메뉴 건너뛰기




Volumn 20, Issue 1, 2007, Pages 109-117

Epithelial Sodium Channel Inhibition in Cardiovascular Disease. A Potential Role for Amiloride

Author keywords

amiloride; cardiovascular disease; epithelial sodium channel; Hypertension

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; 5 (N,N DIMETHYL)AMILORIDE; ALDOSTERONE; AMILORIDE; AMILORIDE DERIVATIVE; ANGIOTENSIN RECEPTOR ANTAGONIST; BENZAMIL; CARIPORIDE; DEOXYCORTICOSTERONE ACETATE; DICHLOROBENZAMIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENIPORIDE; HYDROCHLOROTHIAZIDE; IODOAMILORIDE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; PLACEBO; POTASSIUM SPARING DIURETIC AGENT; PROTEIN INHIBITOR; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN INHIBITOR; SPIRONOLACTONE; TRIAMTERENE; UNCLASSIFIED DRUG;

EID: 33845730030     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjhyper.2006.05.022     Document Type: Review
Times cited : (78)

References (60)
  • 3
    • 0036023427 scopus 로고    scopus 로고
    • Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and MCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopusoocytes
    • Vuagniaux G., Vallet V., Jaeger N.F., Hummler E., and Rossier B.C. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and MCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopusoocytes. J Gen Physiol 120 (2002) 191-201
    • (2002) J Gen Physiol , vol.120 , pp. 191-201
    • Vuagniaux, G.1    Vallet, V.2    Jaeger, N.F.3    Hummler, E.4    Rossier, B.C.5
  • 4
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B., Zannad F., Remme W.J., Cody R., Castaigne A., Perez A., Palensky J., and Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341 (1999) 709-717
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3    Cody, R.4    Castaigne, A.5    Perez, A.6    Palensky, J.7    Wittes, J.8
  • 5
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators
    • Pitt B., Remme W., Zannad F., Neaton J., Martinez F., Roniker B., Bittman R., Hurley S., Kleiman J., Gatlin M., and Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 348 (2003) 1309-1321
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3    Neaton, J.4    Martinez, F.5    Roniker, B.6    Bittman, R.7    Hurley, S.8    Kleiman, J.9    Gatlin, M.10
  • 6
    • 0030587794 scopus 로고    scopus 로고
    • Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (the Randomized Aldactone Evaluation Study)
    • RALES Investigators
    • RALES Investigators. Effectiveness of spironolactone added to an angiotensin-converting enzyme inhibitor and a loop diuretic for severe chronic congestive heart failure (the Randomized Aldactone Evaluation Study). Am J Cardiol 78 (1996) 902-907
    • (1996) Am J Cardiol , vol.78 , pp. 902-907
  • 7
    • 0035922443 scopus 로고    scopus 로고
    • Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease
    • Chrysostomou A., and Becker G. Spironolactone in addition to ACE inhibition to reduce proteinuria in patients with chronic renal disease. N Engl J Med 345 (2001) 925-926
    • (2001) N Engl J Med , vol.345 , pp. 925-926
    • Chrysostomou, A.1    Becker, G.2
  • 8
    • 0001644827 scopus 로고    scopus 로고
    • Eplerenone reduces proteinuria in type II diabetes mellitus: implications for aldosterone involvement in the pathogenesis for renal dysfunction
    • Epstein M. Eplerenone reduces proteinuria in type II diabetes mellitus: implications for aldosterone involvement in the pathogenesis for renal dysfunction. J Am Coll Cardiol 39 (2002) 249A
    • (2002) J Am Coll Cardiol , vol.39
    • Epstein, M.1
  • 9
    • 0037222490 scopus 로고    scopus 로고
    • Effectiveness of aldosterone blockade in patients with diabetic nephropathy
    • Sato A., Hayashi K., Naruse M., and Saruta T. Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension 41 (2003) 64-68
    • (2003) Hypertension , vol.41 , pp. 64-68
    • Sato, A.1    Hayashi, K.2    Naruse, M.3    Saruta, T.4
  • 11
    • 0029586683 scopus 로고
