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Volumn 10, Issue 14, 2009, Pages 2343-2356

Doxofylline: A promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease

Author keywords

Asthma; Chronic obstructive pulmonary disease; Clinical efficacy; Doxofylline; Low side effects; Safety; Tolerability

Indexed keywords

ALLOPURINOL; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; AMINOPHYLLINE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM CHANNEL; CIMETIDINE; CLINDAMYCIN; DOXOFYLLINE; EPHEDRINE; ERYTHROMYCIN; ETOFYLLINE; INFLUENZA VACCINE; LINCOMYCIN; PHOSPHODIESTERASE; PROPRANOLOL; QUINOLONE DERIVATIVE; RANITIDINE; SALBUTAMOL; THEOPHYLLINE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; ZORDOX;

EID: 70349378493     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656560903200667     Document Type: Review
Times cited : (58)

References (52)
  • 1
    • 84868337504 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease
    • Jan Available from: Last accessed 16 June 2009
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Global initiative for chronic obstructive lung disease. Jan 2009. Available from: http://www.goldcopd.com [Last accessed 16 June 2009]
    • (2009) Global Initiative for Chronic Obstructive Lung Disease
  • 3
    • 33846179650 scopus 로고    scopus 로고
    • Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): Focus on virus induced exacerbations
    • DOI 10.2174/138161207779313777
    • Mallia P, Contoli M, Caramori G, et al. Exacerbations of asthma and chronic obstructive pulmonary disease (COPD): focus on virus induced exacerbations. Curr Pharm Des 2007;13:73-97 (Pubitemid 46085301)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.1 , pp. 73-97
    • Mallia, P.1    Contoli, M.2    Caramori, G.3    Pandit, A.4    Johnston, S.L.5    Papi, A.6
  • 5
    • 0031001720 scopus 로고    scopus 로고
    • Alternative projections of mortality and disability by cause 1990-2020: Global burden of disease study
    • Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet 1997;349:1498-1504
    • (1997) Lancet , vol.349 , pp. 1498-1504
    • Murray, C.J.1    Lopez, A.D.2
  • 7
    • 18644376713 scopus 로고    scopus 로고
    • The next generation of phosphodiesterase inhibitors: Structural clues to ligand and substrate selectivity of phosphodiesterases
    • Manallack DT, Hughes RA, Thompson PE. The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J Med Chem 2005;48:3449-3462
    • (2005) J Med Chem , vol.48 , pp. 3449-3462
    • Manallack, D.T.1    Hughes, R.A.2    Thompson, P.E.3
  • 8
    • 14544272401 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: Advances in the development of specific phosphodiesterase inhibitors
    • DOI 10.1002/med.20020
    • Castro A, Jerez MJ, Gil C, Martinez A. Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors. Med Res Rev 2005;25:229-244 (Pubitemid 40299847)
    • (2005) Medicinal Research Reviews , vol.25 , Issue.2 , pp. 229-244
    • Castro, A.1    Jerez, M.J.2    Gil, C.3    Martinez, A.4
  • 9
    • 3242804420 scopus 로고    scopus 로고
    • PDE4 inhibition: A novel approach for the treatment of inflammatory bowel disease
    • DOI 10.1016/j.tips.2004.06.008, PII S0165614704001774
    • Banner KH, Trevethick MA. PDE4 inhibition: a novel approach for the treatment of inflammatory bowel disease. Trends Pharmacol Sci 2004;25:430-436 (Pubitemid 38981559)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.8 , pp. 430-436
    • Banner, K.H.1    Trevethick, M.A.2
  • 10
    • 1242268903 scopus 로고    scopus 로고
    • Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3, 5-dichloro-pyrid-4-yl)- [1-(4- fluorobenzyl)-5-hydroxy- indole-3-yl]-glycoxylic acid amide (AWD 12-281), in human cell preparations
