High-Septal Pacing Reduces Ventricular Electrical Remodeling and Proarrhythmia in Chronic Atrioventricular Block Dogs

Journal of the American College of Cardiology

Volumn 50, Issue 9, 2007, Pages 906-913

  Winckels, Stephan K G ^a   Thomsen, Morten B ^a   Oosterhoff, Peter ^a,b   Oros, Avram ^a   Beekman, Jet D M ^a   Attevelt, Nico J M ^a   Kretzers, Leo ^b   Vos, Marc A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b MEDTRONIC BAKKEN RESEARCH CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DOFETILIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE DURATION; DOG; ELECTRIC ACTIVITY; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; HEART BEAT; HEART PACING; HEART PROARRHYTHMIA; HEART REPOLARIZATION; HEART VENTRICLE REMODELING; HIS BUNDLE; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; TORSADE DES POINTES;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIA; BRADYCARDIA; CARDIAC PACING, ARTIFICIAL; DISEASE MODELS, ANIMAL; DOGS; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEART BLOCK; HEART CONDUCTION SYSTEM; HEART VENTRICLES; VENTRICULAR REMODELING;

EID: 34548047919     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2007.05.019     Document Type: Article

References (33)

1. De Groot S., Schoenmakers M., Molenschot M., Leunissen J., Wellens H., and Vos M. Contractile adaptations preserving cardiac output predispose the hypertrophied canine heart to delayed afterdepolarization-dependent ventricular arrhythmias. Circulation 102 (2000) 2145-2151
2. Donker D., Volders P., Arts T., et al. End-diastolic myofiber stress and ejection strain increase with ventricular volume overload-serial in-vivo analyses in dogs with complete atrioventricular block. Basic Res Cardiol 100 (2005) 372-382
3. Ramakers C., Stengl M., Spatjens R., Moorman A., and Vos M. Molecular and electrical characterization of the canine cardiac ventricular septum. J Mol Cell Cardiol 38 (2005) 153-161
4. Schoenmakers M., Ramakers C., Van Opstal J., Leunissen J., Londono C., and Vos M. Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog. Cardiovasc Res 59 (2003) 351-359
5. Schreiner K., Kelemen K., Zehelein J., et al. Biventricular hypertrophy in dogs with chronic AV block: effects of cyclosporin A on morphology and electrophysiology. Am J Physiol Heart Circ Physiol 287 (2004) H2891-H2898
6. Suto F., Zhu W., Cahill S., Greenwald I., Navarro A., and Gross G. Ventricular rate determines early bradycardic electrical remodeling. Heart Rhythm 2 (2005) 293-300
7. Thomsen M.B., Truin M., Van Opstal J., et al. Sudden cardiac death in dogs with remodeled hearts is associated with larger beat-to-beat variability of repolarization. Basic Res Cardiol 100 (2005) 279-287
8. Thomsen M.B., Volders P.G., Beekman J.D., Matz J., and Vos M.A. Beat-to-beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes. J Am Coll Cardiol 48 (2006) 1268-1276
9. Tsuji Y., Opthof T., Yasui K., et al. Ionic mechanisms of acquired QT prolongation and torsades de pointes in rabbits with chronic complete atrioventricular block. Circulation 106 (2002) 2012-2018
10. Tsuji Y., Zicha S., Qi X., Kodama I., and Nattel S. Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes. Circulation 113 (2006) 345-355
11. Van Opstal J., Verduyn S., Leunissen H., De Groot S., Wellens H., and Vos M. Electrophysiological parameters indicative of sudden cardiac death in the dog with chronic complete AV-block. Cardiovasc Res 50 (2001) 354-361
12. Verduyn S., Ramakers C., Snoep G., Leunissen J., Wellens H., and Vos M. Time course of structural adaptations in chronic AV block dogs: evidence for differential ventricular remodeling. Am J Physiol Heart Circ Physiol 280 (2001) H2882-H2890
13. Volders P., Sipido K., Vos M., et al. Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes. Circulation 100 (1999) 2455-2461
