Efficient induction of cytotoxic T lymphocytes specific for severe acute respiratory syndrome (SARS)-associated coronavirus by immunization with surface-linked liposomal peptides derived from a non-structural polyprotein 1a

Antiviral Research

Volumn 84, Issue 2, 2009, Pages 168-177

  Kohyama, Shunsuke ^a,b   Ohno, Satoshi ^a,b   Suda, Tatsuya ^a   Taneichi, Maiko ^c   Yokoyama, Shoichi ^d   Mori, Masahito ^d   Kobayashi, Akiharu ^d   Hayashi, Hidenori ^b   Uchida, Tetsuya ^c   Matsui, Masanori ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b JOSAI UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^d JAPAN ENERGY CORPORATION   (Japan)

Author keywords

Cytotoxic T lymphocyte; Liposome; Peptide; Polyprotein 1a; SARS coronavirus; Vaccine

Indexed keywords

EPITOPE; GAMMA INTERFERON; HLA A ANTIGEN; LIPOSOME; POLYPROTEIN; POLYPROTEIN 1A; SEVERE ACUTE RESPIRATORY SYNDROME VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CORONAVIRUS; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; IMMUNOGENICITY; INTERFERON PRODUCTION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEVERE ACUTE RESPIRATORY SYNDROME;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; EPITOPES, T-LYMPHOCYTE; HUMANS; IMMUNIZATION; LIPOSOMES; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDES; RNA REPLICASE; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; T-LYMPHOCYTES, CYTOTOXIC; VIRAL NONSTRUCTURAL PROTEINS; VIRAL VACCINES;

CORONAVIRUS; MUS; SARS CORONAVIRUS;

EID: 70349446448     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.09.004     Document Type: Article

References (40)

