Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis

Journal of Cellular and Molecular Medicine

Volumn 13, Issue 8 A, 2009, Pages 1549-1564

  Kwon, Hayeong ^a   Jeong, Kyuho ^a   Pak, Yunbae ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

Actin cytoskeleton; C Jun; Caveolin 2 (Y19A) mutant; Caveolin 2 siRNA; CyclinD1; ERK; Insulin; PY19 Caveolin 2

Indexed keywords

EID: 70349314750     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00391.x     Document Type: Article

References (46)

1. Saltiel AR, Pessin JE. Insulin signaling pathways in time and space. Trends Cell Biol. 2002 12 : 65 71.
2. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 414 : 799 806.
3. Le Roith D, Zick Y. Recent advances in our understanding of insulin action and insulin resistance. Diabetes Care. 2001 24 : 588 597.
4. Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol. 1999 19 : 2435 2444.
5. Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol. 1997 9 : 180 186.
6. Lavoie JN, L'Allemain G, Brunet A, et al. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOG MAPK pathway. J Biol Chem. 1996 271 : 20608 20616.
7. Brunet A, Roux D, Lenormand P, et al. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J. 1999 18 : 664 674.
8. Wilkinson MG, Millar JBA. Control of the eukaryotic cell cycle by MAP kinase signalling pathways. FASEB J. 2000 14 : 2147 2157.
9. Pearson G, Robinson F, Beers Gibson T, et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev. 2001 22 : 153 183.
10. Yoon S, Seger R. The extracellular signal-regulated kinase multiple substrates regulate diverse cellular functions. Growth Factors. 2006 24 : 21 44.
11. Whitmarsh AJ, Davis RJ. A central control for cell growth. Nature. 2000 403 : 255 256.
12. Lenormand P, Brondello JM, Brunet A, Pouysségur J. Growth factor-induced p42/p44 MAPK nuclear translocation and retention requires both MAPK activation and. neosynthesis of nuclear anchoring proteins. J Cell Biol. 1998 142 : 625 633.
13. Khokhlatchev AV, Canagarajah B, Wilsbacher J, et al. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell. 1998 93 : 605 615.
14. Ebisuya M, Kondoh K, Nishida E. The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci. 2005 118 : 2997 3002.
15. Murphy LO, MacKeigan JP, Blenis J. A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Mol Cell Biol. 2004 24 : 144 153.
16. Minshull J, Sun H, Tonks NK, Murray AW. A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts. Cell. 1994 79 : 475 486.
17. Cohen AW, Combs TP, Scherer PE, Lisanti MP. Role of caveolin and caveolae in insulin signaling and diabetes. Am J Physiol Endocrinol Metab. 2003 285 : E1151 60.
18. Gratton J P, Bernatchez P, Sessa WC. Caveolae and caveolins in the cardiovascular system. Circ Res. 2004 94 : 1408 1417.
19. Scherer PE, Lewis RY, Volonte D, et al. Cell-type and tissue-specific expression of caveolin-2. J Biol Chem. 1997 272 : 29337 29346.
20. Razani B, Woodman SE, Lisanti MP. Caveolae: from cell biology to animal physiology. Pharmacol Rev. 2002 54 : 431 467.
21. Liu P, Rudick M, Anderson RGW. Multiple functions of caveolin-1. J Biol Chem. 2002 277 : 41295 41298.
22. Engelman JA, Lee RJ, Karnezis A, et al. Reciprocal regulation of neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo: implications for human breast cancer. J Biol Chem. 1998 271 : 6518 6522.
23. Lee SW, Reimer CL, Oh P, et al. Tumor cell growth inhibition by caveolin reexpression in human breast cancer cells. Oncogene. 1998 16 : 1391 1397.
24. Hulit J, Bash T, Fu M, et al. The cyclin D1 gene is transcriptionally repressed by caveolin-1. J Biol Chem. 2000 275 : 21203 21209.
25. Engelman JA, Chu C, Lin A, et al. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett. 1998 428 : 205 211.
26. Galbiati F, Volonté D, Engelman JA, et al. Targeted down-regulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. EMBO J. 1998 17 : 6633 6648.
27. Cho KA, Ryu SJ, Park JS, et al. Senescent phenotype can be reversed by reduction of caveolin status. J Biol Chem. 2003 278 : 27789 27795.
28. Cho KA, Ryu SJ, Oh YS, et al. Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem. 2004 279 : 42270 42278.
29. Volonte D, Zhang K, Lisanti M P, Galbiati F. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell. 2002 13 : 2502 2517.
30. Scherer PE, Okamoto T, Chun M, et al. Identification, sequence and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci USA. 1996 93 : 131 135.
31. Lee H, Park DS, Wang XB, et al. Src-induced phosphorylation of caveolin-2 on tyrosine 19. J Biol Chem. 2002 277 : 34556 34567.
32. Wang XB, Lee H, Capozza F, et al. Tyrosine phosphorylation of caveolin-2 at residue 27: differences in the spatial and temporal behavior of phospho-cav-2 (pY19 and pY27). Biochemistry. 2004 43 : 13694 13706.
33. Sowa G, Pypaert M, Fulton D, Sessa WC. The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Proc Natl Acad Sci USA. 2003 100 : 6511 6516.
34. Razani B, Wang XB, Engelman JA, et al. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Mol Cell Biol. 2002 22 : 2329 2344.
35. Kim S, Pak Y. Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells. Biochem Biophys Res Comm. 2005 330 : 88 96.
36. Head BP, Patel HH, Roth DM, et al. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 281 : 26391 26399.
37. Lockwich TP, Liu X, Singh BB, et al. Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains. J Biol Chem. 2000 275 : 11934 11942.
38. Novitskaya V, Makarava N, Bellon A, et al. Probing the conformation of the prion protein within a single amyloid fibril using a novel immunoconformational assay. J Biol Chem. 2006 281 : 15536 15545.
39. Noursadeghi M, Tsang J, Haustein T, et al. Quantitative imaging assay for NF-κB nuclear translocation in primary human macrophages. J Immunol Methods. 2008 329 : 194 200.
40. Cheng M Sexl V, Sherr CJ, Roussel MF. Assembly of cyclin D-dependent kinase and titration of p27/KIP1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci USA. 1998 95 : 1091 1096.
41. Evan Gl, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001 411 : 342 348.
42. Clodi M, Vollenweider P, Klarlund J, et al. Effects of general receptor for phosphoinositides on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, GLUT4 translocation, and deoxyribonucleic acid synthesis. Endocrinology. 1998 139 : 4984 4990.
43. Wang QH, Bilan PJ, Tsakiridis T, et al. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1 adipocytes. Biochem J. 1998 331 : 917 928.
44. Kawamura S, Miyamoto S, Brown JH. Initiation and transduction of stretch induced Rho and Rac1 activation through caveolae. J Biol Chem. 2003 278 : 31111 31117.
45. Numaguchi K, Eguchi S, Yamakawa T, et al. Mechanotrans-duction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments. Circ Res. 1999 85 : 5 11.
46. Liu Y, Suzuki YJ, Day RM, Fanburg BL. Rho kinase-induced nuclear translocation of ERK1/2 in smooth muscle cell mitogen-esis caused by serotonin. Circ Res. 2004 95 : 579 586.