G72/G30 (DAOA) and juvenile-onset mood disorders

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 150, Issue 7, 2009, Pages 1007-1012

  Gomez, Lissette ^a   Wigg, Karen ^a   Feng, Yu ^a   Kiss, Eniko ^b   Kapornai, Krisztina ^b   Tamás, Zsuzsa ^c   Mayer, László ^b   Baji, Ildikó ^c   Daróczi, Gabriella ^b   Benák, István ^b   Kothencné, Viola Osváth ^b   Dombovári, Edit ^b   Kaczvinszk, Emília ^b   Besnyo, Márta ^c   Gádoros, Julia ^c   King, Nicole ^d   Székely, Judit ^e   Kovacs, Maria ^f   Vetró, Ágnes ^b   Kennedy, James L ^d   Barr, Cathy L ^a,g   more..

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF SZEGED   (Hungary)

^c Vadaskert Hospital   (Hungary)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^e SEMMELWEIS UNIVERSITY   (Hungary)

^f UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^g HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Association; Bipolar disorder; Child; DAOA; Depression; G72 G30; Genetics; Mood disorders

Indexed keywords

ADOLESCENT; ARTICLE; CHILD; DEXTRO AMINO ACID OXIDASE ACTIVATOR GENE; GENE; GENETIC ASSOCIATION; GENETIC LINKAGE; HUMAN; JUVENILE; MAJOR CLINICAL STUDY; MOOD DISORDER; NUCLEAR FAMILY; ONSET AGE; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; AGE OF ONSET; CHILD; D-AMINO-ACID OXIDASE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HUNGARY; LINKAGE DISEQUILIBRIUM; META-ANALYSIS AS TOPIC; MOOD DISORDERS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 70349306866     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30904     Document Type: Article