    • A de novo missence mutation of the beta subunit of the epithelial Na channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity
    • 11495-1149
    • Hansson J.H., Schild L., Lu Y., Wilson T.A., Gautschi I., Shimkets R., Nelson-Williams C., Rossier B.C., and Lifton R.P. A de novo missence mutation of the beta subunit of the epithelial Na channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci USA 92 (1995) 11495-1149
    • (1995) Proc Natl Acad Sci USA , vol.92
    • Hansson, J.H.1    Schild, L.2    Lu, Y.3    Wilson, T.A.4    Gautschi, I.5    Shimkets, R.6    Nelson-Williams, C.7    Rossier, B.C.8    Lifton, R.P.9
  • 13
    • 0013951462 scopus 로고
    • Hyperkalemic effects of triamterene
    • Cohen A.B. Hyperkalemic effects of triamterene. Ann Intern Med 65 (1966) 521-527
    • (1966) Ann Intern Med , vol.65 , pp. 521-527
    • Cohen, A.B.1
  • 15
    • 0033166503 scopus 로고    scopus 로고
    • DEG/ENaC channels: a touchy superfamily that watches salt
    • Mano I., and Driscoll M. DEG/ENaC channels: a touchy superfamily that watches salt. Bioassays 21 (1999) 568-578
    • (1999) Bioassays , vol.21 , pp. 568-578
    • Mano, I.1    Driscoll, M.2
  • 16
    • 0034811390 scopus 로고    scopus 로고
    • Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton
    • Golestaneh N., Klein C., Valamanesh F., Suarez G., Agarwal M.K., and Mirshahi M. Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton. Biochem Biophys Res Commun 280 (2001) 1300-1306
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 1300-1306
    • Golestaneh, N.1    Klein, C.2    Valamanesh, F.3    Suarez, G.4    Agarwal, M.K.5    Mirshahi, M.6
  • 17
    • 0034696799 scopus 로고    scopus 로고
    • Paradoxical effects of mineralocorticoids on the ion gated sodium channel in embryologically diverse cells
    • Mirshahi M., Golestaneh N., Valamanesh F., and Agarwal M.K. Paradoxical effects of mineralocorticoids on the ion gated sodium channel in embryologically diverse cells. Biochem Biophys Res Commun 270 (2000) 811-815
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 811-815
    • Mirshahi, M.1    Golestaneh, N.2    Valamanesh, F.3    Agarwal, M.K.4
  • 24
    • 2442661532 scopus 로고    scopus 로고
    • Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats
    • Sepehrdad R., Chander P.N., Singh G., and Stier Jr. C.T. Sodium transport antagonism reduces thrombotic microangiopathy in stroke-prone spontaneously hypertensive rats. Am J Physiol Renal Physiol 286 (2004) 1185-1192
    • (2004) Am J Physiol Renal Physiol , vol.286 , pp. 1185-1192
    • Sepehrdad, R.1    Chander, P.N.2    Singh, G.3    Stier Jr., C.T.4
  • 25
    • 0023807201 scopus 로고
    • Amiloride and its analogs as tools in the study of ion transport
    • Kleyman T., and Cragoe E. Amiloride and its analogs as tools in the study of ion transport. J Membrane Biol (1988) 105-121
    • (1988) J Membrane Biol , pp. 105-121
    • Kleyman, T.1    Cragoe, E.2
  • 27
    • 0011233672 scopus 로고
    • Structure-activity relationships in the amiloride series
    • Cuthbert A., Fanelli G., and Scriabine A. (Eds), Urban & Schwarzberg, Baltimore, MD
    • Cragoe E. Structure-activity relationships in the amiloride series. In: Cuthbert A., Fanelli G., and Scriabine A. (Eds). Amiloride and Epithelial Sodium Transport (1978), Urban & Schwarzberg, Baltimore, MD 1-20
    • (1978) Amiloride and Epithelial Sodium Transport , pp. 1-20
    • Cragoe, E.1
  • 30
    • 0018184460 scopus 로고
    • Effects of some pyrazinecarboxamides on sodium transport in frog skin
    • Cuthbert A.W., and Fanelli G.M. Effects of some pyrazinecarboxamides on sodium transport in frog skin. Br J Pharmacol 63 (1978) 139-149
    • (1978) Br J Pharmacol , vol.63 , pp. 139-149
    • Cuthbert, A.W.1    Fanelli, G.M.2
  • 34
    • 0028859727 scopus 로고
    • Effect of central infusion of benzamil on Dahl S rat hypertension
