Calcitonin gene-related peptide, adrenomedullin and flushing

Maturitas

Volumn 64, Issue 2, 2009, Pages 104-108

  Hay, Debbie L ^a   Poyner, David R ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b ASTON UNIVERSITY   (United Kingdom)

Author keywords

Adrenomedullin; CGRP; Hot flushes; Hypothalamus; Menopause; Peripheral vasodilation

Indexed keywords

ADRENOMEDULLIN; ALPHA CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; INTERMEDIN; OLCAGEPANT; TELCAGEPANT; UNCLASSIFIED DRUG;

ANDROGEN DEPRIVATION THERAPY; ESTROGEN THERAPY; FLUSHING; HOT FLUSH; HUMAN; HYPOTHALAMUS; POSTMENOPAUSE; PREMENOPAUSE; PROTEIN BLOOD LEVEL; REVIEW; SWEATING; THERMOREGULATION; URINE LEVEL; VASODILATATION;

ADRENOMEDULLIN; CALCITONIN GENE-RELATED PEPTIDE; FEMALE; HOT FLASHES; HUMANS; MALE; POSTMENOPAUSE;

EID: 70349738088     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2009.08.011     Document Type: Review

References (37)

1. Gennari C., Nami R., Pecchi S., De Franco V., Panza F., and Pavese G. Plethysmographic evaluation of the vascular effects of human calcitonin gene-related peptide in man. Angiology 42 (1991) 462-467
2. Sturdee D.W. The menopausal hot flush-anything new?. Maturitas 60 (2008) 42-49
3. Engstrom C.A. Hot flashes in prostate cancer: state of the science. Am J Mens Health 2 (2008) 122-132
4. Freedman R.R. Pathophysiology and treatment of menopausal hot flashes. Semin Reprod Med 23 (2005) 117-125
5. Holzer P. Neurogenic vasodilatation and plasma leakage in the skin. Gen Pharmacol 30 (1998) 5-11
6. Brain S.D., Williams T.J., Tippins J.R., Morris H.R., and MacIntyre I. Calcitonin gene-related peptide is a potent vasodilator. Nature 313 (1985) 54-56
7. Williams T.J., Brain S.D., Hellewell P.G., Jose P.J., Nourshargh S., and Rampart M. Alteration in microvascular permeability induced by products released during inflammation. Prog Clin Biol Res 263 (1988) 55-69
8. Jernbeck J., Edner M., Dalsgaard C.J., and Pernow B. The effect of calcitonin gene-related peptide (CGRP) on human forearm blood flow. Clin Physiol 10 (1990) 335-343
9. Chen J.T., Hirai Y., Seimiya Y., Hasumi K., and Shiraki M. Menopausal flushes and calcitonin-gene-related peptide. Lancet 342 (1993) 49
10. Valentini A., Petraglia F., De Vita D., et al. Changes of plasma calcitonin gene-related peptide levels in postmenopausal women. Am J Obstet Gynecol 175 (1996) 638-642
11. Wyon Y.A., Spetz A.C., Theodorsson G.E., and Hammar M.L. Concentrations of calcitonin gene-related peptide and neuropeptide Y in plasma increase during flushes in postmenopausal women. Menopause 7 (2000) 25-30
12. Chen J.T., and Shiraki M. Menopausal hot flash and calcitonin gene-related peptide; effect of Keishi-bukuryo-gan, a kampo medicine, related to plasma calcitonin gene-related peptide level. Maturitas 45 (2003) 199-204
13. Gupta P., Harte A., Sturdee D.W., et al. Effects of menopausal status on circulating calcitonin gene-related peptide and adipokines: implications for insulin resistance and cardiovascular risks. Climacteric 11 (2008) 364-372
14. Wyon Y., Frisk J., Lundeberg T., Theodorsson E., and Hammar M. Postmenopausal women with vasomotor symptoms have increased urinary excretion of calcitonin gene-related peptide. Maturitas 30 (1998) 289-294
15. Gupta P., Harte A.L., da Silva N.F., et al. Expression of calcitonin gene-related peptide, adrenomedullin, and receptor modifying proteins in human adipose tissue and alteration in their expression with menopause status. Menopause 14 (2007) 1031-1038
16. Wyon Y., Spetz A.C., Hammar M., Theodorsson E., and Varenhorst E. Urinary excretion of calcitonin gene-related peptide in males with hot flushes after castration for carcinoma of the prostate. Scand J Urol Nephrol 35 (2001) 92-96
17. Spetz A.C., Pettersson B., Varenhorst E., Theodorsson E., Thorell L.H., and Hammar M. Momentary increase in plasma calcitonin gene-related peptide is involved in hot flashes in men treated with castration for carcinoma of the prostate. J Urol 166 (2001) 1720-1723