1. Allen T.M., Altfeld M., Yu X.G., O'Sullivan K.M., Lichterfeld M., Le Gall S., John M., Mothe B.R., Lee P.K., Kalife E.T., Cohen D.E., Freedberg K.A., Strick D.A., Johnston M.N., Sette A., Rosenberg E.S., Mallal S.A., Goulder P.J., Brander C., and Walker B. Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J. Virol. 78 (2004) 7069-7078
2. Alving C.R., Koulchin V., Glenn G.M., and Rao M. Liposomes as carriers of peptide antigens: induction of antibodies and cytotoxic T lymphocytes to conjugated and unconjugated peptides. Immunol. Rev. 145 (1995) 5-31
3. + T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals. J. Immunol. 175 (2005) 591-598
4. + cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D. J. Immunol. 180 (2008) 426-437
5. Davila E., Kennedy R., and Celis E. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res. 63 (2003) pp. 3281-2388
6. Draenert R., Le Gall S., Pfafferott K.J., Leslie A.J., Chetty P., Brander C., Holmes E.C., Chang S.C., Feeney M.E., Addo M.M., Ruiz L., Ramduth D., Jeena P., Altfeld M., Thomas S., Tang Y., Verrill C.L., Dixon C., Prado J.G., Kiepiela P., Martinez-Picado J., Walker B.D., and Goulder P.J. Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J. Exp. Med. 199 (2004) 905-915
7. Drosten C., Günther S., Preiser W., van der Werf S., Brodt H.R., Becker S., Rabenau H., Panning M., Kolesnikova L., Fouchier R.A., Berger A., Burguière A.M., Cinatl J., Eickmann M., Escriou N., Grywna K., Kramme S., Manuguerra J.C., Müller S., Rickerts V., Stürmer M., Vieth S., Klenk H.D., Osterhaus A.D., Schmitz H., and Doerr H.W. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med. 348 (2003) 1967-1976
8. Groneberg D.A., Hilgenfeld R., and Zabel P. Molecular mechanisms of severe acute respiratory syndrome (SARS). Respir. Res. 6 8 (2005) 1-16
9. Groneberg D.A., Zhang L., Welte T., Zabel P., and Chung K.F. Severe acute respiratory syndrome: global initiatives for disease diagnosis. Q. J. Med. 96 (2003) 845-852
10. Ksiazek T.G., Erdman D., Goldsmith C.S., Zaki S.R., Peret T., Emery S., Tong S., Urbani C., Comer J.A., Lim W., Rollin P.E., Dowell S.F., Ling A.E., Humphrey C.D., Shieh W.J., Guarner J., Paddock C.D., Rota P., Fields B., DeRisi J., Yang J.Y., Cox N., Hughes J.M., LeDuc J.W., Bellini W.J., Anderson L.J., and SARS Working Group. A novel coronavirus associated with severe acute respiratory syndrome. N. Engl. J. Med. 348 (2003) 1953-1966
11. Le Gall S., Stamegna P., and Walker B.D. Portable flanking sequences modulate CTL epitope processing. J. Clin. Invest. 117 (2007) 3563-3575
12. Li G., Chen X., and Xu A. Profile of specific antibodies to the SARS-associated coronavirus. N. Engl. J. Med. 349 (2003) 508-509
13. Li W., Moore M.J., Vasilieva N., Sui J., Wong S.K., Berne M.A., Somasundaran M., Sullivan J.L., Luzuriaga K., Greenough T.C., Choe H., and Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426 (2003) 450-454
14. Lin M., Tseng H.K., Trejaut J.A., Lee H.L., Loo J.H., Chu C.C., Chen P.J., Su Y.W., Lim K.H., Tsai Z.U., Lin R.Y., Lin R.S., and Huang C.H. Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Med. Genet. 4 (2003) 9-15
15. Matsui M., Moriya O., Belladonna M.L., Kamiya S., Lemonnier F.A., Yoshimoto T., and Akatsuka T. Adjuvant activities of novel cytokines, interleukine (IL)-23 and IL-27 for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice. J. Virol. 78 (2004) 9093-9104
16. Matsui M., Moriya O., Yoshimoto T., and Akatsuka T. T-bet is required for protection against vaccinia virus infection. J. Virol. 79 (2005) 12798-12806
17. + T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef. J. Immunol. 175 (2005) 4618-4626
18. Nagata T., Toyota T., Ishigaki H., Ichihashi T., Kajino K., Kashima Y., Itoh Y., Mori M., Oda H., Yamamura H., Taneichi M., Uchida T., and Ogasawara K. Peptides coupled to the surface of a kind of liposome protect infection of influenza viruses. Vaccine 25 (2007) 4914-4921
19. Ng M.H., Lau K.M., Li L., Cheng S.H., Chan W.Y., Hui P.K., Zee B., Leung C.B., and Sung J.J. Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome. J. Infect. Dis. 190 (2004) 515-518
20. Ohno S., Kohyama S., Taneichi M., Moriya O., Hayashi H., Oda H., Mori M., Kobayashi A., Akatsuka T., Uchida T., and Matsui M. Synthetic peptides coupled to the surface of liposomes effectively induce SARS coronavirus-specific cytotoxic T lymphocytes and viral clearance in HLA-A*0201 transgenic mice. Vaccine 27 (2009) 3912-3920
21. Ohno S., Moriya O., Yoshimoto T., Hayashi H., Akatsuka T., and Matsui M. Immunogenic variation between multiple HLA-A*0201-restricted, hepatitis C virus-derived epitopes for cytotoxic T lymphocytes. Viral. Immunol. 19 (2006) 458-467
22. Parham P., and Brodsky F.M. Partial purification and some properties of BB7.2: A cytotoxic monoclonal antibody with specificity for HLA-A2 and a variant of HLA-A28. Hum. Immunol. 3 (1981) 277-299
23. Parker K.C., Bednarek M.A., and Coligan J.E. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J. Immunol. 152 (1994) 163-175
24. b β2m double knockout mice. J. Exp. Med. 185 (1997) 2043-2051
25. Peiris J.S., Lai S.T., Poon L.L., Guan Y., Yam L.Y., Lim W., Nicholls J., Yee W.K., Yan W.W., Cheung M.T., Cheng V.C., Chan K.H., Tsang D.N., Yung R.W., Ng T.K., Yuen K.Y., and SARS study group. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 361 (2003) 1319-1325
26. Rammensee H.-G., Bachmann J., Emmerich N.P.N., Bachor O.A., and Stevanovic S. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics 50 (1999) 213-219
27. Salter R.D., Howell D.N., and Cresswell P. Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids. Immunogenetics 21 (1985) 235-246
28. Sette A., and Sidney J. Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism. Immunogenetics 50 (1999) 201-212
29. Street M.D., Doan T., Herd K.A., and Tindle R.W. Limitations of HLA-transgenic mice in presentation of HLA-restricted cytotoxic T-cell epitopes from endogenously processed human papillomavirus type 16 E7 protein. Immunology 106 (2002) 526-536
30. + T cell responses. J. Exp. Med. 198 (2003) 889-901
31. + T cells and induce potent antitumor immunity. J. Immunol. 177 (2006) 2324-2330
32. Tang X., Yin C., Zhang F., Fu Y., Chen W., Chen Y., Wang J., Jia W., and Xu A. Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance. Chin. Med. J. 116 (2003) 827-830
33. Tsao N.-P., Lin J.-Y., Jan J.-T., Leng C.-H., Chu C.-C., Yang Y.-C., and Chen S.-L. HLA-A*0201 T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus nucleocapsid and spike proteins. Biochem. Biophys. Res. Commun. 344 (2006) 63-71
34. + T-cell epitope SSp-1 of SARS-CoV spike protein. Blood 104 (2004) 200-206
35. Wang Y.D., Sin W.Y., Xu G.B., Yang H.H., Wong T.Y., Pang X.W., He X.Y., Zhang H.G., Ng J.N., Cheng C.S., Yu J., Meng L., Yang R.F., Lai S.T., Guo Z.H., Wie Y., and Chen W.F. T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS. J. Virol. 78 (2004) 5612-5618
36. Winter C.C., Carreno B.M., Turner R.V., Koenig S., and Biddison W.E. The 45 pocket of HLA-A2.1 plays a role in presentation of influenza virus matrix peptide and alloantigens. J. Immunol. 146 (1991) 3508-3512
37. Yang Z.Y., Kong W.P., Huang Y., Roberts A., Murphy B.R., Subbarao K., and Nabel G.J. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428 (2004) 561-564
38. + T cells and protects against herpes simplex virus type 2 challenge. Mucosal. Immunol. 2 (2009) 129-143
39. Zhou M., Xu D., Li X., Li H., Shan M., Tang J., Wang M., Wang F.-S., Zhu X., Tao H., He W., Tien P., and Gao G.F. Screening and identification of severe acute respiratory syndrome-associated coronavirus-specific CTL epitopes. J. Immunol. 177 (2006) 2138-2145
40. ε-palmitoyllysine moiety increase uptake and maturation of dendritic cells through a Toll-like receptor-2 pathway and trigger a Th1-dependent protective immunity. Eur. J. Immunol. 34 (2004) 3102-3114