    • Gomez-Sanchez E.P., and Gomez-Sanchez C.E. Effect of central infusion of benzamil on Dahl S rat hypertension. Am J Physiol 26 (1995) H1044-H1047
    • (1995) Am J Physiol , vol.26
    • Gomez-Sanchez, E.P.1    Gomez-Sanchez, C.E.2
  • 35
    • 0031897283 scopus 로고    scopus 로고
    • Benzamil blockade of brain Na+ channels averts Na(+)-induced hypertension in rats
    • Nishimura M., Ohtsuka K., Nanbu A., Takahashi H., and Yoshimura M. Benzamil blockade of brain Na+ channels averts Na(+)-induced hypertension in rats. Am J Physiol 274 (1998) R635-R644
    • (1998) Am J Physiol , vol.274
    • Nishimura, M.1    Ohtsuka, K.2    Nanbu, A.3    Takahashi, H.4    Yoshimura, M.5
  • 36
    • 18044389350 scopus 로고    scopus 로고
    • Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI
    • Huang B.S., and Leenen F.H. Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI. Am J Physiol Heart Circ Physiol 288 (2005) H2491-H2497
    • (2005) Am J Physiol Heart Circ Physiol , vol.288
    • Huang, B.S.1    Leenen, F.H.2
  • 37
    • 27844492749 scopus 로고    scopus 로고
    • Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain
    • Amin M.S., Wang H.W., Reza E., Whitman S.C., Tuana B.S., and Leenen F.H. Distribution of epithelial sodium channels and mineralocorticoid receptors in cardiovascular regulatory centers in rat brain. Am J Physiol Regul Integr Comp Physiol 289 (2005) R1787-R1797
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289
    • Amin, M.S.1    Wang, H.W.2    Reza, E.3    Whitman, S.C.4    Tuana, B.S.5    Leenen, F.H.6
  • 38
    • 0028910934 scopus 로고
    • Aldosterone (ALDO) increases transmembrane influx of Na+ in vascular smooth muscle (VSM) cells through increased synthesis of Na+ channels
    • Kornel L., and Smoszna-Konaszewska B. Aldosterone (ALDO) increases transmembrane influx of Na+ in vascular smooth muscle (VSM) cells through increased synthesis of Na+ channels. Steroids 60 (1995) 114-119
    • (1995) Steroids , vol.60 , pp. 114-119
    • Kornel, L.1    Smoszna-Konaszewska, B.2
  • 39
    • 0028262228 scopus 로고
    • Perspectives in receptor-mediated mineralocorticoid hormone action
    • Agarwal M. Perspectives in receptor-mediated mineralocorticoid hormone action. Pharmacol Rev 46 (1994) 67-87
    • (1994) Pharmacol Rev , vol.46 , pp. 67-87
    • Agarwal, M.1
  • 40
    • 2342634618 scopus 로고    scopus 로고
    • The many targets of aldosterone
    • Schiffrin E.L. The many targets of aldosterone. Hypertension 43 (2004) 938-940
    • (2004) Hypertension , vol.43 , pp. 938-940
    • Schiffrin, E.L.1
  • 41
    • 0008894049 scopus 로고
    • Toxic effects of deoxycorticosterone esters in dogs
    • Kuhlman D., Ragan C., Ferrebee J., Atchley D., and Loeb R. Toxic effects of deoxycorticosterone esters in dogs. Science 90 (1939) 496-497
    • (1939) Science , vol.90 , pp. 496-497
    • Kuhlman, D.1    Ragan, C.2    Ferrebee, J.3    Atchley, D.4    Loeb, R.5
  • 42
    • 0032951864 scopus 로고    scopus 로고
    • Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system
    • Brown L., Duce B., Miric G., and Sernia C. Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system. J Am Soc Nephrol 10 (1999) S143-S148
    • (1999) J Am Soc Nephrol , vol.10
    • Brown, L.1    Duce, B.2    Miric, G.3    Sernia, C.4
  • 43
    • 0025894763 scopus 로고
    • Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect
    • Stier Jr. C.T., Chander P., Gutstein W.H., Levine S., and Itskovitz H.D. Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect. Am J Hypertens 4 (1991) 680-687
    • (1991) Am J Hypertens , vol.4 , pp. 680-687
    • Stier Jr., C.T.1    Chander, P.2    Gutstein, W.H.3    Levine, S.4    Itskovitz, H.D.5
  • 44
    • 0027412739 scopus 로고
    • Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats
    • Stier Jr. C.T., Adler L.A., Levine S., and Chander P.N. Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats. J Hypertens 11 (1993) S37-S42
    • (1993) J Hypertens , vol.11
    • Stier Jr., C.T.1    Adler, L.A.2    Levine, S.3    Chander, P.N.4
