Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells

Blood

Volumn 114, Issue 11, 2009, Pages 2236-2243

  Calado, Rodrigo T ^a   Yewdell, William T ^a   Wilkerson, Keisha L ^a   Regal, Joshua A ^a   Kajigaya, Sachiko ^a   Stratakis, Constantine A ^b   Young, Neal S ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUTAMIDE; LETROZOLE; MESSENGER RNA; SEX HORMONE; SMALL INTERFERING RNA; TAMOXIFEN; TELOMERASE; ANDROGEN RECEPTOR; ANTIANDROGEN; ANTIESTROGEN; AROMATASE INHIBITOR; ESR1 PROTEIN, HUMAN; ESTROGEN; NITRILE; TERT PROTEIN, HUMAN; TRIAZOLE DERIVATIVE;

AROMATIZATION; ARTICLE; BONE MARROW; BONE MARROW DEPRESSION; CD34 SELECTION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENE MUTATION; HEMATOPOIETIC CELL; HETEROZYGOTE; HORMONAL THERAPY; HUMAN; HUMAN CELL; IN VITRO STUDY; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; APLASTIC ANEMIA; BIOSYNTHESIS; DRUG ANTAGONISM; DYSKERATOSIS CONGENITA; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC STEM CELL; LYMPHOCYTE; MALE; METABOLISM; MUTATION; PATHOLOGY;

ANDROGEN ANTAGONISTS; ANDROGENS; ANEMIA, APLASTIC; AROMATASE INHIBITORS; DYSKERATOSIS CONGENITA; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; FLUTAMIDE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEMATOPOIETIC STEM CELLS; HETEROZYGOTE; HUMANS; LYMPHOCYTES; MALE; MUTATION; NITRILES; RECEPTORS, ANDROGEN; TAMOXIFEN; TELOMERASE; TRIAZOLES;

EID: 70349569075     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-09-178871     Document Type: Article

References (43)

