Lipid emulsions as vehicles for enhanced nasal delivery of insulin

International Journal of Pharmaceutics

Volumn 205, Issue 1-2, 2000, Pages 127-134

  Mitra, Ranjana ^a   Pezron, Isabelle ^a,b   Chu, Waihei A ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

Author keywords

Absorption enhancement; Insulin; Lipid emulsion; Nasal absorption; Systemic bioavailability

Indexed keywords

DRUG VEHICLE; INSULIN ZINC SUSPENSION; LIPID EMULSION; POLYSORBATE 80; SORBITAN OLEATE; SOYBEAN OIL; WATER OIL CREAM;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; IN VIVO STUDY; MALE; NONHUMAN; NOSE CAVITY; NOSE MUCOSA; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INTRANASAL; ANIMAL; DRUG DELIVERY SYSTEMS; EMULSIONS; HYPOGLYCEMIC AGENTS; INSULIN; NASAL CAVITY; RATS; SOYBEAN OIL; SUPPORT, NON-U.S. GOV'T;

EID: 0034665475     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00506-8     Document Type: Article

References (29)

1. Banks, W.A., Kastin, A.J., 1985. Peptides and the blood-brain barrier lipophilicity as a predictor of permeability. Brain Res. Bull., 15, 287-292.
2. Chandler S.G., Thomas N.W., Illum L. Nasal absorption in the rat. III. Effect of lysophospholipids on insulin absorption and nasal histology. Pharm. Res. 11:1994;1623-1630.
3. Constantidines P.P., Scalart J.P., Lancaster C., Marcello J., Marks G., Ellen H., Smith P.L. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions and incorporating medium-chain glycerides. Pharm. Res. 11:1994;1385-1390.
4. Drekker K., Vaag A., Bech K., Hansen P., Sorensen A.R., Mygind N. Intranasal administration of insulin with phospholipid as absorption enhancer: pharmacokinetics in normal subjects. Diabet. Med. 9:1992;335-340.
5. Gordon G.S., Moses A.C., Silver R.D., Flier J.S., Carey M.C. Nasal absorption of insulin: enhancement by hydrophobic bile salts. Proc. Natl. Acad. Sci. USA. 82:1985;7419-7423.
6. Hirai S., Yashki T., Mima H. Effect of surfactants on the nasal absorption of insulin in rats. Int. J. Pharm. 9:1981;165-172.
7. Hirai S., Yashki T., Mima H. Mechanisms for the enhancement of the nasal absorption of insulin by surfactants. Int. J. Pharm. 9:1981;173-184.
8. Hirai S., Yashiki T., Matsuzawa T., Mima H. Absorption of drugs from the nasal mucosa of rat. Int. J. Pharm. 7:1981;317-325.
9. Huang C.H., Kimura R., Nassar R.B., Hussain A. Mechanism of nasal absorption of drugs. I. Physicochemical parameters influencing the rate of in situ nasal absorption of drugs in rats. J. Pharm. Sci. 74:1985;608-611.
10. Hussain A.A. Intranasal drug delivery. Adv. Drug Deliv. Rev. 29:1998;39-49.
11. Hvidt S. Insulin association in neutral solutions studied by light scattering. Biophys. Chem. 39:1991;205-213.
12. Li Y., Shao Z., Denicola D.B., Mitra A.K. Effect of a conjugated bile salt on the pulmonary absorption of insulin in rats. Eur. J. Pharm. Biopharm. 39:1993;216-221.
13. Liu F., Shao Z., Kildsig D.O., Mitra A.K. Pulmonary delivery of free and liposomal insulin. Pharm. Res. 10:1993;228-232.
14. Martin E., Verhoef J.C., Romeijn S.G., Merkus F.W.H.M. Effects of absorption enhancers on rat nasal epithelium in vivo: release of marker compounds in the nasal cavity. Pharm. Res. 12:1995;1151-1156.
15. Martin E., Schipper N.G.M., Verhoef J.C., Merkus F.W.H.M. Nasal mucociliary clearance as a factor in nasal drug delivery. Adv. Drug Deliv. Rev. 29:1998;13-38.
16. Merkus F.W.H.M., Verhoef J.C., Romeijn S.G., Schipper N.G.M. Absorption enhancing effetc of cyclodextrins on intranasally administrated insulin in rats. Pharm. Res. 8:1991;588-592.
17. Mouristen O.G., Jorgensen K., Honger T. Permeability of lipid bilayers near the phase transition. Disalvo E.A., Simon S.A. Permeability and Stability of Lipid. 1995;137-160 CRC Press, Boca Raton, FL.
18. Pereswetoff-Morath L. Microspheres as nasal drug delivery systems. Adv. Drug Deliv. Rev. 29:1998;185-194.
19. Quraishi M.S., Jones N.S., Mason J.D.T. The nasal delivery of drug. Clin. Otolaryngol. 22:1997;289-301.
20. Sakar M.A. Drug metabolism in the nasal mucosa. Pharm. Res. 9:1992;1-9.
21. Shao Z., Mitra A.K. Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport. Pharm. Res. 9:1992;1184-1189.
22. Shao Z., Krishnamoorthy R., Mitra A.K. Cyclodextrins as nasal absorption promoters of insulin: mechanistic evaluations. Pharm. Res. 9:1992;1157-1163.
23. Shao Z., Li Y., Krishnamoorthy R., Chermak T., Mitra A.K. Differential effects of anionic, cationic, nonionic and physiologic surfactants on the dissociation, alpha-chimotryptic degradation, and enteral absorption of insulin hexamers. Pharm. Res. 10:1993;243-251.
24. Shinoda K., Kunieda K. Phase properties of emulsions: PIT and HLB. Becher P. Encyclopedia of Emulsion Technology. I:1983;337-367 Dekker, New York.
25. Silva Cuhna A., Grossiord J.L., Puisieux F., Seiller M. Insulin in w/o/w multiple emulsions: biological activity after oral administration in normal and diabetic rats. J. Microencapsul. 14:1997;321-333.
26. Suzuki A., Morishita M., Kajita M., Takayama K., Isowa K., Chiba Y., Tokiwa S., Nagai T. Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. J. Pharm. Sci. 87:1998;1196-1202.
27. Tengamnuay P., Mitra A.K. Bile salt-fatty acid mixed micelles as nasal absorption promoters of peptides. II. In vivo nasal absorption of insulin in rats and effects of mixed micelles on the morphological integrity of the nasal mucosa. Pharm. Res. 7:1990;370-375.
28. Tenktrog T., Muller B.W. Preparation and characterization of a peptide containing w/o emulsion. Int. J. Pharm. 123:1995;199-207.
29. Wiessner J.H., Hwang K.J. Binding of insulin to the external surface of liposomes. Effect of surface curvature, temperature, and lipid composition. Biochim. Biophys. Acta. 689:1982;490-498.