    • Draheim R, Egerland U, Rundfeldt C. Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3, 5-dichloro-pyrid-4-yl)- [1-(4- fluorobenzyl)-5-hydroxy- indole-3-yl]-glycoxylic acid amide (AWD 12-281), in human cell preparations. J Pharmacol Exp Ther 2004;308:555-563
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 555-563
    • Draheim, R.1    Egerland, U.2    Rundfeldt, C.3
  • 11
    • 10644253750 scopus 로고    scopus 로고
    • Phosphodiesterase 4-selective inhibition: Novel therapy for the inflammation of COPD
    • DOI 10.1016/j.pupt.2004.09.027, PII S1094553904000938
    • Jeffery P. Phosphodiesterase 4-selective inhibition: novel therapy for the inflammation of COPD. Pulm Pharmacol Ther 2005;18:9-17 (Pubitemid 39647748)
    • (2005) Pulmonary Pharmacology and Therapeutics , vol.18 , Issue.1 , pp. 9-17
    • Jeffery, P.1
  • 12
    • 1342264246 scopus 로고    scopus 로고
    • Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
    • DOI 10.1016/j.tips.2004.01.003
    • O'Donnell JM, Zhang HT. Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4). Trends Pharmacol Sci 2004;25:158-163 (Pubitemid 38264507)
    • (2004) Trends in Pharmacological Sciences , vol.25 , Issue.3 , pp. 158-163
    • O'Donnell, J.M.1    Zhang, H.-T.2
  • 13
    • 4444330207 scopus 로고    scopus 로고
    • The potential of PDE4 inhibitors in respiratory disease
    • DOI 10.2174/1568010043343822
    • Spina D. The potential of PDE4 inhibitors in respiratory disease. Curr Drug Targets Inflamm Allergy 2004;3:231-236 (Pubitemid 39206651)
    • (2004) Current Drug Targets: Inflammation and Allergy , vol.3 , Issue.3 , pp. 231-236
    • Spina, D.1
  • 14
    • 13544273183 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells
    • DOI 10.1136/thx.2004.025692
    • Mata M, Sarria B, Buenestado A, et al. Phosphodiesterase 4 inhibition decreases MUC5AC expression induced by epidermal growth factor in human airway epithelial cells. Thorax 2005;60:144-152 (Pubitemid 40222898)
    • (2005) Thorax , vol.60 , Issue.2 , pp. 144-152
    • Mata, M.1    Sarria, B.2    Buenestado, A.3    Cortijo, J.4    Cerda, M.5    Morcillo, E.J.6
  • 15
    • 21144437565 scopus 로고    scopus 로고
    • Phosphodiesterase: Overview of protein structures, potential therapeutic applications and recent progress in drug development
    • Jeon YH, Heo YS, Kim CM, et al. Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development. Cell Mol Life Sci 2005;62:1198-1220
    • (2005) Cell Mol Life Sci , vol.62 , pp. 1198-1220
    • Jeon, Y.H.1    Heo, Y.S.2    Kim, C.M.3
  • 17
    • 0035101284 scopus 로고    scopus 로고
    • Doxofylline: A new generation xanthine bronchodilator devoid of major cardiovascular adverse effects
    • DOI 10.1185/030079901750120196
    • Dini FL, Cogo R. Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects. Curr Med Res Opin 2001;16:258-268 (Pubitemid 32221483)
    • (2001) Current Medical Research and Opinion , vol.16 , Issue.4 , pp. 258-268
    • Dini, F.L.1    Cogo, R.2
  • 18
    • 33750019000 scopus 로고    scopus 로고
    • Functional KCa 3.1 K+ channels are required for human lung mast cell migration
    • Cruse G, Duffy SM, Brightling CE, Bradding P. Functional KCa 3.1 K+ channels are required for human lung mast cell migration. Thorax 2006;61:880-885
    • (2006) Thorax , vol.61 , pp. 880-885
    • Cruse, G.1    Duffy, S.M.2    Brightling, C.E.3    Bradding, P.4
  • 19
    • 33751090986 scopus 로고    scopus 로고
    • Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma
    • Zhou B, Cai SX, Zou F, et al. Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma. Zhonghua Jie He He Hu Xi Za Zhi 2005;28:817-819 (Pubitemid 44763489)