1. Calado RT, Young NS. Telomere maintenance and human bone marrow failure. Blood. 2008;111:4446-4455.
2. Blackburn EH. Switching and signaling at the telomere. Cell. 2001;106:661-673.
3. Watson JD. Origin of concatemeric T7 DNA. Nat New Biol. 1972;239:197-201.
4. Kim NW, Piatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266:2011-2015.
5. Heiss NS, Knight SW, Vulliamy TJ, et al. X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functions. Nat Genet. 1998;19:32-38.
6. Knight SW, Heiss NS, Vulliamy TJ, et al. X-linked dyskeratosis congenita is predominantly caused by missense mutations in the DKC1 gene. Am J Hum Genet. 1999;65:50-58.
7. Vulliamy T, Marrone A, Goldman F, et al. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature. 2001;413:432-435. (Pubitemid 32928599)
8. Vulliamy T, Walne A, Baskaradas A, et al. Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure. Blood Cells Mol Dis. 2005;34:257-263. (Pubitemid 40693563)
9. Savage SA, Giri N, Baerlocher GM, et al. TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet. 2008;82:501-509.
10. Walne AJ, Vulliamy T, Marrone A, et al. Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. Hum Mol Genet. 2007;16:1619-1629. (Pubitemid 47050675)
11. Marrone A, Walne A, Tamary H, et al. Telomerase reverse transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. Blood. 2007;110:4198-4205.
12. Fogarty PF, Yamaguchi H, Wiestner A, et al. Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet. 2003;362:1628-1630. (Pubitemid 37443532)
13. Yamaguchi H, Baerlocher GM, Lansdorp PM, et al. Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood. 2003;102:916-918. (Pubitemid 36917783)
14. Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood. 2006;108:2511-2521.
15. Ly H, Calado RT, Allard P, et al. Functional characterization of telomerase RNA variants found in patients with hematological disorders. Blood. 2005;105:2332-2339. (Pubitemid 40387027)
16. Yamaguchi H, Calado RT, Ly H, et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med. 2005;352:1413-1424. (Pubitemid 40471449)
17. Dokal I, Vulliamy T. Dyskeratosis congenita: its link to telomerase and aplastic anaemia. Blood Rev. 2003;17:217-225. (Pubitemid 37356392)
18. Guo C, Armbruster BN, Price DT, Counter CM. In vivo regulation of hTERT expression and telomerase activity by androgen. J Urol. 2003;170:615-618. (Pubitemid 36870271)
19. Bayne S, Liu JP. Hormones and growth factors regulate telomerase activity in ageing and cancer. Mol Cell Endocrinol. 2005;240:11-22. (Pubitemid 41133367)
20. Nakamura TM, Morin GB, Chapman KB, et al. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997;277:955-959.
21. Kyo S, Takakura M, Kanaya T, et al. Estrogen activates telomerase. Cancer Res. 1999;59:5917-5921.
22. Misiti S, Nanni S, Fontemaggi G, et al. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol. 2000;20:3764-3771. (Pubitemid 30314476)
23. Vottero A, Kirschner LS, Yue W, Brodie A, Stratakis CA. P450arom gene expression in peripheral blood lymphocytes: identification of a cryptic splice site for exon-1 after Epstein-Barr virus transformation. J Steroid Biochem Mol Biol. 1998;64:245-250. (Pubitemid 28221627)
24. Vottero A, Rochira V, Capelletti M, et al. Aromatase is differentially expressed in peripheral blood leukocytes from children, and adult female and male subjects. Eur J Endocrinol. 2006;154:425-431.
25. Larionov AA, Poroshina TE, Zimarina TS, Leenman EE, Berstein LM. Aromatase (estrogen-synthetase) gene expression in human leukocytes. Russ J Physiol. 2000;80:10-17.
26. Shahidi NT. Androgens and erythropoiesis. N Engl J Med. 1973;289:72-80.
27. Sanchez-Medal L, Gomez-Leal A, Duarte L, Rico MG. Anabolic androgenic steroids in the treatment of acquired aplastic anemia. Blood. 1969;34:283-295.
28. Najean Y, Haguenauer O. Long-term (5 to 20 years) evolution of nongrafted aplastic anemia. Blood. 1990;76:2222-2228.
29. Champlin RE, Ho WG, Feig SA, et al. Do androgens enhance the response to antithymocyte globulin in patients with aplastic anemia? A prospective randomized trial. Blood. 1985;66:184-188.
30. Bacigalupo A, Chaple M, Hows J, et al. Treatment of aplastic anemia (AA) with antilymphocyte globulin (ALG) and methylprednisolone (MPred) with or without androgens: a randomized trial from the EBMT SAA working party. Br J Haematol. 1993;83:145-151. (Pubitemid 23030186)
31. Stebler C, Tichelli A, Gratwohl A, Hoffmann T, Nissen C, Speck B. Androgen dependence in patients with severe aplastic anemia after antilymphocyte globulin therapy. Bone Marrow Transplant. 1991;7(suppl 2):101.
32. Li X, Leteurtre F, Rocha V, et al. Abnormal telomere metabolism in Fanconi's anaemia correlates with genomic instability and the probability of developing severe aplastic anaemia. Br J Haematol. 2003;120:836-845. (Pubitemid 36315108)
33. Bagby G, Alter B. Fanconi anemia. Semin Hematol. 2006;43:147-156.
34. Fried W, Morley C. Effects of androgenic steroids on erythropoiesis. Steroids. 1985;46:799-826.
35. Soda H, Raymond E, Sharma S, et al. Effects of androgens on telomerase activity in normal and malignant prostate cells in vitro. Prostate. 2000;43:161-168. (Pubitemid 30230451)
36. Nanni S, Narducci M, Della Pietra L, et al. Signaling through estrogen receptors modulates telomerase activity in human prostate cancer. J Clin Invest. 2002;110:219-227. (Pubitemid 34787359)
37. Samy TSA, Zheng R, Matsutani T, et al. Mechanism for normal splenic T lymphocyte functions in proestrus females after trauma: enhanced local synthesis of 17beta-estradiol. Am J Physiol Cell Physiol. 2003;285:C139-C149. (Pubitemid 36736346)
38. Federman DD. The biology of human sex differences. N Engl J Med. 2006;354:1507-1514.
39. Vasa-Nicotera M, Brouilette S, Mangino M, et al. Mapping of a major locus that determines telomere length in humans. Am J Hum Genet. 2005;76:174-1151
40. Lee DC, Imm JA, Kim JH, Lee HR, Shim JY. Effect of long-term hormone therapy on telomere length in postmenopausal women. Yonsei Med J. 2005;46:471-479. (Pubitemid 41283056)
41. Frenck RW Jr, Blackburn EH, Shannon KM. The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A. 1998;95:5607-5610.
42. Artandi SE, Chang S, Lee SL, et al. Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice. Nature. 2000;406:641-645. (Pubitemid 30641052)
43. Calado RT, Regal JA, Hills M, et al. Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Nat Acad Sci U S A. 2009;106:1187-1192.