Treatment strategies for central venous catheter infections

Expert Opinion on Pharmacotherapy

Volumn 10, Issue 14, 2009, Pages 2231-2243

  Sabatier, Caroline ^a   Ferrer, Ricard ^a   Vallés, Jordi ^a  

^a HOSPITAL DE SABADELL   (Spain)

Author keywords

Antibiotic; Bacteremia; Catheter related infections; Management

Indexed keywords

AMIKACIN; AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; ANIDULAFUNGIN; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CASPOFUNGIN; CHLORHEXIDINE GLUCONATE; CIPROFLOXACIN; CLOXACILLIN; DALBAVANCIN; DAPTOMYCIN; ECHINOCANDIN; FLUCONAZOLE; GENTAMICIN; HEPARIN; LINEZOLID; METICILLIN; MICAFUNGIN; POLYPEPTIDE ANTIBIOTIC AGENT; POVIDONE IODINE; SULFADIAZINE; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ANTISEPSIS; BACTEREMIA; BACTERIAL ENDOCARDITIS; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BLOOD CULTURE; CANDIDIASIS; CATHETER INFECTION; CATHETER REMOVAL; CLINICAL TRIAL; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTAMINATION; DIFFERENTIAL DIAGNOSIS; DRUG FATALITY; EDUCATION PROGRAM; GRAM NEGATIVE INFECTION; HEALTH CARE COST; HOSPITAL INFECTION; HUMAN; INFECTION PREVENTION; INTRAVENOUS CATHETER; LENGTH OF STAY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MICROSCOPY; MONOTHERAPY; MORBIDITY; MORTALITY; NEPHROTOXICITY; PATIENT EDUCATION; REVIEW; SKIN CULTURE; STAPHYLOCOCCUS INFECTION;

ANTI-BACTERIAL AGENTS; BACTEREMIA; CATHETERIZATION, CENTRAL VENOUS; CATHETERS, INDWELLING; EQUIPMENT CONTAMINATION; HUMANS; INTENSIVE CARE UNITS; MICROBIAL SENSITIVITY TESTS;

EID: 70349395889     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656560903133819     Document Type: Review

References (120)

1. Vandjick DM, Depaemelaere M, Labeau SO, et al. Daily cost of antimicrobial therapy in patients with Intensive Care Unit-acquired, laboratory-confirmed bloodstream infection. Int J Antimicrob Agents 2008;31:161-165
2. Muñoz P, Bouza E, San Juan R, et al.; Co-Operative Group of the European Study Group on Nosocomial Infections (ESGNI). Clinical-epidemiological characteristics and outcome of patients with catheter-related bloodstream infections in Europe (ESGIN-006 Study). Clin Microbiol Infect 2004;10(9):843-845
3. Palomar M, Grupo de trabajo de enfermedades infecciosas de la sociedad española de medicina intensiva, et al. Informe 2007 Estudio Nacional de Vigilancia de Infección Nosocomial en Servicios de Medicina Intensiva (ENVIN). 2007
4. Alvarez-Lerma F, Palomar M, Olaechea P, et al.; Grupo de Estudio de Vigilancia de Infección Nosocomial en UCI. National Study of Control Of Nosocomial Infection in Intensiva care Units. Evolutive report of the years 2003-2005. Med Intensiva 2007;31(1):6-17
5. Rosenthal VD, Maki DG, Mehta A, et al. International Nosocomial Infection Control Consortium report, data summary for 2002-2007, issued January 2008. Am J Infect Control 2008;36(9):627-637
6. Rosenthal V, Maki DG, Salomao R, et al. Device-associated nosocomial infections in 55 intensive care units of 8 developing countries. Ann Intern Med 2006;145(8):582-592 (Pubitemid 46780937)
7. Wisplinghoff H, Bischoff T, Tallent SM, et al. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis 2004;39(3):309-317 (Pubitemid 39050477)
8. Rello J, Ochagavia A, Sabanes E, et al. Evaluation of outcome of intravenous catheter-related infections in critically ill patients. Am J Respir Crit Care Med 2000;162:1027-1037
9. Warren DK, Quadir WW, Hollenbeak CS, et al. Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital. Crit Care Med 2006;34(8):2084-2089
10. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients:excesss length of stay, extra costs and attribuatable mortality. JAMA 1994;271(20):1598-1601 (Pubitemid 24987508)
11. Pittet D, Tarara D, Wenzel RP. Outcomes of primary and catheter-related bacteriemia. Am J Respir Crit Care Med 2001;163:1584-1590
12. Garrouste Orgeas M, Timsit JF, Soufir L, et al.; Outcomerea Study Group. Impact of adverse event on outcomes in intensive care patients, in Critical Care medicine. 2008;36(7):2041-2047
13. Pronovost P. Interventions to decrease catheter-related bloodstream infections in the ICU: the Keystone Intensive Care Unit Project. Am J Infect Control 2008;36(10):S171.e1-5
14. Maki D, Kluger D, Crnich C. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 prospectives published studies. Mayo Clin Proc 2006;81(9):1159-1171 (Pubitemid 44316281)
15. Seldinger SI. A simple method of catheterization of the spleen and liver. Acta Radiol 1957;48(2):93-96
16. Calandra T, Cohen J. International Sepsis Forum Definition of Infection in the ICU Consensus Conference. The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit. Crit Care Med 2005;33(7):1538-1548
17. Pearson ML. Guidelines for prevention of intravascular-device-related infections. Infect Control Hosp Epidemiol 1996;17:438-476
18. Mermel LA, Farr BM, Sherertz RJ, et al.; Infectious Diseases Society of America, American College of Critical Care Medicine, Society for Healthcare Epidemiology of America. Guidelines for the Management of Intravascular Catheter-Related Infections. Clin Infect Dis 2001;32:1242-1272
19. Leona C, Arizab J, et al. Guías para el tratamiento de las infecciones relacionadas con catéteres intravasculares de corta permanencia en adultos: conferencia de consenso SEIMC-SEMICYUC. Enferm Infecc Microbiol Clin 2004;22(2):92-101
20. Safdar N, Maki DG. Inflammation at the insertion site is not predictive of catheter-related blodstream infection with short-term, non-cuffed central venous catheters. Crit Care Med 2002;30:2632-2635 (Pubitemid 36870561)
21. Weinstein MP, Towns ML, Quartey SM, et al. The clinical significance of positive blood cultures in the 1990s: A propsective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults. Clin Infect Dis 1997;24:584-602
22. Safdar N, Fine JP, Maki DG. Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann Intern Med 2005;142(6):451-466 (Pubitemid 40365432)
23. Bouza E, Alvarado N, Alcalá L, et al. A randomized and prospective study of 3 procedures for the diagnosis of catheter-related bloodstream infection without catheter withdrawal. Clin Infect Dis 2007;44(6):820-826 (Pubitemid 46365307)
24. Blot F, Schmidt E, Nitenberg G, et al. Earlier positivity of central-venous versus peripheral-blood cultures is highly predictive of catheter-related sepsis. J Clin Microbiol 1998;36:105-109 (Pubitemid 28047442)
25. Blot F, Nitenberg G, Chachaty E, et al. Diagnosis of catheter-related bacteriaemia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet 1999;354:1071-1077 (Pubitemid 29452819)
26. Garcia X, Ferrer R, Duarte M, et al. Differential time to positivity of blood cultures. A valid alternative method for the diagnosis of catheter-related bloodstream infection. Intensive Care Med 2007;33(Suppl 2):S183
27. Tighe MJ, Kite P, Thomas D, et al. Rapid diagnosis of catheter-related sepsis using the acridine orange leukocyte cytospin test and an endoluminal brush. JPEN 1996;20:215-218 (Pubitemid 26000042)
28. Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying intravenous-catheter relatd infection. N Engl J Med 1977;296:1305-1309 (Pubitemid 8103695)
