p53-mediated differentiation of the erythroleukemia cell line K562

Cell Growth and Differentiation

Volumn 11, Issue 6, 2000, Pages 315-324

  Chylicki, Kristina ^a   Ehinger, Mats ^b   Svedberg, Helena ^b   Bergh, Gösta ^b   Olsson, Inge ^b   Gullberg, Urban ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD9 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR; HEMIN; MEMBRANE ANTIGEN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL STRAIN K 562; CELL VIABILITY; CONTROLLED STUDY; ERYTHROLEUKEMIA CELL; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTIGENS, CD; BENZIDINES; BLOTTING, WESTERN; CELL CYCLE; CELL DEATH; CELL DIFFERENTIATION; CELL SEPARATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; GENETIC VECTORS; HEMIN; HEMOGLOBINS; HUMANS; INTEGRIN BETA3; K562 CELLS; MEMBRANE GLYCOPROTEINS; MICE; MUTAGENESIS; PHENOTYPE; PHOSPHORYLATION; PLATELET MEMBRANE GLYCOPROTEINS; PRECIPITIN TESTS; TEMPERATURE; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033922952     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Ko, L. J., and Prives, C. p53: puzzle and paradigm. Genes Dev., 10: 1054-1072, 1996.
2. Lang, D. Miknyoczki, S. J., Huang, L., and Ruggeri, B. A. Stable reintroduction of wild-type p53 (MTmp53ts) causes the induction of apoptosis and neuroendocrine-like differentiation in human ductal pancreatic carcinoma cells. Oncogene, 16: 1593-1602, 1998.
3. Soddu, S., Blandino, G., Scardigli, R., Coen, S., Marchetti, A., Rizzo, M. G., Bossi, G., Cimino, L., Crescenzi, M., and Sacchi, A. Interference with p53 protein inhibits hematopoietic and muscle differentiation. J. Cell Biol., 134: 193-204, 1996.
4. Almog, N., and Rotter, V. Involvement of p53 in cell differentiation and development. Biochim. Biophys. Acta, 7333: 1-27, 1997.
5. Shaulsky, G., Goldfinger, N., Peled, A., and Rotter, V. Involvement of wild-type p53 in pre-B-cell differentiation in vitro. Proc. Natl. Acad. Sci. USA, 88: 8982-8986, 1991.
6. Banerjee, D., Lenz, H. J., Schnieders, B., Manno, D. J., Ju, J. F., Spears, C. P., Hochhauser, D., Danenberg, K., Danenberg, P., and Bertino, J. R. Transfection of wild-type but not mutant p53 induces early monocytic differentiation in HL60 cells and increases their sensitivity to stress. Cell Growth Differ., 6: 1405-1413, 1995.
7. Feinstein, E., Gale, R. P., Reed, J., and Canaani, E. Expression of the normal p53 gene induces differentiation of K562 cells. Oncogene, 7: 1853-1857, 1992.
8. Ehinger, M., Nilsson, E., Persson, A. M., Olsson, I., and Gullberg, U. Involvement of the tumor suppressor gene p53 in tumor necrosis factor-induced differentiation of the leukemic cell line K562. Cell Growth Differ., 6: 9-17, 1995.
9. Johnson, P., Chung, S., and Benchimol, S. Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin. Mol. Cell. Biol., 73: 1456-1463, 1993.
10. Ehinger, M., Bergh, G., Olofsson, T., Baldetorp, B., Olsson, I., and Gullberg, U. Expression of the p53 tumor suppressor gene induces differentiation and promotes induction of differentiation by 1,25-dihydroxycholecalciferol in leukemic U-937 cells. Blood, 87: 1064-1074, 1996.
11. el-Deiry, W. S., Tokino, T., Velculescu V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., and Vogelstein, B. WAF1, a potential mediator of p53 tumor suppression. Cell, 75: 817-825, 1993.
12. Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
13. Liu, M., Iavarone, A., and Freedman, L. P. Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation. J. Biol. Chem., 271: 31723-31728, 1996.
14. Jiang, H., Lin, J., Su, Z. Z., Collart, F. R., Huberman, E., and Fisher, P. B. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene, 9: 3397-3406, 1994.
15. Steinman, R. A., Huang, J., Yaroslavskiy, B., Goff, J. P., Ball, E. D., and Nguyen, A. Regulation of p21(WAF1) expression during normal myeloid differentiation. Blood, 97: 4531-4542, 1998.
16. Ehinger, M., Bergh, G., Johnsson, E., Gullberg, U., and Olsson, I. The tumor suppressor gene p53 can mediate transforming the growth factor β1-induced differentiation of leukemic cells independently of activation of the retinoblastoma protein. Cell Growth Differ., 8: 1127-1137, 1997.
17. Asada, M., Yamada, T., Fukumuro, K., and Mizutani, S. p21Cip1/ WAF1 is important for differentiation and survival of U937 cells. Leukemia (Baltimore), 12: 1944-1950, 1998.
18. Wang, Z., Su, Z. Z., Fisher, P. B., Wang, S., VanTuyle, G., and Grant, S. Evidence of a functional role for the cyclin-dependent kinase inhibitor p21(WAF1/CIP1/MDA6) in the reciprocal regulation of PKC activator-induced apoptosis and differentiation in human myelomonocytic leukemia cells. Exp. Cell Res., 244: 105-116, 1998.
19. Ehinger, M., Bergh, G., Johnsson, E., Baldetorp, B., Olsson, I., and Gullberg, U. p53-dependent and p53-independent differentiation of leukemic U-937 cells-relationship to cell cycle control. Exp. Hematol., 26: 1043-1052, 1998.
20. Lubbert, M., Miller, C. W., Crawford, L., and Koeffler, H. P. p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression. J. Exp. Med., 167: 873-886, 1988.
