Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors

Cellular and Molecular Life Sciences

Volumn 66, Issue 11-12, 2009, Pages 1962-1973

  Limb, J K ^a   Yoon, S ^a   Lee, K E ^a   Kim, B H ^a   Lee, S ^a   Bae, Y S ^a   Jhon, G J ^a   Kim, J ^a  

^a Ewha Womans University   (South Korea)

Author keywords

AP 1; CD41; FosB; K562; Megakaryocyte

Indexed keywords

ALPHA2 INTEGRIN; CD9 ANTIGEN; FOSB PROTEIN, HUMAN; GLYCOPROTEIN IIB; INHIBIN; INHIBIN BETA A SUBUNIT; ITGA2B PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN C FOS; PROTEIN KINASE C; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN K 562; CHROMATIN IMMUNOPRECIPITATION; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; HUMAN; MEGAKARYOCYTE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANTIGENS, CD; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; DOWN-REGULATION; GENE EXPRESSION PROFILING; HUMANS; INHIBIN-BETA SUBUNITS; INTEGRIN ALPHA2; K562 CELLS; MAP KINASE SIGNALING SYSTEM; MEGAKARYOCYTES; MEMBRANE GLYCOPROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLATELET MEMBRANE GLYCOPROTEIN IIB; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

EID: 70349339321     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-8775-5     Document Type: Article

References (37)