29. Raad II, Sabbagh MF, Rand KH, Sherertz RJ. Quantitative tip culture methods and the diagnosis of central venous catheter-related infections. Diagn Microbiol Infect Dis 1992;15:13-20
30. Rello J, Gatell JM, Almirall J, et al. Evaluation of culture techniques for identification of catheter-related infection in haemodialysis patient. Eur J Clin Microbiol Infect Dis 1989;8:620-622 (Pubitemid 19189882)
31. O'Grady NP, Alexander M, Dellinger EP, et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. MMWR Recomm Rep 2002;51(RR-101):1-29
32. Widmer AF, Frei R, et al. Diagnosis of central-venous catheter-related infection: comparison of the roll-plate and sonication technique in 1000 catheters. 43rd Annual Intersicence Conference on Antimicrobial Agents Chemoteraphy; Chicago IL USA, 2003:14-17
33. Boyce JM, Pittet D; Healthcare Infection Control Practices Advisory Committee. Society for Healthcare Epidemiology of America. Association for Professionals in Infection Control. Infectious Diseases Society of America. Hand Hygiene Task Force. Guideline for hand hygiene in health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/ SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Professionals in Infection Control/Infectious Diseases Society of America. Morb Mortal Wkly Rep 2002;51:1-45
34. Eggimann P. Prevention of intravascular catheter infection. Curr Opin Infect Dis 2007;20:360-369
35. Pronovost P, Needham D, Berenholtz S, et al. An Intervention to Decrease Catheter-Related Bloodstream Infections in the ICU. N Engl J Med 2006;355(26):2725-2732 (Pubitemid 46021509)
36. Rosenthal VD, Guzman S, Pezzotto SM, Crnich CJ. Effect of an infection control program using education and performance feedback on rates of intravascular device-associated bloodstream infections in intensive care units in Argentina. Am J Infect C 2003;31:405-409 (Pubitemid 37392962)
37. Young EM, Commiskey ML, Wilson SJ. Translating evidence into practice to prevent central venous catheter-associated bloodstream infections: a systems-based intervention. Am J Infect C 2006;34:503-506
38. Goetz AM, Wagener MM, Miller JM, Muder RR. Risk of infection due to central venous catheters: effect of site of placement and catheter type. Infect Control Hosp Epidemiol 1998;19:842-845
39. Merrer J, De Jonghe B, Golliot F, et al.; French Catheter Study Group in Intensive Care. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA 2001;286:700-707
40. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792-801 (Pubitemid 34568649)
41. Vallés J, Fernández I, Alcaraz D, et al. Prospective randomized trial of 3 antiseptic solutions for prevention of catheter colonization in an intensive care unit for adult patients. Infect Control Hosp Epidemiol 2008;29(9):847-853
42. Ho KM, Linton E. Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis. J Antimicrob Chemother 2006;58:281-287
43. Walder B, Pittet D, Tramer M. Benefit of antiseptic and antimicrobial coating of central venous catheters: a systematic review. Infect Control Hosp Epidemiol 2002;23:748-756 (Pubitemid 34158135)
44. Falagas ME, Fragoulis K, Bliziotis IA, Chatzinikolaou I. Rifampicin-impregnated central venous catheters: a meta-analysis of randomized controlled trials. J Antimicrob Chemother 2007;59:359-369 (Pubitemid 47073442)
45. Brun-Buisson C, Doyon F, Sollet JP, et al. Prevention of intravascular catheter-related infection with newer chlorhexidine-silver sulfadiazinecoated catheters: a randomized controlled trial. Intensive Care Med 2004;30:837-843 (Pubitemid 38639475)