21. Eliyahu, D., Michalovitz, D., and Oren, M. Overproduction of p53 antigen makes established cells highly tumorigenic. Nature (Lond.), 316: 158-160, 1985.
22. Michalovitz, D., Halevy, O., and Oren, M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell, 62: 671-680, 1990.
23. Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsperger, C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J. Immunol. Methods, 184: 39-51, 1995.
24. Rutherford, T. R., Clegg, J. B., and Weatherall, D. J. K562 human leukemic cells synthesize embryonic hemoglobin in response to hemin. Nature (Lond.), 280: 164-165, 1979.
25. Tetteroo, P. A., Massaro, F., Mulder, A., Schreuder-van Gelder, R., and von dem Borne, A. E. Megakaryoblastic differentiation of proerythroblastic K562 cell-line cells. Leuk. Res., 8: 197-206, 1984.
26. Magnelli, L., Cinelli, M., and Chiarugi, V. Phorbol esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-P53/ K562 from apoptosis. Biochem. Biophys. Res. Commun., 215: 641-645, 1995.
27. Skouv, J., Jensen, P. O., Forchhammer, J., Larsen, J. K., and Lund, L. R. Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle. Cell Growth Differ., 5: 329-340, 1994.
28. Le Naour, F., Francastel, C., Prenant, M., Lantz, O., Boucheix, C., and Rubinstein, E. Upregulation of CD9 expression during TPA treatment of K562 cells. Leukemia, 77: 1290-1297, 1997.
29. Gorospe, M., Cirielli, C., Wang, X., Seth, P., Capogrossi, M. C., and Holbrook, N. J. p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells. Oncogene, 14: 929-935, 1997.
30. Wang, J., and Walsh, K. Resistance to apoptosis conferred by Cdk inhibitors during myocyte differentiation. Science (Washington DC), 273: 359-361, 1996.
31. Ewen, M. E., Sluss, H. K., Sherr, C. J., Matsushime, H., Kato, J., and Livingstone, D. M. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell, 73: 487-497, 1993.
32. Harper, J. W., Adami, G. R., Wei, N., Keyomarski, K., and Elledge, S. J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 75: 805-816, 1993.
33. Smith, M. L., Zhan, Q., Bae, I., and Fornace, A. J., Jr. Role of retino-blastoma gene product in p53-mediated DNA damage response. Exp. Cell Res., 215: 386-389, 1994.
34. Evan, G. I., Brown, L., Whyte, M., and Harrington, E. Apoptosis and the cell cycle. Curr. Opin. Cell Biol., 7: 825-834, 1995.
35. Gottlieb, T. M., and Oren, M. p53 in growth control and neoplasia. Biochim. Biophys. Acta, 1287: 77-102, 1996.
36. Nishioka, W. K., and Welsh, R. M. Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target. J. Exp. Med., 179: 769-774, 1994.
37. Zhang, P., Wong, C., Liu, D., Finegold, M., Harper, J. W., and Elledge, S. J. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev., 13: 213-224, 1999.
38. Erhardt, J. A., and Pittman, R. N. p21WAF1 induces permanent growth arrest and enhances differentiation, but does not alter apoptosis in PC12 cells. Oncogene, 16: 443-451, 1998.
39. Rizzo, M. G., Zepparoni, A., Cristofanelli, B., Scardigli, R., Crescenzi, M., Blandino, G., Giuliacci, S., Ferrari, S., Soddu, S., and Sacchi, A. Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation. Br. J. Cancer, 77: 1429-1438, 1998.
40. Lotem, J., and Sachs, L. Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes. Leukemia (Baltimore), 10: 925-931, 1996.
41. Ronen, D., Schwartz, D., Teitz, Y., Goldfinger, N., and Rotter, V. Induction of HL-60 cells to undergo apoptosis is determined by high levels of wild-type p53 protein whereas differentiation of the cells is mediated by lower p53 levels. Cell Growth Differ., 7: 21-30, 1996.
42. Weinberg, W. C., Azzoli, C. G., Chapman, K., Levine, A. J., and Yuspa, S. H. p53-mediated transcriptional activity increases in differentiating epidermal keratinocytes in association with decreased p53 protein. Oncogene, 10: 2271-2279, 1995.
43. Hoshikawa, Y., Mori, A., Amimoto, K., Iwabe, K., and Hatekeymara, M. Control of the retinoblastoma protein-independent hematopoietic cell cycle by the pRb-related p130. Proc. Natl. Acad. Sci. USA, 95: 8574-8579, 1998.
44. Lozzio, C. B., and Lozzio B. B. Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood, 45: 321-324, 1975.
45. Garwicz, D., Lindmark, A., Hellmark, T., Gladh, M., Jögi, J., and Gullberg, U. Characterization of the processing and granular targeting of human proteinase 3 after transfection to the rat RBL or the murine 32D leukemic cell lines. J. Leukocyte Biol., 61: 113-121, 1997.
46. Svedberg, H., Chylicki, K., Baldetorp, B., Rauscher, F. J. R., and Gullberg, U. Constitutive expression of the Wilms' tumor gene (WT1) in the leukemic cell line U937 blocks parts of the differentiation program. Oncogene, 16: 925-932, 1998.
47. Bergh, G., Ehinger, M., Olofsson, T., Baldetorp, B., Johnsson, E., Brycke, H., Lindgren, G., Olsson, I., and Gullberg, U. Altered expression of the retinoblastoma tumor-suppressor gene in leukemic cell lines inhibits induction of differentiation but not G1-accumulation. Blood, 89: 2938-2950, 1997.