Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis?

Atherosclerosis

Volumn 206, Issue 2, 2009, Pages 390-396

  Jagielska, Joanna ^a   Salguero, Gustavo ^a   Schieffer, Bernhard ^a   Bavendiek, Udo ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Apoptosis; Digitoxin; Endothelial cells; Endothelial NO synthase; Inflammation; Intracellular signaling

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; DIGITOXIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CELL CULTURE; CELL MIGRATION; CHELATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MONOCYTE; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANTI-INFLAMMATORY AGENTS; ATHEROSCLEROSIS; CELL ADHESION; CELLS, CULTURED; DIGITOXIN; DIGOXIN; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE III; VASCULAR CELL ADHESION MOLECULE-1;

EID: 70349411605     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.03.019     Document Type: Article

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