Calcitonin gene-related peptide alters the firing rates of hypothalamic temperature sensitive and insensitive neurons

BMC Neuroscience

Volumn 9, Issue , 2008, Pages

  Braasch, Daniel C ^a   Deegan, Erin M ^a   Grimm, Eleanor R ^a   Griffin, John D ^a  

^a Dept of Economics and Thomas Jefferson Program in Public Policy at the College of William and Mary   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE;

ANIMAL TISSUE; ANTERIOR HYPOTHALAMUS; ARTICLE; CONTROLLED STUDY; HEAT SENSITIVITY; HYPERTHERMIA; MALE; NERVE POTENTIAL; NONHUMAN; PREOPTIC NUCLEUS; RAT; TEMPERATURE SENSITIVITY; THERMOREGULATION; TISSUE SLICE; WARMING; ACTION POTENTIAL; ANIMAL; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; INSTRUMENTATION; METHODOLOGY; MICROELECTRODE; NERVE CELL; NERVE TRACT; PHYSIOLOGY; PREOPTIC AREA; REGRESSION ANALYSIS; SPRAGUE DAWLEY RAT; TEMPERATURE; TISSUE CULTURE TECHNIQUE;

ACTION POTENTIALS; ANIMALS; ANTERIOR HYPOTHALAMIC NUCLEUS; BODY TEMPERATURE REGULATION; CALCITONIN GENE-RELATED PEPTIDE; ELECTROPHYSIOLOGY; HYPOTHALAMUS, ANTERIOR; MALE; MICROELECTRODES; NEURAL PATHWAYS; NEURONS; PREOPTIC AREA; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; TEMPERATURE; TISSUE CULTURE TECHNIQUES;

EID: 47949090013     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-9-64     Document Type: Article

References (29)

