Effect of doxofylline on calcium-activated potassium channels in human peripheral blood eosinophils in asthma

Zhonghua Jiehe he Huxi Zazhi

Volumn 28, Issue 12, 2005, Pages 817-819

  Zhou, Bin ^a   Cai, Shao Xi ^b   Zou, Fei ^b   Cai, Chun Qing ^b   Zhao, Hai Jin ^b  

^a FIRST MILITARY MEDICAL UNIVERSITY   (China)

^b NONE

Author keywords

Asthma; Calcium activated potassium channels; Doxofylline; Eosinophils

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; DOXOFYLLINE; DRUG DERIVATIVE; THEOPHYLLINE;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; BLOOD; DRUG EFFECT; EOSINOPHIL; FEMALE; HUMAN; MALE; METABOLISM; PATCH CLAMP;

ADOLESCENT; ADULT; ASTHMA; EOSINOPHILS; FEMALE; HUMANS; MALE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; THEOPHYLLINE; YOUNG ADULT;

EID: 33751090986     PISSN: 10010939     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Wills-Karp M, Karp CL. Biomedicine. Eosinophils in asthma: remodeling a tangled tale. Science, 2004, 305:1726-1729.
2. + channels in human eosinophils. Am J Physiol, 1997, 273(1 Pt 1):L16-L21.
3. 2+ channels in eosinophils. FASEB J, 1996, 10:792-798.
4. Banner KH, Page CP. Anti-inflammatory effects of theophylline and selective phosphodiesterase inhibitors. Clin Exp Allergy, 1996, 26 (Suppl 2):2-9.
5. Franzone JS, Cirillo R, Biffignandi P. Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF. Eur J Pharmacol, 1989, 165:269-277.
6. Sullivan P, Bekir S, Jaffar Z, et al. Anti-inflammatory effects of low-dose oral theophylline in atopic asthma. Lancet, 1994, 343:1006-1008.
7. Sagara H, Fukuda T, Okada T, et al. Theophylline at therapeutic concentration suppresses PAF-induced upregulation of Mac-1 on human eosinophils. Clin Exp Allergy, 1996, 26(Suppl 2):16-21.
8. Goldstein MF, Chervinsky P. Efficacy and safety of doxofylline compared to theophylline in chronic reversible asthma-a double-blind randomized placebo-controlled multicentre clinical trial. Med Sci Monit, 2002, 8:CR297-CR304.
9. Dini FL, Cogo R. Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects. Curr Med Res Opin, 2001, 16:258-268.
10. Cirillo R, Barone D, Franzone JS. Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors. Arch Int Pharmacodyn Ther, 1988, 295:221-237.