Induction of epithelial mesenchimal transition and vasculogenesis in the lenses of Dbl oncogene transgenic mice

PLoS ONE

Volumn 4, Issue 9, 2009, Pages

  Fardin, Paolo ^a   Ognibene, Marzia ^a   Vanni, Cristina ^a   De Santanna, Amleto ^b   Varesio, Luigi ^a   Eva, Alessandra ^a  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; ALPHA6 INTEGRIN; BETA CRYSTALLIN A1; BETA CRYSTALLIN B2; CADHERIN 1; CADHERIN 2; CELL MARKER; COMPLEMENTARY DNA; GAMMA CRYSTALLIN B; GAMMA CRYSTALLIN C; GAMMA CRYSTALLIN D; GAMMA CRYSTALLIN F; GAMMA CRYSTALLIN S; GENE PRODUCT; GUANINE NUCLEOTIDE; LAMININ ALPHA2; MACROPHAGE ELASTASE; METALLOTHIONEIN; NOTCH RECEPTOR; OLIGONUCLEOTIDE; P CADHERIN; PROCOLLAGEN TYPE I ALPHA 1; PROCOLLAGEN TYPE IV ALPHA 1; PROCOLLAGEN TYPE IV ALPHA 2; PROCOLLAGEN TYPE IV ALPHA 3; PROTEIN DBL; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MCF2 PROTEIN, MOUSE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ADHESION; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EXPERIMENTAL MOUSE; EYE DEVELOPMENT; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LENS; LYMPHANGIOGENESIS; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE; RAT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; UNINDEXED SEQUENCE; UPREGULATION; ANIMAL; CELL MOTION; CHEMISTRY; EPITHELIUM; FEMALE; GENETICS; MALE; MESODERM; METABOLISM; MOUSE; PHYSIOLOGY; VASCULARIZATION;

MUS; MUS MUSCULUS;

ANIMALS; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; LENS, CRYSTALLINE; MALE; MESODERM; METALLOTHIONEIN; MICE; MICE, TRANSGENIC; RHO GTP-BINDING PROTEINS;

EID: 70349512278     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007058     Document Type: Article

References (65)

