Ultraviolet radiation and immunosuppression

British Journal of Dermatology

Volumn 161, Issue SUPPL. 3, 2009, Pages 90-95

  Murphy, G M ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

Apoptosis; Carcinogenesis; DNA repair; Human papilloma virus; Immune surveillance; Immuno suppression; Ultraviolet radiation

Indexed keywords

AZATHIOPRINE; CELL DNA; CYCLOSPORIN; EVEROLIMUS; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PROTEIN BAK; PROTEIN E6; PROTEIN P53; RAPAMYCIN; TACROLIMUS;

APOPTOSIS; BASAL CELL CARCINOMA; CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; DNA DAMAGE; DRUG DEPENDENCE; DRUG DOSE REDUCTION; EXCISION REPAIR; GENE MUTATION; GRAFT REJECTION; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN PAPILLOMAVIRUS TYPE 31; HUMAN PAPILLOMAVIRUS TYPE 33; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOSURVEILLANCE; LYMPHOCYTOPENIA; MELANOMA; MOLECULAR MECHANICS; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; RADIATION RESPONSE; REVIEW; SKIN CANCER; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; SUN EXPOSURE; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ULTRAVIOLET RADIATION; VIRUS PATHOGENESIS;

ANIMALS; APOPTOSIS; DNA DAMAGE; HUMANS; IMMUNOSUPPRESSION; MICE; MICE, INBRED C57BL; NEOPLASMS, RADIATION-INDUCED; SKIN; ULTRAVIOLET RAYS;

EID: 70349337140     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2009.09455.x     Document Type: Review

References (70)