18. Kobayashi A., Osaka T., Namba Y., Inoue S., and Kimura S. CGRP microinjection into the ventromedial or dorsomedial hypothalamic nucleus activates heat production. Brain Res 827 (1999) 176-184
19. Kobayashi A., Osaka T., Namba Y., Inoue S., and Kimura S. Involvement of sympathetic activation and brown adipose tissue in calcitonin gene-related peptide-induced heat production in the rat. Brain Res 849 (1999) 196-202
20. Braasch D.C., Deegan E.M., Grimm E.R., and Griffin J.D. Calcitonin gene-related peptide alters the firing rates of hypothalamic temperature sensitive and insensitive neurons. BMC Neurosci 9 (2008) 64
21. Bowe J.E., Li X.F., Kinsey-Jones J.S., et al. Calcitonin gene-related peptide-induced suppression of luteinizing hormone pulses in the rat: the role of endogenous opioid peptides. J Physiol 566 (2005) 921-928
22. Brain S.D., and Grant A.D. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 84 (2004) 903-934
23. Schlereth T., Dittmar J.O., Seewald B., and Birklein F. Peripheral amplification of sweating-a role for calcitonin gene-related peptide. J Physiol 576 (2006) 823-832
24. Gangula P.R., Thota C., Wimalawansa S.J., Bukoski R.D., and Yallampalli C. Mechanisms involved in calcitonin gene-related peptide-induced relaxation in pregnant rat uterine artery. Biol Reprod 69 (2003) 1635-1641
25. Mowa C.N., Usip S., Collins J., Storey-Workley M., Hargreaves K.M., and Papka R.E. The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord. Peptides 24 (2003) 1163-1174
26. Thota C., Gangula P.R., Dong Y.L., and Yallampalli C. Changes in the expression of calcitonin receptor-like receptor, receptor activity-modifying protein (RAMP) 1, RAMP2, and RAMP3 in rat uterus during pregnancy, labor, and by steroid hormone treatments. Biol Reprod 69 (2003) 1432-1437
27. Dong Y.L., Vegiraju S., Chauhan M., and Yallampalli C. Expression of calcitonin gene-related peptide receptor components, calcitonin receptor-like receptor and receptor activity modifying protein 1, in the rat placenta during pregnancy and their cellular localization. Mol Hum Reprod 9 (2003) 481-490
28. Yang Y., Ozawa H., Lu H., et al. Immunocytochemical analysis of sex differences in calcitonin gene-related peptide in the rat dorsal root ganglion, with special reference to estrogen and its receptor. Brain Res 791 (1998) 35-42
29. Tumati S., Yamamura H.I., Vanderah T.W., Roeske W.R., and Varga E.V. Sustained morphine treatment augments capsaicin-evoked CGRP release from primary sensory neurons in a PKA and Raf-1-dependent manner. J Pharmacol Exp Ther (2009)
30. Trang T., Quirion R., and Jhamandas K. The spinal basis of opioid tolerance and physical dependence: involvement of calcitonin gene-related peptide, substance P, and arachidonic acid-derived metabolites. Peptides 26 (2005) 1346-1355
31. Capuano A., De Corato A., Tringali G., Curro D., Dello Russo C., and Navarra P. Buprenorphine inhibits bradykinin-induced release of calcitonin gene-related peptide from rat trigeminal neurons via both mu-opioid and nociceptin/orphanin peptide receptors. Eur J Pharmacol 609 (2009) 45-50
32. Spetz A.C., Ellefsen K., Theodorsson E., Lassvik C.T., and Hammar M.L. Calcitonin gene-related peptide during sweating in young healthy women. Gynecol Obstet Invest 60 (2005) 149-153
33. Tfelt-Hansen P., and Le H. Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. J Headache Pain 10 (2009) 137-143
34. Petersen K.A., Birk S., Kitamura K., and Olesen J. Effect of adrenomedullin on the cerebral circulation: relevance to primary headache disorders. Cephalalgia 29 (2009) 23-30
35. Poyner D.R., Sexton P.M., Marshall I., et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54 (2002) 233-246
36. Recober A., and Russo A.F. Calcitonin gene-related peptide: an update on the biology. Curr Opin Neurol 22 (2009) 241-246
37. Roldos V., Martin-Santamaria S., Julian M., et al. Small-molecule negative modulators of adrenomedullin: design, synthesis, and 3D-QSAR study. ChemMedChem 3 (2008) 1345-1355