Alteration of oligomeric state and domain architecture is essential for functional transformation between transferase and hydrolase with the same scaffold

Protein Science

Volumn 18, Issue 10, 2009, Pages 2060-2066

  Koike, Ryotaro ^a,b   Kidera, Akinori ^b,c,d   Ota, Motonori ^a,b  

^a NAGOYA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d RIKEN   (Japan)

Author keywords

Domain fusion; Enzyme; Evolution; Oligomerization; Superfamily

Indexed keywords

HYDROLASE; OLIGOMER; SCAFFOLD PROTEIN; SOLVENT; TRANSFERASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBUNIT; LIGAND BINDING; MOLECULE; OLIGOMERIZATION; PRIORITY JOURNAL;

CATALYTIC DOMAIN; DATABASES, PROTEIN; HYDROLASES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES;

EID: 70349452284     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.218     Document Type: Article

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