Effect of a solution containing citrate/Methylene Blue/parabens on Staphylococcus aureus bacteria and biofilm, and comparison with various heparin solutions

Journal of Antimicrobial Chemotherapy

Volumn 63, Issue 5, 2009, Pages 937-945

  Sauer, Karin ^a   Steczko, Janusz ^b   Ash, Stephen R ^b,c,d  

^a BINGHAMTON UNIVERSITY   (United States)

^b R and D   (United States)

^c Clarian Arnett Health   (United States)

^d PURDUE UNIVERSITY   (United States)

Author keywords

Antimicrobial effect; Catheter infection; CRBSI; Haemodialysis; Lock solution

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; CITRIC ACID; HEPARIN; METHYLENE BLUE;

ARTICLE; BACTERIAL SURVIVAL; BACTERICIDAL ACTIVITY; BIOFILM; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BIOFILMS; BIOMASS; CITRIC ACID; HEPARIN; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; METHYLENE BLUE; MICROBIAL VIABILITY; MICROSCOPY, CONFOCAL; PARABENS; STAPHYLOCOCCUS AUREUS;

EID: 64649090998     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp060     Document Type: Article

References (45)

1. Xavier JB, Picioreanu C, Rani SA et al. Biofilm-control strategies based on enzymic disruption of the extracellular polymeric substance matrix - a modelling study. Microbiology 2005; 151: 3817-32.
2. Kolter R, Greenberg EP. Microbial sciences: The superficial life of microbes. Nature 2006; 441: 300-2.
3. Parsek MR, Singh PK. Bacterial biofilms: An emerging link to disease pathogenesis. Annu Rev Microbiol 2003; 57: 677-701.
4. Costerton JW. Introduction to biofilm. Int J Antimicrob Agents 1999; 11: 217-21; discussion 237-9.
5. Davies DG, Parsek MR, Pearson JP et al. The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science 1998; 280: 295-8.
6. Curtin JJ, Donlan RM. Using bacteriophages to reduce formation of catheter-associated biofilms by Staphylococcus epidermidis. Antimicrob Agents Chemother 2006; 50: 1268-75.
7. Hanna R, Raad II. Diagnosis of catheter-related bloodstream infection. Curr Infect Dis Rep 2005; 7: 413-9.
8. Stewart PS, Costerton JW. Antibiotic resistance of bacteria in biofilms. Lancet 2001; 358: 135-8.
9. Hoffman LR, D'Argenio DA, MacCoss MJ et al. Aminoglycoside antibiotics induce bacterial biofilm formation. Nature 2005; 436: 1171-5.
10. Sauer K, Camper AK, Ehrlich GD et al. Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm. J Bacteriol 2002; 184: 1140-54.
11. Bateman BT, Donegan NP, Jarry TM et al. Evaluation of a tetracycline-inducible promoter in Staphylococcus aureus in vitro and in vivo and its application in demonstrating the role of sigB in microcolony formation. Infect Immun 2001; 69: 7851-7.
12. Heydorn A, Nielsen AT, Hentzer M et al. Quantification of biofilm structures by the novel computer program COMSTAT. Microbiology 2000; 146: 2395-407.
13. Allon M. Prophylactic effect of antibiotic lock solution on bacteremia related to use of uncuffed hemodialysis catheters. Nat Clin Pract Nephrol 2006; 2: 418-9.
14. Guerraoui A, Dacosta EE, Roche BB et al. Emergence of multiresistant Staphylococcus epidermidis (MRSE) after lock antibiotic regimen by gentamicin in permanent hemodialysis catheters. Perspective study, 1999-2003. J Am Soc Nephrol 2004; 15: 368A.
15. McIntyre CW, Hulme LJ, Taal M et al. Locking of tunneled hemodialysis catheters with gentamicin and heparin. Kidney Int 2004; 66: 801-5.
16. Dogra GK, Herson H, Hutchison B et al. Prevention of tunneled hemodialysis catheter-related infections using catheter-restricted filling with gentamicin and citrate: A randomized controlled study. J Am Soc Nephrol 2002; 13: 2133-9.
17. Weijmer MC, van den Dorpel MA, Van de Ven PJ et al. Randomized, clinical trial comparison of trisodium citrate 30% and heparin as catheter-locking solution in hemodialysis patients. J Am Soc Nephrol 2005; 16: 2769-77.
18. Karaaslan H, Peyronnet P, Benevent D et al. Risk of heparin lock-related bleeding when using indwelling venous catheter in haemodialysis. Nephrol Dial Transplant 2001; 16: 2072-4.
19. Kishimoto TK, Viswanathan K, Ganguly T et al. Contaminated heparin associated with adverse clinical events and activation of the contact system. N Engl J Med 2008; 358: 2457-67.
20. Allon M. Prophylaxis against dialysis catheter-related bacteremia: A glimmer of hope. Am J Kidney Dis 2008; 51: 165-8.
21. Stas KJ, Vanwalleghem J, De Moor B et al. Trisodium citrate 30% vs. heparin 5% as catheter lock in the interdialytic period in twin- or double-lumen dialysis catheters for intermittent haemodialysis. Nephrol Dial Transplant 2001; 16: 1521-2.
