Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation

Experimental Hematology

Volumn 35, Issue 3, 2007, Pages

  Fuhrken, Peter G ^a   Chen, Chi ^b   Miller, William M ^a,b,c   Papoutsakis, Eleftherios T ^a,c  

^a Northwestern University   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; JANUS KINASE 2; PHORBOL ESTER; PROTEIN P53; STAT5 PROTEIN; TRANSCRIPTION FACTOR GATA 1;

APOPTOSIS; ARTICLE; CD34 SELECTION; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CONTROLLED STUDY; DNA BINDING; DNA MICROARRAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; INFLAMMATION; INTERMETHOD COMPARISON; MEGAKARYOBLAST; MEGAKARYOCYTE; MEGAKARYOPOIESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

EID: 33847044392     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2006.10.017     Document Type: Article

References (59)

1. Ogura M., Morishima Y., Ohno R., et al. Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome. Blood 66 (1985) 1384-1392
2. Sato T., Fuse A., Eguchi M., et al. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia. Br J Haematol 72 (1989) 184-190
3. Fugman D., Witte D., Jones C., Aronow B., and Lieberman M. In vitro establishment and characterization of a human megakaryoblastic cell line. Blood 75 (1990) 1252-1261
4. Lozzio C.B., and Lozzio B.B. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 45 (1975) 321-334
5. Schulze H., and Shivdasani R.A. Molecular mechanisms of megakaryocyte differentiation. Semin Thromb Hemost 30 (2004) 389-398
6. Gaines P., Geiger J.N., Knudsen G., Seshasayee D., and Wojchowski D.M. GATA-1- and FOG-dependent activation of megakaryocytic alpha IIB gene expression. J Biol Chem 275 (2000) 34114-34121
7. Deveaux S., Filipe A., Lemarchandel V., Ghysdael J., Romeo P.H., and Mignotte V. Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Blood 87 (1996) 4678-4685
8. Lecine P., Italiano Jr. J.E., Kim S.W., Villeval J.L., and Shivdasani R.A. Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood 96 (2000) 1366-1373
9. + cells ex vivo expanded by thrombopoietin. Stem Cells 20 (2002) 402-416
10. lo cells differentiating along the megakaryocyte lineage. Exp Hematol 32 (2004) 638-648
11. Balduini A., d'Apolito M., Arcelli D., et al. Cord blood in vitro expanded CD41 cells: identification of novel components of megakaryocytopoiesis. J Thromb Haemost 4 (2006) 848-860
12. Harris A.J., Dial S.L., and Casciano D.A. Comparison of basal gene expression profiles and effects of hepatocarcinogens on gene expression in cultured primary human hepatocytes and HepG2 cells. Mutat Res 549 (2004) 79-99
13. Gebauer M., Saas J., Sohler F., et al. Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1β. Osteoarthritis Cartilage 13 (2005) 697-708
14. Jacquel A., Herrant M., Defamie V., et al. A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis. Oncogene 25 (2006) 781-794
15. Yang H., Miller W.M., and Papoutsakis E.T. Higher pH promotes megakaryocytic maturation and apoptosis. Stem Cells 20 (2002) 320-328
16. Herault O., Colombat P., Domenech J., et al. A rapid single-laser flow cytometric method for discrimination of early apoptotic cells in a heterogenous cell population. Br J Haematol 104 (1999) 530-537
17. Hevehan D.L., Miller W.M., and Papoutsakis E.T. Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Blood 99 (2002) 1627-1637
18. Churchill G.A. Fundamentals of experimental design for cDNA microarrays. Nat Genet 32 Suppl (2002) 490-495
19. Giammona L.G., Fuhrken P.G., Papoutsakis E.T., and Miller W.M. Nicotinamide (vitamin B3) increases the polyploidization and proplatelet formation of cultured primary human megakaryocytes. Br J Haematol 135 (2006) 554-566
20. Saeed A.I., Sharov V., White J., et al. TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34 (2003) 374-378
21. Mostafa S.S., Miller W.M., and Papoutsakis E.T. Oxygen tension influences the differentiation, maturation and apoptosis of human megakaryocytes. Br J Haematol 111 (2000) 879-889
22. Metcalf D., Carpinelli M.R., Hyland C., et al. Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene. Blood 105 (2005) 3480-3487
23. Zhang Y., Nagata Y., Yu G., et al. Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression. Blood 103 (2004) 3717-3726
24. Geddis A.E., and Kaushansky K. Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation. Cell Cycle 5 (2006) 538-545
25. Blaser S., Horn J., Wurmell P., et al. The novel human platelet septin SEPT8 is an interaction partner of SEPT4. Thromb Haemost 91 (2004) 959-966
26. Shavit J.A., Motohashi H., Onodera K., Akasaka J., Yamamoto M., and Engel J.D. Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice. Genes Dev 12 (1998) 2164-2174
27. Li J., and Kuter D.J. The end is just the beginning: megakaryocyte apoptosis and platelet release. Int J Hematol 74 (2001) 365-374
28. Gurbuxani S., Xu Y., Keerthivasan G., Wickrema A., and Crispino J.D. Differential requirements for survivin in hematopoietic cell development. Proc Natl Acad Sci U S A 102 (2005) 11480-11485