    • (2005) Zhonghua Jiehe He Huxi Zazhi , vol.28 , Issue.12 , pp. 817-819
    • Zhou, B.1    Cai, S.-X.2    Zou, F.3    Cai, C.-Q.4    Zhao, H.-J.5
  • 20
    • 0028344025 scopus 로고
    • Anti-inflammatory effects of low-dose oral theophylline in atopic asthma
    • DOI 10.1016/S0140-6736(94)90127-9
    • Sullivan P, Jaffar Z, Page C, et al. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet 1994;343:1006-1008 (Pubitemid 24122609)
    • (1994) Lancet , vol.343 , Issue.8904 , pp. 1006-1008
    • Sullivan, P.1    Bekir, S.2    Jaffar, Z.3    Page, C.4    Jeffery, P.5    Costello, J.6
  • 21
    • 0024346143 scopus 로고
    • Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF
    • Franzone JS, Cirillo R, Biffignandi P. Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF. Eur J Pharmacol 1989;165:269-277 (Pubitemid 19181795)
    • (1989) European Journal of Pharmacology , vol.165 , Issue.2-3 , pp. 269-277
    • Franzone, J.S.1    Cirillo, R.2    Biffignandi, P.3
  • 22
    • 0023775969 scopus 로고
    • Doxofylline and theophylline are xanthines with partly different mechanisms of action in animals
    • Franzone JS, Cirillo R, Barone D. Doxofylline and theophylline are xanthines with partly different mechanisms of action in animals. Drug Explt Clin Res 1988;14:479-489 (Pubitemid 18277545)
    • (1988) Drugs under Experimental and Clinical Research , vol.14 , Issue.7 , pp. 479-489
    • Franzone, J.S.1    Cirillo, R.2    Barone, D.3
  • 23
    • 0025952099 scopus 로고
    • Doxofylline differs from methylxanthines in its movement of cytosolic calcium
    • Franzone JS, Cirillo R, Reboani MC. Doxofylline differs from methylxanthines in its movement of cytosolic calcium. Int J Tissue React 1991;13:131-138
    • (1991) Int J Tissue React , vol.13 , pp. 131-138
    • Franzone, J.S.1    Cirillo, R.2    Reboani, M.C.3
  • 24
    • 0031290805 scopus 로고    scopus 로고
    • Preliminary study on the absorption, distribution and excretion of doxophylline in rats
    • Guo H, Xu XY, He LY, Huang JH. Preliminary study on the absorption, distribution and excretion of doxophylline in rats. Yao Xue Xue Bao 1997;32:81-84 (Pubitemid 127463700)
    • (1997) Yaoxue Xuebao , vol.32 , Issue.2 , pp. 81-84
    • Guo, H.1    Xu, X.Y.2    He, L.Y.3    Huang, J.H.4
  • 26
    • 70349382946 scopus 로고    scopus 로고
    • The pharmacokinetics of doxofylline in Chinese
    • Jian G, Chunyan Z, Zhaolong C, et al. The pharmacokinetics of doxofylline in Chinese. Chin J New Drugs 2000;6:396-398
    • (2000) Chin J New Drugs , vol.6 , pp. 396-398
    • Jian, G.1    Chunyan, Z.2    Zhaolong, C.3
  • 27
    • 38749117102 scopus 로고    scopus 로고
    • Development and validation of a stability-indicating RP-HPLC method for analysis of doxofylline in human serum. Application of the method to a pharmacokinetic study
    • Gannu R, Bandari S, Sudke SG, et al. Development and validation of a stability-indicating RP-HPLC method for analysis of doxofylline in human serum. Application of the method to a pharmacokinetic study. Acta Chromatographica 2007;19:149-160
    • (2007) Acta Chromatographica , vol.19 , pp. 149-160
    • Gannu, R.1    Bandari, S.2    Sudke, S.G.3
  • 28
    • 70349394065 scopus 로고    scopus 로고
    • The pharmacokinetic profiles of oral doxofylline and factors influencing the serum level
    • Poster-2116
    • Lee JH, Namgung HW, Kwon SY, et al. The pharmacokinetic profiles of oral doxofylline and factors influencing the serum level. Eur Res Cong Abstact Book 2007;Poster-2116: 350s
    • (2007) Eur Res Cong Abstact Book
    • Lee, J.H.1    Namgung, H.W.2    Kwon, S.Y.3
  • 29
    • 30644463917 scopus 로고    scopus 로고
    • Evaluation of in-vitro dissolution and in-vivo absorption for two different film-coated pellets of clarithromycin
