Bolus intravenous injection of obestatin does not change blood pressure level of spontaneously hypertensive rat

Peptides

Volumn 30, Issue 10, 2009, Pages 1928-1930

  Li, Zhao Feng ^a,b   Song, Shu Wei ^b   Qin, Yong Wen ^a   Zhang, Jian Liang ^a   Zhao, Xian Xian ^a   Zhang, Bi Li ^a   Ren, An Jing ^c   Guo, Zhi Fu ^a   Zheng, Xing ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b PLA   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; OBESTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BOLUS INJECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; ESSENTIAL HYPERTENSION; HEART CYCLE; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; BAROREFLEX; BLOOD PRESSURE; GHRELIN; HEART RATE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; RANDOM ALLOCATION; RATS; RATS, INBRED SHR;

RATTUS;

EID: 70349319359     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.07.013     Document Type: Article

References (17)

1. Anderwald-Stadler M., Krebs M., Promintzer M., Mandl M., Bischof M.G., Nowotny P., et al. Plasma obestatin is lower at fasting and not suppressed by insulin in insulin-resistant humans. Am J Physiol Endocrinol Metab 293 (2007) E1393-E1398
2. Fu Y.J., Shu H., Miao C.Y., Wang M.W., and Su D.F. Restoration of baroreflex function by ketanserin is not blood pressure dependent in conscious freely moving rats. J Hypertens 22 (2004) 1165-1172
3. Guo Z.F., Zheng X., Qin Y.W., Hu J.Q., Chen S.P., and Zhang Z. Circulating preprandial ghrelin to obestatin ratio is increased in human obesity. J Clin Endocrinol Metab 92 (2007) 1875-1880
4. Kiewiet R.M., Gauna C., van Aken M.O., van de Zande B., and van der Lely A.J. Bolus administration of obestatin does not change glucose and insulin levels neither in the systemic nor in the portal circulation of the rat. Peptides (2008) 2144-2149
5. Lin Y., Matsumura K., Fukuhara M., Kagiyama S., Fujii K., and Iida M. Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in rats. Hypertension 43 (2004) 977-982
6. Liu A.J., Ma X.J., Shen F.M., Liu J.G., Chen H., and Su D.F. Arterial baroreflex: a novel target for preventing stroke in rat hypertension. Stroke 38 (2007) 1916-1923
7. Matsumura K., Tsuchihashi T., Fujii K., Abe I., and Iida M. Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension 40 (2002) 694-699
8. Nagaya N., Kojima M., Uematsu M., Yamagishi M., Hosoda H., Oya H., et al. Hemodynamic and hormonal effects of human ghrelin in healthy voluntees. Am J Physiol Regul Integr Comp Physiol 280 (2001) R1483-R1487
9. Nagaya N., Uematsu M., Kojima M., Ikeda Y., Yoshihara F., Shimizu W., et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 104 (2001) 1430-1435
10. Norman Jr. R.A., Coleman T.G., and Dent A.C. Continuous monitoring of arterial pressure indicates sinoaortic denervated rats are not hypertensive. Hypertension 3 (1981) 119-124
11. Okumura H., Nagaya N., Enomoto M., Nakagawa E., Oya H., and Kangawa K. Vasodilatory effect of ghrelin, an endogenous peptide from the stomach. J Cardiovasc Pharmacol 39 (2002) 779-783
12. Pan W., Tu H., and Kastin A.J. Differential BBB interactions of three ingestive peptides: obestatin, ghrelin, and adiponectin. Peptides 27 (2006) 911-916
13. Ren A.J., Guo Z.F., Wang Y.K., Wang L.G., Wang W.Z., Lin L., et al. Inhibitory effects of obestatin on glucose-induced insulin secretion in rats. Biochem Biophys Res Commun 369 (2008) 969-972
14. Soares J.B., and Leite-Moreira A.F. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides 29 (2008) 1255-1270
15. Wiley K.E., and Davenport A.P. Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1. Br J Pharmacol 136 (2002) 1146-1152
16. Xie H.H., Miao C.Y., Liu J.G., and Su D.F. Effects of long-term treatment with candesartan on organ damages in sinoaortic denervated rats. J Cardiovasc Pharmacol 41 (2003) 325-331
17. Zhang J.V., Ren P.G., Avsian-Kretchmer O., Luo C.W., Rauch R., Klein C., et al. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310 (2005) 996-999