46. Norris P, Noble M, Francolini I, et al. Ultrasonically controlled release of ciprofloxacin from self-assembled coatings on poly(2-hydroxyethyl methacrylate) hydrogels for Pseudomonas aeruginosa biofilm prevention. Antimicrob Agents Chemother 2005;49(10):4272-4279 (Pubitemid 41400974)
47. Safdar N, Maki DG. Use of vancomycin-containing lock or flush solutions for prevention of bloodstream infection associated with central venous access devices: a meta-analysis of prospective,randomized trials. Clin Infect Dis 2006;43:474-484 (Pubitemid 44157156)
48. Yahav D, Rozen-Zvi B, Gafter-Gvili A, et al. Antimicrobial Lock Solutions for the Prevention of Infections Associated with Intravascular Catheters in Patients Undergoing Hemodialysis: Systematic Review and Meta-analysis of Randomized, Controlled Trials. Clin Infect Dis 2008;47:83-93 (Pubitemid 351920592)
49. Segarra-Newhan M, Martin-Cooper EM. Antibiotic lock technique: a review of the literature. Ann Pharmacother 2005;39:311-318 (Pubitemid 40165222)
50. Pagani JL, Eggimann P. Management of catheter-related infections. Expert Rev Anti Infect Ther 2008;6(1):31-37
51. León C, Ariza J. SEIMC SEMICYUC guidelines for the treatment of short-term intravascular catheter-related infections in adults; SEIMC SEMICYUC Consensus Conference. Enferm Infecc Microbiol Clin 2004;22:92-101 (Pubitemid 38585448)
52. Rijnders BJ, Peetermans WE, Verwaest C, et al. Watchful waiting versus immediate catheter removal in ICU patients with suspected catheter-related infection: a randomizaed trial. Intensive Care Med 2004;30(6):1073-1080 (Pubitemid 38833358)
53. Bouza E, Burillo A, Munoz P. Empiric therapy for intravenous central line infections and nosocomially-acquired acute bacterial endocarditis. Crit Care Clin 2008;24:293-312
54. Martínez E, Mensa J, Rovira M, et al. Central venous cathter exchange by guidewire for treatment of cathter-related bacteremia in patients undergoing BMT or intensive chemoterapy. Bone Marrow Transplant 1999;23:41-44 (Pubitemid 29050177)
55. Garnacho-Montero J, Aldabó-Pallás T, Palomar- Martínez M, et al. Risk factors and prognosis of catheter-related bloodstream infection in critically ill patients: a multicenter study. Intensive Care Med 2008;34(12):2185-2193
56. Cook D, Randolph A, Kernerman P, et al. Central venous catheter replacement strategies: a systematic review of the literature. Crit Care Med 1997;25:1417-1424 (Pubitemid 27347310)
57. Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Clin 2004;32(3):852-873 (Pubitemid 38344143)
58. Araya CE, Fennell RS, Neiberger RE, Dharnidharka VR. Hemodialysis catheter-related bacteremia in children: increasing antibiotic resistance and changing bacteriological profile. Am J Kidney Dis 2007;50(1):119-123
59. Viale P, Pagani L, Petrosillo N, et al.; Italian Hospital and HIV Infection Group. Antibiotic lock-technique for the treatment of catheter-related bloodstream infections. J Chemother 2003;15(2):152-156
60. Capdevila JA, Segarra A, Planes AM, et al. Succesfull treatment of haemodialysis catheter-related sepsis without cathter removal. Nephrol Dial Transplant 1993;8:231-234 (Pubitemid 23122974)
61. Ruiz-Valverde MP. Successful treatment of cathter-related sepsis and extraluminal cathter thrombosis with vancomycin and fraxiparin without cathter removal. Nephron 1997;5:354-355
62. Khalifa R, Dahyot-Fizelier C, Laksiri L, et al. Indwelling time and risk of colonization of peripheral arterial catheters in critically ill patients. Intensive Care Med 2008;34(10):1820-1826
63. Rupp ME. Coagulase-negative staphylococcal infections; an update regarding recognition and management. Curr Clin Top Infect Dis 1997;17:51-87