1. Spry M, Scott T, Pierce H, D'Orazio JA. DNA repair pathways and hereditary cancer susceptibility syndromes. Front Biosci 2007 12 : 4191 4207.
2. Young AR, Chadwick CA, Harrison GI et al. The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema. J Invest Dermatol 1998 111 : 982 988.
3. Yarosh DB. DNA repair, immunosuppression, and skin cancer. Cutis 2004 74 (Suppl. 5 10 13.
4. Yarosh D, Klein J, O'Connor A et al. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: a randomised study. Xeroderma Pigmentosum Study Group. Lancet 2001 357 : 926 929.
5. Yamada M, Udono MU, Hori M et al. Aged human skin removes UVB-induced pyrimidine dimers from the epidermis more slowly than younger adult skin in vivo. Arch Dermatol Res 2006 297 : 294 302.
6. Mouret S, Baudouin C, Charveron M et al. Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation. Proc Natl Acad Sci U S A 2006 103 : 13765 13770.
7. Melnikova VO, Ananthaswamy HN. Cellular and molecular events leading to the development of skin cancer. Mutat Res 2005 571 : 91 106.
8. Murphy M, Mabruk MJ, Lenane P et al. The expression of p53, p21, Bax and induction of apoptosis in normal volunteers in response to different doses of ultraviolet radiation. Br J Dermatol 2002 147 : 110 117.
9. Fisher MS, Kripke ML. Systemic alteration induced in mice by ultraviolet light irradiation and itsrelationship to ultraviolet carcinogenesis. Proc Natl Acad Sci U S A 1977 74 : 1688 1692.
10. Walker SL, Young AR. An action spectrum (290-320 nm) for TNF alpha protein in human skin in vivo suggests that basal-layer epidermal DNA is the chromophore. Proc Natl Acad Sci U S A 2007 104 : 19051 19054.
11. Murphy GM, Norris PG, Young AR et al. Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells. Br J Dermatol 1993 129 : 674 677.
12. Powles AV, Murphy GM, Rutman AJ et al. Effect of simulated sunlight on Langerhans' cells in malignant melanoma patients. Acta Derm Venereol 1989 69 : 482 486.
13. Lembo S, Fallon J, O'Kelly P, Murphy GM. Polymorphic light eruption and skin cancer prevalence: is one protective against the other? Br J Dermatol 2008 159 : 1342 1347.
14. Timares L, Katiyar SK, Elmets CA. DNA damage, apoptosis and langerhans cells - Activators of UV-induced immune tolerance. Photochem Photobiol 2008 84 : 422 436.
15. Jonason AS, Kunala S, Price GJ et al. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci U S A 1996 93 : 14025 14029.
16. Kuchel JM, Barnetson RS, Halliday GM. Cyclobutane pyrimidine dimer formation is a molecular trigger for solar-simulated ultraviolet radiation-induced suppression of memory immunity in humans. Photochem Photobiol Sci 2005 4 : 577 582. Epub 2005 Jul 8. PubMed PMID: 16052262.
17. Leibeling D, Laspe P, Emmert S. Nucleotide excision repair and cancer. J Mol Histol 2006 37 : 225 238.
18. Arad S, Konnikov N, Goukassian DA, Gilchrest BA. T-oligos augment UV-induced protective responses in human skin. FASEB J 2006 20 : 1895 1897.
19. De Fabo EC, Noonan FP. Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med 1983 158 : 84 98.
20. McLoone P, Simics E, Barton A et al. An action spectrum for the production of cis-urocanic acid in human skin in vivo. J Invest Dermatol 2005 124 : 1071 1074.
21. Kurimoto I, Streilein JW. cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-alpha. J Immunol 1992 148 : 3072 3078.
22. Ross JA, Howie SE, Norval M et al. Ultraviolet-irradiated urocanic acid suppresses delayed-type hypersensitivity to herpes simplex virus in mice. J Invest Dermatol 1986 87 : 630 633. (Pubitemid 17178895)
23. Zheng Z, Chen R, Prystowsky J. UVB radiation induces phosphorylation of the epidermal growth factor receptor decreases EGF binding and blocks EGF induction of ornithine decarboxylase gene expression in SV-40-transfomed human keratinocytes. Exp Dermatol 1993 2 : 257 265.
24. Sachsenmaier C, Radler-Pohl A, Zinck R et al. Involvement of growth factor receptors in the mammalian UVC response. Cell 1994 78 : 963 972.
25. 2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes. J Invest Dermatol 1998 110 : 966 971.
26. Peus D, Vasa RA, Beyerle A et al. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J Invest Dermatol 1999 112 : 751 756.
27. Murphy GM, Dowd PM, Hudspith BN et al. Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo. Photodermatol 1989 6 : 268 274.
28. Ghoreishi M, Dutz JP. Tolerance induction by transcutaneous immunization through ultraviolet-irradiated skin is transferable through CD4+CD25+ T regulatory cells and is dependent on host-derived IL-10. J Immunol 2006 176 : 2635 2644.
29. Rivas JM, Ullrich SE. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J Immunol 1992 149 : 3865 3871.
30. Zhang Q, Yao Y, Konger RL et al. UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system J Invest Dermatol 2008 128 : 1780 1787.
31. Wolf P, Nghiem DX, Walterscheid JP et al. Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. Am J Pathol 2006 169 : 795 805.
32. Hill LL, Shreedhar VK, Kripke ML, Owen-Schaub LB. A critical role for Fas ligand in the active suppression of systemic immune responses by ultraviolet radiation. J Exp Med 1999 189 : 1285 1294.
33. Bang B, Gniadecki R, Larsen J et al. In vivo UVB irradiation induces clustering of Fas (CD95) on human epidermal cells. Exp Dermatol 2003 12 : 791 798.
34. Seiffert K, Granstein RD. Neuropeptides and neuroendocrine hormones in ultraviolet radiation-induced immunosuppression. Methods 2002 28 : 97 103.
35. Scott MC, Suzuki I, Abdel-Malek ZA. Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation. Pigment Cell Res 2002 15 : 433 439.
36. Elmets CA, Bergstresser PR, Tigelaar RE et al. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med 1983 158 : 781 794.
