Neuropathology of Lewy body disorders

Brain Research Bulletin

Volumn 80, Issue 4-5, 2009, Pages 203-210

  Kövari, Enikö ^a   Horvath, Judit ^a   Bouras, Constantin ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Alpha synuclein; Dementia; Lewy body; Parkinson's disease

Indexed keywords

NEUROLEPTIC AGENT;

ALZHEIMER DISEASE; AUTONOMIC DYSFUNCTION; AUTOPSY; COGNITIVE DEFECT; DEMENTIA; DIAGNOSTIC ACCURACY; DIAGNOSTIC PROCEDURE; DIFFUSE LEWY BODY DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; DYSPHAGIA; HUMAN; INCIDENCE; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; PROGNOSIS; REVIEW;

AUTONOMIC NERVOUS SYSTEM DISEASES; BRAIN; DEGLUTITION DISORDERS; HUMANS; LEWY BODIES; LEWY BODY DISEASE; PARKINSON DISEASE;

EID: 70349434716     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.06.018     Document Type: Review

References (96)

1. Aarsland D., Andersen K., Larsen J.P., Lolk A., Nielsen H., and Kragh-Sorensen P. Risk of dementia in Parkinson's disease: a community-based, prospective study. Neurology 56 (2001) 730-736
2. Aarsland D., Beyer M.K., and Kurz M.W. Dementia in Parkinson's disease. Curr. Opin. Neurol. 21 (2008) 676-682
3. Aarsland D., Tandberg E., Larsen J.P., and Cummings J.L. Frequency of dementia in Parkinson disease. Arch. Neurol. 53 (1996) 538-542
4. Adler C.H. Nonmotor complications in Parkinson's disease. Mov. Disord. 20 Suppl. 11 (2005) S23-29
5. Apaydin H., Ahlskog J.E., Parisi J.E., Boeve B.F., and Dickson D.W. Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response. Arch. Neurol. 59 (2002) 102-112
6. Braak H., and Braak E. Cognitive impairment in Parkinson's disease: amyloid plaques, neurofibrillary tangles, and neuropil threads in the cerebral cortex. J. Neural Transm. Park. Dis. Dement. Sect. 2 (1990) 45-57
7. Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. (Berl.) 82 (1991) 239-259
8. Braak H., Braak E., Yilmazer D., de Vos R.A., Jansen E.N., and Bohl J. Pattern of brain destruction in Parkinson's and Alzheimer's diseases. J. Neural Transm. 103 (1996) 455-490
9. Braak H., de Vos R.A., Bohl J., and Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci. Lett. 396 (2006) 67-72
10. Braak H., Del Tredici K., Bohl J., Bratzke H., and Braak E. Pathological changes in the parahippocampal region in select non-Alzheimer's dementias. Ann. N. Y. Acad. Sci. 911 (2000) 221-239
11. Braak H., Del Tredici K., Bratzke H., Hamm-Clement J., Sandmann-Keil D., and Rüb U. Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages). J. Neurol. 249 3 Suppl. (2002) III/1-5
12. Braak H., Del Tredici K., Rüb U., de Vos R.A., Jansen Steur E.N., and Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 24 (2003) 197-211
13. Braak H., Ghebremedhin E., Rüb U., Bratzke H., and Del Tredici K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res. 318 (2004) 121-134
14. Braak H., Sastre M., Bohl J.R., de Vos R.A., and Del Tredici K. Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol. 113 (2007) 421-429
15. Burns J.M., Galvin J.E., Roe C.M., Morris J.C., and McKeel D.W. The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs. Neurology 64 (2005) 1397-1403
16. Bushmann M., Dobmeyer S.M., Leeker L., and Perlmutter J.S. Swallowing abnormalities and their response to treatment in Parkinson's disease. Neurology 39 (1989) 1309-1314
17. Chang H.Y., Mashimo H., and Goyal R.K. Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am. J. Physiol. Gastrointest. Liver Physiol. 284 (2003) G357-366
18. Churchyard A., and Lees A.J. The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease. Neurology 49 (1997) 1570-1576
19. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology, Neurology 46 (1996) 1470.
20. Dale G.E., Probst A., Luthert P., Martin J., Anderton B.H., and Leigh P.N. Relationships between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathol. (Berl.) 83 (1992) 525-529
21. de Vos R.A., Jansen E.N., Stam F.C., Ravid R., and Swaab D.F. 'Lewy body disease': clinico-pathological correlations in 18 consecutive cases of Parkinson's disease with and without dementia. Clin. Neurol. Neurosurg. 97 (1995) 13-22
22. Den Hartog Jager W.A., and Bethlem J. The distribution of Lewy bodies in the central and autonomic nervous system in idiopathic paralysis agitans. J. Neurol. Neurosurg. Psychiatr. 23 (1960) 283-290
23. Devinsky O., Morrell M.J., and Vogt B.A. Contributions of anterior cingulate cortex to behaviour. Brain 118 Pt 1 (1995) 279-306
24. Dickson D.W., Ruan D., Crystal H., Mark M.H., Davies P., Kress Y., and Yen S.H. Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 41 (1991) 1402-1409
25. Dickson D.W., Schmidt M.L., Lee V.M., Zhao M.L., Yen S.H., and Trojanowski J.Q. Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease. Acta Neuropathol. (Berl.) 87 (1994) 269-276
26. Duyckaerts C., Gaspar P., Costa C., Bonnet A.M., and Hauw J.J. Dementia in Parkinson's disease. Morphometric data. Adv. Neurol. 60 (1993) 447-455
27. Edwards L.L., Quigley E.M., and Pfeiffer R.F. Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology. Neurology 42 (1992) 726-732
28. Emre M., Aarsland D., Brown R., Burn D.J., Duyckaerts C., Mizuno Y., Broe G.A., Cummings J., Dickson D.W., Gauthier S., Goldman J., Goetz C., Korczyn A., Lees A., Levy R., Litvan I., McKeith I., Olanow W., Poewe W., Quinn N., Sampaio C., Tolosa E., and Dubois B. Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov. Disord. 22 (2007) 1689-1707 quiz 1837
29. Forman M.S., Schmidt M.L., Kasturi S., Perl D.P., Lee V.M., and Trojanowski J.Q. Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. Am. J. Pathol. 160 (2002) 1725-1731
30. Francis P.T., and Perry E.K. Cholinergic and other neurotransmitter mechanisms in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. Mov. Disord. 22 17 Suppl. (2007) S351-357
31. Gilman S., Wenning G.K., Low P.A., Brooks D.J., Mathias C.J., Trojanowski J.Q., Wood N.W., Colosimo C., Durr A., Fowler C.J., Kaufmann H., Klockgether T., Lees A., Poewe W., Quinn N., Revesz T., Robertson D., Sandroni P., Seppi K., and Vidailhet M. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 71 (2008) 670-676
32. Goldstein D.S. Dysautonomia in Parkinson's disease: neurocardiological abnormalities. Lancet Neurol. 2 (2003) 669-676
33. Hansen L., Salmon D., Galasko D., Masliah E., Katzman R., DeTeresa R., Thal L., Pay M.M., Hofstetter R., Klauber M., et al. The Lewy body variant of Alzheimer's disease: a clinical and pathologic entity. Neurology 40 (1990) 1-8
34. Hansen L.A. Tautological tangles in neuropathological criteria for dementias associated with Lewy bodies. In: Perry R., McKeith I., and Perry E. (Eds). Dementia with Lewy bodies (1996), Cambridge University Press, Cambridge 204-211
35. Hansen L.A., and Samuel W. Criteria for Alzheimer's disease and the nosology of dementia with Lewy bodies. Neurology 48 (1997) 126-132
36. Harding A.J., Broe G.A., and Halliday G.M. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 125 (2002) 391-403
37. Harding A.J., Stimson E., Henderson J.M., and Halliday G.M. Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease. Brain 125 (2002) 2431-2445
38. Heyman A., Fillenbaum G.G., Gearing M., Mirra S.S., Welsh-Bohmer K.A., Peterson B., and Pieper C. Comparison of Lewy body variant of Alzheimer's disease with pure Alzheimer's disease: Consortium to Establish a Registry for Alzheimer's Disease, Part XIX. Neurology 52 (1999) 1839-1844
39. Hughes A.J., Daniel S.E., Blankson S., and Lees A.J. A clinicopathologic study of 100 cases of Parkinson's disease. Arch. Neurol. 50 (1993) 140-148
40. Hurtig H.I., Trojanowski J.Q., Galvin J., Ewbank D., Schmidt M.L., Lee V.M., Clark C.M., Glosser G., Stern M.B., Gollomp S.M., and Arnold S.E. Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease. Neurology 54 (2000) 1916-1921
41. Ince P., Irving D., MacArthur F., and Perry R.H. Quantitative neuropathological study of Alzheimer-type pathology in the hippocampus: comparison of senile dementia of Alzheimer type, senile dementia of Lewy body type, Parkinson's disease and non-demented elderly control patients. J. Neurol. Sci. 106 (1991) 142-152
42. Ince P.G., Perry E.K., and Morris C.M. Dementia with Lewy bodies. A distinct non-Alzheimer dementia syndrome?. Brain Pathol. 8 (1998) 299-324
43. Ito K., Nagano-Saito A., Kato T., Arahata Y., Nakamura A., Kawasumi Y., Hatano K., Abe Y., Yamada T., Kachi T., and Brooks D.J. Striatal and extrastriatal dysfunction in Parkinson's disease with dementia: a 6-[18F]fluoro-l-dopa PET study. Brain 125 (2002) 1358-1365
44. Jackson M., Lennox G., Balsitis M., and Lowe J. Lewy body dysphagia. J. Neurol. Neurosurg. Psychiatry 58 (1995) 756-758
45. Jellinger K.A. A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta Neuropathol. 116 (2008) 1-16
46. Jellinger K.A. Significance of brain lesions in Parkinson disease dementia and Lewy body dementia. Front. Neurol. Neurosci. 24 (2009) 114-125
47. Jellinger K.A., and Attems J. Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies?. Acta Neuropathol. 112 (2006) 253-260
48. Jellinger K.A., Seppi K., and Wenning G.K. Grading of neuropathology in multiple system atrophy: proposal for a novel scale. Mov. Disord. 20 12 Suppl. (2005) S29-36
49. Jendroska K., Lees A.J., Poewe W., and Daniel S.E. Amyloid beta-peptide and the dementia of Parkinson's disease. Mov. Disord. 11 (1996) 647-653
50. Kalaitzakis M.E., Graeber M.B., Gentleman S.M., and Pearce R.K. Evidence against a reliable staging system of alpha-synuclein pathology in Parkinson's disease. Neuropathol. Appl. Neurobiol. 35 (2009) 125-126
51. Kalaitzakis M.E., Graeber M.B., Gentleman S.M., and Pearce R.K. Striatal beta-amyloid deposition in Parkinson disease with dementia. J. Neuropathol. Exp. Neurol. 67 (2008) 155-161
52. Kaufmann H., Hague K., and Perl D. Accumulation of alpha-synuclein in autonomic nerves in pure autonomic failure. Neurology 56 (2001) 980-981
53. Kaufmann H., Nahm K., Purohit D., and Wolfe D. Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies. Neurology 63 (2004) 1093-1095
54. Kövari E., Burkhardt K., Lobrinus J.A., and Bouras C. Lewy body dysphagia. Acta Neuropathol. 114 (2007) 295-298
55. Kövari E., Gold G., Herrmann F.R., Canuto A., Hof P.R., Bouras C., and Giannakopoulos P. Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease. Acta Neuropathol. (Berl.) 106 (2003) 83-88
56. Lewy F.H. Paralysis agitans: I Pathologische Anatomie. In: Lewandowsky M. (Ed). Handbuch der Neurologie (1912), Springer, Berlin 920-933
57. Lippa C.F., Schmidt M.L., Lee V.M., and Trojanowski J.Q. Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease. Ann. Neurol. 45 (1999) 353-357
58. Lippa C.F., Smith T.W., and Swearer J.M. Alzheimer's disease and Lewy body disease: a comparative clinicopathological study. Ann. Neurol. 35 (1994) 81-88
59. Marder K., Tang M.X., Cote L., Stern Y., and Mayeux R. The frequency and associated risk factors for dementia in patients with Parkinson's disease. Arch. Neurol. 52 (1995) 695-701