64. Huebner J, Goldman DA. Coagulase-negative staphylococci: role as pathogens. Annu Rev Med 1999;50:223-236
65. Chatzinikolaou I, Hanna H, Darouiche R, et al. Prospective study of the value of quantitative culture of organisms from blood collected through central venous catheters in differentiating between contamination and bloodstream infection. J Clin Microbiol 2006;44:1834-1835 (Pubitemid 43726277)
66. Raad I, Davis S, Khan A. Catheter removal affects recurrence of catheter-related coagulase-negative Staphylococci bacteraemia(CRCNSB). Infect Control Hosp Epidemiol 1992;13:215-221
67. Raad I, Davis S, Khan A, et al. Impact of central venous cathter removal on the recurrence of catheter-related coagulasenegative staphylococcal bacteremia. Infect Control Hosp Epidemiol 1992;13:215-221
68. Raad I, Hanna H, Jiang Y. Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related meticillin-resistant Staphylococcus bacteremic isolates embedded in biofilm. Antimicrob Agents Chemother 2007;51:1656-2560 (Pubitemid 46744141)
69. Pascual A. Pathogenesis of catheter-related infections: lessons for new designs. Clin Microbiol Infect 2002;8(5):256-264 (Pubitemid 34993796)
70. Steenbergen JN, Alder J, Thorne GM, Tally FP. Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections. J Antimicrob Chemother 2005;55(3):283-288 (Pubitemid 40425449)
71. Malli E, Spiliopoulou I, Kolonitsiou F, et al. In vitro activity of daptomycin against Gram-positive cocci: the first multicentre study in Greece. Int J Antimicrobial Agents 2008;32(6):525-528
72. Hair PI, Keam SJ. Daptomycin. A review of its use in the management of complicated skin and soft-tissue infections and Staphylococcus aureus Bacteraemia. Drugs 2007;67(10):1483-1512
73. Raad I, Darouiche R, Vazquez J, et al. Efficacy and safety of weekly dalbavncin in the treatment of catheter-related bloodstream infecyiosn due to Gram-positive pathogens. Clin Infect Dis 2005;40:374-380 (Pubitemid 40216504)
74. FDA, FDA information for healthcare professionals: linezolid (marketed as Zyvox). 2007
75. Raad I, Chatzinikolaou I, Chaiban G, et al. In vitro and ex vivo activity of minocyclinand EDTA against microrganisms embedded in biofilm on catheters surfaces. Antimicrob Agents Chemother 2003;47:3580-3585
76. Sauer K, Steczko J, Ash SR. Effect of a solution containing citrate/Methylene Blue/parabens on Staphylococcus aureus bacteria and biofilm, and comparison with various heparin solutions. J Antimicrob Chemother 2009;63(5):937-945
77. Huigens RW 3rd, Rogers SA, Steinhauer AT, Melander C. Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates. Org Biomol Chem 2009;7(4):794-802
78. Ghanem GA, Boktour M, Warneke C, et al. Catheter-related Staphylococcus aureus bacteraemia in cancer patients: high rate of complications with therapeutic implications. Medicine 2007;86:54-60 (Pubitemid 46104920)
79. Fowler VG Jr, Sanders LL, Sexton DJ, et al. Outcome of Staphylococcus aureus bacteraemia according to compliance with recommendations of infectious disease specialists: experience with 244 patients. Clin Infect Dis 1998;27:478-486
80. Poole CV, Carlton D, Bimbo L, Allon M. Treatment of catheter-related bactaraemia with antibiotic lock protocol: effect of bacterial pathogen. Nephrol Dial Transplant 2004;19(5):1237-1244 (Pubitemid 38628145)
81. Raad I, Hanna H, Dvorak T, et al. Optimal antimicrobial catheter lock solution, using different combinations of minocycline, EDTA and 35 percent ethanol, rapidly erradicates organsims embedded in biofilm. Antimicrob Agents Chemother 2007;51:78-83 (Pubitemid 46047690)
