Astragalus mongholicus polysaccharide inhibits lipopolysaccharide-induced production of TNF-α and interleukin-8

World Journal of Gastroenterology

Volumn 15, Issue 29, 2009, Pages 3676-3680

  Yuan, Yuan ^a,b   Sun, Mei ^a   Li, Ke Shen ^c  

^a CHINA MEDICAL UNIVERSITY   (China)

^b The 211 Hospital of PLA   (China)

^c HARBIN ENGINEERING UNIVERSITY   (China)

Author keywords

Astragalus mongholicus polysaccharide; C Jun amino terminal kinase; Extracellular signal regulated kinase; Interleukin 8; Intestinal epithelial cells; P38 kinase; Tumor necrosis factor

Indexed keywords

ASTRAGALUS MONGHOLICUS EXTRACT; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PLANT EXTRACT; POLYSACCHARIDE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE EXPRESSION; INTESTINE EPITHELIUM CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; ASTRAGALUS PLANT; CELL LINE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLYSACCHARIDES; RATS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70349561832     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.3676     Document Type: Article

References (30)

1. Haller D, Jobin C. Interaction between resident luminal bacteria and the host: can a healthy relationship turn sour? J Pediatr Gastroenterol Nutr 2004; 38: 123-136
2. Lotz M, Ménard S, Hornef M. Innate immune recognition on the intestinal mucosa. Int J Med Microbiol 2007; 297: 379-392
3. Haller D, Holt L, Kim SC, Schwabe RF, Sartor RB, Jobin C. Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation. J Biol Chem 2003; 278: 23851-23860
4. Haller D, Russo MP, Sartor RB, Jobin C. IKK beta and phosphatidylinositol 3-kinase/Akt participate in nonpathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. J Biol Chem 2002; 277: 38168-38178
5. Kim JS, Narula AS, Jobin C. Salvia miltiorrhiza watersoluble extract, but not its constituent salvianolic acid B, abrogates LPS-induced NF-kappaB signalling in intestinal epithelial cells. Clin Exp Immunol 2005; 141: 288-297
6. Zhao KS, Mancini C, Doria G. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharmacology 1990; 20: 225-233
7. Lee YS, Han OK, Park CW, Yang CH, Jeon TW, Yoo WK, Kim SH, Kim HJ. Pro-inflammatory cytokine gene expression and nitric oxide regulation of aqueous extracted Astragali radix in RAW 264.7 macrophage cells. J Ethnopharmacol 2005; 100: 289-294
8. Liu ZQ, Li QZ, Qin GJ. [Effect of Astragalus injection on platelet function and plasma endothelin in patients with early stage diabetic nephropathy] Zhongguo Zhongxiyi Jiehe Zazhi 2001; 21: 274-276
9. Wu L, Liu H, Xue P, Lu ZG, Du KF. [Influence of a triplex superimposed treatment on HBV replication and mutation during treating chronic hepatitis B] Zhonghua Shiyan He Linchuang Bingduxue Zazhi 2001; 15: 236-238
10. Yesilada E, Bedir E, Calis I, Takaishi Y, Ohmoto Y. Effects of triterpene saponins from Astragalus species on in vitro cytokine release. J Ethnopharmacol 2005; 96: 71-77
11. Chen XJ, Bian ZP, Lu S, Xu JD, Gu CR, Yang D, Zhang JN. Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. Am J Chin Med 2006; 34: 493-502
12. Ryu M, Kim EH, Chun M, Kang S, Shim B, Yu YB, Jeong G, Lee JS. Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk. J Ethnopharmacol 2008; 115: 184-193
13. Kim C, Ha H, Kim JS, Kim YT, Kwon SC, Park SW. Induction of growth hormone by the roots of Astragalus membranaceus in pituitary cell culture. Arch Pharm Res 2003; 26: 34-39
14. Sheng MX, Li JZ, Wang HY. [Therapeutic effect of Astragalus and Angelica on renal injury induced by ischemia/reperfusion in rats] Zhongguo Zhongxiyi Jiehe Zazhi 2001; 21: 43-46
15. Yu J, Zhang Y, Sun S, Shen J, Qiu J, Yin X, Yin H, Jiang S. Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats. Can J Physiol Pharmacol 2006; 84: 579-587
16. Yang DZ. [Effect of Astragalus membranaceus on myoelectric activity of small intestine] Zhongguo Zhongxiyi Jiehe Zazhi 1993; 13: 616-617, 582
17. Hei ZQ, Huang HQ, Zhang JJ, Chen BX, Li XY. Protective effect of Astragalus membranaceus on intestinal mucosa reperfusion injury after hemorrhagic shock in rats. World J Gastroenterol 2005; 11: 4986-4991
18. Tzianabos AO. Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function. Clin Microbiol Rev 2000; 13: 523-533
19. Han SB, Kim YH, Lee CW, Park SM, Lee HY, Ahn KS, Kim IH, Kim HM. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunopharmacology 1998; 40: 39-48
20. Shao BM, Xu W, Dai H, Tu P, Li Z, Gao XM. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochem Biophys Res Commun 2004; 320: 1103-1111
21. Cui R, He J, Wang B, Zhang F, Chen G, Yin S, Shen H. Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats. Cancer Chemother Pharmacol 2003; 51: 75-80
22. Dong C, Davis RJ, Flavell RA. MAP kinases in the immune response. Annu Rev Immunol 2002; 20: 55-72
23. Waetzig GH, Seegert D, Rosenstiel P, Nikolaus S, Schreiber S. p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease. J Immunol 2002; 168: 5342-5351
24. Grishin AV, Wang J, Potoka DA, Hackam DJ, Upperman JS, Boyle P, Zamora R, Ford HR. Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. J Immunol 2006; 176: 580-588
25. Haller D, Holt L, Parlesak A, Zanga J, Bäuerlein A, Sartor RB, Jobin C. Differential effect of immune cells on nonpathogenic Gram-negative bacteria-induced nuclear factor-kappaB activation and pro-inflammatory gene expression in intestinal epithelial cells. Immunology 2004; 112: 310-320
26. Kim YS, Kim JS, Jung HC, Song IS. The effects of thalidomide on the stimulation of NF-kappaB activity and TNF-alpha production by lipopolysaccharide in a human colonic epithelial cell line. Mol Cells 2004; 17: 210-216
27. Sumbayev VV, Yasinska IM. Role of MAP kinase-dependent apoptotic pathway in innate immune responses and viral infection. Scand J Immunol 2006; 63: 391-400
28. Nimah M, Zhao B, Denenberg AG, Bueno O, Molkentin J, Wong HR, Shanley TP. Contribution of MKP-1 regulation of p38 to endotoxin tolerance. Shock 2005; 23: 80-87
29. Wu JJ, Bennett AM. Essential role for mitogen-activated protein (MAP) kinase phosphatase-1 in stress-responsive MAP kinase and cell survival signaling. J Biol Chem 2005; 280: 16461-16466
30. Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A, Liu Y. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38. J Biol Chem 2005; 280: 8101-8108