Prospective randomized trial of 3 antiseptic solutions for prevention of catheter colonization in an intensive care unit for adult patients

Infection Control and Hospital Epidemiology

Volumn 29, Issue 9, 2008, Pages 847-853

  Valles J ^a,b   Fernandez I ^a   Alcaraz, D ^a   Chacon E ^a   Cazorla, A ^a   Canals, M ^a   Mariscal, D ^a   Fontanals, D ^a   Moron A ^a  

^a PARC TAULÍ HOSPITAL UNIVERSITARI   (Spain)

^b HOSPITAL DE SABADELL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIINFECTIVE AGENT; CHLORHEXIDINE GLUCONATE; MENALCOL; POVIDONE IODINE; UNCLASSIFIED DRUG;

ADULT; AGED; ANTISEPSIS; AQUEOUS SOLUTION; ARTERY CATHETER; ARTICLE; BACTEREMIA; BACTERIAL COLONIZATION; CANDIDA; CATHETER INFECTION; CENTRAL VENOUS CATHETER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORYNEBACTERIUM; ENTEROBACTER CLOACAE; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; INCIDENCE; INFECTION RATE; INTENSIVE CARE UNIT; KLEBSIELLA OXYTOCA; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; NONHUMAN; PROSPECTIVE STUDY; PROTEUS MIRABILIS; PSEUDOMONAS AERUGINOSA; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SKIN DECONTAMINATION; SKIN INFLAMMATION; STAPHYLOCOCCUS AUREUS; TEACHING HOSPITAL; TREATMENT OUTCOME;

ADULT; AGED; ANTI-INFECTIVE AGENTS, LOCAL; ANTISEPSIS; BACTEREMIA; CATHETERIZATION, CENTRAL VENOUS; CATHETERS, INDWELLING; CHLORHEXIDINE; CROSS INFECTION; EQUIPMENT CONTAMINATION; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HOSPITALS, TEACHING; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; POVIDONE-IODINE; PROSPECTIVE STUDIES; SEPSIS; TREATMENT OUTCOME;

EID: 51849143829     PISSN: 0899823X     EISSN: None     Source Type: Journal    
DOI: 10.1086/590259     Document Type: Article

References (21)

1. Raad I. Intravascular-catheter-related infections. Lancet 1998;351:893-898.
2. Smith RL, Meixler SM, Simberkoff MS. Excess mortality in critically ill patients with nosocomial bloodstream infections. Chest 1991;100:164-167.
3. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients. Excess length of stay, extra costs, and attributable mortality. JAMA 1994;271:1598-1601.
4. Vallés J, León C, Alvarez-Lerma F; Spanish Collaborative Group for Infections in Intensive Care Units of Sociedad Espanola de Medicina Intensiva y Unidades Coronarias (SEMIUC). Nosocomial bacteremia in critically ill patients: a multicenter study evaluating epidemiology and prognosis. Clin Infect Dis 1997;24:387-395.
5. Jarvis WR, Edwards J, Culver DH, et al. Nosocomial infection rates in adult and pediatric intensive care units in the United States. Am J Med 1991;91(Suppl 3B):185S-191S.
6. Renaud B, Brun-Buisson C; ICU-Bacteremia Study Group. Outcomes of primary and catheter.related bacteremia: a cohort and case-control study in critically ill patients. Am J Respir Crit Care Med 2001;163:1584-1590.
7. Blot SI, Depuydt P, Annemans L, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis 2005;41:1591-1598.
8. Raad I, Hohn DC, Gillbreath BJ, et al. Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol 1994;15:231-238.
9. Maki DG, Ringer M, Alvarado CJ. Prospective, randomized trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet 1991;338:339-343.
10. Mimoz O, Pieroni L, Lawrence C, et al. Prospective, randomized trial of two antiseptic solutions for prevention of central venous and arterial catheter colonization and infection in intensive care patients. Crit Care Med 1996;24:1818-1823.
11. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med 2002;136:792-801.
12. O'Grady NP, Alexander M, Patchen Dellinger E, et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 2002;35:1281-1307.
13. Parienti JJ, du Cheyron D, Ramakers M, et al. Alcoholic povidone-iodine to prevent central venous catheter colonization: a randomized unitcrossover study. Crit Care Med 2004;32:708-713.
14. Mimoz O, Villeminey S, Ragot S, et al. Chlorhexidine-based antiseptic solution vs alcohol-based povidone-iodine for central venous catheter care. Arch Intern Med 2007;167:2066-2072.
15. Maki DG, Weise CE, Sarafin HW. A semiquantitative culture method for identifying intravenous catheter related infection. N Engl J Med 1977;296:1305-1309.
16. Murray PR, Baron EJ, Jorgensen JH, Phaller MA, Yolken RH, eds. Manual of Clinical Microbiology. 8th ed. Washington, DC: ASM Press; 2003.
17. Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. 14th and 16th informational supplements. CLSI document. Wayne, PA: CLSI, 2005 and 2006: M100-S15/S16.
18. Safdar N, Maki DG. The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous catheters. Intensive Care Med 2004;30:62-67.
19. Humar A, Ostromecki A, Direnfeld J, et al. Prospective ranzomized trial of 10% povidone-iodine versus 0.5% tincture of chlorhexidine as cutaneous antisepsis for prevention of central venous catheter infection. Clin Infect Dis 2000;31:1001-1007.
20. Shelton DM. A comparison of the effects of two antiseptic agents on Staphylococcus epidermidis colony forming units at the peritoneal dialysis catheter exit site. Adv Perit Dial 1991;7:120-124.
21. Rijnders BJA, Van Wijngaerden E, Peetermans WE. Catheter-tip colonization as a surrogate end point in clinical studies on catheter-related bloodstream infection: how strong is the evidence? Clin Infect Dis 2002;35:1053-1058.