    • Zhang XR, Chen XY, Hu LD, et al. Evaluation of in-vitro dissolution and in-vivo absorption for two different film-coated pellets of clarithromycin. Arch Pharm Res 2005;28:977-982
    • (2005) Arch Pharm Res , vol.28 , pp. 977-982
    • Zhang, X.R.1    Chen, X.Y.2    Hu, L.D.3
  • 30
    • 46949098029 scopus 로고    scopus 로고
    • Preparation and bioavailability of sustained-release doxofylline pellets in beagle dogs
    • DOI 10.1080/03639040701836552, PII 793879412
    • Huang HF, Lu Y, He HB, Tang X. Preparation and bioavailability of sustained-release doxofylline pellets in beagle dogs. Drug Dev Ind Pharm 2008;34:676-682 (Pubitemid 351962338)
    • (2008) Drug Development and Industrial Pharmacy , vol.34 , Issue.7 , pp. 676-682
    • Huang, H.-F.1    Lu, Y.2    He, H.-B.3    Tang, X.4
  • 31
    • 70349387772 scopus 로고    scopus 로고
    • Available from: [Last accessed 16 June 2009]
    • Cipla therapeutic index, respiratory drugs, Zordox. CiplaDoc. Available from: http://www.cipladoc.com/therapeutic/ admin.php?mode=prod&action= disp&id= 650 [Last accessed 16 June 2009]
    • Cipla Therapeutic Index, Respiratory Drugs, Zordox
  • 32
    • 0025824366 scopus 로고
    • Pharmacological studies in animals of beta-hydroxyethyltheophylline, the major metabolite of doxofylline in humans
    • Franzone JS, Cirillo R, Reboani MC. Pharmacological studies in animals of beta-hydroxyethyltheophylline, the major metabolite of doxofylline in humans. Methods Find Exp Clin Pharmacol 1991;13:289-299
    • (1991) Methods Find Exp Clin Pharmacol , vol.13 , pp. 289-299
    • Franzone, J.S.1    Cirillo, R.2    Reboani, M.C.3
  • 33
    • 0033282297 scopus 로고    scopus 로고
    • Tolerability of doxofylline in the maintenance therapy of pediatric patients with bronchial asthma
    • Bagnato GF. Tolerability of doxofylline in the maintenance therapy of pediatric patients with bronchial asthma. Eur Rev Med Pharmacol Sci 1999;3:255-260 (Pubitemid 32154180)
    • (1999) European Review for Medical and Pharmacological Sciences , vol.3 , Issue.6 , pp. 255-260
    • Bagnato, G.F.1
  • 35
    • 0036240519 scopus 로고    scopus 로고
    • Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma - A double-blind randomized placebo-controlled multicentre clinical trial
    • Goldstein MF, Chervinsky P. Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma - a double-blind randomized placebo-controlled multicentre clinical trial. Med Sci Monit 2002;8:CR297-304 (Pubitemid 34453433)
    • (2002) Medical Science Monitor , vol.8 , Issue.4
    • Goldstein, M.F.1    Chervinsky, P.2
  • 37
    • 0024366274 scopus 로고
    • Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure
    • Poggi R, Brandolese R, Bernasconi M, et al. Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure. Chest 1989;96:772-778
    • (1989) Chest , vol.96 , pp. 772-778
    • Poggi, R.1    Brandolese, R.2    Bernasconi, M.3
  • 38
    • 0034439491 scopus 로고    scopus 로고
    • Effects of oral doxofylline on inflammatory changes and altered cell proliferation in chronic obstructive bronchitis
    • Cogo R, Castronuovo A. Effects of oral doxofylline on inflammatory changes and altered cell proliferation in chronic obstructive bronchitis. Eur Rev Med Pharmacol Sci 2004;4:15-20 (Pubitemid 32496403)
    • (2000) European Review for Medical and Pharmacological Sciences , vol.4 , Issue.1-2 , pp. 15-20
    • Cogo, R.1    Castronuovo, A.2
  • 41
    • 0021038397 scopus 로고
    • Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias
    • Benditt DG, Benson DW, Kreitt J, et al. Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias. Am J Cardiol 1983;52:1223-1229 (Pubitemid 14243977)