37. Halliday GM, Rana S. Waveband and dose dependency of sunlight-induced immunomodulation and cellular changes. Photochem Photobiol 2008 84 : 35 46.
38. Poon TSC, Barnetson RSC, Halliday GM. Sunlight-induced immunosuppression in humans is initially because of UVB, then UVA, followed by interactive effects. J Invest Dermatol 2005 125 : 840 846.
39. Norval M. The effect of ultraviolet radiation on human viral infections. Photochem Photobiol 2006 82 : 1495 1504.
40. O'Connor DP, Kay EW, Leader M et al. Altered p53e expression in benign and malignant skin lesions from renal transplant recipients and immunocompetent patients with skin cancer: correlation with human papillomaviruses? Diagn Mol Pathol 2001 10 : 190 199.
41. Jackson S, Harwood C, Thomas M et al. Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins. Genes Dev 2000 14 : 3065 3073.
42. Jackson S, Ghali L, Harwood C, Storey A. Reduced apoptotic levels in squamous but not basal cell carcinomas correlates with detection of cutaneous human papillomavirus. Br J Cancer 2002 87 : 319 323.
43. Simmonds M, Storey A. Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis. Int J Cancer 2008 123 : 2260 2266.
44. Leverrier S, Bergamaschi D, Ghali L et al. Role of HPV E6 proteins inp reventing UVB-induced release of pro-apoptotic factors from the mitochondria Apoptosis 2007 12 : 549 560.
45. Underbrink MP, Howie HL, Bedard KM et al. E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J Virol 2008 82 : 10408 10417.
46. Bedard KM, Underbrink MP, Howie HL, Galloway DA. The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes. J Virol 2008 82 : 3894 3902.
47. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008 319 : 1096 1100.
48. Paulson KG, Lemos BD, Feng B et al. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. J Invest Dermatol 2009 129 : 1547 1555.
49. Moloney FJ, Comber H, O'Lorcain P et al. A population-based study of skin cancer incidence and prevalence in renal transplant recipients. Br J Dermatol 2006 154 : 498 504.
50. Moloney FJ, Comber H, Conlon PJ, Murphy GM. The role of immunosuppression inth e pathogenesis of basal cell carcinoma. Br J Dermatol 2006 154 : 790 791.
51. Laing ME, Moloney FJ, Comber H et al. Malignant melanoma in renal transplant recipients. Br J Dermatol 2006 155 : 857.
52. Laing ME, Moloney FJ, Kay EW et al. Malignant melanoma in transplant patients: review of five cases. Clin Exp Dermatol 2006 31 : 662 664.
53. Laing ME, Dicker P, Moloney FJ et al. Association of methylenetetrahydrofolate reductase polymorphism and the risk of squamous cell carcinoma in renal transplant patients. Transplantation 2007 84 : 113 116.
54. Ho WL, Akhurst R, Laing M et al. Polymorphic variants in PTGS2 and skin cancer risk. Br J Dermatol 2009 161 (Suppl. 1 9.
55. Lavin PJ, Laing ME, O'Kelly P et al. Improved renal allograft survival with vitamin D receptor polymorphism. Ren Fail 2007 29 : 785 789.
56. Moloney FJ, Dicker P, Conlon PJ et al. The frequency and significance of thiopurine S-methyltransferase gene polymorphisms in azathioprine-treated renal transplant recipients. Br J Dermatol 2006 154 : 1199 1200.
57. O'Donovan P, Perrett CM, Zhang X et al. Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science 2005 159 : 198 204.
58. Brem R, Li F, Karran P. Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions. Nucleic Acids Res 2009 37 : 1951 1961.
59. Moloney FJ, Kelly PO, Kay EW et al. Maintenance versus reduction of immunosuppression in renal transplant recipients with aggressive squamous cell carcinoma. Dermatol Surg 2004 30 (4 Pt 2 674 678.
60. Moloney FJ, de Freitas D, Conlon PJ, Murphy GM. Renal transplantation, immunosuppression and the skin: an update. Photodermatol Photoimmunol Photomed 2005 21 : 1 8.
61. Jensen AØ, Thomsen HF, Engebjerg MC et al. Use of oral glucocorticoids and risk of skin cancer and non-Hodgkin's lymphoma: a population-based case-control study. J Heart Lung Transplant 2006 25 : 1186 1191. Epub 2006 Sep 18.
62. Gruber SA, Gillingham K, Sothern RB et al. De novo cancer in cyclosporine-treated and non-cyclosporine-treated adult primary renal allograft recipients. Clin Transplant 1994 8 : 388 395. Br J Cancer. 2009 Jan 13;100(1):200-5.
63. Penn I, First MR. Development and incidence of cancer following cyclosporine therapy. Transplant Proc 1986 18 (2 Suppl. 1 210 215.
64. Canning MT, Nay SL, Peña AV, Yarosh DB. Calcineurin inhibitors reduce nuclear.localization of transcription factor NFAT in UV-irradiated keratinocytes and reduce DNA repair. J Mol Histol 2006 37 : 285 291. Epub 2006 Aug 23.
65. Yarosh DB, Pena AV, Nay SL et al. Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol 2005 125 : 1020 1025.
66. Bichari W, Bartiromo M, Mohey H et al. Significant risk factors for occurrence of cancer after renal transplantation: a single center cohort study of 1265 cases. Transplant Proc 2009 41 : 672 673.
67. O'Neill JO, Edwards LB, Taylor DO. Mycophenolate mofetil and risk of developing malignancy after orthotopic heart transplantation: analysis of the transplant registry of the International Society for Heart and Lung Transplantation. J Heart Lung Transp 2006 25 : 1186 1191.
68. Fernandez A, Hu S, Kirsner RS. Sirolimus: a potential chemopreventive agent. J Invest Dermatol 2008 128 : 2352.
69. Pascual J, Fernández AM, Marcén R, Ortuño J. Conversion to everolimus in a patient with arterial hypertension and recurrent cutaneous neoplasia - a case report. Nephrol Dial Transplant 2006 21 (Suppl. 3 iii38 41.
70. Lebbé C, Euvrard S, Barrou B et al. Sirolimus conversion for patients with posttransplant Kaposi's sarcoma. Am J Transplant 2006 6 : 2164 2168.