Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex

Experimental Cell Research

Volumn 315, Issue 17, 2009, Pages 2914-2920

  Sandoval, Raudel ^a   Pilkinton, Mark ^a   Colamonici, Oscar R ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

CDK4; Cell cycle; LIN 9; Mip LIN 9

Indexed keywords

CELL PROTEIN; CYCLIN DEPENDENT KINASE 4; PROTEIN LIN 9; PROTEIN MIP130; PROTEIN MYB; PROTEIN P107; PROTEIN P130; TRANSCRIPTION FACTOR E2F4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL CYCLE PHASE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC REGULATION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION;

CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 70349564336     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.07.014     Document Type: Article

References (31)

1. Sherr C.J., and Roberts J.M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18 (2004) 2699-2711
2. Ciemerych M.A., and Sicinski P. Cell cycle in mouse development. Oncogene 24 (2005) 2877-2898
3. Deshpande A., Sicinski P., and Hinds P.W. Cyclins and cdks in development and cancer: a perspective. Oncogene 24 (2005) 2909-2915
4. Cobrinik D. Pocket proteins and cell cycle control. Oncogene 24 (2005) 2796-2809
5. van den Heuvel S., and Dyson N.J. Conserved functions of the pRB and E2F families. Nat. Rev. Mol. Cell Biol. 9 (2008) 713-724
6. Attwooll C., Lazzerini Denchi E., and Helin K. The E2F family: specific functions and overlapping interests. EMBO J. 23 (2004) 4709-4716
7. Blais A., and Dynlacht B.D. Hitting their targets: an emerging picture of E2F and cell cycle control. Curr. Opin. Genet. Dev. 14 (2004) 527-532
8. Frolov M.V., and Dyson N.J. Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J. Cell. Sci. 117 (2004) 2173-2181
9. Dimova D.K., and Dyson N.J. The E2F transcriptional network: old acquaintances with new faces. Oncogene 24 (2005) 2810-2826
10. Fung T.Y., and Poon Y.C. A roller coaster ride with the mitotic cyclins. Semin. Cell Dev. Biol. 16 (2005) 335-342
11. Du W., and Pogoriler J. Retinoblastoma family genes. Oncogene 25 (2006) 5190-5200
12. Beijersbergen R.L., Carlee L., Kerkhoven R.M., and Bernards R. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 9 (1995) 1340-1353
13. Xiao Z.X., Ginsberg D., Ewen M., and Livingston D.M. Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 4633-4637
14. Leng X., Noble M., Adams P.D., Qin J., and Harper J.W. Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol. Cell. Biol. 22 (2002) 2242-2254
15. Hansen K., Farkas T., Lukas J., Holm K., Ronnstrand L., and Bartek J. Phosphorylation-dependent and -independent functions of p130 cooperate to evoke a sustained G1 block. EMBO J. 20 (2001) 422-432
16. Ferreira R., Magnaghi-Jaulin L., Robin P., Harel-Bellan A., and Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 10493-10498
17. Lindeman G.J., Gaubatz S., Livingston D.M., and Ginsberg D. The subcellular localization of E2F-4 is cell-cycle dependent. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 5095-5100
18. Muller H., Moroni M.C., Vigo E., Petersen B.O., Bartek J., and Helin K. Induction of S-phase entry by E2F transcription factors depends on their nuclear localization. Mol. Cell. Biol. 17 (1997) 5508-5520
19. Verona R., Moberg K., Estes S., Starz M., Vernon J.P., and Lees J.A. E2F activity is regulated by cell cycle-dependent changes in subcellular localization. Mol. Cell. Biol. 17 (1997) 7268-7282
20. Zhu W., Giangrande P.H., and Nevins J.R. E2Fs link the control of G1/S and G2/M transcription. EMBO J. 23 (2004) 4615-4626
21. Pilkinton M., Sandoval R., Song J., Ness S.A., and Colamonici O.R. Mip/LIN-9 regulates the expression of B-Myb, and the induction of cyclin A, cyclin B and CDK1. J. Biol. Chem. 282 (2007) 168-175
22. Osterloh L., von Eyss B., Schmit F., Rein L., Hubner D., Samans B., Hauser S., and Gaubatz S. The human synMuv-like protein LIN-9 is required for transcription of G2/M genes and for entry into mitosis. EMBO J. 26 (2007) 144-157
23. Pilkinton M., Sandoval R., and Colamonici O.R. Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex. Oncogene 26 (2007) 7535-7546
24. Sandoval R., Xue J., Tian X., Barrett K., Pilkinton M., Baida G., Ucker D., Raychaudhuri P., Cook J.L., Kineman R.D., Luque R.M., Zou X., Valli V.E., Kiyokawa H., and Colamonici O.R. A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repression on E2F-regulated genes. Exp. Cell Res. 312 (2006) 2465-2475
25. Beall E.L., Bell M., Georlette D., and Botchan M.R. Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes Dev. 18 (2004) 1667-1680
26. Korenjak M., Taylor-Harding B., Binne U.K., Satterlee J.S., Stevaux O., Aasland R., White-Cooper H., Dyson N., and Brehm A. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell 119 (2004) 181-193
27. Lewis P.W., Beall E.L., Fleischer T.C., Georlette D., Link A.J., and Botchan M.R. Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes Dev. 18 (2004) 2929-2940
28. Litovchick L., Sadasivam S., Florens L., Zhu X., Swanson S.K., Velmurugan S., Chen R., Washburn M.P., Liu X.S., and Decaprio J.A. Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence. Mol. Cell 26 (2007) 539-551
29. Schmit F., Korenjak M., Mannefeld M., Schmitt K., Franke C., von Eyss B., Gagrica S., Hanel F., Brehm A., and Gaubatz S. LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes. Cell Cycle 6 (2007) 1903-1913
30. Pilkinton M., Sandoval R., Barrett K., Tian X., and Colamonici O.R. Mip/LIN-9 can inhibit cell proliferation independent of the pocket proteins. Blood Cells Mol. Dis. 39 (2007) 272-277
31. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(- Delta Delta C(T)) Method. Methods 25 (2001) 402-408