29. Chen L., Willis S.N., Wei A., et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17 (2005) 393-403
30. Yu J., and Zhang L. No PUMA, no death: implications for p53-dependent apoptosis. Cancer Cell 4 (2003) 248-249
31. Tomasini R., Samir A.A., Carrier A., et al. TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. J Biol Chem 278 (2003) 37722-37729
32. Miyashita T., Krajewski S., Krajewska M., et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9 (1994) 1799-1805
33. Polyak K., Xia Y., Zweier J.L., Kinzler K.W., and Vogelstein B. A model for p53-induced apoptosis. Nature 389 (1997) 300-305
34. Jagelska E., Brazda V., Pospisilova S., Vojtesek B., and Palecek E. New ELISA technique for analysis of p53 protein/DNA binding properties. J Immunol Methods 267 (2002) 227-235
35. Gnatenko D.V., Dunn J.J., McCorkle S.R., Weissmann D., Perrotta P.L., and Bahou W.F. Transcript profiling of human platelets using microarray and serial analysis of gene expression. Blood 101 (2003) 2285-2293
36. McRedmond J.P., Park S.D., Reilly D.F., et al. Integration of proteomics and genomics in platelets: a profile of platelet proteins and platelet-specific genes. Mol Cell Proteomics 3 (2004) 133-144
37. Sabri S., Jandrot-Perrus M., Bertoglio J., et al. Differential regulation of actin stress fiber assembly and proplatelet formation by α2β1 integrin and GPVI in human megakaryocytes. Blood 104 (2004) 3117-3125
38. Takada M., Morii N., Kumagai S., and Ryo R. The involvement of the rho gene product, a small molecular weight GTP-binding protein, in polyploidization of a human megakaryocytic cell line, CMK. Exp Hematol 24 (1996) 524-530
39. Schoenwaelder S.M., Hughan S.C., Boniface K., et al. RhoA sustains integrin αIIbβ3 adhesion contacts under high shear. J Biol Chem 277 (2002) 14738-14746
40. Aspenstrom P., Richnau N., and Johansson A.S. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res 312 (2006) 2180-2194
41. Prakash S.K., Paylor R., Jenna S., et al. Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum Mol Genet 9 (2000) 477-488
42. Berthebaud M., Riviere C., Jarrier P., et al. RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes. Blood 106 (2005) 2962-2968
43. Yowe D., Weich N., Prabhudas M., et al. RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes. Biochem J 359 (2001) 109-118
44. Takeuchi K., Higuchi T., Yamashita T., and Koike K. Chemokine production by human megakaryocytes derived from CD34-positive cord blood cells. Cytokine 11 (1999) 424-434
45. + cells and megakaryoblasts secrete beta-chemokines that block infection of hematopoietic cells by M-tropic R5 HIV. J Clin Invest 104 (1999) 1739-1749
46. + cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner. Blood 97 (2001) 3075-3085
47. Klinger M.H.F. Platelets and inflammation. Anat Embryol (Berl) 196 (1997) 1-11
48. Krotz F., Sohn H.Y., Gloe T., et al. NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment. Blood 100 (2002) 917-924
49. Vlodavsky I., Eldor A., Haimovitz-Friedman A., et al. Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation. Invasion Metastasis 12 (1992) 112-127
50. Hawrylowicz C.M., Howells G.L., and Feldmann M. Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med 174 (1991) 785-790
51. Testi R., Pulcinelli F., Frati L., Gazzaniga P., and Santoni A. CD69 is expressed on platelets and mediates platelet activation and aggregation. J Exp Med 172 (1990) 701-707
52. Der S.D., Zhou A., Williams B.R.G., and Silverman R.H. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A 95 (1998) 15623-15628
53. Mercher T., Wernig G., Moore S.A., et al. JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Blood 108 (2006) 2770-2779
54. Bellucci S., and Michiels J.J. The role of JAK2 V617F mutation, spontaneous erythropoiesis and megakaryocytopoiesis, hypersensitive platelets, activated leukocytes, and endothelial cells in the etiology of thrombotic manifestations in polycythemia vera and essential thrombocythemia. Semin Thromb Hemost 32 (2006) 381-398
55. Brierley M.M., and Fish E.N. Stats: multifaceted regulators of transcription. J Interferon Cytokine Res 25 (2005) 733-744
56. Wlodarski P., Wasik M., Ratajczak M.Z., et al. Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood 91 (1998) 2998-3006
57. Donehower L.A., Harvey M., Slagle B.L., et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992) 215-221
58. Sigurjonsson O.E., Gudmundsson K.O., Haraldsdottir V., Rafnar T., Agnarsson B.A., and Gudmundsson S. Flt3/Flk-2 ligand in combination with thrombopoietin decreases apoptosis in megakaryocyte development. Stem Cells Dev 13 (2004) 183-191
59. Mahdi T., Brizard A., Millet C., Dore P., Tanzer J., and Kitzis A. In vitro p53 and/or Rb antisense oligonucleotide treatment in association with growth factors induces the proliferation of peripheral hematopoietic progenitors. J Cell Sci 108 Pt 3 (1995) 1287-1293