Dedifferentiated fat cells convert to cardiomyocyte phenotype and repair infarcted cardiac tissue in rats

Journal of Molecular and Cellular Cardiology

Volumn 47, Issue 5, 2009, Pages 565-575

  Jumabay, Medet ^a   Matsumoto, Taro ^a   Yokoyama, Shin ichiro ^a   Kano, Koichiro ^b   Kusumi, Yoshiaki ^a   Masuko, Takayuki ^a   Mitsumata, Masako ^a   Saito, Satoshi ^a   Hirayama, Atsushi ^a   Mugishima, Hideo ^a   Fukuda, Noboru ^a,b  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIHON UNIVERSITY   (Japan)

Author keywords

Adipocyte; Cardiac tissue regeneration; Cardiogenesis; Cardiomyocytes; Cell transplantation; Dedifferentiated fat cells

Indexed keywords

ACTIN; GREEN FLUORESCENT PROTEIN;

ACUTE HEART INFARCTION; ADIPOCYTE; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY DENSITY; CELL DEDIFFERENTIATION; CELL LINE; CELL LINEAGE; CELL REGENERATION; CELL TRANSPLANTATION; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE SEVERITY; HEART MUSCLE CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; ISCHEMIC HEART DISEASE; MALE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOMERE; TISSUE REGENERATION; TISSUE REPAIR; TRANSGENIC RAT;

ADIPOCYTES; ANIMALS; CELL DEDIFFERENTIATION; CELL TRANSPLANTATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MALE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS;

EID: 70349739571     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.08.004     Document Type: Article

References (34)

1. Herzog E.L., Chai L., and Krause D.S. Plasticity of marrow-derived stem cells. Blood 102 (2003) 3483-3493
2. Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. 85 (1999) 221-228
3. Tateishi-Yuyama E., Matsubara H., Murohara T., Ikeda U., Shintani S., Masaki H., et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 360 (2002) 427-435
4. Assmus B., Schachinger V., Teupe C., Britten M., Lehmann R., Dobert N., et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 106 (2002) 3009-3017
5. Schachinger V., Assmus B., Britten M.B., Honold J., Lehmann R., Teupe C., et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J. Am. Coll. Cardiol. 44 (2004) 1690-1699
6. Wollert K.C., Meyer G.P., Lotz J., Ringes-Lichtenberg S., Lippolt P., Breidenbach C., et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364 (2004) 141-148
7. Schachinger V., Erbs S., Elsasser A., Haberbosch W., Hambrecht R., Holschermann H., et al. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur. Heart J. 27 (2006) 2775-2783
8. Mitchell J.B., McIntosh K., Zvonic S., Garrett S., Floyd Z.E., Kloster A., et al. Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 24 (2006) 376-385
9. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., et al. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 13 (2002) 4279-4295
10. Halvorsen Y.D., Franklin D., Bond A.L., Hitt D.C., Auchter C., Boskey A.L., et al. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng. 7 (2001) 729-741
11. Tholpady S.S., Llull R., Ogle R.C., Rubin J.P., Futrell J.W., and Katz A.J. Adipose tissue: stem cells and beyond. Clin. Plast Surg. 33 (2006) 55-62 vi
12. Yagi K., Kondo D., Okazaki Y., and Kano K. A novel preadipocyte cell line established from mouse adult mature adipocytes. Biochem. Biophys. Res. Commun. 321 (2004) 967-974
13. Matsumoto T., Kano K., Kondo D., Fukuda N., Iribe Y., Tanaka N., et al. Mature adipocyte-derived dedifferentiated fat cells exhibit multilineage potential. J. Cell Physiol. 215 (2008) 210-222
14. Sugihara H., Yonemitsu N., Miyabara S., and Yun K. Primary cultures of unilocular fat cells: characteristics of growth in vitro and changes in differentiation properties. Differentiation 31 (1986) 42-49
15. Chen J., Larsson L., Haugen E., Fedorkova O., Angwald E., Waagstein F., et al. Effects of autoantibodies removed by immunoadsorption from patients with dilated cardiomyopathy on neonatal rat cardiomyocytes. Eur. J. Heart Fail. 8 (2006) 460-467
16. Pittenger M.F., and Martin B.J. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ. Res. 95 (2004) 9-20
17. Beltrami A.P., Barlucchi L., Torella D., Baker M., Limana F., Chimenti S., et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114 (2003) 763-776
18. Planat-Benard V., Menard C., Andre M., Puceat M., Perez A., Garcia-Verdugo J.M., et al. Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells. Circ. Res. 94 (2004) 223-229
19. Clark B.R., and Keating A. Biology of bone marrow stroma. Ann. N. Y. Acad. Sci. 770 (1995) 70-78
20. Zuk P.A., Zhu M., Mizuno H., Huang J., Futrell J.W., Katz A.J., et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 7 (2001) 211-228
21. Makino S., Fukuda K., Miyoshi S., Konishi F., Kodama H., Pan J., et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103 (1999) 697-705
22. Miller C.L., and Lai B. Human and mouse hematopoietic colony-forming cell assays. Methods Mol. Biol. 290 (2005) 71-89
23. Guilak F., Lott K.E., Awad H.A., Cao Q., Hicok K.C., Fermor B., et al. Clonal analysis of the differentiation potential of human adipose-derived adult stem cells. J. Cell Physiol. 206 (2006) 229-237
24. Rose R.A., Jiang H., Wang X., Helke S., Tsoporis J.N., Gong N., et al. Bone marrow-derived mesenchymal stromal cells express cardiac-specific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells 26 (2008) 2884-2892
25. Alvarez-Dolado M., Pardal R., Garcia-Verdugo J.M., Fike J.R., Lee H.O., Preffer K., et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 423 (2003) 968-973
26. Nagaya N., Fujii T., Iwase T., Ohgushi H., Itoh T., Uematsu M., et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am. J. Physiol. Heart Circ. Physiol. 287 (2004) H2670-H2676
27. Kajstura J., Rota M., Whang B., Cascapera S., Hosoda T., Bearzi C., et al. Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ. Res. 96 (2005) 127-137
28. Laflamme M.A., and Murry C.E. Regenerating the heart. Nat. Biotechnol. 23 (2005) 845-856
29. Nobusue H., Endo T., and Kano K. Establishment of a preadipocyte cell line derived from mature adipocytes of GFP transgenic mice and formation of adipose tissue. Cell Tissue Res. 332 (2008) 435-446
30. Breitbach M., Bostani T., Roell W., Xia Y., Dewald O., Nygren J.M., et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood 110 (2007) 1362-1369
31. Gnecchi M., Zhang Z., Ni A., and Dzau V.J. Paracrine mechanisms in adult stem cell signaling and therapy. Circ. Res. 103 (2008) 1204-1219
32. Kinnaird T., Stabile E., Burnett M.S., Lee C.W., Barr S., Fuchs S., et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ. Res. 94 (2004) 678-685
33. Kinnaird T., Stabile E., Burnett M.S., and Epstein S.E. Bone-marrow-derived cells for enhancing collateral development: mechanisms, animal data, and initial clinical experiences. Circ. Res. 95 (2004) 354-363
34. Nakagami H., Maeda K., Morishita R., Iguchi S., Nishikawa T., Takami Y., et al. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 2542-2547