1. Demirer, T., Ilhan, O., Arat, M., Genc, Y., Ozcan, M., Dalva, K., Celebi, H., Beksac, M., Akan, H., Gurman, G., Konuk, N., Uysal, A., Arslan, O. and Koc, H. (2001) CD41+ and CD42+ hematopoietic progenitor cells may predict platelet engraftment after allogeneic peripheral blood stem cell transplantation. J. Clin. Apher. 16, 67-73.
2. Drexler, H. G., Zaborski, M. and Quentmeier, H. (1997) Cytokine response profiles of human myeloid factor-dependent leukemia cell lines. Leukemia 11, 701-708.
3. Majka, M., Baj-Krzyworzeka, M., Kijowski, J., Reca, R., Ratajczak, J. and Ratajczak, M. Z. (2001) In vitro expansion of human megakaryocytes as a tool for studying megakaryocytic development and function. Platelets 12, 325-332.
4. Patel, S. R., Hartwig, J. H. and Italiano, J. E., Jr. (2005) The biogenesis of platelets from megakaryocyte proplatelets. J. Clin. Invest. 115, 3348-3354.
5. Gordge, M. P. (2005) Megakaryocyte apoptosis: sorting out the signals. Br. J. Pharmacol. 145, 271-273.
6. Li, J. and Kuter, D. J. (2001) The end is just the beginning: megakaryocyte apoptosis and platelet release. Int. J. Hematol. 74, 365-374.
7. Kaushansky, K. (2008) Historical review: megakaryopoiesis and thrombopoiesis. Blood 111, 981-986.
8. McCormack, M. P., Hall, M. A., Schoenwaelder, S. M., Zhao, Q., Ellis, S., Prentice, J. A., Clarke, A. J., Slater, N. J., Salmon, J. M., Jackson, S. P., Jane, S. M. and Curtis, D. J. (2006) A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis. Blood 108, 2248-2256.
9. Fujimoto, T. T., Kohata, S., Suzuki, H., Miyazaki, H. and Fujimura, K. (2003) Production of functional platelets by differentiated embryonic stem (ES) cells in vitro. Blood 102, 4044-4051.
10. Eto, K., Murphy, R., Kerrigan, S. W., Bertoni, A., Stuhlmann, H., Nakano, T., Leavitt, A. D. and Shattil, S. J. (2002) Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. Proc. Natl. Acad. Sci. USA 99, 12819-12824.
11. Levay, K. and Slepak, V. Z. (2007) Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression. J. Clin. Invest. 117, 2672-2683.
12. Jalagadugula, G., Dhanasekaran, D. N., Kim, S., Kunapuli, S. P. and Rao, A. K. (2006) Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells. J. Thromb. Haemost. 4, 2678-2686.
13. Eriksson, M., Arminen, L., Karjalainen-Lindsberg, M. L. and Leppa, S. (2005) AP-1 regulates alpha2beta1 integrin expression by ERK-dependent signals during megakaryocytic differentiation of K562 cells. Exp. Cell Res. 304, 175-186.
14. Jochum, W., Passegue, E. and Wagner, E. F. (2001) AP-1 in mouse development and tumorigenesis. Oncogene 20, 2401-2412.
15. Hess, J., Angel, P. and Schorpp-Kistner, M. (2004) AP-1 subunits: quarrel and harmony among siblings. J. Cell Sci. 117, 5965-5973.
16. Chinenov, Y. and Kerppola, T. K. (2001) Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity. Oncogene 20, 2438-2452.
17. Gewirtz, A. M., Burger, D., Rado, T. A., Benz, E. J., Jr. and Hoffman, R. (1982) Constitutive expression of platelet glycoproteins by the human leukemia cell line K562. Blood 60, 785-789.
18. Alitalo, R., Partanen, J., Pertovaara, L., Holtta, E., Sistonen, L., Andersson, L. and Alitalo, K. (1990) Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter- induced megakaryoblastic differentiation of K562 leukemia cells. Blood 75, 1974-1982.
19. Lai, C. F. and Cheng, S. L. (2002) Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells. J. Biol. Chem. 277, 15514-15522.
20. Yen, J., Wisdom, R. M., Tratner, I. and Verma, I. M. (1991) An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins. Proc. Natl. Acad. Sci. USA 88, 5077-5081.
21. Nimer, S., Zhang, J., Avraham, H. and Miyazaki, Y. (1996) Transcriptional regulation of interleukin-3 expression in megakaryocytes. Blood 88, 66-74.
22. Dorn, G. W., 2nd, Davis, M. G. and D'Angelo, D. D. (1994) Gene expression during phorbol ester-induced differentiation of cultured human megakaryoblastic cells. Am. J. Physiol. 266, C1231-1239.
23. Panterne, B., Hatzfeld, J., Blanchard, J. M., Levesque, J. P., Berthier, R., Ginsbourg, M. and Hatzfeld, A. (1992) c-fos mRNA constitutive expression by mature human megakaryocytes. Oncogene 7, 2341-2344.
24. Somervaille, T. C. and Cleary, M. L. (2006) PU.1 and Junb: suppressing the formation of acute myeloid leukemia stem cells. Cancer Cell 10, 456-457.
25. Friedman, A. D. (2007) C/EBPalpha induces PU.1 and interacts with AP-1 and NF-kappaB to regulate myeloid development. Blood Cells. Mol. Dis. 39, 340-343.
26. Kolonics, A., Apati, A., Nahajevszky, S., Gati, R., Brozik, A. and Magocsi, M. (2001) Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia. Haematologia (Budap) 31, 125-138.
27. Zutter, M. M., Painter, A. D. and Yang, X. (1999) The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. Blood 93, 1600-1611.
28. Fuhrken, P. G., Chen, C., Miller, W. M. and Papoutsakis, E. T. (2007) Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation. Exp. Hematol. 35, 476-489.
29. Kobayashi, S., Teramura, M., Ito, K., Iwabe, K., Inaba, T. and Mizoguchi, H. (1998) Transcription factor NF-E2 is essential for the polyploidization of a human megakaryoblastic cell line, Meg-J. Biochem. Biophys. Res. Commun. 247, 65-69.
30. Stankiewicz, M. J. and Crispino, J. D. (2009) ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood (in print).
31. Terui, K., Takahashi, Y., Kitazawa, J., Toki, T., Yokoyama, M. and Ito, E. (2000) Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin. Tohoku J. Exp. Med. 192, 259-273.
32. Block, K. L. and Poncz, M. (1995) Platelet glycoprotein IIb gene expression as a model of megakaryocyte-specific expression. Stem Cells 13, 135-145.
33. Hilden, K., Tuuri, T., Eramaa, M. and Ritvos, O. (1999) Coordinate expression of activin A and its type I receptor mRNAs during phorbol ester-induced differentiation of human K562 erythroleukemia cells. Mol. Cell. Endocrinol. 153, 137-145.
34. Fujimoto, K., Kawakita, M., Kato, K., Yonemura, Y., Masuda, T., Matsuzaki, H., Hirose, J., Isaji, M., Sasaki, H., Inoue, T. and Takatsuki, K. (1991) Purification of megakaryocyte differentiation activity from a human fibrous histiocytoma cell line: N-terminal sequence homology with activin A. Biochem. Biophys. Res. Commun. 174, 1163-1168.
35. Jeanpierre, S., Nicolini, F. E., Kaniewski, B., Dumontet, C., Rimokh, R., Puisieux, A. and Maguer-Satta, V. (2008) BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood 112, 3154-3163.
36. Clay, D., Rubinstein, E., Mishal, Z., Anjo, A., Prenant, M., Jasmin, C., Boucheix, C. and Le Bousse-Kerdiles, M. C. (2001) CD9 and megakaryocyte differentiation. Blood 97, 1982-1989.
37. Chylicki, K., Ehinger, M., Svedberg, H., Bergh, G., Olsson, I. and Gullberg, U. (2000) p53-mediated differentiation of the erythroleukemia cell line K562. Cell Growth Differ 11, 315-324.