Unregulated activation of STAT-5, ERK1/2 and c-Fos may contribute to the phenotypic transformation from myelodysplastic syndrome to acute leukaemia

Haematologia

Volumn 31, Issue 2, 2001, Pages 125-138

  Kolonics, A ^a   Apati A ^a   Nahajevszky, S ^a   Gati R ^a   Brozik A ^a   Magocsi M ^a  

^a National Institute of Haematology and Immunology Budapest   (Hungary)

Author keywords

Acute myeloid leukaemia; c Fos; Egr 1; ERK1 2; Myelodysplastic syndrome; STAT 5

Indexed keywords

DNA; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; STAT5 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR EGR 1;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ADULT; AGED; APOPTOSIS; ARTICLE; BASAL CELL; BLAST CELL; BLAST TRANSFORMATION; BONE MARROW CELL; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; DYSERYTHROPOIESIS; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; MYELODYSPLASTIC SYNDROME; PHENOTYPE; PREDICTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REFRACTORY ANEMIA; SIGNAL TRANSDUCTION; STEM CELL; UMBILICAL CORD BLOOD;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; BONE MARROW CELLS; CASE-CONTROL STUDIES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ERYTHROPOIETIN; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; LEUKEMIA; MALE; MIDDLE AGED; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MYELODYSPLASTIC SYNDROMES; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0035195559     PISSN: 00176559     EISSN: None     Source Type: Journal    
DOI: 10.1163/15685590152492936     Document Type: Article

References (52)

1. Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes
2. Fas/Apo-1 (CD95) expression and apoptosis in patients with myelodysplastic syndromes
3. The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells
4. A novel mechanism of cooperation between c-Kit and erythropoietin receptor: Stem cell factor induces the expression of Stat5 and erythropoietin receptor resulting in efficient proliferation and survival by erythropoietin
5. Erythropoiesis in myelodysplastic syndrome: Expression of receptors for erythropoietin and kit ligand
6. Erythropoietin-induced activation of STAT-5 is impaired in the myelodysplastic syndrome
7. Ineffective erythropoiesis in myelodysplastic syndromes: Correlation with Fas expression but not with lack of erythropoietin receptor signal transduction
8. Interleukin-3, granulocytemacrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs
9. Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells
10. Acute lymphoblastic leukemia following preleukemic syndromes in adults
11. Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: Relation to disease progression
12. Leukaemia and the disruption of normal haematopoiesis
13. Elevated c-fos expression inhibits differentiation of L6 rat myoblasts
14. Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle
15. Bone and haemapoietic defects in mice lacking c-fos
16. Hematopoietic growth factors (BPA and Epo) induce the expressions of c-myc and c-fos proto-oncogenes in normal human erythroid progenitors
17. The SRE: A growth factor responsive transcriptional regulator
18. The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter
19. Repression of c-fos transcription is mediated through p67SRF bound to the SRE
20. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB
21. Regulation of c-fos gene transcription and myeloid cell differentiation by acute myeloid leukaemia 1 and acute myeloid leukemia-MTG8, a chimeric leukemogenic derivative of acute myeloid leukaemia 1
22. c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1
23. Genetic programs of myeloid cell differentiation
24. A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization
25. Primary response genes induced by growth factors and tumor promoters
26. 2+-mediated egr-1 and c-fos expression in murine erythroleukemia cells by cyclosporin A
27. Transplantation of umbilical cord blood after myeloablative therapy: Analysis of engraftment
28. Graft-versus-leukemia-induced complete remission following unrelated umbilical cord blood transplantation for acute leukemia
29. The role of STATs in proliferation, differentiation, and apoptosis
30. STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells
31. Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase
32. Proliferative but not nonproliferative responses to granulocyte colony-stimulating factor are associated with rapid activation of the p21ras/MAP kinase signalling pathway
33. Granulocyte-macrophage colony-stimulating factor stimulation results in phosphorylation of cAMP response element-binding protein through activation of pp90RSK
34. Serine/threonine phosphorylation in cytokine signal transduction
35. Signal transduction pathways regulating hematopoietic differentiation
36. Granulocyte-macrophage colony-stimulating factor induces the transcriptional activation of egr-1 through a protein kinase A-independent signalling pathway
37. The role of Jun, Fos and the AP-1 complex in cell proliferation and transformation
38. Protooncogene c-fos as a transcription factor
39. Proto-oncogene expression and dissection of myeloid growth to differentiation developmental cascade
40. The regulation of c-fos: Too much is never enough
41. Jun: Oncogene and transcription factor
42. A truncated erythropoietin receptor that fails to prevent programmed cell death of erythroid cells
43. A truncated erythropoietin receptor and cell death: A re-analysis
44. Dominant negative effect of a truncated erythropoietin receptor (EPOR-T) on erythropoietin-induced erythroid differentiation: Possible involvement of EPOR-T in ineffective erythropoiesis of myelodysplastic syndrome
45. The role of STATs in myeloid differentiation and leukaemia
46. Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation
47. Signalling mechanisms and the role of calcineurin in erythropoiesis
48. An expansion phase precedes terminal erythroid differentiation of hematopoietic progenitor cells from cord blood in vitro and is associated with up-regulation of cyclin-dependent kinase 2
49. Proto-oncogene of the fos/jun family of transcription factors are positive regulators of myeloid differentiation
50. c-fos oncogene expression in human hematopoietic malignacies is restricted to acute leukemias with monocytic phenotype and to subsets of B cell leukemias
51. Expression of the protooncogenes c-myc, c-fos, and c-fms in acute myelocytic leukemia at diagnosis and in remission
52. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity