Single Fraction Radiotherapy for Bone Metastases: Clinically Effective, Time Efficient, Cost Conscious and Still Underutilized in the United States?

Clinical Oncology

Volumn 21, Issue 9, 2009, Pages 652-654

  Hartsell, W F ^a   Konski, A A ^b   Lo, S S ^c   Hayman, J A ^d  

^a Advocate Good Samaritan Hospital   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Osseous metastases; radiotherapy; randomised

Indexed keywords

ANALGESIC AGENT; ANTINEOPLASTIC AGENT;

ANALGESIA; BONE METASTASIS; BONE PAIN; CANCER CONTROL; CANCER PAIN; CANCER PALLIATIVE THERAPY; CANCER RECURRENCE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; COST UTILITY ANALYSIS; DOSIMETRY; EDITORIAL; EVIDENCE BASED MEDICINE; HEALTH CARE UTILIZATION; HUMAN; PATHOLOGIC FRACTURE; PRIORITY JOURNAL; QUALITY OF LIFE; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; REIMBURSEMENT; SHORT COURSE THERAPY; TREATMENT DURATION; UNITED STATES; VISCERAL METASTASIS;

BONE NEOPLASMS; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; NEOPLASM METASTASIS; PAIN; PALLIATIVE CARE; UNITED STATES;

EID: 70349412910     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2009.08.003     Document Type: Editorial

References (31)

1. Janjan N. Palliation and supportive care in radiation medicine. Hematol Oncol Clin North Am 20 (2006) 187-211
2. Wu J., Wong R., Johnston M., et al. Meta-analysis of dose-fractionation radiotherapy trials for the palliation of painful bone metastases. Int J Radiat Oncol Biol Phys 55 (2003) 594-605
3. Fairchild A., Barnes E., Ghosh S., et al. International patterns of practice in palliative radiotherapy for painful bone metastases: evidence-based practice?. Int J Radiat Oncol Biol Phys (22 May 2009) (epub ahead of print)
4. Sze W., Shelley M., Held I., et al. Palliation of metastatic bone pain: single fraction vs multifraction radiotherapy-a systematic review of randomized trials. Clin Oncol 15 (2003) 345-352
5. Chow E., Harris K., Fan G., et al. Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol 25 (2007) 1423-1436
6. Konski A. Radiotherapy is a cost-effective palliative treatment for patients with bone metastasis from prostate cancer. Int J Radiat Oncol Biol Phys 60 (2004) 1373-1378
7. Barton M.B., Jacob S.A., and Gebsky V. Utility-adjusted analysis of the cost of palliative radiotherapy for bone metastases. Australas Radiol 47 (2003) 274-278
8. Konski A., James J., Hartsell W., et al. Economic analysis of radiation therapy oncology group 97-14: multiple vs single fraction radiation treatment of patients with bone metastases. Am J Clin Oncol 32 (2009) 423-428
9. Lievens Y., Kesteloot K., Rijnders A., Kutcher G., and Van den Bogaert W. differences in palliative radiotherapy for bone metastases within Western European countries. Radiother Oncol 56 (2000) 297-303
10. Crellin A., Marks A., and Maher E. Why don't British radiotherapists give single fractions of radiotherapy for bone metastases?. Clin Oncol 1 (1989) 63-66
11. Badzio A., Senkus-Konefka E., Jereczek-Fossa B., et al. 20 Gy in five fractions vs 8 Gy in one fraction in palliative radiotherapy of bone metastases: a multicentre randomized study. J Oncol 53 (2003) 261-264
12. van der Linden Y., Lok J., Steenland E., et al. Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone metastasis study controlling for the influence of retreatment. Int J Radiat Oncol Biol Phys 59 (2004) 528-537
13. Hartsell W., Konski A., Scott C., et al. Randomized trial of short vs long-course radiotherapy for palliation of painful bone metastases. J Natl Cancer Inst 97 (2005) 798-804
14. Kaasa S., Brenne E., Lund J.-A., et al. Prospective randomized multicentre trial on single fraction radiotherapy (8 Gy - 1) vs multiple fractions (3 Gy - 10) in the treatment of painful bone metastases. Radiother Oncol 79 (2006) 278-284
15. Sharma V., Macoumba Gaye P., Abdel Wahab S., et al. Patterns of practice of palliative radiotherapy in Africa, part 1: bone and brain metastases. Int J Radiat Oncol Biol Phys 70 (2008) 1195-1201
16. Chow E., Danjoux C., Wong R., et al. Palliation of bone metastases: a survey of patterns of practice among Canadian radiation oncologists. Radiother Oncol 56 (2000) 305-314
17. Roos D. Continuing reluctance to use single fractions of radiotherapy for metastatic bone pain: an Australian and New Zealand practice survey and literature review. Radiother Oncol 56 (2000) 315-322
18. Hartsell W.F., Shah A.B., Graney M., and Kun L.E. Palliation of bone metastases in the USA: a survey of patterns of practice. Support Care Cancer 6 (1998) 175 (Abstr. No. 45)
19. Shakespeare T.P., Lu J.J., Back M.F., Liang S., Mukherjee R.K., and Wynne C.J. Patient preference for radiotherapy fractionation schedule in the palliation of painful bone metastases. J Clin Oncol 21 (2003) 2156-2162
20. Ratanatharathorn V., Powers W.E., Moss W.T., and Perez C.A. Bone metastasis: review and critical analysis of random allocation trials of local field treatment. Int J Radiat Oncol Biol Phys 44 (1999) 1-18
21. Ben-Josef E., Shamsa F., Youssef E., and Porter A.T. External beam radiotherapy for painful osseous metastases: pooled data dose response analysis. Int J Radiat Oncol Biol Phys 45 (1999) 715-719
22. Boyle W.J., Simonet W.S., and Lacey D.L. Osteoclast differentiation and activation. Nature 423 (2003) 337-342
23. Thompson S.W., and Tonge D. Bone cancer gain without the pain. Nat Med 6 (2000) 504-505
24. Steenland E., Leer J.W., van Houwelingen H., et al. The effect of a single fraction compared to multiple fractions on painful bonemetastases: a global analysis of the Dutch bone metastasis Study. Radiother Oncol 52 (1999) 101-109
25. Tong C., Gillick L., and Hendrickson F.R. The palliation of symptomatic osseous metastases: final results of the study by the radiation therapy oncology group. Cancer 50 (1982) 893-899
26. Williams M.V., Summers E.T., Drinkwater K., and Barrett A. Radiotherapy dose fractionation, access and waiting times in the countries of the UK in 2005. Clin Oncol 19 (2007) 273-286
27. Bradley N.M.E., Husted J., Sey M.S.L., et al. Did the pattern of practice in the prescription of palliative radiotherapy for the treatment of uncomplicated bone metastases change between 1999 and 2005 at the rapid response radiotherapy program?. Clin Oncol 5 (2008) 327-336
28. Szumacher E., Llewellyn-Thomas H., Franssen E., et al. Treatment of bone metastases with palliative radiotherapy: patients' treatment preferences. Int J Radiat Oncol Biol Phys 61 (2005) 1473-1481
29. Konski A., Desilvio M., Hartsell W., et al. Continuing evidence for poorer treatment outcomes for single male patients: retreatment data from RTOG 97-14. Int J Radiat Oncol Biol Phys 66 (2006) 229-233
30. van der Linden Y., Steenland E., van Houwelingen, et al. Patients with a favourable prognosis are equally palliated with single and multiple fraction radiotherapy: results on survival in the Dutch bone metastasis study. Radiother Oncol 78 (2006) 245-253
31. Roos D.E., Turner S.L., O'Brien P.C., et al. Randomized trial of 8 Gy in 1 vs 20 Gy in 5 fractions of radiotherapy for neuropathic pain due to bone metastases (trans-tasman radiation oncology group, TROG 96.05). Radiother Oncol 75 (2005) 54-63