22. Ash SR, Mankus RA, Sutton JM et al. Concentrated sodium citrate (23%) for catheter lock. Hemodial Int 2000; 4: 22-31.
23. Weijmer MC, Debets-Ossenkopp YJ, Van De Vondervoort FJ et al. Superior antimicrobial activity of trisodium citrate over heparin for catheter locking. Nephrol Dial Transplant 2002; 17: 2189-95.
24. Polaschegg HD, Sodemann K. Risks related to catheter locking solutions containing concentrated citrate. Nephrol Dial Transplant 2003; 18: 2688-90.
25. Michaud D, Komant T, Pfefferle P. Four percent trisodium citrate as an alternative anticoagulant for maintaining patency of central venous hemodialysis catheters: Case report and discussion. Am J Crit Care 2001; 10: 351-4.
26. Hendrickx L, Kuypers D, Evenepoel P et al. A comparative prospective study on the use of low concentrate citrate lock versus heparin lock in permanent dialysis catheters. Int J Artif Organs 2001; 24: 208-11.
27. Shanks RM, Sargent JL, Martinez RM et al. Catheter lock solutions influence staphylococcal biofilm formation on abiotic surfaces. Nephrol Dial Transplant 2006; 21: 2247-55.
28. Takla TA, Zelenitsky SA, Vercaigne LM. Effectiveness of a 30% ethanol/4% trisodium citrate locking solution in preventing biofilm formation by organisms causing haemodialysis catheter-related infections. J Antimicrob Chemother 2008; 62: 1024-6.
29. Maharaj AR, Zelenitsky SA, Vercaigne LM. Effect of an ethanol/trisodium citrate hemodialysis catheter locking solution on isolates of Candida albicans. Hemodial Int 2008; 12: 342-7.
30. Percival SL, Kite P, Eastwood K et al. Tetrasodium EDTA as a novel central venous catheter lock solution against biofilm. Infect Control Hosp Epidemiol 2005; 26: 515-9.
31. Raad I, Chatzinikolaou I, Chaiban G et al. In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces. Antimicrob Agents Chemother 2003; 47: 3580-5.
32. Steczko J, Ash SR, Nivens DE et al. Microbial inactivation properties of a new antimicrobial/antithrombotic catheter lock solution (citrate/methylene blue/parabens). Nephrol Dial Transplant 2009; doi: 10.1093/ndt/gfn776 (Epub ahead of print 30 January 2009).
33. Polaschegg HD. Catheter locking solution spillage: Theory and experimental verification. Blood Purif 2008; 26: 255-60.
34. Shanks RM, Donegan NP, Graber ML et al. Heparin stimulates Staphylococcus aureus biofilm formation. Infect Immun 2005; 73: 4596-606.
35. Diskin CJ, Stokes TJ, Dansby LM et al. Is systemic heparin a risk factor for catheter-related sepsis in dialysis patients? An evaluation of various biofilm and traditional risk factors. Nephron Clin Pract 2007; 107: C128-32.
36. Kim SH, Song KI, Chang JW et al. Prevention of uncuffed hemodialysis catheter-related bacteremia using an antibiotic lock technique: A prospective, randomized clinical trial. Kidney Int 2006; 69: 161-4.
37. Saxena AK, Panhotra BR, Sundaram DS et al. Enhancing the survival of tunneled haemodialysis catheters using an antibiotic lock in the elderly: A randomised, double-blind clinical trial. Nephrology (Carlton) 2006; 11: 299-305.
38. Bleyer AJ, Mason L, Russell G et al. A randomized, controlled trial of a new vascular catheter flush solution (minocycline-EDTA) in temporary hemodialysis access. Infect Control Hosp Epidemiol 2005; 26: 520-4.
39. Nori US, Manoharan A, Yee J et al. Comparison of low-dose gentamicin with minocycline as catheter lock solutions in the prevention of catheter-related bacteremia. Am J Kidney Dis 2006; 48: 596-605.
40. Betjes MG, van Agteren M. Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution. Nephrol Dial Transplant 2004; 19: 1546-51.
41. Labriola L, Crott R, Jadoul M. Preventing haemodialysis catheter-related bacteraemia with an antimicrobial lock solution: A meta-analysis of prospective randomized trials. Nephrol Dial Transplant 2008; 23 1666-72.
42. Jaffer Y, Selby NM, Taal MW et al. A meta-analysis of hemodialysis catheter locking solutions in the prevention of catheter-related infection. Am J Kidney Dis 2008; 51: 233-41.
43. Yahav D, Rozen-Zvi B, Gafter-Gvili A et al. Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: Systematic review and meta-analysis of randomized, controlled trials. Clin Infect Dis 2008; 47: 83-93.
44. Bradshaw JH, Puntis JW. Taurolidine and catheter-related bloodstream infection: A systematic review of the literature. J Pediatr Gastroenterol Nutr 2008; 47: 179-86.
45. Donlan RM. Biofilms on central venous catheters: Is eradication possible? Curr Top Microbiol Immunol 2008; 322: 133-61.