1. Rossman KL, Der CJ, Sondek J (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6: 167-180.
2. Erickson JW, Cerione RA (2004) Structural elements, mechanism, and evolutionary convergence of Rho protein-guanine nucleotide exchange factor complexes. Biochemistry 43: 837-842.
3. Schmidt A, Hall A (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16: 1587-1609.
4. Jaffe AB, Hall A (2005) Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21: 247-269.
5. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, et al. (2003) Cell migration: integrating signals from front to back. Science 302: 1704-1709.
6. Burridge K, Wennerberg K (2004) Rho and Rac take center stage. Cell 116: 167-179.
7. Ron D, Graziani G, Aaronson SA, Eva A (1989) The N-terminal region of proto-dbl down regulates its transforming activity. Oncogene 4: 1067-1072.
8. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, et al. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146.
9. Westwick JK, Lee RJ, Lambert QT, Symons M, Pestell RG, et al. (1998) Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J Biol Chem 273: 16739-16747.
10. Whitehead IP, Lambert QT, Glaven JA, Abe K, Rossman KL, et al. (1999) Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation. Mol Cell Biol 19: 7759-7770.
11. Eva A, Graziani G, Zannini M, Merin LM, Khillan JS, et al. (1991) Dominant dysplasia of the lens in transgenic mice expressing the dbl oncogene. New Biol 3: 158-168.
12. Thiery JP (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746.
13. Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142.
14. Polyak K, Weinberg RA (2009) Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 9: 265-273.
15. Low MJ, Hammer RE, Goodman RH, Habener JF, Palmiter RD, et al. (1985) Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Cell 41: 211-219.
16. Eva A, Vecchio G, Rao CD, Tronick SR, Aaronson SA (1988) The predicted DBL oncogene product defines a distinct class of transforming proteins. Proc Natl Acad Sci U S A 85: 2061-2065.
17. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, et al. (2003) DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4: 3.
18. Rozen R, Skaletsky HJ (2000) Primer 3 on the WWW for general users and for biological programmers. Bioinformatics Methods and Protocols: Methods in Molecular Biology. pp 365.
19. Pfaffl MW, Tichopad A, Prgomet C, Neuvians TP (2004) Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations. Biotechnol Lett 26: 509-515.
20. Muller PY, Janovjak H, Miserez AR, Dobbie Z (2002) Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32: 1372-1379.
21. Balzac F, Avolio M, Degani S, Kaverina I, Torti M, et al. (2005) E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J Cell Sci 118: 4765-4783.
22. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29.
23. Conti I, Rollins BJ (2004) CCL2 (monocyte chemoattractant protein-1) and cancer. Semin Cancer Biol 14: 149-154.
24. Katoh M, Katoh M (2007) WNT signaling pathway and stem cell signaling network. Clin Cancer Res 13: 4042-4045.
25. Burdsal CA, Damsky CH, Pedersen RA (1993) The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak. Development 118: 829-844.
26. Nieto MA (2001) The early steps of neural crest development. Mech Dev 105: 27-35.
27. Hirsch E, Pozzato M, Vercelli A, Barberis L, Azzolino O, et al. (2002) Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl. Mol Cell Biol 22: 3140-3148.
28. Perng MD, Zhang Q, Quinlan RA (2007) Insights into the beaded filament of the eye lens. Exp Cell Res 313: 2180-2188.
29. Cory S, Adams JM (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656.
30. Adams JM, Cory S (2007) The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26: 1324-1337.
31. Rangaswami H, Bulbule A, Kundu GC (2006) Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol 16: 79-87.
32. Wai PY, Kuo PC (2008) Osteopontin: regulation in tumor metastasis. Cancer Metastasis Rev 27: 103-118.
33. Shapiro SD, Kobayashi DK, Ley TJ (1993) Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J Biol Chem 268: 23824-23829.
34. Sharma MC, Sharma M (2007) The role of annexin II in angiogenesis and tumor progression: a potential therapeutic target. Current Pharmaceutical Design 13: 3568-3575.
35. Fonsatti E, Altomonte M, Nicotra MR, Natali PG, Maio M (2003) Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels. Oncogene 22: 6557-6563.
36. Marcantonio JM, Syam PP, Liu CS, Duncan G (2003) Epithelial transdifferentiation and cataract in the human lens. Exp Eye Res 77: 339-346.
37. Banh A, Deschamps PA, Gauldie J, Overbeek PA, Sivak JG, et al. (2006) Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3. Invest Ophthalmol Vis Sci 47: 3450-3460.
38. Lee EH, Wan XH, Song J, Kang JJ, Cho JW, et al. (2002) Lens epithelial cell death and reduction of anti-apoptotic protein Bcl-2 in human anterior polar cataracts. Mol Vis 8: 235-240.
39. Murphy BJ, Andrews GK, Bittel D, Discher DJ, McCue J, et al. (1999) Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res 59: 1315-1322.
40. Kojima I, Tanaka T, Inagi R, Nishi H, Aburatani H, et al. (2009) Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney. Kidney Int 75: 268-277.
41. Murphy BJ, Kimura T, Sato BG, Shi Y, Andrews GK (2008) Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha. Mol Cancer Res 6: 483-490.
42. Wang B, Wood IS, Trayhurn P (2008) PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes. Biochem Biophys Res Commun 368: 88-93.
43. Zhang HJ, Miao ZC, He ZP, Yang YX, Wang Y, et al. (2005) The existence of epithelial-to-mesenchymal cells with the ability to support hematopoiesis in human fetal liver. Cell Biology International 29: 213-219.
44. Nakaya Y, Sukowati EW, Wu Y, Sheng G (2008) RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulation. Nat Cell Biol 10: 765-775.
45. Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, et al. (2006) ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell 10: 227-239.
46. Wang X, Belguise K, Kersual N, Kirsch KH, Mineva ND, et al. (2007) Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat Cell Biol 9: 470-478.
47. Ma L, Lu MF, Schwartz RJ, Martin JF (2005) Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132: 5601-5611.
48. Yu F, Yao H, Zhu P, Zhang X, Pan Q, et al. (2007) let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109-1123.
49. Robson EJ, Khaled WT, Abell K, Watson CJ (2006) Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines. Differentiation 74: 254-264.
50. Zhang C, Carl TF, Trudeau ED, Simmet T, Klymkowsky MW (2006) An NF-kappaB and slug regulatory loop active in early vertebrate mesoderm. PLoS One 1: e106.
51. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
52. Ghoul A, Serova M, Astorgues-Xerri L, Bieche I, Bousquet G, et al. (2009) Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. Cancer Res 69: 4260-4269.
53. Ohta H, Aoyagi K, Fukaya M, Danjoh I, Ohta A, et al. (2009) Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers. Br J Cancer 100: 389-398.
54. Lehembre F, Yilmaz M, Wicki A, Schomber T, Strittmatter K, et al. (2008) NCAM-induced focal adhesion assembly: a functional switch upon loss of E-cadherin. EMBO J 27: 2603-2615.
55. Xu Y, Wan J, Jiang D, Wu X (2009) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells. J Nephrol 22: 403-410.
56. Boyer B, Valles AM, Edme N (2000) Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol 60: 1091-1099.
57. Alonso-Magdalena P, Brossner C, Reiner A, Cheng G, Sugiyama N, et al. (2009) A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia. Proc Natl Acad Sci U S A 106: 2859-2863.
58. Waldmann J, Feldmann G, Slater EP, Langer P, Buchholz M, et al. (2008) Expression of the zinc-finger transcription factor Snail in adrenocortical carcinoma is associated with decreased survival. Br J Cancer 99: 1900-1907.
59. Rodgers RJ, Irving-Rodgers HF, van Wezel IL (2000) Extracellular matrix in ovarian follicles. Mol Cell Endocrinol 163: 73-79.
60. Przybylo JA, Radisky DC (2007) Matrix metalloproteinase-induced epithelial-mesenchymal transition: tumor progression at Snail's pace. Int J Biochem Cell Biol 39: 1082-1088.
61. Orlichenko LS, Radisky DC (2008) Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis 25: 593-600.
62. Hu K, Mars WM, Liu Y (2008) Novel actions of tissue-type plasminogen activator in chronic kidney disease. Front Biosci 13: 5174-5186.
63. Yoo HJ, Yun BR, Kwon JH, Ahn HS, Seol MA, et al. (2009) Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells. Exp Mol Med 41: 102-115.
64. Chiu ST, Chang KJ, Ting CH, Shen HC, Li H, et al. (2009) Over-expression of EphB3 Enhances Cell-Cell Contacts and Suppresses Tumor Growth in HT-29 Human Colon Cancer Cells. Carcinogenesis.
65. Polette M, Mestdagt M, Bindels S, Nawrocki-Raby B, Hunziker W, et al. (2007) Beta-catenin and ZO-1: shuttle molecules involved in tumor invasion-associated epithelial-mesenchymal transition processes. Cells Tissues Organs 185: 61-65.