  • 45
    • 0035458773 scopus 로고    scopus 로고
    • Pathophysiological effects of aldosterone in cardiovascular tissues
    • Rocha R., and Stier Jr. C.T. Pathophysiological effects of aldosterone in cardiovascular tissues. Trends Endocrinol Metab 12 (2001) 308-314
    • (2001) Trends Endocrinol Metab , vol.12 , pp. 308-314
    • Rocha, R.1    Stier Jr., C.T.2
  • 46
    • 0031600240 scopus 로고    scopus 로고
    • Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats
    • Rocha R., Chander P.N., Khanna K., Zuckerman A., and Stier Jr. C.T. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 31 (1998) 451-458
    • (1998) Hypertension , vol.31 , pp. 451-458
    • Rocha, R.1    Chander, P.N.2    Khanna, K.3    Zuckerman, A.4    Stier Jr., C.T.5
  • 47
    • 0034533441 scopus 로고    scopus 로고
    • Effect of combined K (ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits
    • Hale S.L., and Kloner R.A. Effect of combined K (ATP) channel activation and Na(+)/H(+) exchange inhibition on infarct size in rabbits. Am J Physiol Heart Circ Physiol 279 (2000) H2673-H2677
    • (2000) Am J Physiol Heart Circ Physiol , vol.279
    • Hale, S.L.1    Kloner, R.A.2
  • 48
    • 0037028890 scopus 로고    scopus 로고
    • Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects
    • Avkiran M., and Marber M.S. Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J Am Coll Cardiol 39 (2002) 747-753
    • (2002) J Am Coll Cardiol , vol.39 , pp. 747-753
    • Avkiran, M.1    Marber, M.S.2
  • 49
    • 3242724263 scopus 로고    scopus 로고
    • Cardiac protection during acute myocardial infarction: where do we stand in 2004?
    • Kloner R.A., and Rezkalla S.H. Cardiac protection during acute myocardial infarction: where do we stand in 2004?. J Am Coll Cardiol 44 (2004) 276-286
    • (2004) J Am Coll Cardiol , vol.44 , pp. 276-286
    • Kloner, R.A.1    Rezkalla, S.H.2
  • 50
    • 0042856663 scopus 로고    scopus 로고
    • GUARD During Ischemia Against Necrosis (GUARDIAN) Study Investigators: Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study
    • Boyce S.W., Bartels C., Bolli R., Chaitman B., Chen J.C., Chi E., Jessel A., Kereiakes D., Knight J., Thulin L., and Theroux P. GUARD During Ischemia Against Necrosis (GUARDIAN) Study Investigators: Impact of sodium-hydrogen exchange inhibition by cariporide on death or myocardial infarction in high-risk CABG surgery patients: results of the CABG surgery cohort of the GUARDIAN study. J Thorac Cardiovasc Surg 126 (2003) 420-427
    • (2003) J Thorac Cardiovasc Surg , vol.126 , pp. 420-427
    • Boyce, S.W.1    Bartels, C.2    Bolli, R.3    Chaitman, B.4    Chen, J.C.5    Chi, E.6    Jessel, A.7    Kereiakes, D.8    Knight, J.9    Thulin, L.10    Theroux, P.11
  • 51
    • 2642569621 scopus 로고    scopus 로고
    • Effects of Na+/H+ exchange inhibition by cariporide on death and nonfatal myocardial infarction in patients undergoing coronary artery bypass graft surgery: the Expedition Study
    • Mentzer Jr. R.M. Effects of Na+/H+ exchange inhibition by cariporide on death and nonfatal myocardial infarction in patients undergoing coronary artery bypass graft surgery: the Expedition Study. Circulation 108 (2003) 2723
    • (2003) Circulation , vol.108 , pp. 2723
    • Mentzer Jr., R.M.1
  • 52
    • 0035890319 scopus 로고    scopus 로고
    • The Na (+)/H (+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the Evaluation of the Safety and Cardioprotective Effects of Eniporide in Acute Myocardial Infarction (ESCAMI) trial
    • ESCAMI Investigators
    • Zeymer U., Suryapranata H., Monassier J.P., Opolski G., Davies J., Rasmanis G., Linssen G., Tebbe U., Schroder R., Tiemann R., Machnig T., Neuhaus K.L., and ESCAMI Investigators. The Na (+)/H (+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the Evaluation of the Safety and Cardioprotective Effects of Eniporide in Acute Myocardial Infarction (ESCAMI) trial. J Am Coll Cardiol 38 (2001) 1644-1650