1. Boulant JA Thermoregulation Fever: Basic Mechanisms and Management New York: Raven Press Mackowiak PA 1991:1-22.
2. Boulant JA Hardy JD The effect of spinal and skin temperatures on the firing rate and thermosensitivity of preoptic neurones J Physiol 1974, 240(3):639-660. 1330999 4416218
3. Boulant JA Neuronal basis of Hammel's model for set-point thermoregulation J Appl Physiol 2006, 100(4):1347-1354. 10.1152/ japplphysiol.01064.2005 16540713
4. Hammel HT Neurones and temperature regulation. AMRL-TR-65-232 AMRL TR 1965:1-32. 5317657
5. Romanovsky AA Thermoregulation: Some concepts have changed. Functional architecture of the thermoregulatory system Am J Physiol Regul Integr Comp Physiol 2007, 292(1):R37-46. 17008453
6. Blatteis CM Sehic E Circulating pyrogen signaling of the brain. A new working hypothesis Ann N Y Acad Sci 1997, 813:445-447. 10.1111/ j.1749-6632.1997.tb51731.x 9100919
7. Ranels HJ Griffin JD The effects of prostaglandin E2 on the firing rate activity of thermosensitive and temperature insensitive neurons in the ventromedial preoptic area of the rat hypothalamus Brain Res 2003, 964(1):42-50. 10.1016/S0006-8993(02)04063-5 12573511
8. Kobayashi A Osaka T Namba Y Inoue S Kimura S CGRP microinjection into the ventromedial or dorsomedial hypothalamic nucleus activates heat production Brain Res 1999, 827(1-2):176-184. 10.1016/ S0006-8993(99)01333-5 10320707
9. Yuzurihara M Ikarashi Y Noguchi M Kase Y Takeda S Aburada M Involvement of calcitonin gene-related peptide in elevation of skin temperature in castrated male rats Urology 2003, 62(5):947-951. 10.1016/ S0090-4295(03)00587-9 14624932
10. Spetz AC Pettersson B Varenhorst E Theodorsson E Thorell LH Hammar M Momentary increase in plasma calcitonin gene-related peptide is involved in hot flashes in men treated with castration for carcinoma of the prostate J Urol 2001, 166(5):1720-1723. 10.1016/S0022-5347(05)65660-1 11586209
11. Kobayashi T Ushijima O Chen JT Shiraki M Ohta T Kiyoki M Basal tail skin temperature elevation and augmented response to calcitonin gene-related peptide in ovariectomized rats J Endocrinol 1995, 146(3):431-437. 7595138
12. Takahashi K Mouri T Sone M Murakami O Itoi K Imai Y Ohneda M Yoshinaga K Sasano N Calcitonin gene-related peptide in the human hypothalamus Endocrinol Jpn 1989, 36(3):409-415. 2583060
13. Herbison AE Sexually dimorphic expression of androgen receptor immunoreactivity by somatostatin neurones in rat hypothalamic periventricular nucleus and bed nucleus of the stria terminalis J Neuroendocrinol 1995, 7(7):543-553. 10.1111/j.1365-2826.1995.tb00791.x 7496395
14. Henke H Tschopp FA Fischer JA Distinct binding sites for calcitonin gene-related peptide and salmon calcitonin in rat central nervous system Brain Res 1985, 360(1-2):165-171. 10.1016/0006-8993(85)91232-6 3878184
15. Noguchi M Yuzurihara M Ikarashi Y Effects of the vasoactive neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal polypeptide on skin temperature in ovariectomized rats Neuropeptides 2002, 36(5):327-332. 10.1016/S0143-4179(02)00090-2 12450738
16. Inagaki S Kito S Kubota Y Girgis S Hillyard CJ MacIntyre I Autoradiographic localization of calcitonin gene-related peptide binding sites in human and rat brains Brain Res 1986, 374(2):287-298. 10.1016/ 0006-8993(86)90423-3 3013366
17. Oliver KR Wainwright A Edvinsson L Pickard JD Hill RG Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature J Cereb Blood Flow Metab 2002, 22(5):620-629. 10.1097/ 00004647-200205000-00014 11973435
18. Leuthauser K Gujer R Aldecoa A McKinney RA Muff R Fischer JA Born W Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition Biochem J 2000, 351(Pt 2):347-351. 1221370 11023820 10.1042/0264-6021:3510347
19. Aiyar N Rand K Elshourbagy NA Zeng Z Adamou JE Bergsma DJ Li Y A cDNA encoding the calcitonin gene-related peptide type 1 receptor J Biol Chem 1996, 271(19):11325-11329. 10.1074/jbc.271.19.11325 8626685
20. McLatchie LM Fraser NJ Main MJ Wise A Brown J Thompson N Solari R Lee MG Foord SM RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor Nature 1998, 393(6683):333-339. 10.1038/30666 9620797
21. McGillis JP Humphreys S Rangnekar V Ciallella J Modulation of B lymphocyte differentiation by calcitonin gene-related peptide (CGRP). II. Inhibition of LPS-induced kappa light chain expression by CGRP Cell Immunol 1993, 150(2):405-416. 10.1006/cimm.1993.1208 8396499
22. Zona C Farini D Palma E Eusebi F Modulation of voltage-activated channels by calcitonin gene-related peptide in cultured rat neurones J Physiol 1991, 433:631-643. 1181392 1726796
23. Boulant JA Hypothalamic neurons. Mechanisms of sensitivity to temperature Ann N Y Acad Sci 1998, 856:108-115. 10.1111/ j.1749-6632.1998.tb08319.x 9917871
24. Griffin JD Kaple ML Chow AR Boulant JA Cellular mechanisms for neuronal thermosensitivity in the rat hypothalamus J Physiol 1996, 492(Pt 1):231-242. 1158876 8730598
25. Griffin JD Saper CB Boulant JA Synaptic and morphological characteristics of temperature-sensitive and -insensitive rat hypothalamic neurones J Physiol 2001, 537(Pt 2):521-535. 2278963 11731583 10.1111/j.1469-7793.2001.00521.x
26. Kelso SR Perlmutter MN Boulant JA Thermosensitive single-unit activity of in vitro hypothalamic slices Am J Physiol 1982, 242(1):R77-84. 7058933
27. Belousov AB Pol van den AN Local synaptic release of glutamate from neurons in the rat hypothalamic arcuate nucleus J Physiol 1997, 499(Pt 3):747-761. 1159292 9130170
28. Segal M Intracellular analysis of a postsynaptic action of adenosine in the rat hippocampus Eur J Pharmacol 1982, 79(3-4):193-199. 10.1016/ 0014-2999(82)90625-2 7094996
29. Dean JB Boulant JA In vitro localization of thermosensitive neurons in the rat diencephalon Am J Physiol 1989, 257(1 Pt 2):R57-64. 2750968