    • (1983) American Journal of Cardiology , vol.52 , Issue.10 , pp. 1223-1229
    • Benditt, D.G.1    Woodrow Benson Jr., D.2    Kreitt, J.3
  • 43
    • 0025800337 scopus 로고
    • Chronotropic and arrhythmogenic effects of two methylxanthine bronchodilators, doxofylline and theophylline, evaluated by Holter monitoring
    • Dini FL. Chronotropic and arrhythmogenic effects of two methylxanthine bronchodilators, doxofylline and theophylline, evaluated by Holter monitoring. Curr Ther Res 1991;49:978-984
    • (1991) Curr Ther Res , vol.49 , pp. 978-984
    • Dini, F.L.1
  • 44
    • 0026720298 scopus 로고
    • Heart rhythm changes in patients with chronic obstructive bronchopneumopathies: Effects of different methylxanthine drugs
    • Cipri A, Pozzar F, Dini FL. Heart rhythm changes in patients with chronic obstructive bronchopneumopathies: effects of different methylxanthine drugs. Minerva Cardioangiol 1992;40:31-39
    • (1992) Minerva Cardioangiol , vol.40 , pp. 31-39
    • Cipri, A.1    Pozzar, F.2    Dini, F.L.3
  • 45
    • 0005887862 scopus 로고
    • Treatment with xanthine derivative, doxofylline, in patients intolerant to theophylline
    • Abstract 417
    • Giorgi M, Sestini P, Bracciale PM, et al. Treatment with xanthine derivative, doxofylline, in patients intolerant to theophylline. Eur Respir J 1993;6(Suppl 17): Abstract 417
    • (1993) Eur Respir J , vol.6 , Issue.SUPPL. 17
    • Giorgi, M.1    Sestini, P.2    Bracciale, P.M.3
  • 47
    • 0029036635 scopus 로고
    • The effects of doxofylline versus theophylline on sleep architecture in COPD patients
    • Sacco C, Braghiroli A, Grossi E, Donner CF. The effects of doxofylline versus theophylline on sleep architecture in COPD patients. Monaldi Arch Chest Dis 1995;50:98-103
    • (1995) Monaldi Arch Chest Dis , vol.50 , pp. 98-103
    • Sacco, C.1    Braghiroli, A.2    Grossi, E.3    Donner, C.F.4
  • 48
    • 0025670182 scopus 로고
    • The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients
    • Lazzaroni M, Gross E, Porro GB. The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients. Aliment Pharmacol Ther 1990;4:643-649
    • (1990) Aliment Pharmacol Ther , vol.4 , pp. 643-649
    • Lazzaroni, M.1    Gross, E.2    Porro, G.B.3
  • 49
    • 70349378398 scopus 로고    scopus 로고
    • Information, side effects and warnings of doxofylline methylxanthines
    • Available from: Last accessed 16 June 2009
    • Information, side effects and warnings of doxofylline methylxanthines. Medical, drugs, pharmaceuticals and diseases information. Available from: http://www.wordpress.rudramani.com/ information-side-effects-and-warnings- ofdoxofylline- methylxanthines/ [Last accessed 16 June 2009]
    • Medical, Drugs, Pharmaceuticals and Diseases Information
  • 51
    • 60649107589 scopus 로고    scopus 로고
    • Primary care of the patient with chronic obstructive pulmonary disease in Italy
    • Cazzola M, Bettoncelli G, Sessa E, Cricelli C. Primary care of the patient with chronic obstructive pulmonary disease in Italy. Respir Med 2009;103:582-588
    • (2009) Respir Med , vol.103 , pp. 582-588
    • Cazzola, M.1    Bettoncelli, G.2    Sessa, E.3    Cricelli, C.4
  • 52
    • 0000203434 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitors, structurally unrelated to Rolipram, as promising agents for the treatment of asthma and other pathologies
    • Piaz VD, Giovannoni MP. Phosphodiesterase 4 inhibitors, structurally unrelated to Rolipram, as promising agents for the treatment of asthma and other pathologies. Eur J Med Chem 2000;35:463-480
    • (2000) Eur J Med Chem , vol.35 , pp. 463-480
    • Piaz, V.D.1    Giovannoni, M.P.2


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