    • (2001) J Am Coll Cardiol , vol.38 , pp. 1644-1650
    • Zeymer, U.1    Suryapranata, H.2    Monassier, J.P.3    Opolski, G.4    Davies, J.5    Rasmanis, G.6    Linssen, G.7    Tebbe, U.8    Schroder, R.9    Tiemann, R.10    Machnig, T.11    Neuhaus, K.L.12
  • 53
    • 0013985168 scopus 로고
    • Effects of MK-870 in normal subjects and hypertensive patients
    • Gombos E.A., Freis E.D., and Moghadam A. Effects of MK-870 in normal subjects and hypertensive patients. N Engl J Med 275 (1966) 1215-1220
    • (1966) N Engl J Med , vol.275 , pp. 1215-1220
    • Gombos, E.A.1    Freis, E.D.2    Moghadam, A.3
  • 54
    • 7744227337 scopus 로고    scopus 로고
    • Low-renin status in therapy-resistant hypertension: a clue to efficient treatment
    • Eide I.K., Torjesen P.A., Drolsum A., Babovic A., and Lilledahl N.P. Low-renin status in therapy-resistant hypertension: a clue to efficient treatment. J Hypertens 22 (2004) 2217-2226
    • (2004) J Hypertens , vol.22 , pp. 2217-2226
    • Eide, I.K.1    Torjesen, P.A.2    Drolsum, A.3    Babovic, A.4    Lilledahl, N.P.5
  • 55
    • 25444446626 scopus 로고    scopus 로고
    • Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension
    • Saha C., Eckert G.J., Ambrosius W.T., Chun T.Y., Wagner M.A., Zhao Q., and Pratt J.H. Improvement in blood pressure with inhibition of the epithelial sodium channel in blacks with hypertension. Hypertension 46 (2005) 469-470
    • (2005) Hypertension , vol.46 , pp. 469-470
    • Saha, C.1    Eckert, G.J.2    Ambrosius, W.T.3    Chun, T.Y.4    Wagner, M.A.5    Zhao, Q.6    Pratt, J.H.7
  • 56
    • 0034651798 scopus 로고    scopus 로고
    • Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure
    • Farquharson C.A., and Struthers A.D. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure. Circulation 101 (2000) 594-597
    • (2000) Circulation , vol.101 , pp. 594-597
    • Farquharson, C.A.1    Struthers, A.D.2
  • 57
    • 0036840457 scopus 로고    scopus 로고
    • Increasing plasma potassium with amiloride shortens the QT interval and reduces ventricular extrasystoles but does not change endothelial function or heart rate variability in chronic heart failure
    • Farquharson C.A., and Struthers A.D. Increasing plasma potassium with amiloride shortens the QT interval and reduces ventricular extrasystoles but does not change endothelial function or heart rate variability in chronic heart failure. Heart 88 (2002) 475-480
    • (2002) Heart , vol.88 , pp. 475-480
    • Farquharson, C.A.1    Struthers, A.D.2
  • 58
    • 0019784678 scopus 로고
    • Renal tubule transport and electrolyte effects of amiloride in the chicken
    • Besseghir K., and Rennick B. Renal tubule transport and electrolyte effects of amiloride in the chicken. J Pharmacol Exp Ther 219 (1981) 435-441
    • (1981) J Pharmacol Exp Ther , vol.219 , pp. 435-441
    • Besseghir, K.1    Rennick, B.2
  • 59
    • 0030730947 scopus 로고    scopus 로고
    • Rapid life-threatening hyperkalemia after addition of amiloride HCl/hydrochlorothiazide to angiotensin-converting enzyme inhibitor therapy
    • Chiu T.F., Bullard M.J., Chen J.C., Liaw S.J., and Ng C.J. Rapid life-threatening hyperkalemia after addition of amiloride HCl/hydrochlorothiazide to angiotensin-converting enzyme inhibitor therapy. Ann Emerg Med 30 (1997) 612-615
    • (1997) Ann Emerg Med , vol.30 , pp. 612-615
    • Chiu, T.F.1    Bullard, M.J.2    Chen, J.C.3    Liaw, S.J.4    Ng, C.J.5
  • 60
    • 0014702858 scopus 로고
    • Possible predisposition of diabetic patients to hyperkalemia following administration of potassium-retaining diuretic, amiloride (MK 870)
    • McNay J.L., and Oran E. Possible predisposition of diabetic patients to hyperkalemia following administration of potassium-retaining diuretic, amiloride (MK 870). Metabolism 19 (1970) 58-70
    • (1970) Metabolism , vol.19 , pp. 58-70
    • McNay, J.L.1    Oran, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.