82. Huang YT, Liao CH, Teng LJ, et al. Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan. Clin Microbiol Infect 2008;14(2):124-129
83. Rehm SJ, Boucher H, Levine D, et al. Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates. J Antimicrob Chemother 2008;62(6):1413-1421
84. Lentino JR, Narita M, Yu VL. New antimicrobial agents as therapy for resistant gram-positive cocci. Eur J Clin Microbiol Infect Dis 2008;27(1):3-15 (Pubitemid 350197870)
85. Fowler VG Jr, Olsen MK, Corey GR, et al. Clinical identifiers of complicated Staphylococcus aureus bacteremia. Arch Intern Med 2003;163(17):2066-2072 (Pubitemid 37151249)
86. Lesens O, Hansmann Y, Brannigan E, et al. Positive surveillance blood culture is a predictive factor for secondary metastatic infection in patients with Staphylococcus aureus bacteraemia. J Infect 2004;48(3):245-252 (Pubitemid 38380383)
87. Mensa J, Barberán J, Llinares P, et al.; Sociedad Española de Medicina Interna; Sociedad Española de Medicina Interna; Sociedad Española de Medicina Intensiva, Critica y Unidades Coronarias; Asociacion Española de Cirujanos; Asociacion Española de Hematologia y Hemoterapia. Guidelines for the treatment on infections caused by methicillin-resistant Staphylococcus aureus. Rev Esp Quimioter 2008;21(4):234-258
88. Ehni WF, Reller B. Short-course therapy for catheter-associated Staphylococcus aureus bacteremia. Arch Intern Med 1989;149:533-536 (Pubitemid 19092849)
89. Raad I, Narro J, Khan A, et al. Serious complications of vascular cathter-related S.aureus bacteremia in cancer patients. Eur J Clin Microbiol Infect Dis 1992;11:675-682
90. Raad I, Sabbagh MF. Optimal duration of therapy for catheter-related Staphylococcus aureus bacteremia: a study of 55 cases and review. Clin Infect Dis 1992;14:75-82
91. Hanna H, Afif C, Alakech B, et al. Central venous catheter-related bacteramia due to Gram-negative bacilli.significance of catheter removal in preventing relapse. Infect Control Hosp Epidemiol 2004;25:646-649 (Pubitemid 39095046)
92. Vallés J, León C, Alvarez-Lerma F. Nosocomial bacteremia in critically ill patients: a multicenter study evaluating epidemiology and prognosis. Clin Infect Dis 1997;24:387-395 (Pubitemid 27096793)
93. Garrouste-Orgeas M, Timsit JF, Tafflet M, et al.; OUTCOMEREA Study Group. Excess risk of death from intensive care unit-acquired nosocomial bloodstream infections: A reappraisal. Clin Infect Dis 2006;42:1118-1126
94. Nguyen MH, Peacock JE Jr, Tanner DC, et al. Therapeutic approaches in patients with candidaemia: evaluation in a multicenter, prospective and observational study. Arch Intern Med 1995;155:2429-2435
95. Nucci M, Colombo AL, Silveira F, et al. Risk factors for death in patients with candidaemia. Infect Control Hosp Epidemiol 1998;19:846-850 (Pubitemid 128472207)
96. Rex JH, Bennett JE, Sugar AM, et al. Intravascular catheter-exchange and duration of candidaemia. Clin Infect Dis 1995;21:995-996
97. Raad I, Hanna H, Boktour M, et al. Management of central venous catheters in patients with cancer and candidaemia. Clin Infect Dis 2004;38:1119-1127 (Pubitemid 38951258)
98. Rose HD. Venous catheter-associated candidemia. Am J Med Sci 1978;275:265-269
99. Garey KW, Rege M, Pai MP, et al. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a Multi-Institutional Study. Clin Infect Dis 2006;43:25-31 (Pubitemid 43939072)
100. León C, Ruiz-Santana S, Saavedra P, et al.; EPCAN Study Group. A bedside scoring system ("Candida score") for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med 2006;34(3):913-914
