Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 37, 2009, Pages 15610-15615

  He, Huawei ^a   Yang, Taehong ^a   Terman, Jonathan R ^a   Zhang, Xuewu ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autoinhibition; Axon guidance; Signaling; Structure

Indexed keywords

GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MEMBRANE RECEPTOR; PLEXIN; PLEXIN A3; PLEXIN B1; RAS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RND1 PROTEIN; SEMAPHORIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONFORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; HUMAN; HUMAN CELL; IN VIVO STUDY; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DROSOPHILA PROTEINS; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SEMAPHORINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 70349453563     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0906923106     Document Type: Article

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