Long-term effect of atorvastatin on neurohumoral activation and cardiac function in patients with chronic heart failure: A prospective randomized controlled study

American Heart Journal

Volumn 153, Issue 6, 2007, Pages 1055.e1-1055.e8

  Yamada, Takahisa ^a   Node, Koichi ^b   Mine, Takanao ^a   Morita, Takashi ^a   Kioka, Hidetaka ^a   Tsukamoto, Yasumasa ^a   Tamaki, Shunsuke ^a   Masuda, Masaharu ^a   Okuda, Keiji ^a   Fukunami, Masatake ^a  

^a OSAKA GENERAL MEDICAL CENTER   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRAIN NATRIURETIC PEPTIDE; CARVEDILOL; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METOPROLOL; NEUROHORMONE; RADIOISOTOPE;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; FEMALE; FOLLOW UP; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HORMONE BLOOD LEVEL; HUMAN; MALE; OUTPATIENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEX; STATISTICAL SIGNIFICANCE; UNITED STATES;

EID: 34249311583     PISSN: 00028703     EISSN: 10976744     Source Type: Journal    
DOI: 10.1016/j.ahj.2007.03.027     Document Type: Article

References (29)

1. Torre-Aminoe G. The syndrome of heart failure: emerging concepts in the understanding of its pathogenesis and treatment. Curr Opin Cardiol 14 (1999) 193-195
2. Packer M. Neurohumoral interactions and adaptations in congestive heart failure. Circulation 77 (1988) 721-730
3. Vasan R.S., Sullivan L.M., Roubenoff R., et al. Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation 107 (2003) 1486-1491
4. Belch J.J., Bridges A.B., Scott N., et al. Oxygen free radicals and congestive heart failure. Br Heart J 65 (1991) 245-248
5. Tsutamoto T., Wada A., Mastsumoto T., et al. Relationship between tumor necrosis factor-alpha production and oxidative stress in the failing hearts of patients with dilated cardiomyopathy. J Am Coll Cardiol 37 (2001) 2086-2092
6. Bohm M., Hjalmarson A., Kjekshus J., et al. Heart failure and statins-why do we need a clinical trial?. Z Kardiol 94 (2005) 223-230
7. Horwich T.B., MacLellan W.R., and Fonarow G.C. Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure. J Am Coll Cardiol 43 (2004) 642-648
8. Mozaffarian D., Nye R., and Levy W.C. Statin therapy is associated with lower mortality among patients with severe heart failure. Am J Cardiol 93 (2004) 1124-1129
9. Ray J.G., Gong Y., Sykora K., et al. Statin use and survival outcomes in elderly patients with heart failure. Arch Intern Med 165 (2005) 62-67
10. Foody J.M., Shah R., Galusha D., et al. Statin and mortality among elderly patients hospitalized with heart failure. Circulation 113 (2006) 1086-1092
11. Node K., Fujita M., Kitakaze M., et al. Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation 108 (2003) 839-843
12. Laufs U., Wassermann S., Schackmann S., et al. Beneficial effects of statins in patients with non-ischemic heart failure. Z Karilol 93 (2004) 103-108
13. Sola S., Muhammad Q.S., Lerakis S., et al. Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J Am Coll Cardiol 47 (2006) 332-337
14. Wojnicz R., Wilczek K., Kozielska E., et al. Usefulness of atorvastatin in patients with heart failure due to inflammatory dilated cardiomyopathy and elevated cholesterol levels. Am J Cardiol 97 (2006) 899-904
15. Trochu J.N., Mital S., Zhang X., et al. Preservation of NO production by statins in the treatment of heart failure. Cardiovasc Res 60 (2003) 250-258
16. Mozaffarian D., Minami E., Letterer R., et al. The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. Am J Cardiol 96 (2005) 1699-1704
17. Pliquett R.U., Cornish K.G., and Zucker I.H. Statin therapy restores sympathovagal balance in experimental heart failure. J Appl Physiol 95 (2003) 700-704
18. Hayashidani S., Tsutsui H., Shiomi T., et al. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 105 (2002) 868-873
19. Kioka H., Shimonagata T., Misaki N., et al. What is the major determinant factor of exercise capacity in patients with chronic heart failure. [abstract]. J Card Fail 10 Suppl (2004) S168
20. Fukuta H., Sane D.C., Brucks S., et al. Statin therapy may be associated with lower mortality in patients with diastolic heart failure. A preliminary report. Circulation 112 (2005) 357-363
21. Bleske B.E., Nicklas J.M., Bard R., et al. Neutral effect on markers of heart failure, inflammation, endothelial activation and function, and vagal tone after high-dose HMG-CoA reductase inhibition in non-diabetic patients with non-ischemic cardiomyopathy and average low-density lipoprotein level. J Am Coll Cardiol 47 (2006) 338-341
22. Rauchhaus M., Coats A.J., and Anker S.D. The endotoxin-lipoprotein hypothesis. Lancet 356 (2000) 930-933
23. Dhalla N.S., Temsah R.M., and Netticaden T. Role of oxidative stress in cardiovascular disease. J Hypertens 18 (2000) 655-673
24. Li J.M., Gall N.P., Grieve D.J., et al. Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hyperteniosn 40 (2002) 477-484
25. Maack C., Kartes T., Kilter H., et al. Oxygen free radical release in human failing myocardium is associated with increased activity of Rac1-GTPase and represents a target for statin treatment. Circulation 108 (2003) 1567-1574
26. Tsutsui T., Tsutamoto T., Wada A., et al. Plasma oxidized low-density lipoprotein as a prognostic predictor in patients with chronic congestive heart failure. J Am Coll Cardiol 39 (2003) 957-962
27. Pinsky D.J., Cai B., Yang X., et al. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthetase antagonism or transforming growth factor beta. J Clin Invest 95 (1995) 677-685
28. Antoniades C., Tousoulis D., Vasiliadou C., et al. Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response. Am J Cardiol 94 (2004) 1181-1184
29. Rauchhaus M., Clark A.L., Doehner W., et al. The relationship between cholesterol and survival in patients with chronic heart failure. J Am Coll Cardiol 42 (2003) 1933-1940