60. Mattila P.M., Rinne J.O., Helenius H., Dickson D.W., and Roytta M. Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease. Acta Neuropathol. (Berl.) 100 (2000) 285-290
61. Mattila P.M., Roytta M., Torikka H., Dickson D.W., and Rinne J.O. Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease. Acta Neuropathol. (Berl.) 95 (1998) 576-582
62. Mayeux R., Chen J., Mirabello E., Marder K., Bell K., Dooneief G., Cote L., and Stern Y. An estimate of the incidence of dementia in idiopathic Parkinson's disease. Neurology 40 (1990) 1513-1517
63. Mayeux R., Denaro J., Hemenegildo N., Marder K., Tang M.X., Cote L.J., and Stern Y. A population-based investigation of Parkinson's disease with and without dementia. Relationship to age and gender. Arch. Neurol. 49 (1992) 492-497
64. McKeith I. Dementia with Lewy bodies and Parkinson's disease with dementia: where two worlds collide. Pract. Neurol. 7 (2007) 374-382
65. McKeith I., Mintzer J., Aarsland D., Burn D., Chiu H., Cohen-Mansfield J., Dickson D., Dubois B., Duda J.E., Feldman H., Gauthier S., Halliday G., Lawlor B., Lippa C., Lopez O.L., Carlos Machado J., O'Brien J., Playfer J., and Reid W. Dementia with Lewy bodies. Lancet Neurol. 3 (2004) 19-28
66. McKeith I.G. Clinical Lewy body syndromes. Ann. N. Y. Acad. Sci. 920 (2000) 1-8
67. McKeith I.G., Dickson D.W., Lowe J., Emre M., O'Brien J.T., Feldman H., Cummings J., Duda J.E., Lippa C., Perry E.K., Aarsland D., Arai H., Ballard C.G., Boeve B., Burn D.J., Costa D., Del Ser T., Dubois B., Galasko D., Gauthier S., Goetz C.G., Gomez-Tortosa E., Halliday G., Hansen L.A., Hardy J., Iwatsubo T., Kalaria R.N., Kaufer D., Kenny R.A., Korczyn A., Kosaka K., Lee V.M., Lees A., Litvan I., Londos E., Lopez O.L., Minoshima S., Mizuno Y., Molina J.A., Mukaetova-Ladinska E.B., Pasquier F., Perry R.H., Schulz J.B., Trojanowski J.Q., and Yamada M. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65 (2005) 1863-1872
68. McKeith I.G., Galasko D., Kosaka K., Perry E.K., Dickson D.W., Hansen L.A., Salmon D.P., Lowe J., Mirra S.S., Byrne E.J., Lennox G., Quinn N.P., Edwardson J.A., Ince P.G., Bergeron C., Burns A., Miller B.L., Lovestone S., Collerton D., Jansen E.N., Ballard C., de Vos R.A., Wilcock G.K., Jellinger K.A., and Perry R.H. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47 (1996) 1113-1124
69. McKeith I.G., Perry E.K., and Perry R.H. Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology 53 (1999) 902-905
70. Mirra S.S., Heyman A., McKeel D., Sumi S.M., Crain B.J., Brownlee L.M., Vogel F.S., Hughes J.P., van Belle G., and Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41 (1991) 479-486
71. Mori H., Oda M., Komori T., Arai N., Takanashi M., Mizutani T., Hirai S., and Mizuno Y. Lewy bodies in progressive supranuclear palsy. Acta Neuropathol. 104 (2002) 273-278
72. Muller J., Wenning G.K., Verny M., McKee A., Chaudhuri K.R., Jellinger K., Poewe W., and Litvan I. Progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders. Arch. Neurol. 58 (2001) 259-264
73. National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease, Consensus recommendations for the postmortem diagnosis of Alzheimer's disease, Neurobiol. Aging 18 (1997) S1-2.
74. Papka M., Rubio A., and Schiffer R.B. A review of Lewy body disease, an emerging concept of cortical dementia. J. Neuropsychiatry Clin. Neurosci. 10 (1998) 267-279
75. Papka M., Rubio A., Schiffer R.B., and Cox C. Lewy body disease: can we diagnose it?. J. Neuropsychiatry Clin. Neurosci. 10 (1998) 405-412
