Established neointimal hyperplasia in vein grafts expands via TGF-β-mediated progressive fibrosis

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 4, 2009, Pages

  Jiang, Zhihua ^a,c   Tao, Ming ^b   Omalley, Kerri A ^a   Wang, Danlu ^a   Ozaki, C Keith ^b   Berceli, Scott A ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c NONE   (United States)

Author keywords

Connective tissue growth factor; Stenosis; Transforming growth factor

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; GELATINASE B; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SYNTHESIS; EXPERIMENTAL RABBIT; HEART MUSCLE FIBROSIS; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGICAL TRAIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; VEIN GRAFT; WESTERN BLOTTING;

ANIMALS; CAROTID ARTERY, COMMON; CELL PROLIFERATION; CONNECTIVE TISSUE GROWTH FACTOR; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; FIBROSIS; GRAFT OCCLUSION, VASCULAR; HYPERPLASIA; JUGULAR VEINS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICRODISSECTION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RABBITS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; TUNICA INTIMA; VASCULAR PATENCY;

EID: 70349623329     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00268.2009     Document Type: Article

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