Inhibitory effect of wild-type p53 gene on excessive replication of centrosomes in leukemia cell line K562

Chinese Journal of Cancer

Volumn 28, Issue 2, 2009, Pages 122-126

  Tian, Wen Jun ^a   Feng, Wen Li ^a   Wang, Hong Bin ^a   Huang, Shi Feng ^a   Cao, Wei Xi ^a   Huang, Zong Gan ^b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Aurora A; BubR1; Centrosome; Gadd45a; K562 cell; p53 gene; Signal transduction

Indexed keywords

ADENOVIRUS VECTOR; AURORA A KINASE; BUB1 RELATED PROTEIN; GREEN FLUORESCENT PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45A; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER STAGING; CELL DIVISION; CENTROSOME; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENETIC REGULATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LEUKEMIA CELL; LEUKEMIA CELL LINE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

ADENOVIRIDAE; ANALYSIS OF VARIANCE; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE; CENTROSOME; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENOTYPE; GREEN FLUORESCENT PROTEINS; HUMANS; K562 CELLS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICROSCOPY, CONFOCAL; MUTATION; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70349495239     PISSN: 1000467X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Ye X, Niu Y, Fang ZY. Correlations of centrosome abnormality and genomic instability to tumor [J]. Ai Zheng, 2005,24(10):1290-1292.
2. Kramer A, Neben K, Ho AD. Centrosome replication, genomic instability and cancer [J]. Leukemia, 2002,16(5):767-775.
3. Giehl M, Fabarius A, Frank O, et al. Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability [J]. Leukemia, 2005,19(7):1192-1197.
4. Fukasawa K, Choi T, Kuriyama R, et al. Abnormal centrosome amplification in the absence of p53 [J]. Science, 1996,271(5256):1744-1747.
5. Fry AM. The Nek2 protein kinase: a novel regulator of centrosome structure [J]. Oncogene, 2002,21(40):6184-6194.
6. Shao S, Wang Y, Jin S, et al. Gadd45a interacts with aurora-A and inhibits its kinase activity [J]. J Biol Chem, 2006,281(39):28943-28950.
7. Oikawa T, Okuda M, Ma Z, et al. Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1 [J]. Mol Cell Biol, 2005,25(10):4046-4061.
8. Liu Q, Kaneko S, Yang L, et al. Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215 [J]. J Biol Chem, 2004,279(50):52175-52182.
9. Katayama H, Sasai K, Kawai H, et al. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 [J]. Nat Genet, 2004,36(1):55-62.
10. Dutertre S, Descamps S, Prigent C. On the role of aurora-A in centrosome function [J]. Oncogene, 2002,21(40):6175-6183.
11. Meraldi P, Honda R, Nigg EA. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells [J]. EMBO J, 2002,21(4):483-492.
12. Chen SS, Chang PC, Cheng YW, et al. Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function [J]. EMBO J, 2002,21(17):4491-4499.
13. Ikezoe T, Yang J, Nishioka C, et al. A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia [J]. Mol Cancer Ther, 2007,6(6):1851-1857.