Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4- chloro-benzyl)amino]-N-[[(2,4-dimethylbenzyl)-amino]iminomethyl] -pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na+-Ca 2+ exchanger isoforms NCX1, NCX2, and NCX3 in stably transfected cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 331, Issue 1, 2009, Pages 212-221

  Secondo, Agnese ^a   Pannaccione, Anna ^a   Molinaro, Pasquale ^a   Ambrosino, Paolo ^a   Lippiello, Pellegrino ^a   Esposito, Alba ^a   Cantile, Maria ^a   Khatri, Priti R ^a   Melisi, Daniela ^c   Di Renzo, Gianfranco ^a   Annunziato, Lucio ^a,b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b IRCCS SDN   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 6 CHLORO 5 [(4 CHLORO BENZYL)AMINO] N [[(2,4 DIMETHYLBENZYL)AMINO]IMINOMETHYL]PYRAZINECARBOXAMIDE; AMILORIDE DERIVATIVE; CALCIUM CHANNEL; GLYCINE; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN 1; SODIUM CALCIUM EXCHANGE PROTEIN 2; SODIUM CALCIUM EXCHANGE PROTEIN 3; SODIUM CHANNEL; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN GH3; CONTROLLED STUDY; ELECTRIC POTENTIAL; IC 50; MEMBRANE CURRENT; MITOCHONDRION; MUTAGENESIS; NONHUMAN; PATCH CLAMP; PH; PRIORITY JOURNAL;

AMILORIDE; ANIMALS; CELL LINE; CELLS, CULTURED; CRICETINAE; DOGS; HUMANS; PROTEIN ISOFORMS; RATS; SODIUM-CALCIUM EXCHANGER; TRANSFECTION;

EID: 70349322593     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.152132     Document Type: Article

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