14. Vos M., Verduyn S., Gorgels A., Lipcsei G., and Wellens H. Reproducible induction of early afterdepolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation 91 (1995) 864-872
15. Vos M., De Groot S., Verduyn S., et al. Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling. Circulation 98 (1998) 1125-1135
16. Sugiyama A., Ishida Y., Satoh Y., et al. Electrophysiological, anatomical and histological remodeling of the heart to AV block enhances susceptibility to arrhythmogenic effects of QT-prolonging drugs. Jpn J Pharmacol 88 (2002) 341-350
17. Sipido K., Volders P., De Groot S., et al. Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis. Circulation 102 (2000) 2137-2144
18. Prinzen F., Van Oosterhout M., Vanagt W., Storm C., and Reneman R. Optimization of ventricular function by improving the activation sequence during ventricular pacing. Pacing Clin Electrophysiol 21 (1998) 2256-2260
19. Wilkoff B., Cook J., Epstein A., et al. Dual-chamber pacing or ventricular backup pacing in patients with an implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) trial. JAMA 288 (2002) 3115-3123
20. Deshmukh P., Casavant D., Romanyshyn M., and Anderson K. Permanent, direct His-bundle pacing: a novel approach to cardiac pacing in patients with normal His-Purkinje activation. Circulation 101 (2000) 869-877
21. Zanon F., Baracca E., Aggio S., et al. A feasible approach for direct his-bundle pacing using a new steerable catheter to facilitate precise lead placement. J Cardiovasc Electrophysiol 17 (2006) 29-33
22. Occhetta E., Bortnik M., Magnani A., et al. Prevention of ventricular desynchronization by permanent para-Hisian pacing after atrioventricular node ablation in chronic atrial fibrillation. A crossover, blinded, randomized study versus apical right ventricular pacing. J Am Coll Cardiol 47 (2006) 1938-1945
23. Laske T.G., Skadsberg N.D., Hill A.J., Klein G.J., and Iaizzo P.A. Excitation of the intrinsic conduction system through his and interventricular septal pacing. Pacing Clin Electrophysiol 29 (2006) 397-405
24. Thomsen M., Verduyn S., Stengl M., et al. Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation 110 (2004) 2453-2459
25. Olivier N., Eyster G., Sanders R., et al. Atrioventricular nodal ablation and His-bundle pacing: an acute canine model for proarrhythmic risk assesment. J Cardiovasc Electrophysiol 14 (2003) 1356-1360
26. Thomsen M.B., Oros A., Schoenmakers M., et al. Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation. Cardiovasc Res 73 (2007) 521-530
27. Van de Water A., Verheyen J., Xhonneux R., and Reneman R. An improved method to correct the QT interval of the electrocardiogram for changes in heart rate. J Pharmacol Methods 22 (1989) 207-217
28. Stengl M., Ramakers C., Donker D., et al. Temporal patterns of electrical remodeling in canine ventricular hypertrophy: focus on I(Ks) downregulation and blunted beta-adrenergic activation. Cardiovasc Res 72 (2006) 90-100
29. Peschar M., Vernooy K., Vanagt W., Reneman R., Vos M., and Prinzen F. Absence of reverse electrical remodeling during regression of volume overload hypertrophy in canine ventricles. Cardiovasc Res 58 (2003) 510-517
30. Prinzen F., and Peschar M. Relation between the pacing induced sequence of activation and left ventricular pump function in animals. Pacing Clin Electrophysiol 25 (2002) 484-498
31. Sharma A., Rizo-Patron C., Hallstrom A., et al. Percent right ventricular pacing predicts outcomes in the DAVID trial. Heart Rhythm 2 (2005) 830-834
32. Riedlbauchova L., Kautzner J., Hatala R., and Buckingham T. Is right ventricular outflow tract pacing an alternative to left ventricular/biventricular pacing?. Pacing Clin Electrophysiol 27 (2004) 871-877
33. Thambo J., Bordachar P., Garrigue S., et al. Detrimental ventricular remodeling in patients with congenital complete heart block and chronic right ventricular apical pacing. Circulation 110 (2004) 3766-3772