101. Rex JH, Bennett JE, Sugar AM, et al. A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. N Engl J Med 1994;331:1325-1331
102. Mora-Duarte J, Betts R, Rotstein C, et al.; Caspofungin Invasive Candidiasis Study Group. Comparison of caspofungin and amphotericin B for invasive candidiasis. N Engl J Med 2002;347(25):2020-2029
103. Reboli AC, Rotstein C, Pappas PG, et al.; Anidulafungin Study Group. Anidulafungin versus fluconazole for invasive candidiasis. N Engl J Med 2007;356:2472-2482
104. Raad I, Hanna H, Maki D. Intravascular catheter-related infections:advances in diagnosis, prevention and management. Lancet Infect Dis 2007;7:645-657 (Pubitemid 47444563)
105. Mermel LA, McCormick RD, Springman SR, Maki DG. The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular subtyping. Am J Med 1991;91(Suppl):S197-205
106. Liñares J, Sitges-Serra A, Garau J, et al. Pathogenesis of catheter sepsis: a prospective study with quantitative and semiquantitative cultures of catheter hub and segments. J Clin Microbiol 1985;21:357-360 (Pubitemid 15168645)
107. Raad I, Costerton W, Sabharwal U, et al. Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis 1993;168:400-407 (Pubitemid 23210618)
108. Raad II, Hohn DC, Gilbreath BJ, et al. Prevention of central venous catheter-related infections by using maximale sterile barrier precautions during insertion. Infect Control Hosp Epidemiol 1994;15:231-238
109. Tennenberg S, Lieser M, McCurdy B, et al. A prospective randomized trial of an antibiotic and antiseptic-coated central venous cathter in the prevention of cathter-realted infections. Arch Surg 1997;132:1348-1351 (Pubitemid 28007168)
110. Maki DG, Stolz SM, Wheeler S, Mermel LA. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impreganted cathter. Ann Intern Med 1997;127:257-266
111. Garland JS, Alex CP, Mueller CD, et al. A randomized trial comparing povidone-iodine to a chlorexidine gluconate-impreganted dressing fro prevention of central venous catheter infections in neonates. Pediatrics 2001;107(6):1431-1436
112. Wenzel RP, Edmond MB. Team-based prevention of catheter-related infections. N Engl J Med 2006;355(26):2725-2732
113. Peredo R, Sabatier C, Villagra A. Reduction of the catheter-related bloodstream infections in critically ill patients. 2008: Annual congress of the European society of intensive care medicine. Lisboa
114. Sabatier C, Ferrer R, García X, et al. Use of differential time of positivity of blood cultures as diagnostic technique of catheter-related bloodstream infection: a randomized trial. 2008: Annual congress of the Spanish society of critical care. Valencia
115. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/ Society of Critical Care Medicine. Chest 1992;101(6):1644-1655
116. Dellinger RP, Levy MM, Carlet JM, et al.; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008;34(1):17-60
117. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34(6):1589-1596 (Pubitemid 43810035)
118. Vallés J, Rello J, Ochagavía A, et al. Community- bloodstream infection in critically ill adult patients: impact of shock and innapropiate anitiotic therapy on survival. Chest 2003;123(5):1615-1624 (Pubitemid 36549784)
119. Niederman MS. The importance of de-escalating antimicrobial therapy in patients with ventilator-associated penumonia. Semin Respir Crit Care Med 2006;27(1):45-50
120. Hidron AI, Edwards JR, Patel J, et al.; National Healthcare Safety Network Team; Participating National Healthcare Safety Network Facilities. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008;29(11):996-1011