The nutrigenomics of asthma: Molecular mechanisms of airway neutrophilia following dietary antioxidant withdrawal

OMICS A Journal of Integrative Biology

Volumn 13, Issue 5, 2009, Pages 355-365

  Baines, Katherine J ^a,b   Wood, Lisa G ^a,b   Gibson, Peter G ^a,b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CARBOXYPEPTIDASE D; CD 93 ANTIGEN; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE ALPHA 1; GLUTATHIONE TRANSFERASE ALPHA 2; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; INTERLEUKIN 1 RECEPTOR TYPE II; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 25; RNA; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERPIN PEPTIDASE INHIBITOR CLADE B (OVALBUMIN) MEMBER 3; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GENE EXPRESSION; GENOME ANALYSIS; HUMAN; INNATE IMMUNITY; MALE; MICROARRAY ANALYSIS; MOLECULAR MECHANICS; NEUTROPHIL; NUCLEOTIDE SEQUENCE; NUTRIGENOMICS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPUTUM ANALYSIS; UNINDEXED SEQUENCE; UPREGULATION;

AGED; ANTIOXIDANTS; ASTHMA; DIET; DIETARY SUPPLEMENTS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; IMMUNITY, INNATE; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEUTROPHILS; NUTRIGENOMICS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REACTIVE OXYGEN SPECIES; RESPIRATORY MUCOSA;

EID: 70349680540     PISSN: 15362310     EISSN: None     Source Type: Journal    
DOI: 10.1089/omi.2009.0042     Document Type: Article

References (36)