76. Perl D.P., Olanow C.W., and Calne D. Alzheimer's disease and Parkinson's disease: distinct entities or extremes of a spectrum of neurodegeneration?. Ann. Neurol. 44 (1998) S19-31
77. Perry E.K., Marshall E., Kerwin J., Smith C.J., Jabeen S., Cheng A.V., and Perry R.H. Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia. J. Neurochem. 55 (1990) 1454-1456
78. Perry E.K., Marshall E., Perry R.H., Irving D., Smith C.J., Blessed G., and Fairbairn A.F. Cholinergic and dopaminergic activities in senile dementia of Lewy body type. Alzheimer Dis. Assoc. Disord. 4 (1990) 87-95
79. Potulska A., Friedman A., Krolicki L., and Spychala A. Swallowing disorders in Parkinson's disease. Parkinsonism Relat. Disord. 9 (2003) 349-353
80. Probst A., Bloch A., and Tolnay M. New insights into the pathology of Parkinson's disease: does the peripheral autonomic system become central?. Eur. J. Neurol. 15 1 Suppl. (2008) 1-4
81. Schneider J.A., Watts R.L., Gearing M., Brewer R.P., and Mirra S.S. Corticobasal degeneration: neuropathologic and clinical heterogeneity. Neurology 48 (1997) 959-969
82. Sebeo J., Hof P.R., and Perl D.P. Occurrence of alpha-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex. Acta Neuropathol. 107 (2004) 497-503
83. Senard J.M., Rai S., Lapeyre-Mestre M., Brefel C., Rascol O., Rascol A., and Montastruc J.L. Prevalence of orthostatic hypotension in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 63 (1997) 584-589
84. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., and Goedert M. Alpha-synuclein in Lewy bodies. Nature 388 (1997) 839-840
85. Sutcliffe R.L., Prior R., Mawby B., and McQuillan W.J. Parkinson's disease in the district of the Northampton Health Authority, United Kingdom. A study of prevalence and disability. Acta Neurol. Scand. 72 (1985) 363-379
86. Thal D.R., Rüb U., Schultz C., Sassin I., Ghebremedhin E., Del Tredici K., Braak E., and Braak H. Sequence of Abeta-protein deposition in the human medial temporal lobe. J. Neuropathol. Exp. Neurol. 59 (2000) 733-748
87. Tierney M.C., Fisher R.H., Lewis A.J., Zorzitto M.L., Snow W.G., Reid D.W., and Nieuwstraten P. The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology 38 (1988) 359-364
88. Tison F., Dartigues J.F., Auriacombe S., Letenneur L., Boller F., and Alperovitch A. Dementia in Parkinson's disease: a population-based study in ambulatory and institutionalized individuals. Neurology 45 (1995) 705-708
89. Travagli R.A., Hermann G.E., Browning K.N., and Rogers R.C. Brainstem circuits regulating gastric function. Annu. Rev. Physiol. 68 (2006) 279-305
90. C. Tretiakoff, Contribution à l'étude de l'anatomie pathologique du locus niger de Soemmering, Paris, 1919, p. 293.
91. Vogt B.A., Finch D.M., and Olson C.R. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb. Cortex 2 (1992) 435-443
92. Williams M.M., Xiong C., Morris J.C., and Galvin J.E. Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology 67 (2006) 1935-1941
93. Wood B.H., Bilclough J.A., Bowron A., and Walker R.W. Incidence and prediction of falls in Parkinson's disease: a prospective multidisciplinary study. J. Neurol. Neurosurg. Psychiatry 72 (2002) 721-725
94. Yamazaki M., Arai Y., Baba M., Iwatsubo T., Mori O., Katayama Y., and Oyanagi K. Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam. J. Neuropathol. Exp. Neurol. 59 (2000) 585-591
95. Zaccai J., Brayne C., McKeith I., Matthews F., and Ince P.G. Patterns and stages of alpha-synucleinopathy: relevance in a population-based cohort. Neurology 70 (2008) 1042-1048
96. Zaccai J., McCracken C., and Brayne C. A systematic review of prevalence and incidence studies of dementia with Lewy bodies. Age Ageing 34 (2005) 561-566