells Dev, in press.
11. Katnik C., Guerrero W.R., Pennypacker K.R., Herrera Y., and Cuevas J. Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia. J Pharmacol Exp Ther 319 (2006) 1355-1365
12. Lalancette-Hebert M., Gowing G., Simard A., Weng Y.C., and Kriz J. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J Neurosci 27 (2007) 2596-2605
13. Leonardo C.C., Hall A.A., Collier L.A., Gottschall P.E., and Pennypacker K.R. Inhibition of gelatinase activity reduces neural injury in an ex vivo model of hypoxia-ischemia. Neuroscience 160 (2009) 755-766
14. Li Z., Cui S., Zhang Z., Zhou R., Ge Y., Sokabe M., and Chen L. DHEA-neuroprotection and -neurotoxicity after transient cerebral ischemia in rats. J Cereb Blood Flow Metab 29 (2009) 287-296
15. Marler J.R., and Goldstein L.B. Medicine. Stroke-tPA and the clinic. Science 301 (2003) 1677
16. Morioka T., Kalehua A.N., and Streit W.J. The microglial reaction in the rat dorsal hippocampus following transient forebrain ischemia. J Cereb Blood Flow Metab 11 (1991) 966-973
17. Neuhoff S., Moers J., Rieks M., Grunwald T., Jensen A., Dermietzel R., and Meier C. Proliferation differentiation, and cytokine secretion of human umbilical cord blood-derived mononuclear cells in vitro. Exp Hematol 35 (2007) 1119-1131
18. Newcomb J.D., Ajmo C.T., Sanberg C.D., Sanberg P.R., Pennypacker K.R., and Willing A.E. Timing of cord blood treatment after experimental stroke determine therapeutic efficacy. Cell Transplant 15 (2006) 213-223
19. Nikolic W.V., Hou H., Town T., Zhu Y., Giunta B., Sanberg C.D., Zeng J., Luo D., Ehrhart J., Mori T., Sanberg P.R., and Tan J. Peripherally administered human umbilical cord blood cells reduce parenchymal and vascular beta-amyloid deposits in Alzheimer mice. Stem Cells Dev 17 (2008) 423-439
20. Noraberg J., Poulsen F.R., Blaabjerg M., Kristensen B.W., Bonde C., Montero M., Meyer M., Gramsbergen J.B., and Zimmer J. Organotypic hippocampal slice cultures for studies of brain damage neuroprotection and neurorepair. Curr Drug Targets CNS Neurol Disord 4 (2005) 435-452
21. Offner H., Subramanian S., Parker S.M., Afentoulis M.E., Vandenbark A.A., and Hurn P.D. Experimental stroke induces massive rapid activation of the peripheral immune system. J Cereb Blood Flow Metab 26 (2006) 654-665
22. Pranke P., Failace R.R., Allebrandt W.F., Steibel G., Schmidt F., and Nardi N.B. Hematologic and immunophenotypic characterization of human umbilical cord blood. Acta Haematol 105 (2001) 71-76
23. Schmued L., Albertson C., and Slikker W. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 751 (1997) 37-46
24. Su T.P. Sigma receptors. Putative links between nervous, endocrine and immune systems. Eur J Biochem 200 (1991) 633-642
25. Su T.P., London E.D., and Jaffe J.H. Steroid binding at sigma receptors suggests a link between endocrine nervous, and immune systems. Science 240 (1988) 219-221
26. Vagnerova K., Hurn P.D., Bhardwaj A., and Kirsch J.R. Sigma 1 receptor agonists act as neuroprotective drugs through inhibition of inducible nitric oxide synthase. Anesth Analg 103 (2006) 430-434
27. Vendrame M., Cassady J., Newcomb J., Butler T., Pennypacker K.R., Zigova T., Sanberg C.D., Sanberg P.R., and Willing A.E. Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 35 (2004) 2390-2395
28. Vendrame M., Gemma C., De Mesquita D., Collier L., Bickford P.C., Sanberg C.D., Sanberg P.R., Pennypacker K.R., and Willing A.E. Anti-inflammatory effects of human cord blood cells in a rat model of stroke. Stem Cells Dev 14 (2005) 595-604
29. Yilmaz G., Arumugam T.V., Stokes K.Y., and Granger D.N. Role of T lymphocytes and interferon-gamma in ischemic stroke. Circulation 113 (2006) 2105-2112
30. Zhu L.X., Sharma S., Gardner B., Escuadro B., Atianzar K., Tashkin D.P., and Dubinett S.M. IL-10 mediates sigma 1 receptor-dependent suppression of antitumor immunity. J Immunol 170 (2003) 3585-3591