References (42)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. 2002. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30(1):97-101.
2. Abou Jamra R, Schmael C, Cichon S, Rietschel M, Schumacher J, Nothen MM. 2006. The G72/G30 gene locus in psychiatric disorders: A challenge to diagnostic boundaries? Schizophr Bull 32(4):599-608.
3. Barrett JC, Fry B, Maller J, Daly MJ. 2005. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 21(2):263-265. (Pubitemid 40202029)
4. Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nothen MM, et al. 2007. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 8:8.
5. Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, et al. 1998. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 20(1):70-73. (Pubitemid 28410348)
6. Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, Bassett AS. 1999. Linkage of familial schizophrenia to chromosome 13q32. Am J Hum Genet 65(4):1096-1103. (Pubitemid 30462967)
7. Chen YS, Akula N, Detera-Wadleigh SD, Schulze TG, Thomas J, Potash JB, DePaulo JR, McInnis MG, Cox NJ, McMahon FJ. 2004. Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. Mol Psychiatry 9(1):87-92, image 5. (Pubitemid 38175086)
8. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, et al. 2002. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 99(21):13675-13680. Epub 2002 Oct 3. (Pubitemid 35215440)
9. Clayton D. 1999. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65(4):1170-1177. (Pubitemid 30462974)
10. Craddock N, O'Donovan MC, Owen MJ. 2006. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 32(1):9-16. (Pubitemid 43063811)
11. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. 2005. Efficiency and power in genetic association studies. Nat Genet 37(11):1217-1223.
12. Detera-Wadleigh SD, McMahon FJ. 2006. G72/G30 in schizophrenia and bipolar disorder: Review and meta-analysis. Biol Psychiatry 60(2):106-114. Epub 2006 Apr 11.
13. Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G, Rollins DY, Moses T, Sanders AR, Karkera JD, et al. 1999. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 96(10):5604-5609. (Pubitemid 29234665)
14. Dudbridge F. 2003. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25(2):115-121. (Pubitemid 37064867)
15. Fallin MD, Lasseter VK, Avramopoulos D, Nicodemus KK, Wolyniec PS, McGrath JA, Steel G, Nestadt G, Liang KY, Huganir RL, et al. 2005. Bipolar I disorder and schizophrenia: A 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am J Hum Genet 77(6):918-936. (Pubitemid 41698514)
16. Geller B, Zimerman B, Williams M, Bolhofner K, Craney JL. 2001. Bipolar disorder at prospective follow-up of adults who had prepubertal major depressive disorder. Am J Psychiatry 158(1):125-127. (Pubitemid 32047258)
17. Goes FS, Zandi PP, Miao K, McMahon FJ, Steele J, Willour VL, Mackinnon DF, Mondimore FM, Schweizer B, Nurnberger JI Jr, et al. 2007. Moodincongruent psychotic features in bipolar disorder: Familial aggregation and suggestive linkage to 2p11-q14 and 13q. 21-33. Am J Psychiatry 164(2):236-247. (Pubitemid 46318561)
18. Hamilton SP, Fyer AJ, Durner M, Heiman GA, Baisre de Leon A, Hodge SE, Knowles JA, Weissman MM. 2003. Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q. Proc Natl Acad Sci USA 100(5):2550-2555. (Pubitemid 36297536)
19. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES. 2003. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72(5):1131-1140. Epub 2003 Mar 19. (Pubitemid 36530001)
20. Kapornai K, Gentzler AL, Tepper P, Kiss E, Mayer L, Tamas Z, Kovacs M, Vetro A. 2007. Early developmental characteristics and features of major depressive disorder among child psychiatric patients in Hungary. J Affect Disord 100(1-3):91-101. (Pubitemid 46818432)
21. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, et al. 2001. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98(2):585-590. Epub 2001 Jan 9. (Pubitemid 32105086)
22. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, Rush AJ, Walters EE, Wang PS. 2003. The epidemiology of major depressive disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA 289(23):3095-3105. (Pubitemid 37432885)
23. Kiss E, Gentzler AM, George C, Kapornai K, Tamas Z, Kovacs M, Vetro A. 2007. Factors influencing mother-child reports of depressive symptoms and agreement among clinically referred depressedyoungsters in Hungary. J Affect Disord 100(1-3):143-151. (Pubitemid 46830813)
24. Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D, Bernstein J, Bening-Abu-Shach U, Ben-Asher E, Lancet D, et al. 2004. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. Biol Psychiatry 56(3):169-176. (Pubitemid 38969149)
25. Kovacs M. 1996. Presentation and course of major depressive disorder during childhood and later years of the life span. JAmAcad Child Adolesc Psychiatry 35(6):705-715. (Pubitemid 26174604)
26. Kovacs M. 1997. The Emanuel Miller Memorial Lecture1994.Depressive disorders in childhood: An impressionistic landscape. 38(3):287-298.
27. Kovacs M, Akiskal HS, Gatsonis C, Parrone PL. 1994. Childhood-onset dysthymic disorder. Clinical features and prospective naturalistic outcome. Arch Gen Psychiatry 51(5):365-374.
28. Kvajo M, Dhilla A, Swor DE, Karayiorgou M, Gogos JA. 2007. Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function. Mol Psychiatry 13(7):685-696. (Pubitemid 351861528)
29. Lander E, Kruglyak L. 1995. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11(3):241-247.
30. Liu C, Badner JA, Christian SL, Guroff JJ, Detera-Wadleigh SD, Gershon ES. 2001. Fine mapping supports previous linkage evidence for a bipolar disorder susceptibility locus on 13q32. Am J Med Genet 105(4):375-380.
31. Liu X, Gentzler AL, Tepper P, Kiss E, Kothencne VO, Tamas Z, Vetro A, Kovacs M. 2006. Clinical features of depressed children and adolescents with various forms of suicidality. J Clin Psychiatry 67(9):1442-1450. (Pubitemid 44583394)
32. McGuffin P, Knight J, Breen G, Brewster S, Boyd PR, Craddock N, Gill M, Korszun A, Maier W, Middleton, et al. 2005. Whole genome linkage scan of recurrent depressive disorder from the depression network study. Hum Mol Genet 14(22):3337-3345. (Pubitemid 41672118)
33. McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A. 2003. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 60(5):497-502. (Pubitemid 36539059)
34. Park N, Juo SH, Cheng R, Liu J, Loth JE, Lilliston B, Nee J, Grunn A, Kanyas K, Lerer B, et al. 2004. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry 9(12):1091-1099. (Pubitemid 40065454)
35. Schumacher J, Jamra RA, Freudenberg J, Becker T, Ohlraun S, Otte AC, TulliusM,Kovalenko S, Bogaert AV, MaierW,et al. 2004. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry 9(2):203-207.
36. Schumacher J,AbouJamra R, Becker T, Klopp N, Franke P, Jacob C, Sand P, Fritze J, Ohlraun S, Schulze TG, et al. 2005. Investigation of the DAOA/ G30 locus in panic disorder. Mol Psychiatry 10(5):428-429. (Pubitemid 40646429)
37. Shaw SH, Mroczkowski-Parker Z, Shekhtman T, Alexander M, Remick RA, Sadovnick AD, McElroy SL, Keck PE Jr, Kelsoe JR. 2003. Linkage of a bipolar disorder susceptibility locus to human chromosome 13q32 in a new pedigree series. Mol Psychiatry 8(5):558-564. (Pubitemid 36829697)
38. Shi J, Badner JA, Gershon ES, Liu C. 2008. Allelic association of G72/G30 with schizophrenia and bipolar disorder: A comprehensive meta-analysis. Schizophr Res 98(1-3):89-97. (Pubitemid 350235905)
39. Stine OC, McMahon FJ, Chen L, Xu J, Meyers DA, MacKinnon DF, Simpson S, McInnis MG, Rice JP, Goate A, et al. 1997. Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: Chromosomes 2, 11 13, 14 and X. Am J Med Genet 74(3):263-269. (Pubitemid 27251224)
40. Strober M, Carlson G. 1982. Bipolar illness in adolescents with major depression: Clinical, genetic, and psychopharmacologic predictors in a three- to four-year prospective follow-up investigation. Arch Gen Psychiatry 39(5):549-555.
41. Wigg K, Feng Y, Gomez L, Kiss E, Kapornai K, Tamas Z, Mayer L, Baji I, Daroczi G, Benak I, et al. submitted. Genome scan in sibling pairs with juvenile-onset mood disorders: Evidence for linkage to 13q and Xq. Neuropsychiatr Genet.
42. Williams NM, Green EK, Macgregor S, Dwyer S, Norton N, Williams H, Raybould R, Grozeva D, Hamshere M, Zammit S, et al. 2006. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry 63(4):366-373.