1. Bai, S.K., Lee, S.J., Na, H.J., Ha, K.S., Han, J.A., Lee, H., et al. (2005). Beta-carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation. Exp Mol Med 37, 323-334
2. Balaci, L., Spada, M.C., Olla, N., Sole, G., Loddo, L., Anedda, F., et al. (2007). IRAK-M is involved in the pathogenesis of earlyonset persistent asthma. Am J Hum Genet 80, 1103-1114
3. Ben-Dor, A., Steiner, M., Gheber, L., Danilenko, M., Dubi, N., Linnewiel, K., et al. (2005). Carotenoids activate the antioxidant response element transcription system. Mol Cancer Ther 4, 177-186
4. Carcamo, J.M., Pedraza, A., Borquez-Ojeda, O., and Golde, D.W. (2002). Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation. Biochemistry 41, 12995-13002
5. Ford, E.S., Mannino, D.M., and Redd, S.C. (2004). Serum antioxidant concentrations among U.S. adults with self-reported asthma. J Asthma 41, 179-187
6. Gibson, P.G., Wlodarczyk, J.W., Hensley, M.J., Gleeson, M., Henry, R.L., Cripps, A.W., et al. (1998). Epidemiological association of airway inflammation with asthma symptoms and airway hyperresponsiveness in childhood. Am J Respir Crit Care Med 158, 36-41
7. Grissell, T.V., Powell, H., Shafren, D.R., Boyle, M.J., Hensley, M.J., Jones, P.D., et al. (2005). Interleukin-10 gene expression in acute virus-induced asthma. Am J Respir Crit Care Med 172, 433-439
8. Imboden, M., Downs, S.H., Senn, O., Matyas, G., Brandli, O., Russi, E.W., et al. (2007). Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study. Respir Res 8, 2
9. Imboden, M., Rochat, T., Brutsche, M., Schindler, C., Downs, S.H., Gerbase, M.W., et al. (2008). Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults. Thorax 63, 322-328
10. Kanetaka, Y., Hayashida, M., Hoshika, A., Yanase, N., and Mizuguchi, J. (2008). Interferon-alpha induces transient upregulation of c-FLIP through NF-kappaB activation. Exp Cell Res 314, 246-254
11. Keating, S.E., Maloney, G.M., Moran, E.M., and Bowie, A.G. (2007). IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF-6 ubiquitination. J Biol Chem 282, 33435-33443
12. Kelly, F.J., Mudway, I., Blomberg, A., Frew, A., and Sandstrom, T. (1999). Altered lung antioxidant status in patients with mild asthma. Lancet 354, 482-483
13. Kim, G.Y., Kim, J.H., Ahn, S.C., Lee, H.J., Moon, D.O., Lee, C.M., et al. (2004). Lycopene suppresses the lipopolysaccharideinduced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB. Immunology 113, 203-211
14. Kurt-Jones, E., Mandell, L., Whitney, C., Padgett, A., Gosselin, K., Newburger, P.E., et al. (2002). Role of Toll-like receptor 2 (TLR2) in neutrophil activation: GM-CSF enhances TLR2 expression and TLR2-mediated interleukin 8 responses in neutrophils. Blood 100, 1860-1868
15. Kussmann, M., Raymond, F., and Affolter, M. (2006). OMICSdriven biomarker discovery in nutrition and health. J Biotechnol 124, 758-787
16. Muller, M., and Kersten, S. (2003). Nutrigenomics: goals and strategies. Nat Rev Genet 4, 315-322
17. Nadeem, A., Chhabra, S.K., Masood, A., and Raj, H.G. (2003). Increased oxidative stress and altered levels of antioxidants in asthma. J Allergy Clin Immunol 111, 72-78
18. Ng, L., Nichols, K., O'Rourke, K., Maslen, A., and Kirby, G.M. (2007). Repression of human GSTA1 by interleukin-1B Iss mediated by variant hepatic nuclear factor-1C. Mol Pharmacol 71, 201-208
19. Park, D., Shim, E., Kim, Y., Kim, Y.M., Lee, H.H., Choe, J., et al. (2008). C-FLIP promotes the motility of cancer cells by activating FAK and ERK, and increasing MMP-9 expression. Mol Cells 25, 184-195
20. Paul-Clark, M.J., McMaster, S.K., Sorrentino, R., Sriskandan, S., Bailey, L.K., Moreno, L., et al. (2009). Toll-like receptor 2 is essential for the sensing of oxidants during inflammation. Am J Respir Crit Care Med 179, 299-306
21. Payton, K.S., Sheldon, R.A., Mack, D.W., Zhu, C., Blomgren, K., Ferriero, D.M., et al. (2007). Antioxidant staus alters levels of Fas-associated death domain-like IL-1B-converting enzyme inhibitory protein following neonatal hypoxia-ischemia. Dev Neurosci 29, 403-411
22. Rahman, I. (2003). Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J Biochem Mol Biol 36, 95-109
23. Record, I.R., Dreosti, I.E., and McInerney, J.K. (2001). Changes in plasma antioxidant status following consumption of diets high or low in fruit and vegetables or following dietary supplementation with an antioxidant mixture. Br J Nutr 85, 459-464
24. Reeves, E.P., Lu, H., Jacobs, H.L., Messina, C.G., Bolsover, S., Gabella, G., et al. (2002). Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416, 291-297
25. Rubin, R.N., Navon, L., and Cassano, P.A. (2004). Relationship of serum antioxidants to asthma prevalence in youth. Am J Respir Crit Care Med 169, 393-398
26. Sabroe, I., Jones, E.C., Whyte, M.K., and Dower, S.K. (2005). Regulation of human neutrophil chemokine receptor expression and function by activating Toll-like receptors 2 and 4. Immunology 115, 90-98
27. Sharma, P., Raghavan, S.A., Saini, R., and Dikshit, M. (2004). Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: modulatory effect of nitric oxide. J Leukoc Biol 75, 1070-1078
28. Simpson, J.L., Grissell, T.G., Douwes, J., Scott, R.J., Boyle, M.J., and Gibson, P.G. (2006). Innate immune activation in neutrophilic asthma and bronchiectasis. Thorax 62, 211-218
29. Simpson, J.L., Scott, R.J., Boyle, M.J., and Gibson, P.G. (2006). Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 11, 54-61
30. Strange, R.C., Spiteri, M.A., Ramachandran, S., and Fryer, A.A. (2001). Glutathione-S-tranferase family of enzymes. Mutat Res 482, 21-26
31. Tan, P.H., Sagoo, P., Chan, C., Yates, J.B., Campbell, J., Beutelspacher, S.C., et al. (2005). Inhibition of NF-kB and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol 174, 7633-7644
32. Tauler, P., Aguilo, A., Fuentespina, E., Tur, J.A., and Pons, A. (2002). Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. Pflugers Arch 443, 791-797
33. van der Vliet, A., O'Neill, C., Cross, C.E., Koostra, J.M., Volz, W.G., Halliwell, B., et al. (1999). Determination of lowmolecular- mass anti-oxidant concentrations in human respiratory tract lining fluids. Am J Physiol Lung Cell Mol Physiol 276, L289-L296
34. Vignola, A.M., Bonanno, A., Mirabella, A., Riccobono, L., Mirabella, F., Profita, M., et al. (1998). Increased levels of elastase and a1-antitrypsin in sputum of asthmatic patients. Am J Respir Crit Care Med 157, 505-511
35. Wood, L.G., Garg, M.L., Blake, R.J., Garcia-Caraballo, S., and Gibson, P.G. (2005). Airway and circulating levels of carotenoids in asthma and healthy controls. J Am Coll Nutr 24, 448-455
36. Wood, L.G., Garg, M.L., Powell, H., and Gibson, P.G. (2008). Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: Proof of concept. Free Radic Res 42, 94-102